| scholarly article | Q13442814 |
| P50 | author | Hideki Nishitoh | Q73168283 |
| P2093 | author name string | Hisae Kadowaki | |
| P2860 | cites work | Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress | Q22010800 |
| Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 | ||
| XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease | Q22252318 | ||
| ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1 | Q22254333 | ||
| Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress | Q24290818 | ||
| Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response | Q24290935 | ||
| Plasma cell differentiation requires the transcription factor XBP-1 | Q24291453 | ||
| XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 | ||
| BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER | Q24293288 | ||
| A membrane protein required for dislocation of misfolded proteins from the ER | Q24297703 | ||
| A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol | Q24297732 | ||
| TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death | Q24298384 | ||
| Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum | Q24298901 | ||
| ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats | Q24298956 | ||
| PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage | Q33977034 | ||
| IRE1 and efferent signaling from the endoplasmic reticulum. | Q34062577 | ||
| Quality and quantity control at the endoplasmic reticulum | Q34090425 | ||
| Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis | Q34169287 | ||
| The unfolded protein response in familial amyotrophic lateral sclerosis | Q34549529 | ||
| Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians | Q34619934 | ||
| Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion | Q35008217 | ||
| Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum | Q35381401 | ||
| Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice | Q35709954 | ||
| Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice | Q35870151 | ||
| CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model | Q35870707 | ||
| The impact of the unfolded protein response on human disease | Q36062081 | ||
| Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo | Q36289970 | ||
| The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum | Q36321326 | ||
| Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. | Q36330343 | ||
| Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes | Q36393503 | ||
| The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth | Q36544374 | ||
| Glucose regulated proteins in cancer progression, drug resistance and immunotherapy | Q36544387 | ||
| IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis | Q36600595 | ||
| ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo | Q36640055 | ||
| GRP78 induction in cancer: therapeutic and prognostic implications. | Q36794164 | ||
| Activating transcription factor 4. | Q36805075 | ||
| Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes | Q36861224 | ||
| Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma | Q36943108 | ||
| Antioxidants reduce endoplasmic reticulum stress and improve protein secretion | Q36985084 | ||
| IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. | Q37091581 | ||
| The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice | Q37115015 | ||
| The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus | Q37164517 | ||
| Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits | Q37166665 | ||
| GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice | Q37170811 | ||
| ATF6 modulates SREBP2-mediated lipogenesis. | Q37260315 | ||
| Regulated Ire1-dependent decay of messenger RNAs in mammalian cells | Q37309146 | ||
| Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability | Q37377347 | ||
| Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME. | Q37433487 | ||
| Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells | Q24299603 | ||
| Luman is capable of binding and activating transcription from the unfolded protein response element | Q24300509 | ||
| Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element | Q24301000 | ||
| CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells | Q24301679 | ||
| Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response | Q24304232 | ||
| A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response | Q24305069 | ||
| A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin | Q24308676 | ||
| A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells | Q24309442 | ||
| Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha | Q24322072 | ||
| Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction | Q24324602 | ||
| Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane | Q24336904 | ||
| BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer | Q24337349 | ||
| CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P. | Q24338672 | ||
| Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane | Q24530318 | ||
| Clinical and molecular genetic analysis of 19 Wolfram syndrome kindreds demonstrating a wide spectrum of mutations in WFS1 | Q24539201 | ||
| The ER stress factor XBP1s prevents amyloid-beta neurotoxicity | Q24598012 | ||
| Endoplasmic reticulum stress and the inflammatory basis of metabolic disease | Q24633352 | ||
| XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy | Q24655821 | ||
| Protein folding and quality control in the ER | Q26823157 | ||
| Road to ruin: targeting proteins for degradation in the endoplasmic reticulum | Q26866096 | ||
| A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation | Q27930372 | ||
| Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins | Q27931299 | ||
| Defining the glycan destruction signal for endoplasmic reticulum-associated degradation | Q27932810 | ||
| The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment | Q27932818 | ||
| Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway | Q27932953 | ||
| A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response | Q27938493 | ||
| Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p | Q27938951 | ||
| Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum | Q27939524 | ||
| Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response | Q28139601 | ||
| Perk is essential for translational regulation and cell survival during the unfolded protein response | Q28140062 | ||
| EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome | Q28142981 | ||
| A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1 | Q28184746 | ||
| Translational control is required for the unfolded protein response and in vivo glucose homeostasis | Q28204066 | ||
| Hyperubiquitination of proteins in dilated cardiomyopathy | Q28211649 | ||
| The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi | Q28217040 | ||
| Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis | Q28258427 | ||
| Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis | Q28275274 | ||
| Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin | Q28276832 | ||
| Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase | Q28296183 | ||
| A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation | Q28296585 | ||
| A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress | Q28306995 | ||
| Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice | Q28359871 | ||
| Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death | Q28363890 | ||
| Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes | Q28506402 | ||
| PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation | Q28507769 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity | Q28508974 | ||
| CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum | Q28509611 | ||
| The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation | Q28510062 | ||
| EDEM1 accelerates the trimming of alpha1,2-linked mannose on the C branch of N-glycans | Q28510507 | ||
| ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER | Q28512215 | ||
| CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum | Q28512249 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis | Q28576685 | ||
| OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes | Q28580776 | ||
| Cloning of mammalian Ire1 reveals diversity in the ER stress responses | Q28587224 | ||
| Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion | Q28589308 | ||
| XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks | Q28591575 | ||
| Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway | Q28592107 | ||
| EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming | Q28593084 | ||
| Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival | Q28593963 | ||
| ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response | Q28611502 | ||
| Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response | Q29547299 | ||
| An integrated stress response regulates amino acid metabolism and resistance to oxidative stress | Q29547441 | ||
| Protein folding in the cell | Q29547792 | ||
| Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes | Q29615503 | ||
| Biological and chemical approaches to diseases of proteostasis deficiency | Q29616633 | ||
| ER stress triggers apoptosis by activating BH3-only protein Bim | Q29617730 | ||
| A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity | Q29617874 | ||
| The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol | Q29618773 | ||
| BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis | Q29620466 | ||
| Abeta(1-42) and aluminum induce stress in the endoplasmic reticulum in rabbit hippocampus, involving nuclear translocation of gadd 153 and NF-kappaB. | Q30308336 | ||
| Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. | Q30488194 | ||
| Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice | Q30494698 | ||
| Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma | Q30496396 | ||
| Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins | Q33262919 | ||
| The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells | Q33320542 | ||
| Activation of PERK signaling attenuates Abeta-mediated ER stress | Q33576967 | ||
| An essential role for XBP-1 in host protection against immune activation in C. elegans | Q33710158 | ||
| Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response | Q33713564 | ||
| Tripartite management of unfolded proteins in the endoplasmic reticulum | Q33941135 | ||
| Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway | Q33943895 | ||
| Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets. | Q51006407 | ||
| Modulation of ER stress and apoptosis by endoplasmic reticulum calcium leak via translocon during unfolded protein response: involvement of GRP78. | Q52633373 | ||
| A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery. | Q52931787 | ||
| Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance. | Q53181684 | ||
| A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants | Q57266990 | ||
| Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes | Q57920468 | ||
| A time-dependent phase shift in the mammalian unfolded protein response | Q72997174 | ||
| ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum | Q80935578 | ||
| Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1 | Q80979487 | ||
| Depression of proteasome activities during the progression of cardiac dysfunction in pressure-overloaded heart of mice | Q82222281 | ||
| Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses | Q84654008 | ||
| Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis | Q37465347 | ||
| ER stress-induced inflammation: does it aid or impede disease progression? | Q38033784 | ||
| Pharmacological targeting of endoplasmic reticulum stress signaling in cancer | Q38045731 | ||
| Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. | Q38311676 | ||
| Targeted disruption of CRE-binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stage | Q38322371 | ||
| Ablation of C/EBP homologous protein attenuates endoplasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overload | Q38342543 | ||
| Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways | Q38394944 | ||
| Overexpression of human X-box binding protein 1 (XBP-1) in colorectal adenomas and adenocarcinomas. | Q38433525 | ||
| Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response | Q38845249 | ||
| ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. | Q38947838 | ||
| Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion | Q39193328 | ||
| CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis | Q39709114 | ||
| Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation | Q39726471 | ||
| IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. | Q39814866 | ||
| The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis | Q39843795 | ||
| Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins | Q40015897 | ||
| High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes | Q40137823 | ||
| Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes | Q40176269 | ||
| Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer | Q40190855 | ||
| WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells | Q40367285 | ||
| XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. | Q40519913 | ||
| Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153). | Q40789492 | ||
| The stress response in Chinese hamster ovary cells. Regulation of ERp72 and protein disulfide isomerase expression and secretion. | Q41710374 | ||
| The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis | Q41791624 | ||
| Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity | Q42042260 | ||
| The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques. | Q42961940 | ||
| X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes | Q43156368 | ||
| Global changes to the ubiquitin system in Huntington's disease. | Q45305824 | ||
| A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice | Q46070173 | ||
| Inhibition of cardiac remodeling by pravastatin is associated with amelioration of endoplasmic reticulum stress | Q46241154 | ||
| Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells | Q46736495 | ||
| NF-kappaB activated by ER calcium release inhibits Abeta-mediated expression of CHOP protein: enhancement by AD-linked mutant presenilin 1. | Q46957270 | ||
| Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians | Q46966552 | ||
| The unfolded protein response is activated in Alzheimer's disease. | Q48839954 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 3 | |
| P921 | main subject | endoplasmic reticulum | Q79927 |
| P304 | page(s) | 306-333 | |
| P577 | publication date | 2013-07-01 | |
| P1433 | published in | Genes | Q5532699 |
| P1476 | title | Signaling pathways from the endoplasmic reticulum and their roles in disease | |
| P478 | volume | 4 |
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