Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis

Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1055/S-0039-1681032
P932PMC publication ID6530577
P698PubMed publication ID30912096

P2093author name stringHarmeet Malhi
Jessica L Maiers
P2860cites workIdentification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factorsQ22008465
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cellsQ37388595
The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through AutophagyQ37519318
Role of Protein Quality Control Failure in Alcoholic Hepatitis PathogenesisQ37729414
The role of MAPK signalling pathways in the response to endoplasmic reticulum stressQ38179717
Kupffer cells: increasingly significant role in nonalcoholic fatty liver diseaseQ38242840
XBP1s Is an Anti-lipogenic ProteinQ38291938
METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.Q38297313
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress responseQ38326929
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed miceQ38354947
Lysophosphatidylcholine and lysophosphatidylinosiol--novel promissing signaling molecules and their possible therapeutic activityQ38368661
4μ8C Inhibits Insulin Secretion Independent of IRE1α RNase ActivityQ38742646
Unfolded protein response induced by Brefeldin A increases collagen type I levels in hepatic stellate cells through an IRE1α, p38 MAPK and Smad-dependent pathway.Q38772620
Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein responseQ38845249
Endoplasmic reticulum stress-induced hepatic stellate cell apoptosis through calcium-mediated JNK/P38 MAPK and Calpain/Caspase-12 pathwaysQ38981604
Inhibition of sphingosine 1-phosphate signaling ameliorates murine nonalcoholic steatohepatitisQ39049164
CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosisQ39709114
C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis.Q39726227
Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosisQ39731721
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.Q39814866
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytesQ40064603
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cellsQ40313352
Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2.Q40966919
Physiological/pathological ramifications of transcription factors in the unfolded protein responseQ41583320
Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese hamster ovary cellsQ41758613
Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing.Q41811106
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in miceQ41825121
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC developmentQ42199386
Autophagy mediated by endoplasmic reticulum stress enhances the caffeine-induced apoptosis of hepatic stellate cellsQ42280211
ER Stress-induced Inflammasome Activation Contributes to Hepatic Inflammation and SteatosisQ42355577
Synthesis of all plasma protein fractions except gamma globulins by the liver; the use of zone electrophoresis and lysine-epsilon-C14 to define the plasma proteins synthesized by the isolated perfused liverQ42926854
Pioglitazone reduces ER stress in the liver: direct monitoring of in vivo ER stress using ER stress-activated indicator transgenic mice.Q43269505
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.Q45345766
An unfolded protein-induced conformational switch activates mammalian IRE1.Q46020686
Current and Future Therapeutic Regimens for Non-alcoholic Fatty Liver Disease (NAFLD) and Non-alcoholic Steatohepatitis (NASH).Q46057830
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.Q46228637
Fatty acid cycling in human hepatoma cells and the effects of troglitazoneQ46508430
The effect of oleic and palmitic acid on induction of steatosis and cytotoxicity on rat hepatocytes in primary cultureQ46623219
Acyl chain-dependent effect of lysophosphatidylcholine on human neutrophilsQ46989306
In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stressQ47230349
Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulumQ47388417
Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4.Q47863231
The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesityQ48043703
The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerizationQ49545301
Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signalingQ49850608
The synthesis rates of total liver protein and plasma albumin determined simultaneously in vivo in humansQ50161065
Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteinsQ50336381
Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis.Q50485855
The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice.Q51224682
Quercetin stimulates mitochondrial apoptosis dependent on activation of endoplasmic reticulum stress in hepatic stellate cells.Q51544437
Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT/enhancer-binding protein homologous protein deficiency.Q51767284
Toxoplasma gondii dense granule protein 15 induces apoptosis in choriocarcinoma JEG-3 cells through endoplasmic reticulum stress.Q52582464
Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation.Q52657397
Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance.Q53181684
Endoplasmic reticulum stress of Kupffer cells involved in the conversion of natural regulatory T cells to Th17 cells in liver ischemia-reperfusion injury.Q53336916
Ischemia-reperfusion injury of the liver with special reference to calcium-dependent mechanismsQ34548138
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expressionQ34563098
The RtcB RNA ligase is an essential component of the metazoan unfolded protein responseQ34691382
The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cellsQ34807567
Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagyQ35152201
Mmu-miR-615-3p regulates lipoapoptosis by inhibiting C/EBP homologous proteinQ35330939
Death receptor 5 signaling promotes hepatocyte lipoapoptosisQ35604362
ER stress activates the NLRP3 inflammasome via an UPR-independent pathwayQ35723848
Hepatocyte transplantation into diseased mouse liver. Kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid hepatocytesQ35829671
Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone CalnexinQ35930512
Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosisQ35939383
Structural Insights into IRE1 Functions in the Unfolded Protein ResponseQ36148938
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodentsQ36183590
A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cellsQ36189494
ER stress induces NLRP3 inflammasome activation and hepatocyte death.Q36293033
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress responseQ36322641
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injectionQ36365792
Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar dietQ36382065
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domainsQ36712468
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetesQ36861041
Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagyQ36941185
C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitisQ36967242
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.Q37091581
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight lossQ37105351
Liver Injury and the Activation of the Hepatic MyofibroblastsQ37109402
ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice.Q37132127
ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading.Q37188851
ATF6 modulates SREBP2-mediated lipogenesis.Q37260315
Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER StressQ37294234
Membrane phospholipid synthesis and endoplasmic reticulum functionQ37308781
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stressQ58545168
IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs.Q64999429
Betaine effects on hepatic methionine metabolism elicited by short-term ethanol feedingQ71721014
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosisQ81441036
ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosisQ84283864
Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic SteatohepatitisQ89115325
IRE1α aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cellsQ89406106
Alcoholic liver diseaseQ90988810
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell FateQ91004301
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein responseQ24292966
A synthetic biology approach identifies the mammalian UPR RNA ligase RtcBQ24301555
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradationQ24302539
Palmitoylated calnexin is a key component of the ribosome-translocon complexQ24304833
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cellsQ24309442
Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathwayQ24537844
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosisQ24554008
Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac FibrosisQ27333658
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis networkQ27933904
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein responseQ28589998
Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assemblyQ28624200
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stressQ29615495
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseQ29619334
Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent mannerQ30701525
A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in miceQ33604576
Azithromycin for idiopathic acute exacerbation of idiopathic pulmonary fibrosis: a retrospective single-center studyQ33814559
Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell deathQ33840334
Regulation of basal cellular physiology by the homeostatic unfolded protein responseQ33886820
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.Q33960826
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesityQ34181503
Extensive translatome remodeling during ER stress response in mammalian cellsQ34264546
Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feedingQ34524224
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)235-248
P577publication date2019-05-01
P1433published inSeminars in Liver DiseaseQ15724477
P1476titleEndoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis
P478volume39

Reverse relations

cites work (P2860)
Q98612728Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats
Q89574652Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development
Q92528732Effects of Portulaca Oleracea Extract on Acute Alcoholic Liver Injury of Rats
Q99609335Lipid-Induced Mechanisms of Metabolic Syndrome
Q89650897Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis
Q92156218Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis

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