Human SGT interacts with Bag-6/Bat-3/Scythe and cells with reduced levels of either protein display persistence of few misaligned chromosomes and mitotic arrest

scientific article published on 13 May 2006

Human SGT interacts with Bag-6/Bat-3/Scythe and cells with reduced levels of either protein display persistence of few misaligned chromosomes and mitotic arrest is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YEXCR.2006.04.020
P698PubMed publication ID16777091

P50authorMartina SchnölzerQ32307470
P2093author name stringEugene C Gan
Herbert Spring
Tobias A Knoch
Jean Rommelaere
Marc Winnefeld
Annabel Grewenig
Celina Cziepluch
P2860cites workA family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like StchQ33890149
CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cellsQ33946743
A trimeric protein complex functions as a synaptic chaperone machine.Q34093245
Characterization of the G alpha(s) regulator cysteine string proteinQ34428333
Aurora kinases link chromosome segregation and cell division to cancer susceptibilityQ35756009
Progress in the discovery of polo-like kinase inhibitors.Q36107336
Progress in the development of selective inhibitors of Aurora kinasesQ36107339
Different combinations of the heat-shock cognate protein 70 (hsc70) C-terminal functional groups are utilized to interact with distinct tetratricopeptide repeat-containing proteinsQ38296271
Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40.Q38354169
Mutational analysis of narrow pores at the fivefold symmetry axes of adeno-associated virus type 2 capsids reveals a dual role in genome packaging and activation of phospholipase A2 activityQ40463686
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanismsQ41197754
Mammalian protein RAP46: an interaction partner and modulator of 70 kDa heat shock proteinsQ42061663
Activation of the ATPase activity of heat-shock proteins Hsc70/Hsp70 by cysteine-string proteinQ42216617
Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1.Q45952803
CENP-E as an essential component of the mitotic checkpoint in vitro.Q46518322
Aneuploidy and cancerQ56224730
Structural and functional analysis of poly(ADP ribose) polymerase: an immunological studyQ69029900
SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complexQ22003770
Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III regionQ24301622
Identification of a novel cellular TPR-containing protein, SGT, that interacts with the nonstructural protein NS1 of parvovirus H-1.Q24523131
GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1Q24536019
Reversible inhibition of Hsp70 chaperone function by Scythe and ReaperQ24545641
Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delayQ24561583
A hitchhiker's guide to the human Hsp70 familyQ24597572
Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosisQ24676290
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machineQ27622332
Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factorsQ27630011
RNA interference is mediated by 21- and 22-nucleotide RNAsQ27860764
A new technique for the assay of infectivity of human adenovirus 5 DNAQ27860797
Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeatsQ28138187
Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosisQ28190428
The human small glutamine-rich TPR-containing protein is required for progress through cell divisionQ28239233
Microtubules as a target for anticancer drugsQ28253993
A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string proteinQ28504634
Hip, a novel cochaperone involved in the eukaryotic hsc70/hsp40 reaction cycleQ28569622
Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functionsQ28572700
The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian developmentQ28586611
Alpha-cyano-4-hydroxycinnamic acid affinity sample preparation. A protocol for MALDI-MS peptide analysis in proteomicsQ30655285
Trichostatin A-induced histone acetylation causes decondensation of interphase chromatinQ33205477
P433issue13
P304page(s)2500-2514
P577publication date2006-05-13
P1433published inExperimental Cell ResearchQ1524289
P1476titleHuman SGT interacts with Bag-6/Bat-3/Scythe and cells with reduced levels of either protein display persistence of few misaligned chromosomes and mitotic arrest
P478volume312

Reverse relations

cites work (P2860)
Q34256996A novel BAT3 sequence generated by alternative RNA splicing of exon 11B displays cell type-specific expression and impacts on subcellular localization
Q28385780A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle
Q38040951A portrait of the GET pathway as a surprisingly complicated young man.
Q38168708BAG-6, a jack of all trades in health and disease
Q41482461BAG6 regulates the quality control of a polytopic ERAD substrate
Q36744209BAT3 interacts with transforming growth factor-beta (TGF-beta) receptors and enhances TGF-beta1-induced type I collagen expression in mesangial cells
Q28727070BAT3 regulates Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis of macrophages
Q36377233Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.
Q41113412Bat3 promotes the membrane integration of tail-anchored proteins
Q39647451Cotranslational Intersection between the SRP and GET Targeting Pathways to the Endoplasmic Reticulum of Saccharomyces cerevisiae
Q27659241Crystal Structure of Get4-Get5 Complex and Its Interactions with Sgt2, Get3, and Ydj1
Q43926288Expression and clinical role of small glutamine-rich tetratricopeptide repeat (TPR)-containing protein alpha (SGTA) as a novel cell cycle protein in NSCLC.
Q39159398Expression and prognostic role of SGTA in human breast carcinoma correlates with tumor cell proliferation
Q39128328Expression of SGTA correlates with prognosis and tumor cell proliferation in human hepatocellular carcinoma.
Q39688173Expression, purification and preliminary crystallographic analysis of recombinant human small glutamine-rich tetratricopeptide-repeat protein
Q27676804Get5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get4/Get5 Complex
Q100235790Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Q34179638Membrane protein insertion at the endoplasmic reticulum
Q27931740SGT2 and MDY2 interact with molecular chaperone YDJ1 in Saccharomyces cerevisiae
Q28596609SGTA antagonizes BAG6-mediated protein triage
Q24306367SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation
Q42186480SGTA regulates the cytosolic quality control of hydrophobic substrates
Q38118665SGTA: a new player in the molecular co-chaperone game
Q37054276Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice
Q37399343Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome
Q28545114Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A
Q55657250Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control.
Q36570230Structures of Get3, Get4, and Get5 provide new models for TA membrane protein targeting
Q27675050Structures of the Sgt2/SGTA Dimerization Domain with the Get5/UBL4A UBL Domain Reveal an Interaction that Forms a Conserved Dynamic Interface
Q37140792Tail-anchored membrane protein insertion into the endoplasmic reticulum
Q100157385Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP
Q39658274Temporal and Spatial Expression of LGR5 After Acute Spinal Cord Injury in Adult Rats
Q34637885The association of BAG6 with SGTA and tail-anchored proteins
Q34861540The co-chaperone SGT of Leishmania donovani is essential for the parasite's viability
Q35986793The complex process of GETting tail-anchored membrane proteins to the ER.
Q50862635Up-regulation of SGTB is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide.

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