Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice

scientific article published on 5 October 2017

Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLMET.2017.09.006
P932PMC publication ID5699917
P698PubMed publication ID29157602

P2093author name stringShantel Olivares
Anne S Henkel
P2860cites workA regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein responseQ24305069
FGF-21 as a novel metabolic regulatorQ24523933
Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant StateQ24625976
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivoQ24632545
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation responseQ24653481
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytesQ28571616
FGF21 is an endocrine signal of protein restrictionQ28572009
Fibroblast growth factor 21 is induced by endoplasmic reticulum stressQ28581415
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic statesQ29615208
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21Q29615209
FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in HumansQ29655262
Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitisQ33553744
ATF4- and CHOP-dependent induction of FGF21 through endoplasmic reticulum stressQ33681667
Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding.Q34299026
Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosisQ34396839
A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ miceQ34503382
Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitusQ34699946
Fibroblast growth factor 21 corrects obesity in miceQ34805555
p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasisQ35419603
Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient dietQ35613153
Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out miceQ35709954
Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient dietsQ36061647
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar dietQ36382065
Hepatic Xbp1 Gene Deletion Promotes Endoplasmic Reticulum Stress-induced Liver Injury and ApoptosisQ36444262
The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolismQ36497151
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Fibroblast growth factor 21 mediates specific glucagon actionsQ36796145
Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic dietQ36889022
Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver diseaseQ36889026
Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivityQ37328872
Interplay between FGF21 and insulin action in the liver regulates metabolismQ37524205
A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism.Q37571422
PPARalpha is a key regulator of hepatic FGF21.Q38300403
Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance.Q41760918
Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease.Q42972684
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese miceQ43224118
Response to carbohydrate and fat refeeding in the expression of genes involved in nutrient partitioning and metabolism: striking effects on fibroblast growth factor-21 induction.Q43259536
Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man.Q45966977
Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver.Q46327498
The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.Q46445480
Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humansQ46770146
FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fastingQ48659709
Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.Q51324999
Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity.Q51379603
Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress.Q53654532
A high-fat, ketogenic diet induces a unique metabolic state in miceQ79771171
Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21Q84079985
P433issue12
P304page(s)1616-1624
P577publication date2017-10-05
P1433published inMolecular MetabolismQ27724805
P1476titleInduction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice
P478volume6

Reverse relations

cites work (P2860)
Q93350086The role of X-box binding protein 1 in the hepatic response to refeeding in mice
Q91940222XBP1 inhibits mesangial cell apoptosis in response to oxidative stress via the PTEN/AKT pathway in diabetic nephropathy

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