IRE1α-XBP1 signaling pathway regulates IL-6 expression and promotes progression of hepatocellular carcinoma.

scientific article

IRE1α-XBP1 signaling pathway regulates IL-6 expression and promotes progression of hepatocellular carcinoma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/OL.2018.9176
P932PMC publication ID6126152
P698PubMed publication ID30214606

P2093author name stringJie Li
Yi Zheng
Lingli Zhou
Shanshan Huang
Hengwei Fan
Guangyao Zhou
Peipei Fang
Chenwei Pan
Lingxiang Jin
Lu Zhuge
Luxia Xiang
P2860cites workX-box Binding Protein 1 Regulates Unfolded Protein, Acute-Phase, and DNA Damage Responses During Regeneration of Mouse LiverQ45863602
The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesityQ48043703
Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.Q51324999
XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress.Q53676823
Serum levels of cytokines in chronic liver diseasesQ68169595
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Global cancer statistics, 2012Q27860501
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Hepatocellular carcinoma: epidemiology and molecular carcinogenesisQ28306363
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Regulation of glucose homeostasis through a XBP-1-FoxO1 interactionQ28592129
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
The mammalian unfolded protein responseQ29547400
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expressionQ29615766
Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence.Q33973463
Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.Q34572339
STAT3 is necessary for proliferation and survival in colon cancer-initiating cellsQ34971936
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.Q35041384
A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alphaQ35183001
NF-κB and STAT3 - key players in liver inflammation and cancerQ35347976
Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomasQ36407235
The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolismQ36497151
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt.Q37165847
Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesisQ37255168
IRE1α-XBP1 pathway promotes melanoma progression by regulating IL-6/STAT3 signalingQ37658270
IL-6 and related cytokines as the critical lynchpins between inflammation and cancerQ38189509
IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1.Q38347956
Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differencesQ39964655
High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B.Q39997004
Role for the endoplasmic reticulum stress sensor IRE1α in liver regenerative responsesQ41628812
ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC developmentQ42199386
The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cellsQ42858034
Roles of activated Src and Stat3 signaling in melanoma tumor cell growthQ44172485
P433issue4
P304page(s)4729-4736
P577publication date2018-07-19
P1433published inOncology LettersQ20640514
P1476titleIRE1α-XBP1 signaling pathway regulates IL-6 expression and promotes progression of hepatocellular carcinoma.
P478volume16

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cites work (P2860)
Q93155378Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis
Q90423329HNF4α-Deficient Fatty Liver Provides a Permissive Environment for Sex-Independent Hepatocellular Carcinoma
Q92538749Molecular Insight Into the IRE1α-Mediated Type I Interferon Response Induced by Proteasome Impairment in Myeloid Cells of the Brain
Q93173659Thapsigargin promotes colorectal cancer cell migration through upregulation of lncRNA MALAT1
Q92795478Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells

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