From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis

scientific article published on September 2009

From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1111/J.1749-6632.2009.04956.X
P932PMC publication ID3096021
P698PubMed publication ID19751410
P5875ResearchGate publication ID26809446

P50authorLaurie GlimcherQ6501587
Ann-Hwee LeeQ124214884
P2860cites workXBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans developmentQ24292104
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress responseQ24303865
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathwayQ24316367
Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding proteinQ24555088
Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcriptionQ24561983
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nucleaseQ24805574
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob miceQ28144106
Proteasome inhibitors disrupt the unfolded protein response in myeloma cellsQ28155919
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factorQ28238069
SREBP-1c transcription factor and lipid homeostasis: clinical perspectiveQ28291930
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevationQ28365331
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysisQ28508851
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liverQ28583240
Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in miceQ28584854
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Decreased lipid synthesis in livers of mice with disrupted Site-1 protease geneQ28588943
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
An essential role in liver development for transcription factor XBP-1Q28593777
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.Q33777806
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout miceQ33852162
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genesQ33878155
APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradationQ34001437
Insulin resistance and cardiovascular diseaseQ34011027
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationQ34345459
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.Q34451430
Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesisQ34497858
Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liverQ34532657
The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membraneQ34673029
Obesity, metabolic syndrome, and type 2 diabetes: emerging epidemics and their cardiovascular implicationsQ35926379
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodentsQ36183590
Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetesQ36321560
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
Metabolic syndrome: focus on dyslipidemiaQ36461906
Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesisQ36557194
Clinical practice. HypertriglyceridemiaQ36931446
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1aQ37360326
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cellsQ37364195
Regulation of sterol regulatory element binding proteins in livers of fasted and refed miceQ37375695
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.Q37382401
The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterolsQ38296407
Glucose and insulin function through two distinct transcription factors to stimulate expression of lipogenic enzyme genes in liver.Q38305621
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.Q38311106
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
The nuclear receptor LXR is a glucose sensorQ40190911
Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolismQ40709438
Regulation of the expression of lipogenic enzyme genes by carbohydrateQ41548602
Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAktQ42996869
Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes.Q42997321
Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcriptionQ43560420
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1cQ43848640
Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER.Q44317091
Functional analysis of secreted and transmembrane proteins critical to mouse development.Q46905044
Liver-specific inactivation of the abetalipoproteinemia gene completely abrogates very low density lipoprotein/low density lipoprotein production in a viable conditional knockout mouseQ64381636
A time-dependent phase shift in the mammalian unfolded protein responseQ72997174
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosisQ81441036
P407language of work or nameEnglishQ1860
P304page(s)E2-9
P577publication date2009-09-01
P1433published inAnnals of the New York Academy of SciencesQ2431664
P1476titleFrom sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis
P478volume1173 Suppl 1

Reverse relations

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