The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

scientific article published on 15 March 2011

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/EMBOJ.2011.52
P932PMC publication ID3094110
P698PubMed publication ID21407177
P5875ResearchGate publication ID50399174

P2093author name stringSung Hoon Back
Randal J Kaufman
Suzanne Jackowski
Y Eugene Chen
Roberta Leonardi
Shiyu Wang
Lin Chang
Wenbo Xu
Guohui Wang
Kezhong Zhang
Hongzhi Miao
Justin R Hassler
Jyoti Malhotra
P2860cites workCoupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
Plasma cell differentiation requires the transcription factor XBP-1Q24291453
Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family membersQ24291503
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans developmentQ24292104
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cellsQ24297587
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsQ24298956
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory responseQ24304232
Evolutionarily conserved gene family important for fat storageQ24305054
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cellsQ24309442
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alphaQ24322072
Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein responseQ24534422
Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related proteinQ24564221
Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alphaQ24631304
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesisQ24645996
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error applicationQ24803815
DAVID: Database for Annotation, Visualization, and Integrated DiscoveryQ27499374
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleusQ27930818
IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiaeQ27935778
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
Proteasome inhibitors disrupt the unfolded protein response in myeloma cellsQ28155919
Translational control is required for the unfolded protein response and in vivo glucose homeostasisQ28204066
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
The organization, promoter analysis, and expression of the human PPARgamma geneQ28244071
Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated proteinQ28256013
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocationQ28510062
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaQ28512201
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Cloning of mammalian Ire1 reveals diversity in the ER stress responsesQ28587224
An essential role in liver development for transcription factor XBP-1Q28593777
The mammalian unfolded protein responseQ29547400
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controlsQ29547730
Lipid droplets: a unified view of a dynamic organelleQ29614467
Fat and beyond: the diverse biology of PPARgammaQ29615416
Coping with stress: eIF2 kinases and translational controlQ29619787
A phase 2 study of bortezomib in relapsed, refractory myelomaQ33348702
Bortezomib-induced severe hepatitis in multiple myeloma: a case reportQ33365214
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.Q33777806
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.Q42832143
Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signalingQ43073146
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.Q44477314
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophagesQ44542540
Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers.Q53543252
Liver regenerationQ55883809
DNA excision in liver by an albumin-Cre transgene occurs progressively with ageQ61203358
An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fatQ64374832
Enzymatic determination of total serum cholesterolQ69744405
Very-low-density lipoprotein assembly and secretionQ33939429
Liver regeneration: from laboratory to clinicQ34419499
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypesQ34835012
Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseasesQ34992771
Translational control of C/EBPalpha and C/EBPbeta isoform expression.Q35199785
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodentsQ36183590
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
Bortezomib: proteasome inhibition as an effective anticancer therapyQ36366801
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered miceQ36479005
Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoidsQ36561243
A proposed model of fat packaging by exchangeable lipid droplet proteinsQ36589548
Gene therapy, bioengineered clotting factors and novel technologies for hemophilia treatmentQ36801646
Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27.Q36983521
Antioxidants reduce endoplasmic reticulum stress and improve protein secretionQ36985084
Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity.Q36986765
From endoplasmic-reticulum stress to the inflammatory responseQ37225354
The endoplasmic reticulum stress response in immunity and autoimmunityQ37231726
Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD).Q37281827
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver diseaseQ37310283
Mechanisms of disease progression in nonalcoholic fatty liver diseaseQ37310288
Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoidsQ37367423
Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis.Q37447893
Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assemblyQ37746984
Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis.Q38309701
PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes.Q38332175
Bioengineering of coagulation factor VIII for improved secretionQ38345967
Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways.Q39622895
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesisQ39843795
Mechanisms targeting apolipoprotein B100 to proteasomal degradation: evidence that degradation is initiated by BiP binding at the N terminus and the formation of a p97 complex at the C terminusQ39891720
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Inhibition of proteasome by bortezomib causes intracellular aggregation of hepatic serpins and increases the latent circulating form of antithrombin.Q40025076
Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells.Q40291997
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cellsQ40313352
Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cellsQ40339637
Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivoQ40385723
Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesisQ41291617
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stressQ42518206
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)1357-1375
P577publication date2011-03-15
P1433published inThe EMBO JournalQ1278554
P1476titleThe unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis
P478volume30

Reverse relations

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