Mechanistic basis for a molecular triage reaction

scientific article published on January 2017

Mechanistic basis for a molecular triage reaction is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCIENCE.AAH6130
P932PMC publication ID5380214
P698PubMed publication ID28104892

P50authorRamanujan Shankar HegdeQ24004353
Sichen ShaoQ41953076
P2093author name stringMonica C Rodrigo-Brenni
Maryann H Kivlen
P2860cites workA ribosome-associating factor chaperones tail-anchored membrane proteinsQ24293683
Defining human ERAD networks through an integrative mapping strategyQ24298439
Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6Q24300029
SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradationQ24306367
Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domainQ24311324
The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologyQ27015793
The structural basis of tail-anchored membrane protein recognition by Get3Q27656979
Structural characterization of the Get4/Get5 complex and its interaction with Get3Q27662391
Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor ComplexQ27670623
The mechanism of membrane-associated steps in tail-anchored protein insertionQ27671975
Structures of the Sgt2/SGTA Dimerization Domain with the Get5/UBL4A UBL Domain Reveal an Interaction that Forms a Conserved Dynamic InterfaceQ27675050
Crystal structure of ATP-bound Get3–Get4–Get5 complex reveals regulation of Get3 by Get4Q27683285
Key steps in ERAD of luminal ER proteins reconstituted with purified componentsQ27929992
A Chaperone Cascade Sorts Proteins for Posttranslational Membrane Insertion into the Endoplasmic ReticulumQ27931629
The GET complex mediates insertion of tail-anchored proteins into the ER membraneQ27932687
Comprehensive characterization of genes required for protein folding in the endoplasmic reticulumQ27937991
Adapting proteostasis for disease interventionQ28131818
Identification of a targeting factor for posttranslational membrane protein insertion into the ERQ28294726
The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCTQ28590650
SGTA antagonizes BAG6-mediated protein triageQ28596609
The association of BAG6 with SGTA and tail-anchored proteinsQ34637885
In vitro dissection of protein translocation into the mammalian endoplasmic reticulumQ35065009
WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membraneQ35083500
Protein targeting and degradation are coupled for elimination of mislocalized proteinsQ35147351
A calmodulin-dependent translocation pathway for small secretory proteinsQ35751874
Cooperation of molecular chaperones with the ubiquitin/proteasome systemQ35967558
Mechanism of Assembly of a Substrate Transfer Complex during Tail-anchored Protein TargetingQ36444249
Precise timing of ATPase activation drives targeting of tail-anchored proteinsQ36835510
Tail-anchored membrane protein insertion into the endoplasmic reticulumQ37140792
Hsp104 and ClpB: protein disaggregating machinesQ37325250
Differential scales of protein quality controlQ38200251
Target Selection during Protein Quality ControlQ38656236
A biochemical analysis of the constraints of tail-anchored protein biogenesis.Q38780873
Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cellsQ39028018
The mechanism of tail-anchored protein insertion into the ER membraneQ39502102
Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargoQ40031008
Bat3 promotes the membrane integration of tail-anchored proteinsQ41113412
Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and PhosphorylationQ41884789
Structural and functional insights into the E3 ligase, RNF126.Q42011073
SGTA regulates the cytosolic quality control of hydrophobic substratesQ42186480
PURE technologyQ43142125
Binding of SGTA to Rpn13 selectively modulates protein quality controlQ43240834
Asna1/TRC40-mediated membrane insertion of tail-anchored proteinsQ44964243
Asymmetric damage segregation at cell division via protein aggregate fusion and attachment to organelles.Q52943994
High-yield cell-free protein synthesis for site-specific incorporation of unnatural amino acids at two sites.Q54343197
P433issue6322
P407language of work or nameEnglishQ1860
P304page(s)298-302
P577publication date2017-01-01
P1433published inScienceQ192864
P1476titleMechanistic basis for a molecular triage reaction
P478volume355

Reverse relations

cites work (P2860)
Q92680773A Polarity-Sensitive Fluorescent Amino Acid and its Incorporation into Peptides for the Ratiometric Detection of Biomolecular Interactions
Q57166648A structural perspective on tail-anchored protein biogenesis by the GET pathway
Q92642062A trap mutant reveals the physiological client spectrum of TRC40
Q92479518BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4
Q92270950BAG6 deficiency induces mis-distribution of mitochondrial clusters under depolarization
Q100157394BAG6:GET4:UBL4A binds mislocalized membrane protein:SGTA and ASNA1:ATP
Q64104486Cytoplasmic control of Rab family small GTPases through BAG6
Q90424090Guiding tail-anchored membrane proteins to the endoplasmic reticulum in a chaperone cascade
Q91727097In vitro Assays for Targeting and Insertion of Tail-Anchored Proteins Into the ER Membrane
Q100235790Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Q46465153Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion.
Q47108141Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins
Q89323809Myeloid-derived growth factor is a resident endoplasmic reticulum protein
Q90740558Quality Control of Orphaned Proteins
Q83227218Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins
Q90678120SGTA associates with nascent membrane protein precursors
Q100157383SGTA binds Tail-anchored protein
Q100157392SGTA binds mislocalized membrane protein
Q55657250Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control.
Q42700283Structure and Interactions of the TPR Domain of Sgt2 with Yeast Chaperones and Ybr137wp
Q89421739Substrate relay in an Hsp70-cochaperone cascade safeguards tail-anchored membrane protein targeting
Q100157385Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP
Q100157386Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP
Q47287563Targeting and translocation of proteins to the endoplasmic reticulum at a glance
Q47292355The ER membrane protein complex is a transmembrane domain insertase
Q52312170The VCP-UBXN1 complex mediates triage of ubiquitylated cytosolic proteins bound to the BAG6 complex.
Q95851107The architecture of EMC reveals a path for membrane protein insertion
Q49358535The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane
Q47993287UBE2O is a quality control factor for orphans of multiprotein complexes.

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