BAG-6, a jack of all trades in health and disease

scientific article published on 04 December 2013

BAG-6, a jack of all trades in health and disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00018-013-1522-Y
P698PubMed publication ID24305946

P2093author name stringJoachim Koch
Janina Binici
P2860cites workA ribosome-associating factor chaperones tail-anchored membrane proteinsQ24293683
Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomesQ24294847
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53Q24301527
A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradationQ24305231
SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradationQ24306367
BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expressionQ24309660
Reversible inhibition of Hsp70 chaperone function by Scythe and ReaperQ24545641
A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domainQ24558733
Pleiotropic effects of the 8.1 HLA haplotype in patients with autoimmune myasthenia gravis and thymus hyperplasiaQ24562160
Common 5p15.33 and 6p21.33 variants influence lung cancer riskQ24646182
Crystal Structure of Get4-Get5 Complex and Its Interactions with Sgt2, Get3, and Ydj1Q27659241
The mechanism of membrane-associated steps in tail-anchored protein insertionQ27671975
The GET complex mediates insertion of tail-anchored proteins into the ER membraneQ27932687
Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.Q27937556
Molecular chaperone targeting and regulation by BAG family proteinsQ28190053
Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosisQ28190428
The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell linesQ28213806
Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3Q28244908
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunityQ28281686
Identification of a targeting factor for posttranslational membrane protein insertion into the ERQ28294726
BAG-6 is essential for selective elimination of defective proteasomal substratesQ28505838
Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosisQ28586062
The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian developmentQ28586611
Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesisQ28592901
BAT3 regulates Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis of macrophagesQ28727070
Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer functionQ28854563
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's diseaseQ28943440
Regulation of class II MHC expression in APCs: roles of types I, III, and IV class II transactivatorQ74500086
Cutting edge: neosynthesis is required for the presentation of a T cell epitope from a long-lived viral proteinQ74844304
The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cellsQ78842088
Human SGT interacts with Bag-6/Bat-3/Scythe and cells with reduced levels of either protein display persistence of few misaligned chromosomes and mitotic arrestQ84001054
Ceramide triggers budding of exosome vesicles into multivesicular endosomesQ29616811
A soluble fragment of the tumor antigen BCL2-associated athanogene 6 (BAG-6) is essential and sufficient for inhibition of NKp30 receptor-dependent cytotoxicity of natural killer cellsQ33292224
Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cellsQ33292289
Scythe: a novel reaper-binding apoptotic regulator.Q33889778
Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activityQ33891286
BAT3 guides misfolded glycoproteins out of the endoplasmic reticulumQ34103187
E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substratesQ34119372
What's in the 'BAG'?--A functional domain analysis of the BAG-family proteins.Q34156806
A novel BAT3 sequence generated by alternative RNA splicing of exon 11B displays cell type-specific expression and impacts on subcellular localizationQ34256996
AIF and Scythe (Bat3) regulate phosphatidylserine exposure and macrophage clearance of cells undergoing Fas (APO-1)-mediated apoptosisQ34450733
Protein targeting and degradation are coupled for elimination of mislocalized proteinsQ35147351
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.Q36377233
The macromolecular peptide-loading complex in MHC class I-dependent antigen presentationQ36390413
BAT3 interacts with transforming growth factor-beta (TGF-beta) receptors and enhances TGF-beta1-induced type I collagen expression in mesangial cellsQ36744209
A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradationQ36947746
Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death.Q37012498
The ubiquitylation machinery of the endoplasmic reticulumQ37424805
Biogenesis of tail-anchored proteins: the beginning for the end?Q37610681
BAG3: a multifaceted protein that regulates major cell pathwaysQ37862582
Mechanisms of tumor and viral immune escape from natural killer cell-mediated surveillanceQ37876089
Activating natural cytotoxicity receptors of natural killer cells in cancer and infectionQ38082002
Rescue of impaired NK cell activity in hodgkin lymphoma with bispecific antibodies in vitro and in patientsQ39185522
Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phasesQ39388766
Scythe cleavage during Fas (APO-1)-and staurosporine-mediated apoptosisQ39405079
γ-Interferon-regulated chaperone governs human lymphocyte antigen class II expressionQ39469460
Differential mechanisms of shedding of the glycosylphosphatidylinositol (GPI)-anchored NKG2D ligandsQ39614809
Sequential interplay between BAG6 and HSP70 upon heat shockQ39862448
The ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating caspase expressionQ40171434
Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cellsQ40211704
Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activityQ40372471
A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosisQ40723230
BAG-1 accelerates cell motility of human gastric cancer cellsQ40950288
Bat3 promotes the membrane integration of tail-anchored proteinsQ41113412
Ancestral haplotypes reveal the role of the central MHC in the immunogenetics of IDDMQ41649796
Scythe regulates apoptosis through modulating ubiquitin-mediated proteolysis of the Xenopus elongation factor XEF1AO.Q41895930
New prospects on the NKG2D/NKG2DL system for oncologyQ42796257
Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblastsQ43507062
Unique proteasome subunit Xrpn10c is a specific receptor for the antiapoptotic ubiquitin-like protein ScytheQ48109396
Regulation of apoptosis by Bat3-enhanced YWK-II/APLP2 protein stability.Q51758768
Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm.Q53312945
Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritisQ57667629
The major substrates for TAP in vivo are derived from newly synthesized proteinsQ59068841
Expression of BAG-1 in invasive breast carcinomasQ73181470
P433issue10
P304page(s)1829-1837
P577publication date2013-12-04
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleBAG-6, a jack of all trades in health and disease
P478volume71

Reverse relations

cites work (P2860)
Q40215164A conserved island of BAG6/Scythe is related to ubiquitin domains and participates in short hydrophobicity recognition.
Q33634944BAG2 structure, function and involvement in disease
Q92270950BAG6 deficiency induces mis-distribution of mitochondrial clusters under depolarization
Q24311324Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain
Q35611763Biological properties of extracellular vesicles and their physiological functions.
Q50291630CMVPP65 binds NCR3
Q55055302Cancer-derived extracellular vesicles: friend and foe of tumour immunosurveillance.
Q28081315Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates
Q36247731Collective Genetic Interaction Effects and the Role of Antigen-Presenting Cells in Autoimmune Diseases
Q64104486Cytoplasmic control of Rab family small GTPases through BAG6
Q36821101Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC.
Q92469390Differential Expression in Testis and Liver Transcriptomes from Four Species of Peromyscus (Rodentia: Cricetidae)
Q37670668E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia.
Q44897873Elimination of a signal sequence-uncleaved form of defective HLA protein through BAG6.
Q100387948Genes with 5' terminal oligopyrimidine tracts preferentially escape global suppression of translation by the SARS-CoV-2 NSP1 protein
Q39055067Homo-oligomerization of the activating natural killer cell receptor NKp30 ectodomain increases its binding affinity for cellular ligands
Q34046541Immunological off-target effects of imatinib
Q50291629NCR3LG1 binds NCR3
Q39181844RIG-I activation induces the release of extracellular vesicles with antitumor activity
Q39474998Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis
Q64248384The Natural Cytotoxicity Receptors in Health and Disease
Q40501505The Stalk Domain of NKp30 Contributes to Ligand Binding and Signaling of a Preassembled NKp30-CD3ζ Complex.
Q90319729The dynamic changes in the number of uterine natural killer cells are specific to the eutopic but not to the ectopic endometrium in women and in a baboon model of endometriosis
Q44571594The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress
Q38775370UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation