A conserved island of BAG6/Scythe is related to ubiquitin domains and participates in short hydrophobicity recognition.

scientific article published on 10 December 2015

A conserved island of BAG6/Scythe is related to ubiquitin domains and participates in short hydrophobicity recognition. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/FEBS.13618
P8608Fatcat IDrelease_y6ysnlood5aurcvfxcj2anj76m
P698PubMed publication ID26663859

P50authorNaoyuki KuwabaraQ64682251
Tsunehiro MizushimaQ64682277
P2093author name stringHirofumi Tanaka
Ryuichi Kato
Toshiki Takahashi
Hiroyuki Kawahara
Masumi Shimada
Naoto Yokota
Yiming Xie
Ryosuke Minami
Yuko Yanagi
Rigel Suzuki
Mizuki Hayashishita
P2860cites workA ribosome-associating factor chaperones tail-anchored membrane proteinsQ24293683
Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6Q24300029
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53Q24301527
A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradationQ24305231
SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradationQ24306367
Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domainQ24311324
USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradationQ24320201
A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domainQ24558733
Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradationQ26828990
Structures of the Sgt2/SGTA Dimerization Domain with the Get5/UBL4A UBL Domain Reveal an Interaction that Forms a Conserved Dynamic InterfaceQ27675050
Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.Q27937556
Scythe regulates apoptosis through modulating ubiquitin-mediated proteolysis of the Xenopus elongation factor XEF1AO.Q41895930
SGTA regulates the cytosolic quality control of hydrophobic substratesQ42186480
Unique proteasome subunit Xrpn10c is a specific receptor for the antiapoptotic ubiquitin-like protein ScytheQ48109396
BAG6/BAT3 modulates autophagy by affecting EP300/p300 intracellular localizationQ28118502
Molecular chaperones in the cytosol: from nascent chain to folded proteinQ28205903
Protein aggregation and neurodegenerative diseaseQ28273600
Aggresomes: a cellular response to misfolded proteinsQ28292275
BAG-6 is essential for selective elimination of defective proteasomal substratesQ28505838
SGTA antagonizes BAG6-mediated protein triageQ28596609
BAT3 regulates Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis of macrophagesQ28727070
Impairment of the ubiquitin-proteasome system by protein aggregationQ29614556
Protein degradation and protection against misfolded or damaged proteinsQ29618400
Degradation signals for ubiquitin system proteolysis in Saccharomyces cerevisiaeQ32064390
A soluble fragment of the tumor antigen BCL2-associated athanogene 6 (BAG-6) is essential and sufficient for inhibition of NKp30 receptor-dependent cytotoxicity of natural killer cellsQ33292224
Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cellsQ33292289
Scythe: a novel reaper-binding apoptotic regulator.Q33889778
BAT3 guides misfolded glycoproteins out of the endoplasmic reticulumQ34103187
The association of BAG6 with SGTA and tail-anchored proteinsQ34637885
Hydrophobicity as a driver of MHC class I antigen processingQ35007960
The chaperone BAG6 captures dislocated glycoproteins in the cytosol.Q35110985
Protein targeting and degradation are coupled for elimination of mislocalized proteinsQ35147351
Dendritic cell aggresome-like induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteinsQ36322083
A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradationQ36947746
Tail-anchored membrane protein insertion into the endoplasmic reticulumQ37140792
The role of molecular chaperones in human misfolding diseasesQ37459598
BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagyQ37659719
Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms.Q37802039
BAG6/BAT3: emerging roles in quality control for nascent polypeptidesQ38070391
Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation.Q38082449
BAG-6, a jack of all trades in health and diseaseQ38168708
Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesisQ39474998
A cellular model to monitor proteasome dysfunction by alpha-synucleinQ39821184
Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activityQ40372471
Bat3 promotes the membrane integration of tail-anchored proteinsQ41113412
BAG6 regulates the quality control of a polytopic ERAD substrateQ41482461
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecthydrophobicityQ41854968
P304page(s)662-677
P577publication date2015-12-31
P1433published inFEBS JournalQ1388041
P1476titleA conserved island of BAG6/Scythe is related to ubiquitin domains and participates in short hydrophobicity recognition
P478volume283

Reverse relations

cites work (P2860)
Q47103155A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis.
Q92479518BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4
Q92270950BAG6 deficiency induces mis-distribution of mitochondrial clusters under depolarization
Q38842180Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases
Q64104486Cytoplasmic control of Rab family small GTPases through BAG6
Q44897873Elimination of a signal sequence-uncleaved form of defective HLA protein through BAG6.
Q42011073Structural and functional insights into the E3 ligase, RNF126.

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