| biological pathway | Q4915012 |
| protein insertion into ER membrane | Q21102060 |
| P2888 | exact match | https://identifiers.org/reactome:R-HSA-9609523 |
| P3937 | Reactome ID | R-HSA-9609523 |
| P2860 | cites work | A ribosome-associating factor chaperones tail-anchored membrane proteins | Q24293683 |
| Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6 | Q24300029 | ||
| A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation | Q24305231 | ||
| SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation | Q24306367 | ||
| Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain | Q24311324 | ||
| Structures of the Sgt2/SGTA Dimerization Domain with the Get5/UBL4A UBL Domain Reveal an Interaction that Forms a Conserved Dynamic Interface | Q27675050 | ||
| SGTA antagonizes BAG6-mediated protein triage | Q28596609 | ||
| The SND proteins constitute an alternative targeting route to the endoplasmic reticulum | Q33364351 | ||
| Targeting pathways of C-tail-anchored proteins. | Q34127127 | ||
| The association of BAG6 with SGTA and tail-anchored proteins | Q34637885 | ||
| WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane | Q35083500 | ||
| The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase | Q35127549 | ||
| Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation. | Q38082449 | ||
| A biochemical analysis of the constraints of tail-anchored protein biogenesis. | Q38780873 | ||
| On the road to nowhere: cross-talk between post-translational protein targeting and cytosolic quality control. | Q38860895 | ||
| Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis | Q39474998 | ||
| Structural and functional insights into the E3 ligase, RNF126. | Q42011073 | ||
| SGTA regulates the cytosolic quality control of hydrophobic substrates | Q42186480 | ||
| WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane | Q42280602 | ||
| Mechanistic basis for a molecular triage reaction | Q42292851 | ||
| Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing | Q44181535 | ||
| Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion. | Q46465153 | ||
| Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins | Q47108141 | ||
| Human SGT interacts with Bag-6/Bat-3/Scythe and cells with reduced levels of either protein display persistence of few misaligned chromosomes and mitotic arrest | Q84001054 | ||
| Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control | Q88456756 | ||
| P703 | found in taxon | Homo sapiens | Q15978631 |
| P527 | has part(s) | SGTA binds Tail-anchored protein | Q100157383 |
| Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP | Q100157385 | ||
| Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP | Q100157386 | ||
| Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane | Q100157389 | ||
| Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane | Q100157391 | ||
| SGTA binds mislocalized membrane protein | Q100157392 | ||
| BAG6:GET4:UBL4A binds mislocalized membrane protein:SGTA and ASNA1:ATP | Q100157394 | ||
| P361 | part of | Protein localization | Q56860999 |
| Q100157394 | BAG6:GET4:UBL4A binds mislocalized membrane protein:SGTA and ASNA1:ATP |
| Q100157383 | SGTA binds Tail-anchored protein |
| Q100157392 | SGTA binds mislocalized membrane protein |
| Q100157389 | Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane |
| Q100157391 | Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane |
| Q100157385 | Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP |
| Q100157386 | Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP |
| Q56860999 | Protein localization | has part(s) | P527 |
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