Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

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Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents is …
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scholarly articleQ13442814

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P356DOI10.1172/JCI32752
P932PMC publication ID2104481
P698PubMed publication ID18060040
P5875ResearchGate publication ID5788258

P2093author name stringTsuguhito Ota
Henry N Ginsberg
Constance Gayet
P2860cites workXBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78Q24306877
Inflammation, stress, and diabetesQ24523336
A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell deathQ24540224
A simple method for the isolation and purification of total lipides from animal tissuesQ25939009
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathwaysQ28365886
Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overloadQ28506232
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteinsQ28573980
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosisQ28576685
Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein BQ28625242
Banting lecture 1988. Role of insulin resistance in human diseaseQ29547283
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicityQ29614932
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Apolipoprotein B in the rough endoplasmic reticulum: translation, translocation and the initiation of lipoprotein assemblyQ33537983
Tripartite management of unfolded proteins in the endoplasmic reticulumQ33941135
Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic associationQ34112671
Microsomal triglyceride transfer protein binding and lipid transfer activities are independent of each other, but both are required for secretion of apolipoprotein B lipoproteins from liver cellsQ73894187
Conformational changes in apolipoprotein B modulate intracellular assembly and degradation of ApoB-containing lipoprotein particles in HepG2 cellsQ73965905
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosisQ81441036
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosisQ82677113
Therapeutic approaches to protein-misfolding diseasesQ34285075
Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteinsQ34634838
The unfolded protein response in nutrient sensing and differentiationQ34664763
Transcriptional and translational control in the Mammalian unfolded protein responseQ34762452
Mechanisms of metabolic dyslipidemia in insulin resistant states: deregulation of hepatic and intestinal lipoprotein secretionQ35011167
Regulation of plasma triglycerides in insulin resistance and diabetesQ36144459
Review: The role of insulin resistance in nonalcoholic fatty liver diseaseQ36591903
Endoplasmic reticulum stress signaling in diseaseQ36610455
Fatty liver and the metabolic syndromeQ36724600
Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiencyQ37118167
In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR.Q37374706
Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL productionQ37698834
Factors affecting lipoprotein metabolismQ40038704
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosisQ40294776
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cellsQ40313352
ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicityQ40386955
The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.Q40453939
Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation: evidence for Grp78-mediated targeting to proteasomal degradation.Q40477226
Increasing prevalence of the metabolic syndrome among u.s. Adults.Q40479545
Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophyQ40775950
Inhibition of translocation of nascent apolipoprotein B across the endoplasmic reticulum membrane is associated with selective inhibition of the synthesis of apolipoprotein B.Q40875126
Apolipoprotein B-100 destined for lipoprotein assembly and intracellular degradation undergoes efficient translocation across the endoplasmic reticulum membraneQ41161594
Intracellular degradation of newly synthesized apolipoprotein B.Q41646693
Transient arrest in proteasomal degradation during inhibition of translation in the unfolded protein responseQ42088013
The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathwaysQ43564087
Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B lipoproteins in a mouse with selective deficiency of brown adipose tissue, obesity, and insulin resistanceQ43764702
Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver diseaseQ44316104
Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER.Q44317091
Modulation of the JNK pathway in liver affects insulin resistance statusQ45032503
Involvement of endoplasmic reticulum stress in insulin resistance and diabetesQ45127777
Intracellular assembly of VLDL: two major steps in separate cell compartmentsQ45345943
Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosisQ46695184
Overproduction of large VLDL particles is driven by increased liver fat content in man.Q46931621
Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individualsQ47392377
Regulation of hepatic apolipoprotein B-lipoprotein assembly and secretion by the availability of fatty acids. I. Differential response to the delivery of fatty acids via albumin or remnant-like emulsion particles.Q51031951
The use of a non-ionic detergent (Triton WR 1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditionsQ52756540
Liver pathology and the metabolic syndrome X in severe obesity.Q54096450
Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion.Q54191086
Regulated Co-translational ubiquitination of apolipoprotein B100. A new paradigm for proteasomal degradation of a secretory proteinQ56971926
The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70Q56971940
Effects of fatty acids on apolipoprotein B secretion by McArdle RH-7777 rat hepatoma cellsQ60641840
Techniques for the chronic cannulation of the jugular vein in miceQ66948837
Homocystinuria due to cystathionine synthase deficiency: enzymatic and ultrastructural studiesQ69735284
VLDL output by hepatocytes from obese Zucker rats is resistant to the inhibitory effect of insulinQ72005778
Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cellsQ72571322
Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteinsQ73039105
Lipid metabolismQ73165028
Defective regulation of triglyceride metabolism by insulin in the liver in NIDDMQ73250750
Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamQ73561026
Metabolic basis of hypotriglyceridemic effects of insulin in normal menQ73596778
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)316-332
P577publication date2008-01-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleInhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
P478volume118

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