scholarly article | Q13442814 |
P2093 | author name string | Sung Hoon Back | |
Randal J Kaufman | |||
Suzanne Jackowski | |||
Y Eugene Chen | |||
Roberta Leonardi | |||
Shiyu Wang | |||
Lin Chang | |||
Wenbo Xu | |||
Guohui Wang | |||
Kezhong Zhang | |||
Hongzhi Miao | |||
Justin R Hassler | |||
Jyoti Malhotra | |||
P2860 | cites work | Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 |
Plasma cell differentiation requires the transcription factor XBP-1 | Q24291453 | ||
Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members | Q24291503 | ||
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 | ||
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development | Q24292104 | ||
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells | Q24297587 | ||
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats | Q24298956 | ||
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response | Q24304232 | ||
Evolutionarily conserved gene family important for fat storage | Q24305054 | ||
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells | Q24309442 | ||
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha | Q24322072 | ||
Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response | Q24534422 | ||
Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein | Q24564221 | ||
Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha | Q24631304 | ||
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis | Q24645996 | ||
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response | Q24672592 | ||
Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application | Q24803815 | ||
DAVID: Database for Annotation, Visualization, and Integrated Discovery | Q27499374 | ||
Signal integration in the endoplasmic reticulum unfolded protein response | Q27860577 | ||
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus | Q27930818 | ||
IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae | Q27935778 | ||
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase | Q27938837 | ||
Proteasome inhibitors disrupt the unfolded protein response in myeloma cells | Q28155919 | ||
Translational control is required for the unfolded protein response and in vivo glucose homeostasis | Q28204066 | ||
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA | Q28214814 | ||
The organization, promoter analysis, and expression of the human PPARgamma gene | Q28244071 | ||
Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein | Q28256013 | ||
Regulated translation initiation controls stress-induced gene expression in mammalian cells | Q28506388 | ||
Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation | Q28510062 | ||
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha | Q28512201 | ||
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response | Q28585314 | ||
Cloning of mammalian Ire1 reveals diversity in the ER stress responses | Q28587224 | ||
An essential role in liver development for transcription factor XBP-1 | Q28593777 | ||
The mammalian unfolded protein response | Q29547400 | ||
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress | Q29547441 | ||
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls | Q29547730 | ||
Lipid droplets: a unified view of a dynamic organelle | Q29614467 | ||
Fat and beyond: the diverse biology of PPARgamma | Q29615416 | ||
Coping with stress: eIF2 kinases and translational control | Q29619787 | ||
A phase 2 study of bortezomib in relapsed, refractory myeloma | Q33348702 | ||
Bortezomib-induced severe hepatitis in multiple myeloma: a case report | Q33365214 | ||
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. | Q33777806 | ||
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis. | Q42832143 | ||
Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling | Q43073146 | ||
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. | Q44477314 | ||
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages | Q44542540 | ||
Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers. | Q53543252 | ||
Liver regeneration | Q55883809 | ||
DNA excision in liver by an albumin-Cre transgene occurs progressively with age | Q61203358 | ||
An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat | Q64374832 | ||
Enzymatic determination of total serum cholesterol | Q69744405 | ||
Very-low-density lipoprotein assembly and secretion | Q33939429 | ||
Liver regeneration: from laboratory to clinic | Q34419499 | ||
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes | Q34835012 | ||
Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases | Q34992771 | ||
Translational control of C/EBPalpha and C/EBPbeta isoform expression. | Q35199785 | ||
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents | Q36183590 | ||
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. | Q36322684 | ||
Bortezomib: proteasome inhibition as an effective anticancer therapy | Q36366801 | ||
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice | Q36479005 | ||
Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids | Q36561243 | ||
A proposed model of fat packaging by exchangeable lipid droplet proteins | Q36589548 | ||
Gene therapy, bioengineered clotting factors and novel technologies for hemophilia treatment | Q36801646 | ||
Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. | Q36983521 | ||
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion | Q36985084 | ||
Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity. | Q36986765 | ||
From endoplasmic-reticulum stress to the inflammatory response | Q37225354 | ||
The endoplasmic reticulum stress response in immunity and autoimmunity | Q37231726 | ||
Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). | Q37281827 | ||
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease | Q37310283 | ||
Mechanisms of disease progression in nonalcoholic fatty liver disease | Q37310288 | ||
Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids | Q37367423 | ||
Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis. | Q37447893 | ||
Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assembly | Q37746984 | ||
Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. | Q38309701 | ||
PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes. | Q38332175 | ||
Bioengineering of coagulation factor VIII for improved secretion | Q38345967 | ||
Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. | Q39622895 | ||
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis | Q39843795 | ||
Mechanisms targeting apolipoprotein B100 to proteasomal degradation: evidence that degradation is initiated by BiP binding at the N terminus and the formation of a p97 complex at the C terminus | Q39891720 | ||
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice | Q39975807 | ||
Inhibition of proteasome by bortezomib causes intracellular aggregation of hepatic serpins and increases the latent circulating form of antithrombin. | Q40025076 | ||
Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells. | Q40291997 | ||
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells | Q40313352 | ||
Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells | Q40339637 | ||
Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo | Q40385723 | ||
Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis | Q41291617 | ||
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. | Q42041480 | ||
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress | Q42518206 | ||
P433 | issue | 7 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 1357-1375 | |
P577 | publication date | 2011-03-15 | |
P1433 | published in | The EMBO Journal | Q1278554 |
P1476 | title | The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis | |
P478 | volume | 30 |
Q37622393 | A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability |
Q52317839 | A data-entrained computational model for testing the regulatory logic of the vertebrate unfolded protein response. |
Q28539163 | Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish |
Q36867522 | Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress. |
Q35747758 | Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells |
Q91755491 | Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells via Hepatocyte Growth Factor/c-Met Signaling in Obesity-Associated Kidney Injury |
Q49687928 | Autophagy Dysregulation and Obesity-Associated Pathologies. |
Q37000389 | Bax Inhibitor-1 regulates hepatic lipid accumulation via ApoB secretion |
Q36596344 | C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver |
Q35067403 | CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model |
Q47860370 | CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response |
Q35897574 | COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis |
Q35843947 | Chronic Alcohol Consumption Results in Greater Damage to the Pancreas Than to the Liver in the Rats |
Q59341869 | Chronic fructose intake does not induce liver steatosis and inflammation in female Sprague–Dawley rats, but causes hypertriglyceridemia related to decreased VLDL receptor expression |
Q28505255 | Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity |
Q47813504 | Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response |
Q92255067 | Coupling of COPII vesicle trafficking to nutrient availability by the IRE1α-XBP1s axis |
Q50987952 | Cross-Talk Between FSH and Endoplasmic Reticulum Stress: A Mutually Suppressive Relationship. |
Q90196919 | Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis |
Q91089901 | Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Contributes to Hepatic Steatosis |
Q35040219 | Differential responses of hepatic endoplasmic reticulum stress and inflammation in diet-induced obese rats with high-fat diet rich in lard oil or soybean oil |
Q38001126 | Do hepatitis B virus and hepatitis C virus co-infections increase hepatocellular carcinoma occurrence through synergistically modulating lipogenic gene expression? |
Q36507547 | Docosahexaenoic Acid Ameliorates Fructose-Induced Hepatic Steatosis Involving ER Stress Response in Primary Mouse Hepatocytes |
Q50968208 | ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis. |
Q92188856 | ER Stress and the UPR in Shaping Intestinal Tissue Homeostasis and Immunity |
Q42355577 | ER Stress-induced Inflammasome Activation Contributes to Hepatic Inflammation and Steatosis |
Q33620277 | ER stress and hepatic lipid metabolism |
Q36709748 | ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice |
Q34297659 | ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways. |
Q93159480 | Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1α-XBP1 |
Q38387968 | Endoplasmic Reticulum Stress Is Implicated in Intestinal Failure-Associated Liver Disease |
Q37618082 | Endoplasmic Reticulum Stress and Related Pathological Processes |
Q55456504 | Endoplasmic Reticulum Stress in Metabolic Disorders. |
Q64057135 | Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis |
Q35821225 | Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes |
Q38073952 | Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration |
Q35204677 | Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis |
Q38925531 | Endoplasmic reticulum proteostasis in hepatic steatosis. |
Q38557011 | Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease |
Q35614922 | Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential |
Q97522970 | Endoplasmic reticulum stress and liver diseases |
Q33828303 | Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease |
Q41962104 | Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells |
Q27027733 | Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases |
Q38989169 | Endoplasmic reticulum stress in the regulation of liver diseases: Involvement of Regulated IRE1α and β-dependent decay and miRNA. |
Q45200756 | Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor |
Q35870151 | Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice |
Q37137783 | Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease |
Q54402929 | Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury. |
Q28818754 | Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression |
Q36729260 | Exposure to fine airborne particulate matter induces macrophage infiltration, unfolded protein response, and lipid deposition in white adipose tissue |
Q58738376 | FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease |
Q51246528 | Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid β-oxidation and ketogenesis via activating XBP1 signaling in liver. |
Q34396839 | Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis |
Q41990861 | Fine-tuning PERK signaling to control cell fate under stress |
Q49920833 | HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation |
Q42501673 | Hepatic BSCL2 (Seipin) Deficiency Disrupts Lipid Droplet Homeostasis and Increases Lipid Metabolism via SCD1 Activity. |
Q51324999 | Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling. |
Q58616116 | Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH |
Q50319304 | Hepatic ZIP14-mediated zinc transport is required for adaptation to endoplasmic reticulum stress |
Q33654494 | Hepatic p63 regulates steatosis via IKKβ/ER stress |
Q91062570 | Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases |
Q90047443 | Hepatocyte Injury and Hepatic Stem Cell Niche in the Progression of Non-Alcoholic Steatohepatitis |
Q30701525 | Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner |
Q28115216 | Hepatoprotective role of Sestrin2 against chronic ER stress |
Q34533090 | Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammation |
Q41788624 | Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone-induced liver damage through inflammation and endoplasmic reticulum stress. |
Q36951181 | ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis |
Q35790874 | IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin |
Q35821598 | IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions |
Q35760821 | IRE1α activation protects mice against acetaminophen-induced hepatotoxicity |
Q64999429 | IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs. |
Q36600595 | IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis |
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Q50957789 | Insulin Resistance, Obesity and Lipotoxicity. |
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Q41140219 | Interplay of Energetics and ER Stress Exacerbates Alzheimer's Amyloid-β (Aβ) Toxicity in Yeast |
Q36743972 | Ire1 supports normal ER differentiation in developing Drosophila photoreceptors |
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Q30355131 | Lipotoxicity in the liver. |
Q49843619 | Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response |
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Q37703451 | Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. |
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