IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis

scientific article published on October 2012

IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CMET.2012.09.003
P932PMC publication ID3569089
P698PubMed publication ID23040069
P5875ResearchGate publication ID232064802

P2093author name stringBrian N Finck
Randal J Kaufman
Vivian Lam
Shiyu Wang
Nicholas O Davidson
Zhouji Chen
Jaeseok Han
Justin Hassler
P2860cites workEndoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory responseQ24304232
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease riskQ27003094
A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomeraseQ28294961
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteinsQ28573980
Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidationQ28590076
Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48Q28594252
Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assemblyQ28624200
Inducible gene targeting in miceQ29614544
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistanceQ33604466
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout miceQ33852162
Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretionQ33863614
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) stimulates VLDL assembly through activation of cell death-inducing DFFA-like effector B (CideB)Q34074263
Protein disulfide isomerases contribute differentially to the endoplasmic reticulum-associated degradation of apolipoprotein B and other substratesQ35756661
Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in miceQ35870151
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodentsQ36183590
Obesity and atherogenic dyslipidemiaQ36820192
ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob miceQ36836010
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.Q37157342
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndromeQ37195515
From endoplasmic-reticulum stress to the inflammatory responseQ37225354
Endoplasmic reticulum stress: a new actor in the development of hepatic steatosis.Q37750327
IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA.Q39422225
Diurnal regulation of MTP and plasma triglyceride by CLOCK is mediated by SHP.Q39673179
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.Q40236795
Epoxide hydrolase is a marker for the smooth endoplasmic reticulum in rat liverQ41425827
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolismQ41909224
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Effects of high-fructose diet on lipogenic enzymes and their substrate and effector levels in diabetic ratsQ54080858
Protein disulfide isomerase appears necessary to maintain the catalytically active structure of the microsomal triglyceride transfer proteinQ68000602
Assembly of rat hepatic very low density lipoproteins in the endoplasmic reticulumQ70550719
Independence of the chaperone activity of protein disulfide isomerase from its thioredoxin-like active siteQ71891840
Origin of triacylglycerol moiety of plasma very low density lipoproteins in the rat: structural studiesQ72133666
The microsomal triglyceride transfer protein catalyzes the post-translational assembly of apolipoprotein B-100 very low density lipoprotein in McA-RH7777 cellsQ74230917
Use of cytosolic triacylglycerol hydrolysis products and of exogenous fatty acid for the synthesis of triacylglycerol secreted by cultured rat hepatocytesQ77313684
Quantitative proteomics analysis of the secretory pathwayQ79438532
P4510describes a project that usesImageJQ1659584
P433issue4
P304page(s)473-486
P577publication date2012-10-01
P1433published inCell MetabolismQ1254684
P1476titleIRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis
P478volume16

Reverse relations

cites work (P2860)
Q51444023Acetoacetic acid induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes.
Q37597070Adipocyte spliced form of X-box-binding protein 1 promotes adiponectin multimerization and systemic glucose homeostasis
Q33858526Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion.
Q36596344C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver
Q41826140Cholesteryl ester transfer protein alters liver and plasma triglyceride metabolism through two liver networks in female mice
Q47813504Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response
Q92255067Coupling of COPII vesicle trafficking to nutrient availability by the IRE1α-XBP1s axis
Q50987952Cross-Talk Between FSH and Endoplasmic Reticulum Stress: A Mutually Suppressive Relationship.
Q49884136Cyclophilin D Deficiency Attenuates Mitochondrial Perturbation and Ameliorates Hepatic Steatosis.
Q90196919Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis
Q42362670Dysregulated expression of proteins associated with ER stress, autophagy and apoptosis in tissues from nonalcoholic fatty liver disease
Q50968208ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis.
Q33620277ER stress and hepatic lipid metabolism
Q37366999ER-stress in Alzheimer's disease: turning the scale?
Q37189088Endoplasmic Reticulum Stress May Play a Pivotal Role in Lipid Metabolic Disorders in a Novel Mouse Model of Subclinical Hypothyroidism
Q37673642Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice
Q64057135Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis
Q38557011Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease
Q97522970Endoplasmic reticulum stress and liver diseases
Q33828303Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease
Q57243233Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications
Q51246528Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid β-oxidation and ketogenesis via activating XBP1 signaling in liver.
Q64949783Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.
Q50075685Harnessing the Power of Invariant Natural Killer T Cells in Cancer Immunotherapy
Q50898708Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion.
Q51324999Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.
Q39048675Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice
Q36382065Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet
Q102220441Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α
Q33945101Hsp90 modulates PPARγ activity in a mouse model of nonalcoholic fatty liver disease
Q64999429IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs.
Q37658270IRE1α-XBP1 pathway promotes melanoma progression by regulating IL-6/STAT3 signaling
Q64896373IRE1α-XBP1 signaling pathway regulates IL-6 expression and promotes progression of hepatocellular carcinoma.
Q35077000Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100.
Q47104419Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice
Q34988108Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells
Q87753980Interaction between stress responses and circadian metabolism in metabolic disease
Q27015015Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases
Q37469224LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition
Q64067098Leaf Extract Reverts Hypertriglyceridemia via Downregulation of the Hepatic XBP-1s/PDI/MTP Axis in Monosodium L-Glutamate-Induced Obese Rats
Q34107296Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling.
Q49843619Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response
Q36286532MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo
Q90484369MicroRNAs: Unfolding the Link Between Inositol-Requiring Enzyme 1α and Fatty Liver
Q36850321Microsomal triglyceride transfer protein inhibition induces endoplasmic reticulum stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST
Q38076705Minireview: endoplasmic reticulum stress: control in protein, lipid, and signal homeostasis.
Q60908807Modulation of Protein Synthesis by eIF2α Phosphorylation Protects Cell from Heat Stress-Mediated Apoptosis
Q37602836Molecular signal networks and regulating mechanisms of the unfolded protein response
Q61443337Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
Q64923775PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.
Q90245451Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy
Q41583320Physiological/pathological ramifications of transcription factors in the unfolded protein response
Q38704807Protein misfolding in the endoplasmic reticulum as a conduit to human disease
Q98578238Redox Regulation of Metabolic Syndrome: Recent Developments in Skeletal Muscle Insulin Resistance and Non-alcoholic Fatty Liver Disease (NAFLD)
Q91740491Regulation of the homeostasis of hepatic endoplasmic reticulum and cytochrome P450 enzymes by autophagy
Q26853645Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease
Q37463911SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease
Q38202500Signaling pathways from the endoplasmic reticulum and their roles in disease
Q41175972Sublethal endoplasmic reticulum stress caused by the mutation of immunoglobulin heavy chain-binding protein induces the synthesis of a mitochondrial protein, pyrroline-5-carboxylate reductase 1.
Q37512024Synthetic embryonic lethality upon deletion of the ER cochaperone p58(IPK) and the ER stress sensor ATF6α
Q38074493Targeting endoplasmic reticulum stress in metabolic disease
Q38969073Targeting microsomal triglyceride transfer protein and lipoprotein assembly to treat homozygous familial hypercholesterolemia
Q42970598Temporal clustering of gene expression links the metabolic transcription factor HNF4α to the ER stress-dependent gene regulatory network
Q89903604The patatin-like phospholipase domain containing protein 7 facilitates VLDL secretion by modulating ApoE stability
Q38410893The pathophysiology of intestinal lipoprotein production.
Q27023425The regulatory role of invariant NKT cells in tumor immunity
Q38825911The role of ER stress in lipid metabolism and lipotoxicity
Q93350086The role of X-box binding protein 1 in the hepatic response to refeeding in mice
Q28587096The role of adipocyte XBP1 in metabolic regulation during lactation
Q38248723The transcription factor X-box binding protein-1 in neurodegenerative diseases
Q36866561The unfolded protein response and gastrointestinal disease
Q38162132The unfolded protein response in fatty liver disease
Q34372272Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress.
Q35666919Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress
Q55073068Transcriptional profiling of swine mammary gland during the transition from colostrogenesis to lactogenesis using RNA sequencing.
Q37488392Unfolded protein response signaling and metabolic diseases
Q34923990Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.
Q92795478Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells
Q89685069Vitamin D receptor targets hepatocyte nuclear factor 4α and mediates protective effects of vitamin D in nonalcoholic fatty liver disease

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