Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet

scientific article

Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPGI.00132.2015
P932PMC publication ID4683298
P698PubMed publication ID26472223

P2093author name stringXiaoying Liu
Richard M Green
Kristy A Anderson
Matthew J Schipma
Anne S Henkel
Brian E LeCuyer
P2860cites workSpironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose dietQ43138230
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese miceQ43224118
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injuryQ46823993
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosisQ82677113
Deficiency in apolipoprotein E has a protective effect on diet-induced nonalcoholic fatty liver disease in miceQ84526280
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and CufflinksQ24633890
Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994Q28384968
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox stateQ28572472
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver diseaseQ29614897
The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological AssociationQ29617157
The natural history of nonalcoholic fatty liver disease: a population-based cohort studyQ29617161
Nonalcoholic fatty liver diseaseQ29619354
In vitro and in vivo models of non-alcoholic fatty liver disease (NAFLD).Q30452333
Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liverQ34078580
Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver diseaseQ34404491
Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of diseaseQ34427653
PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic diseaseQ34759018
Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human conditionQ35562084
Cytokines and the pathogenesis of non-alcoholic steatohepatitisQ35598104
GENECODIS: a web-based tool for finding significant concurrent annotations in gene listsQ35724720
A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver diseaseQ36028519
Endoplasmic reticulum stress in liver diseaseQ36031838
Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient dietsQ36061647
GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomicsQ36088447
Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient dietQ36114917
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver diseaseQ36889026
Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistanceQ37038490
GeneCodis: interpreting gene lists through enrichment analysis and integration of diverse biological informationQ37245619
Correlates and heritability of nonalcoholic fatty liver disease in a minority cohortQ37259440
The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver diseaseQ37412003
Endoplasmic reticulum stress, obesity and diabetesQ37926034
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitisQ37953770
Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalentQ40762653
Non-alcoholic fatty liver disease (NAFLD): a tale of fat and sugar?Q41766493
Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in miceQ42428652
P433issue12
P304page(s)G965-74
P577publication date2015-10-15
P1433published inAmerican Journal of Physiology - Gastrointestinal and Liver PhysiologyQ15765756
P1476titleHepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet
P478volume309

Reverse relations

cites work (P2860)
Q472160073D-Printed Gelatin Scaffolds of Differing Pore Geometry Modulate Hepatocyte Function and Gene Expression
Q55503094Apoptosis and non-alcoholic fatty liver diseases.
Q50420689Developmental origins of non-alcoholic fatty liver disease as a risk factor for exaggerated metabolic and cardiovascular-renal disease.
Q64057135Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis
Q97522970Endoplasmic reticulum stress and liver diseases
Q47643998Farnesoid X Receptor Signaling Activates the Hepatic X-box Binding Protein 1 Pathway in vitro and in Mice
Q39048675Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice
Q102220441Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α
Q64999429IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs.
Q47104419Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice
Q87753980Interaction between stress responses and circadian metabolism in metabolic disease
Q38759104Lipotoxicity pathways intersect in hepatocytes: Endoplasmic reticulum stress, c-Jun N-terminal kinase-1, and death receptors
Q49843619Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response
Q57057500Loss of hepatocyte β-Catenin protects mice from experimental porphyria-associated liver injury
Q37519318The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy
Q36302806Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice.

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