Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis

scientific article published on 20 September 2019

Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S12276-019-0309-0
P932PMC publication ID6802632
P698PubMed publication ID31541078

P50authorByung-Chul OhQ40331860
P2093author name stringSangkyu Lee
Eun Ju Bae
Byung-Hyun Park
Oh Kwang Kwon
Dami Park
Lihua Hao
In Hyuk Bang
Myung-Ja Chung
P2860cites workXBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of PparγQ24294883
Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylationQ24303825
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatinQ24310658
Nonalcoholic fatty liver disease: update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionineQ26992163
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein responseQ28589998
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
In-gel digestion for mass spectrometric characterization of proteins and proteomesQ29547583
Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseQ29614930
Mediators of endoplasmic reticulum stress-induced apoptosisQ29615496
Nonalcoholic fatty liver diseaseQ29619354
The Identification of a SIRT6 Activator from Brown Algae Fucus distichusQ33833447
Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride SynthesisQ34112535
Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out miceQ35709954
Endoplasmic reticulum stress in liver diseaseQ36031838
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestrationQ36139803
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.Q36501622
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver diseaseQ37463911
Sirtuin 2 aggravates postischemic liver injury by deacetylating mitogen-activated protein kinase phosphatase-1.Q37561307
Endoplasmic reticulum stress in nonalcoholic fatty liver diseaseQ38027194
Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesityQ38287666
Anti-diabetic effect of 3-hydroxy-2-naphthoic acid, an endoplasmic reticulum stress-reducing chemical chaperoneQ38293182
SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescenceQ38780858
Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistanceQ39388424
Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.Q39821961
A protocol for rapid generation of recombinant adenoviruses using the AdEasy systemQ40124490
Resveratrol prevents hepatic steatosis and endoplasmic reticulum stress and regulates the expression of genes involved in lipid metabolism, insulin resistance, and inflammation in ratsQ40857241
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolismQ41762089
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressorQ42510083
Overexpression of sirtuin 6 suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritisQ44447800
Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptorQ45200756
Integrated approach for manual evaluation of peptides identified by searching protein sequence databases with tandem mass spectra.Q51435922
Natural polyphenols as sirtuin 6 modulators.Q51743284
Overexpression of sirtuin 6 suppresses allergic airway inflammation through deacetylation of GATA3.Q53150086
UBC9 regulates the stability of XBP1, a key transcription factor controlling the ER stress responseQ86309337
Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor αQ91762663
Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synoviumQ93078303
P433issue9
P921main subjectsteatosisQ1365091
P304page(s)1-11
P577publication date2019-09-20
P1433published inExperimental and Molecular MedicineQ15758292
P1476titleDeacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis
P478volume51

Reverse relations

Q96342094Sirt6 alleviated liver fibrosis by deacetylating conserved lysine 54 on Smad2 in hepatic stellate cellscites workP2860

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