| scholarly article | Q13442814 |
| P50 | author | Laurie Glimcher | Q6501587 |
| Andreas Birkenfeld | Q56953506 | ||
| Blas A Guigni | Q82834816 | ||
| Varman T Samuel | Q92904946 | ||
| Mario Kahn | Q114735206 | ||
| Ann-Hwee Lee | Q124214884 | ||
| Michael J. Jurczak | Q42172823 | ||
| François R Jornayvaz | Q47154382 | ||
| Gerald I. Shulman | Q52509909 | ||
| P2093 | author name string | Hui-Young Lee | |
| P2860 | cites work | Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 |
| XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 | ||
| Endoplasmic reticulum stress and the inflammatory basis of metabolic disease | Q24633352 | ||
| Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation | Q24673179 | ||
| The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307) | Q28139056 | ||
| IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA | Q28214814 | ||
| Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance | Q28253498 | ||
| Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4 | Q28343432 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease | Q28571421 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance | Q28583146 | ||
| XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response | Q28585314 | ||
| XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks | Q28591575 | ||
| Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction | Q28592129 | ||
| Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice | Q28593025 | ||
| Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity | Q29614241 | ||
| Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes | Q29615503 | ||
| Cellular mechanisms of insulin resistance | Q29619549 | ||
| A central role for JNK in obesity and insulin resistance | Q29619778 | ||
| Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance | Q33556664 | ||
| Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance | Q33558164 | ||
| Prevention of steatosis by hepatic JNK1 | Q33580974 | ||
| Diacylglycerol-mediated insulin resistance | Q34109119 | ||
| Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. | Q53614203 | ||
| Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy | Q34237562 | ||
| A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain | Q34305197 | ||
| XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation | Q34345459 | ||
| Lipid-induced insulin resistance: unravelling the mechanism | Q34370958 | ||
| Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. | Q34454336 | ||
| Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. | Q35101294 | ||
| Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease | Q35239565 | ||
| Ceramides as modulators of cellular and whole-body metabolism | Q35484864 | ||
| The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome | Q35901803 | ||
| Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity | Q36082167 | ||
| Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice | Q37136747 | ||
| GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization. | Q37625838 | ||
| JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction | Q37725556 | ||
| Chromium alleviates glucose intolerance, insulin resistance, and hepatic ER stress in obese mice | Q38292063 | ||
| Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. | Q38297724 | ||
| Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice | Q39890544 | ||
| The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. | Q40453939 | ||
| A stress signaling pathway in adipose tissue regulates hepatic insulin resistance | Q41811449 | ||
| Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. | Q42033681 | ||
| UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. | Q42041480 | ||
| SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function | Q42153763 | ||
| Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice | Q42427575 | ||
| Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress | Q42451739 | ||
| Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. | Q42462295 | ||
| Irs1 serine 307 promotes insulin sensitivity in mice | Q42563623 | ||
| Analyzing JNK and p38 mitogen-activated protein kinase activity | Q43576969 | ||
| Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle | Q43990155 | ||
| Involvement of endoplasmic reticulum stress in insulin resistance and diabetes | Q45127777 | ||
| Fasting does not impair insulin-stimulated glucose uptake but alters intracellular glucose metabolism in conscious rats. | Q45994575 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | insulin resistance | Q1053470 |
| preproinsulin | Q7240673 | ||
| P304 | page(s) | 2558-2567 | |
| P577 | publication date | 2011-11-28 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice | |
| P478 | volume | 287 |
| Q100568447 | A MicroRNA Linking Human Positive Selection and Metabolic Disorders |
| Q51090438 | A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice. |
| Q28392033 | A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches |
| Q37580289 | Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. |
| Q36867522 | Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress. |
| Q93039449 | Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model |
| Q46255295 | Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling |
| Q37624383 | Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance |
| Q40744393 | Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency |
| Q41159195 | CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha |
| Q33720375 | Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP. |
| Q36628493 | Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance |
| Q33827309 | Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression |
| Q90196919 | Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis |
| Q35196985 | Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy |
| Q50420689 | Developmental origins of non-alcoholic fatty liver disease as a risk factor for exaggerated metabolic and cardiovascular-renal disease. |
| Q35964800 | Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance |
| Q38812145 | Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance. |
| Q58756411 | ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes |
| Q36507568 | Effect of Cudrania tricuspidata and Kaempferol in Endoplasmic Reticulum Stress-Induced Inflammation and Hepatic Insulin Resistance in HepG2 Cells |
| Q55285283 | Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia. |
| Q38925531 | Endoplasmic reticulum proteostasis in hepatic steatosis. |
| Q44826419 | Endoplasmic reticulum stress: from physiology to pathogenesis of type 2 diabetes |
| Q38287666 | Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity |
| Q37012363 | Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle |
| Q36746091 | Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes. |
| Q36236384 | Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism. |
| Q42368231 | Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease. |
| Q40170609 | Glucose-regulated protein 78 is an antiviral against hepatitis A virus replication |
| Q64971617 | H19 lncRNA Promotes Skeletal Muscle Insulin Sensitivity in Part by Targeting AMPK. |
| Q36461013 | Have guidelines addressing physical activity been established in nonalcoholic fatty liver disease? |
| Q54533780 | Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver. |
| Q64096707 | Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism |
| Q58616116 | Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH |
| Q102220441 | Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α |
| Q37611624 | Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance |
| Q47104419 | Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice |
| Q37174503 | Inflammation during obesity is not all bad: evidence from animal and human studies |
| Q34550852 | Inflammation, metaflammation and immunometabolic disorders |
| Q34627663 | Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II. |
| Q42284517 | Insights into the Hexose Liver Metabolism-Glucose versus Fructose |
| Q37711785 | Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion |
| Q27015015 | Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases |
| Q47200958 | Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation |
| Q35130458 | Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis |
| Q38872713 | Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment |
| Q49843619 | Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response |
| Q89216457 | Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction |
| Q36444070 | Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity |
| Q47296522 | Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice |
| Q47610898 | Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes |
| Q29620447 | Mechanisms for insulin resistance: common threads and missing links |
| Q90685522 | Mechanisms of Insulin Action and Insulin Resistance |
| Q28397370 | Nickel chloride (NiCl2) in hepatic toxicity: apoptosis, G2/M cell cycle arrest and inflammatory response |
| Q42127633 | Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). |
| Q37624982 | Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes |
| Q36527942 | Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways |
| Q34377342 | PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. |
| Q50089788 | Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms |
| Q37139415 | Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice. |
| Q34826217 | Refeeding-induced brown adipose tissue glycogen hyper-accumulation in mice is mediated by insulin and catecholamines |
| Q26772023 | Research Advances on Pathways of Nickel-Induced Apoptosis |
| Q36818384 | Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease |
| Q38760082 | Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance |
| Q37068691 | Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo |
| Q38202500 | Signaling pathways from the endoplasmic reticulum and their roles in disease |
| Q36330343 | Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. |
| Q36850263 | Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue. |
| Q90597304 | Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14 |
| Q34413057 | The Role of INDY in Metabolic Regulation |
| Q30249128 | The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis |
| Q36501622 | The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. |
| Q37024780 | The role of lipids in the pathogenesis and treatment of type 2 diabetes and associated co-morbidities |
| Q38093057 | The role of the unfolded protein response in diabetes mellitus |
| Q41828232 | The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease |
| Q34483620 | The transcription factor XBP1 is selectively required for eosinophil differentiation |
| Q38291938 | XBP1s Is an Anti-lipogenic Protein |
| Q41195914 | eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet |
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