SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation

scientific article

SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CELREP.2012.11.010
P3181OpenCitations bibliographic resource ID1511436
P932PMC publication ID3534891
P698PubMed publication ID23246001
P5875ResearchGate publication ID233939759

P2093author name stringLan Huang
Yihong Ye
Yingying Yang
Yue Xu
Mengli Cai
P2860cites workStructures of larger proteins in solution: three- and four-dimensional heteronuclear NMR spectroscopyQ22065583
The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulumQ24291942
A ribosome-associating factor chaperones tail-anchored membrane proteinsQ24293683
Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseQ24293757
Role of EDEM in the release of misfolded glycoproteins from the calnexin cycleQ24296412
Defining human ERAD networks through an integrative mapping strategyQ24298439
A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradationQ24305231
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chainsQ24307429
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERADQ24312778
Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membraneQ24336904
The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding siteQ24535990
Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein responseQ24548363
One step at a time: endoplasmic reticulum-associated degradationQ24658302
Structural determinants for the binding of ubiquitin-like domains to the proteasomeQ24685639
Road to ruin: targeting proteins for degradation in the endoplasmic reticulumQ26866096
Mechanism of ubiquitin recognition by the CUE domain of Vps9pQ27641385
Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin bindingQ27641386
Ubiquitin-like proteinsQ37992156
The mechanism of tail-anchored protein insertion into the ER membraneQ39502102
Bat3 promotes the membrane integration of tail-anchored proteinsQ41113412
Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require HerpQ42820056
A transgenic mouse model for monitoring endoplasmic reticulum stressQ44711192
A common sense approach to peak picking in two-, three-, and four-dimensional spectra using automatic computer analysis of contour diagrams. 1991.Q51479050
A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.Q52931787
Correlating backbone amide and side chain resonances in larger proteins by multiple relayed triple resonance NMRQ57080269
Protein Disulfide Isomerase Acts as a Redox-Dependent Chaperone to Unfold Cholera ToxinQ57180002
Human SGT interacts with Bag-6/Bat-3/Scythe and cells with reduced levels of either protein display persistence of few misaligned chromosomes and mitotic arrestQ84001054
Cooperative and independent activities of Sgt2 and Get5 in the targeting of tail-anchored proteinsQ84210293
Allosteric Activation of E2-RING Finger-Mediated Ubiquitylation by a Structurally Defined Specific E2-Binding Region of gp78Q27646351
Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2Q27653834
Crystal Structure of Get4-Get5 Complex and Its Interactions with Sgt2, Get3, and Ydj1Q27659241
A Structural Model of the Sgt2 Protein and Its Interactions with Chaperones and the Get4/Get5 ComplexQ27671664
Structures of the Sgt2/SGTA Dimerization Domain with the Get5/UBL4A UBL Domain Reveal an Interaction that Forms a Conserved Dynamic InterfaceQ27675050
NMRPipe: a multidimensional spectral processing system based on UNIX pipesQ27860859
A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradationQ27930372
Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumenQ27930448
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.Q27930706
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteinsQ27931299
A Chaperone Cascade Sorts Proteins for Posttranslational Membrane Insertion into the Endoplasmic ReticulumQ27931629
Yos9p detects and targets misfolded glycoproteins for ER-associated degradationQ27933494
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosolQ27936514
Comprehensive characterization of genes required for protein folding in the endoplasmic reticulumQ27937991
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1pQ27938951
HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteinsQ27939971
AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradationQ27939982
EDEM as an acceptor of terminally misfolded glycoproteins released from calnexinQ28212764
Modification of proteins by ubiquitin and ubiquitin-like proteinsQ28244250
The role of a novel p97/valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum-associated degradationQ28264480
ERAD: the long road to destructionQ28264823
BAG-6 is essential for selective elimination of defective proteasomal substratesQ28505838
Ubiquitin-binding domainsQ29614358
Role of intramembrane charged residues in the quality control of unassembled T-cell receptor alpha-chains at the endoplasmic reticulumQ33748594
Ubiquitin and its kin: how close are the family ties?Q33960480
Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functionsQ34266494
Retro-translocation of proteins from the endoplasmic reticulum into the cytosolQ34627241
Regulation of the 26S proteasome complex during oxidative stressQ35120069
Protein targeting and degradation are coupled for elimination of mislocalized proteinsQ35147351
Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapyQ35469778
Ubiquitin and ubiquitin-like proteins in cancer pathogenesisQ36601000
Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signalingQ36984127
ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulumQ37784156
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
chaperone bindingQ14633877
BAT3 complex bindingQ21109272
P304page(s)1633-44
P577publication date2012-12-27
P1433published inCell ReportsQ5058165
P1476titleSGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation
P478volume2

Reverse relations

cites work (P2860)
Q28087358A bacterial toxin and a nonenveloped virus hijack ER-to-cytosol membrane translocation pathways to cause disease
Q40215164A conserved island of BAG6/Scythe is related to ubiquitin domains and participates in short hydrophobicity recognition.
Q38542913A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum.
Q36947746A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation
Q64238335Absence of GdX/UBL4A Protects against Inflammatory Diseases by Regulating NF-кB Signaling in Macrophages and Dendritic Cells
Q38093231All roads lead to Rome (but some may be harder to travel): SRP-independent translocation into the endoplasmic reticulum
Q38168708BAG-6, a jack of all trades in health and disease
Q41482461BAG6 regulates the quality control of a polytopic ERAD substrate
Q24311324Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain
Q38082449Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation.
Q92178350Balancing the Photoreceptor Proteome: Proteostasis Network Therapeutics for Inherited Retinal Disease
Q43240834Binding of SGTA to Rpn13 selectively modulates protein quality control
Q28237362Cleaning up in the endoplasmic reticulum: ubiquitin in charge
Q96690036Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation
Q38863830Endoplasmic Reticulum-Associated Degradation and Lipid Homeostasis
Q43926288Expression and clinical role of small glutamine-rich tetratricopeptide repeat (TPR)-containing protein alpha (SGTA) as a novel cell cycle protein in NSCLC.
Q27468807How Polyomaviruses Exploit the ERAD Machinery to Cause Infection
Q100235790Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Q46465153Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion.
Q42292851Mechanistic basis for a molecular triage reaction
Q42224037Overexpression of BAT3 alleviates prion protein fragment PrP106-126-induced neuronal apoptosis.
Q28306492Perilous journey: a tour of the ubiquitin-proteasome system
Q26825374Prohibitin 2: At a communications crossroads
Q57036995Protein Quality Control in the Endoplasmic Reticulum and Cancer
Q38196654Quality control: ER-associated degradation: protein quality control and beyond
Q90678120SGTA associates with nascent membrane protein precursors
Q100157392SGTA binds mislocalized membrane protein
Q42371745SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism.
Q42186480SGTA regulates the cytosolic quality control of hydrophobic substrates
Q38709698SGTA-Dependent Regulation of Hsc70 Promotes Cytosol Entry of Simian Virus 40 from the Endoplasmic Reticulum
Q28545114Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A
Q26770509Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha
Q27929900Structural and functional characterization of ybr137wp implicates its involvement in the targeting of tail-anchored proteins to membranes
Q42011073Structural and functional insights into the E3 ligase, RNF126.
Q55657250Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control.
Q39474998Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis
Q35915784Subcellular Fractionation Analysis of the Extraction of Ubiquitinated Polytopic Membrane Substrate during ER-Associated Degradation
Q100157385Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP
Q36824020The Vpu-interacting Protein SGTA Regulates Expression of a Non-glycosylated Tetherin Species
Q34637885The association of BAG6 with SGTA and tail-anchored proteins
Q34075879The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors
Q33980716The final moments of misfolded proteins en route to the proteasome
Q24320201USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation
Q27321740Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching
Q50073383Unfolded Protein Response of the Endoplasmic Reticulum in Tumor Progression and Immunogenicity.

Search more.