Regulation of hepatic lipogenesis by the transcription factor XBP1

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Regulation of hepatic lipogenesis by the transcription factor XBP1 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.1158042
P3181OpenCitations bibliographic resource ID585740
P932PMC publication ID3620093
P698PubMed publication ID18556558
P5875ResearchGate publication ID5299300

P50authorLaurie GlimcherQ6501587
P2093author name stringAnn-Hwee Lee
David E. Cohen
Erez F. Scapa
P2860cites workPlasma cell differentiation requires the transcription factor XBP-1Q24291453
Fructose, insulin resistance, and metabolic dyslipidemiaQ24556527
Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate dietsQ24683319
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Lipopenia and skin barrier abnormalities in DGAT2-deficient miceQ28585990
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
An essential role in liver development for transcription factor XBP-1Q28593777
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposityQ33960868
APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradationQ34001437
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationQ34345459
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1cQ34682304
Microsomal triglyceride transfer protein: a multifunctional proteinQ35109358
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
Metabolic syndrome: focus on dyslipidemiaQ36461906
Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese miceQ38323956
Role for stearoyl-CoA desaturase-1 in leptin-mediated weight lossQ38364224
Regulation of the expression of lipogenic enzyme genes by carbohydrateQ41548602
Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanismsQ44832224
Effect of triton on lipoprotein lipase of rat plasmaQ74440651
P433issue5882
P407language of work or nameEnglishQ1860
P921main subjectX-box binding protein 1Q21992827
P304page(s)1492–1496
P577publication date2008-06-13
P1433published inScienceQ192864
P1476titleRegulation of hepatic lipogenesis by the transcription factor XBP1
P478volume320

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Q36024871Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis.
Q55023648Percutaneous muscle biopsy-induced tissue injury causes local endoplasmic reticulum stress.
Q46484710Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome
Q35907138Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model.
Q35747483Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation
Q52372960Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer.
Q28478056Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity
Q41583320Physiological/pathological ramifications of transcription factors in the unfolded protein response
Q42548169Physiology. Unfolding lipid metabolism
Q24628936Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease
Q90750222Potential Therapeutic Application of Estrogen in Gender Disparity of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Q34575640Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1.
Q52308796Preemptive activation of the integrated stress response protects mice from diet-induced obesity and insulin resistance via fibroblast growth factor 21 induction.
Q36635369Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver
Q36324486Protective Effects of Alisma orientale Extract against Hepatic Steatosis via Inhibition of Endoplasmic Reticulum Stress
Q88163993Protective effect of total flavonoid C-glycosides from Abrus mollis extract on lipopolysaccharide-induced lipotoxicity in mice
Q36196818Protein kinase R-like endoplasmic reticulum kinase and glycogen synthase kinase-3α/β regulate foam cell formation
Q38704807Protein misfolding in the endoplasmic reticulum as a conduit to human disease
Q99594846Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions
Q64256539R. verniciflua and E. ulmoides Extract (ILF-RE) Protects against Chronic CCl₄-Induced Liver Damage by Enhancing Antioxidation
Q28577788Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver
Q37802379Redox Balance in the Pathogenesis of Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities
Q33830140Redox control of liver function in health and disease
Q36114917Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet
Q37465347Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
Q47104159Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.
Q33886820Regulation of basal cellular physiology by the homeostatic unfolded protein response
Q34590456Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum
Q37352508Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences.
Q24303825Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation
Q90636660Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation
Q89450069Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice
Q36818384Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease
Q56979449Role of X-Box Binding Protein-1 in Fructose-Induced Lipogenesis in HepG2 Cells
Q37976132Role of endoplasmic reticulum stress in metabolic disease and other disorders.
Q26853645Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease
Q38116979Role of oxidative stress in the pathogenesis of alcohol-induced liver disease
Q54397189Role of the unfolded protein response in organ physiology: lessons from mouse models.
Q38210545Role of the unfolded protein response in β cell compensation and failure during diabetes
Q36497621Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis.
Q41128321Role of unfolded protein response in lipogenesis
Q37463911SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease
Q37236401STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.
Q24307512SUMO modification regulates the transcriptional activity of XBP1
Q35719978Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity
Q39614897Secretion of triacylglycerol-poor VLDL particles from McA-RH7777 cells expressing human hepatic lipase
Q37571396Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival
Q58611393Selenate Prevents Adipogenesis through Induction of Selenoprotein S and Attenuation of Endoplasmic Reticulum Stress
Q38202500Signaling pathways from the endoplasmic reticulum and their roles in disease
Q36330343Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.
Q37402827Simultaneous in vivo time course and dose response evaluation for TCDD-induced impairment of the LPS-stimulated primary IgM response
Q48184845Slfn2 mutation-induced loss of T-cell quiescence leads to elevated de novo sterol synthesis.
Q38318708Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function
Q99594216Stbd1 promotes glycogen clustering during endoplasmic reticulum stress and supports survival of mouse myoblasts
Q31004622Stochastic variation of transcript abundance in C57BL/6J mice
Q42391560Stress Signaling in the Methionine-Choline–Deficient Model of Murine Fatty Liver Disease
Q27009277Stress management: How the unfolded protein response impacts fatty liver disease
Q37894253Stressed out about obesity: IRE1α-XBP1 in metabolic disorders
Q59654517Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not w
Q37176759Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow
Q37512024Synthetic embryonic lethality upon deletion of the ER cochaperone p58(IPK) and the ER stress sensor ATF6α
Q35041384TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.
Q37682288Targeting IRE1 with small molecules counteracts progression of atherosclerosis
Q38811934Targeting endoplasmic reticulum stress in liver disease.
Q38489729Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases
Q35909430Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy
Q38132652Targeting the unfolded protein response in disease.
Q42970598Temporal clustering of gene expression links the metabolic transcription factor HNF4α to the ER stress-dependent gene regulatory network
Q57300008The Antidiabetic Drug Lobeglitazone Protects Mice From Lipogenesis-Induced Liver Injury via Mechanistic Target of Rapamycin Complex 1 Inhibition
Q64079826The Autophagic Flux Inhibitor Bafilomycine A1 Affects the Expression of Intermediary Metabolism-Related Genes in Trout Hepatocytes
Q35826684The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms
Q92000954The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc
Q39843795The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis
Q26776377The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment
Q37835256The Roles of Unfolded Protein Response Pathways in Chlamydia Pathogenesis
Q30249128The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis
Q55410760The TLR4-IRE1α pathway activation contributes to palmitate-elicited lipotoxicity in hepatocytes.
Q38093786The UPR and lung disease
Q37519318The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy
Q36497151The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism
Q37412003The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease
Q35085852The cell biology of the unfolded protein response.
Q37430626The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response
Q34860549The contribution of endoplasmic reticulum stress to liver diseases
Q35551757The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.
Q38206145The endoplasmic reticulum and unfolded protein response in the control of mammalian recombinant protein production
Q36954679The endoplasmic reticulum as a potential therapeutic target in nonalcoholic fatty liver disease
Q37231726The endoplasmic reticulum stress response in immunity and autoimmunity
Q55372811The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life.
Q37264190The genetics of neutral lipid biosynthesis: an evolutionary perspective
Q36062081The impact of the unfolded protein response on human disease
Q46273814The ins and outs of endoplasmic reticulum-controlled lipid biosynthesis
Q37168885The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans
Q37867697The mechanistic basis for the induction of hepatic steatosis by xenobiotics
Q27933904The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network
Q27023425The regulatory role of invariant NKT cells in tumor immunity
Q42363448The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development
Q38825911The role of ER stress in lipid metabolism and lipotoxicity
Q93350086The role of X-box binding protein 1 in the hepatic response to refeeding in mice
Q28587096The role of adipocyte XBP1 in metabolic regulation during lactation
Q27016052The role of dietary sugars and de novo lipogenesis in non-alcoholic fatty liver disease
Q38319892The role of the carbohydrate response element-binding protein in male fructose-fed rats
Q38093057The role of the unfolded protein response in diabetes mellitus
Q38248723The transcription factor X-box binding protein-1 in neurodegenerative diseases
Q36866561The unfolded protein response and gastrointestinal disease
Q38162132The unfolded protein response in fatty liver disease
Q38784676The unfolded protein response in skeletal development and homeostasis
Q37804460The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells
Q41904044The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis
Q29615499The unfolded protein response: controlling cell fate decisions under ER stress and beyond
Q24293771The unfolded protein response: integrating stress signals through the stress sensor IRE1α
Q38309617The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells.
Q34817393Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis
Q33743689Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization
Q34372272Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress.
Q38776013Tipping the Balance: Hepatotoxicity and the 4 Apical Key Events of Hepatic Steatosis
Q28589300Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis
Q36302806Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice.
Q41136131Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPARγ Signaling and Inflammation in Murine Mammary Tissue
Q33668708Transcriptional Regulation by CHIP/LDB Complexes
Q36744754Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function
Q34292835Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis
Q43263160Transcriptional changes associated with reduced spontaneous liver tumor incidence in mice chronically exposed to high dose arsenic
Q55073068Transcriptional profiling of swine mammary gland during the transition from colostrogenesis to lactogenesis using RNA sequencing.
Q24303861Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking
Q38343651Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site.
Q42559592Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice
Q42041480UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.
Q92166012Unfolded Protein Response as a Therapeutic Target in Cardiovascular Disease
Q57812386Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria, and Plasma Membrane
Q38218108Unfolded protein response in hepatitis C virus infection
Q41997586Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish
Q29248716Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer
Q55411030Unveiling “Musica Universalis” of the Cell: A Brief History of Biological 12-Hour Rhythms.
Q52699081Up-regulation of golgi α-mannosidase IA and down-regulation of golgi α-mannosidase IC activates unfolded protein response during hepatocarcinogenesis.
Q91832092Upregulation of Scavenger Receptor B1 Is Required for Steroidogenic and Nonsteroidogenic Cholesterol Metabolism in Prostate Cancer
Q53028338Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes.
Q38602520Ursodeoxycholic acid: effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients.
Q46740738Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress
Q55253186Vildagliptin Can Alleviate Endoplasmic Reticulum Stress in the Liver Induced by a High Fat Diet.
Q42820945X-box binding protein 1 enhances adipogenic differentiation of 3T3-L1 cells through the downregulation of Wnt10b expression
Q42835425X-box binding protein 1 is a novel key regulator of peroxisome proliferator-activated receptor γ2.
Q37015048X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function
Q34310315X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium
Q91960771XBP-1 Remodels Lipid Metabolism to Extend Longevity
Q24655821XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
Q24658399XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells
Q33739777XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.
Q39659690XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum
Q37377432XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development
Q104073438XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis
Q38291938XBP1s Is an Anti-lipogenic Protein
Q37381743Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila
Q26998690Xenobiotic perturbation of ER stress and the unfolded protein response
Q54260683[Modulating endoplasmic reticulum stress in the treatment of cancer].
Q90676339circDLPAG4/HECTD1 mediates ischaemia/reperfusion injury in endothelial cells via ER stress
Q28573820hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress
Q49714205p32 regulates ER stress and lipid homeostasis by down-regulating GCS1 expression

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