Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.

scientific article published on 27 March 2014

Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014NatCo...5.3528S
P356DOI10.1038/NCOMMS4528
P698PubMed publication ID24670948
P5875ResearchGate publication ID261138343

P50authorMengle ShaoQ37377253
Yifu QiuQ61786046
P2093author name stringYang Liu
Yong Liu
Jia Li
Weiping Jia
Ying Wu
Liu Yang
Shan Jiang
Liangyou Rui
Yiping Deng
Jingya Li
Cheng Yan
Ting Mao
Yubo Zhou
Bo Shan
P2860cites workMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cellsQ24297587
Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylationQ24303825
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fastingQ24563197
Endocrine fibroblast growth factors 15/19 and 21: from feast to famineQ24629260
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injectionQ24646028
The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signalingQ27008029
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein responseQ27933479
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disordersQ28116120
Peroxisome proliferator-activated receptors: nuclear control of metabolismQ28374684
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Regulation of glucose homeostasis through a XBP-1-FoxO1 interactionQ28592129
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic statesQ29615208
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21Q29615209
A Phos-tag-based approach reveals the extent of physiological endoplasmic reticulum stressQ33641274
PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolismQ35229188
p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasisQ35419603
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolismQ36497151
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
The role for endoplasmic reticulum stress in diabetes mellitusQ37019672
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.Q39616865
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesisQ39843795
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.Q40236795
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesisQ41791624
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Experimental diabetic ketoacidosis. Sequential changes of metabolic intermediates in blood, liver, cerebrospinal fluid and brain after acute insulin deprivation in the streptozotocin-diabetic ratQ42560988
A transgenic mouse model for monitoring endoplasmic reticulum stressQ44711192
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-IIQ81144490
P407language of work or nameEnglishQ1860
P304page(s)3528
P577publication date2014-03-27
P1433published inNature CommunicationsQ573880
P1476titleHepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling
P478volume5

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