Endoplasmic reticulum stress: from physiology to pathogenesis of type 2 diabetes

scientific article published in August 2013

Endoplasmic reticulum stress: from physiology to pathogenesis of type 2 diabetes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1051/MEDSCI/2013298015
P9108Erudit article ID2013298015
P698PubMed publication ID24005631
P5875ResearchGate publication ID256449239

P50authorFabienne FoufelleQ57058031
P2093author name stringMélissa Flamment
P2860cites workCoupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
Endoplasmic reticulum stress and type 2 diabetesQ26864238
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndromeQ28142981
Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cellQ28145075
Translational control is required for the unfolded protein response and in vivo glucose homeostasisQ28204066
Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1cQ28297047
Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetesQ28506554
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosisQ28576685
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survivalQ28593963
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cellsQ33320542
Misfolded proinsulin affects bystander proinsulin in neonatal diabetesQ33581459
Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cellsQ33709904
Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transportQ33719171
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.Q34024266
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell deathQ34564595
Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humansQ34615491
Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connectionQ35073626
Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out miceQ35709954
The impact of the unfolded protein response on human diseaseQ36062081
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodentsQ36183590
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetesQ36861224
Initiation and execution of lipotoxic ER stress in pancreatic beta-cellsQ36910693
Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.Q36943752
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight lossQ37105351
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
New insights into ER stress-induced insulin resistance.Q38024445
Targeting endoplasmic reticulum stress in metabolic diseaseQ38074493
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cellsQ38331321
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasomeQ39299566
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.Q39299575
Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cellsQ39456738
Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress.Q39523027
A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.Q39603113
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetesQ40137823
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetesQ40176269
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.Q40236795
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosisQ40294776
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
Epidemiology of diabetes: frightening predictionsQ46649690
Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6.Q50527927
Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets.Q51006407
P433issue8-9
P407language of work or nameFrenchQ150
P921main subjectendoplasmic reticulumQ79927
type 2 diabetesQ3025883
P304page(s)756-764
P577publication date2013-08-01
P1433published inmédecine/sciencesQ3332441
P1476titleEndoplasmic reticulum stress: from physiology to pathogenesis of type 2 diabetes
P478volume29

Reverse relations

cites work (P2860)
Q53657401Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart.
Q53091487[Interaction between environment and genetic background in type 2 diabetes: lessons from animal models].

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