Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration

scientific article published on January 2013

Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/B978-0-12-407704-1.00005-1
P932PMC publication ID3666557
P698PubMed publication ID23317820
P5875ResearchGate publication ID234132845

P50authorSergio LavanderoQ30112219
Roberto BravoQ57015059
Valentina ParraQ58907470
Natalia TorrealbaQ58907566
P2093author name stringAndrew F G Quest
Joseph A Hill
Antonio Zorzano
Enrique Jaimovich
Andrea E Rodriguez
Damián Gatica
Zhao V Wang
Felipe Paredes
P2860cites workAtlasin GTPases shape up ER networksQ84418565
Autophagy eliminates a specific species of misfolded procollagen and plays a protective role in cell survival against ER stressQ84725704
Cardioprotection by endoplasmic reticulum stress-induced autophagyQ84778523
The potential of proteasome inhibitors in cancer therapyQ94700475
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)Q22003951
Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factorsQ22008465
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stressQ22254718
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stressQ24290818
Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein responseQ24290935
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78Q24293643
Role of EDEM in the release of misfolded glycoproteins from the calnexin cycleQ24296412
Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ERQ24296860
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosolQ24297732
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activationQ24298757
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsQ24298956
Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERTQ24299291
Luman is capable of binding and activating transcription from the unfolded protein response elementQ24300509
Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response elementQ24301000
Dysregulation of HSG triggers vascular proliferative disordersQ24301690
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutationsQ24301868
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1Q24302464
ER stress and the unfolded protein responseQ35986601
Insulin gene mutations as a cause of permanent neonatal diabetesQ36002587
Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.Q36119444
The glycan code of the endoplasmic reticulum: asparagine-linked carbohydrates as protein maturation and quality-control tagsQ36153965
Isolation and characterization of the sarcoplasmic reticulum of skeletal muscleQ36194383
Microtubules and the endoplasmic reticulum are highly interdependent structuresQ36215523
Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animalsQ36241923
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similaritiesQ36321572
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
Role of the unfolded protein response in cell deathQ36351719
From acute ER stress to physiological roles of the Unfolded Protein ResponseQ36362397
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.Q36393034
Remodelling Ca2+ signalling systems and cardiac hypertrophyQ36424286
Etiology of insulin resistanceQ36431215
Calcium uptake by rat kidney mitochondriaQ36441249
Protein quality control in the early secretory pathwayQ36446833
Interaction of the smooth endoplasmic reticulum and mitochondriaQ36482062
Rough sheets and smooth tubulesQ36562472
Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitusQ36597501
A century of Alzheimer's diseaseQ36643414
Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic primingQ36702104
Methods for monitoring autophagy from yeast to humanQ36708691
The subcellular distribution of calnexin is mediated by PACS-2Q36739888
Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patientsQ36778260
ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivoQ36802449
Modulation of the ryanodine receptor and intracellular calciumQ36824050
Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells.Q36836856
Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.Q36870862
Initiation and execution of lipotoxic ER stress in pancreatic beta-cellsQ36910693
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?Q36989869
Endoplasmic reticulum stress in the heartQ36996959
Chemical induction of the unfolded protein response in the liver increases glucose production and is activated during insulin-induced hypoglycaemia in ratsQ37001677
Calcium dysregulation in Alzheimer's diseaseQ37012642
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
Impaired balance of mitochondrial fission and fusion in Alzheimer's diseaseQ28854335
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene inductionQ28854565
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Regulation mechanisms and signaling pathways of autophagyQ29547416
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
Autophagy is activated for cell survival after endoplasmic reticulum stressQ29614485
Global and societal implications of the diabetes epidemicQ29614551
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapsesQ29615239
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stressQ29615495
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
The biology of vascular endothelial growth factorQ29615946
Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responsesQ29616076
mTOR regulation of autophagyQ29616301
The Beclin 1 network regulates autophagy and apoptosisQ29616539
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetesQ29616567
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesisQ29617644
Mitofusin 2 tethers endoplasmic reticulum to mitochondriaQ29619861
ER tubules mark sites of mitochondrial divisionQ29619991
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleusQ29620179
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta productionQ30482542
Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transportQ30483267
Reduced translocation of nascent prion protein during ER stress contributes to neurodegenerationQ30483989
STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER.Q30485016
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clusteringQ30496639
Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob diseaseQ30871448
PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of miceQ30945763
The nuclear envelope; its structure and relation to cytoplasmic membranesQ30983985
Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion proteinQ33253898
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein responseQ33264844
Inhibition of proliferation by PERK regulates mammary acinar morphogenesis and tumor formationQ33291107
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individualsQ33345339
Transcriptional regulation of VEGF-A by the unfolded protein response pathwayQ33539754
Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetesQ33549736
Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimersQ24302559
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress responseQ24303865
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cellsQ24309442
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alphaQ24310536
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagyQ24312147
AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress responseQ24314664
Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritisQ24314799
A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein responseQ24317491
DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturationQ24320231
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alphaQ24322072
A class of dynamin-like GTPases involved in the generation of the tubular ER networkQ24322595
Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destructionQ24324602
Interaction of ATF6 and serum response factorQ24336048
BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducerQ24337349
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational controlQ24522941
Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ.Q24537406
Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.Q24541469
Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6.Q24550967
A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradationQ24600318
An ER-mitochondria tethering complex revealed by a synthetic biology screenQ24618405
An Overview of Sphingolipid Metabolism: From Synthesis to BreakdownQ24628769
The nuclear envelopeQ24634678
Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosisQ24645884
MAM: more than just a housekeeperQ24648220
Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cellsQ24648786
Inhibition of p97-dependent protein degradation by Eeyarestatin IQ24648805
Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell SurvivalQ24653078
One step at a time: endoplasmic reticulum-associated degradationQ24658302
Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpinsQ24658387
Divergent effects of PERK and IRE1 signaling on cell viabilityQ27438124
The structure of the PERK kinase domain suggests the mechanism for its activationQ27667715
Sec61p is part of the endoplasmic reticulum-associated degradation machineryQ27930621
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteinsQ27931299
Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteinsQ27932183
The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulumQ27932262
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein responseQ27933479
Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteinsQ27934337
IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiaeQ27935778
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosolQ27936514
Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sitesQ27937449
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein responseQ27938493
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1pQ27938951
A class of membrane proteins shaping the tubular endoplasmic reticulumQ27940194
In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human DiseasesQ28109625
Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein responseQ28139950
Ca2+-induced apoptosis through calcineurin dephosphorylation of BADQ28140882
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndromeQ28142981
Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2Q28185092
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survivalQ28255981
Calcium pumps of plasma membrane and cell interiorQ28257824
ERAD: the long road to destructionQ28264823
Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosisQ28275274
The gene product of the gp78/AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulumQ28276396
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
ER chaperones in mammalian development and human diseasesQ28300625
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiationQ28507769
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiologyQ37860033
Role of calcium ions in regulation of mammalian intramitochondrial metabolismQ37875647
Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stressQ38316703
Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress responseQ38326929
Effect on tumor cells of blocking survival response to glucose deprivationQ38337197
Regulation of autophagy by ATF4 in response to severe hypoxia.Q38343634
Identification of a consensus element recognized and cleaved by IRE1 alpha.Q38343711
AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1Q38348926
Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different waysQ38394944
Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.Q38431247
GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancerQ38436413
IRE1-dependent activation of AMPK in response to nitric oxideQ38960360
Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERKQ39142751
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2Q39315996
The transcription factor c-Jun protects against sustained hepatic endoplasmic reticulum stress thereby promoting hepatocyte survivalQ39467135
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growthQ39470144
AMP-activated protein kinase activation during cardioplegia-induced hypoxia/reoxygenation injury attenuates cardiomyocytic apoptosis via reduction of endoplasmic reticulum stressQ39592947
A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.Q39603113
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.Q39676476
Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulumQ39776644
Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cellsQ39802567
Atlastin-1, the dynamin-like GTPase responsible for spastic paraplegia SPG3A, remodels lipid membranes and may form tubules and vesicles in the endoplasmic reticulumQ39830086
Prolyl hydroxylase inhibition attenuates post-ischemic cardiac injury via induction of endoplasmic reticulum stress genes.Q39838507
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesisQ39843795
Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosisQ39845179
Basal autophagy is involved in the degradation of the ERAD component EDEM1.Q39876239
Inhibition of mitochondrial function induces an integrated stress response in oligodendrogliaQ39881247
pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation.Q39898784
Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistanceQ39925487
c-Jun inhibits thapsigargin-induced ER stress through up-regulation of DSCR1/Adapt78.Q39959228
Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.Q39962425
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomasQ39981994
Endoplasmic reticulum stress responsesQ37014237
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epitheliumQ37039595
Knockdown of p180 eliminates the terminal differentiation of a secretory cell lineQ37061525
Regulation of the cardiac muscle ryanodine receptor by O(2) tension and S-nitrosoglutathioneQ37085577
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulumQ37186859
Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protectionQ37207734
Metabolic remodelling of the failing heart: beneficial or detrimental?Q37293624
Membrane phospholipid synthesis and endoplasmic reticulum functionQ37308781
Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum.Q37365629
Heat-shock proteins in infection-mediated inflammation-induced tumorigenesisQ37381884
Dysregulation of calcium homeostasis in Alzheimer's diseaseQ37428942
Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.Q37429250
O-GlcNAc signaling attenuates ER stress-induced cardiomyocyte death.Q37430909
The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2Q37433349
Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidaseQ37456875
The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's diseaseQ37459062
Peripheral ER structure and functionQ37485204
Calcium dysregulation in Alzheimer's disease: from mechanisms to therapeutic opportunitiesQ37576204
Calcium pumps in health and diseaseQ37605483
Membrane biogenesis: networking at the ER with atlastinQ37613818
An emerging role of mTOR in lipid biosynthesis.Q37641438
Calcium binding chaperones of the endoplasmic reticulumQ37679566
Calcium dysregulation in amyotrophic lateral sclerosisQ37684077
The fateful encounter of mitochondria with calcium: how did it happen?Q37729378
Is Alzheimer's disease a disorder of mitochondria-associated membranes?Q37737504
ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulumQ37784156
An intelligent sarco-endoplasmic reticulum Ca2+ store: release and leak channels have differential access to a concealed Ca2+ pool.Q37785336
IP(3) receptors: toward understanding their activation.Q37803478
Endoplasmic reticulum stress as a therapeutic target in cardiovascular diseaseQ37804650
Biology of Endoplasmic Reticulum Stress in the HeartQ37808904
Modulation of cardiac ryanodine receptor activity by ROS and RNS.Q37825162
Unfolded protein response in cancer: the physician's perspectiveQ37846249
Interrelationship between cardiac hypertrophy, heart failure, and chronic kidney disease: endoplasmic reticulum stress as a mediator of pathogenesisQ37849479
Interactions between mammalian cell DNA and inorganic platinum compounds. II. Interstrand cross-linking of isolated and cellular DNA by platinum(IV) compoundsQ47866082
Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.Q47942024
ER vesicles and mitochondria move and communicate at synapsesQ48370191
Ca2+ regulation of interactions between endoplasmic reticulum chaperones.Q50520041
Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets.Q51006407
Intricate links between ER stress and apoptosis.Q51747417
Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma.Q51753373
Endoplasmic reticulum stress: a new pathway to induce autophagy.Q51997673
Presenilins and Alzheimer disease: the calcium conspiracy.Q53382538
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.Q53616050
Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.Q53848758
mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome.Q54351691
Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion.Q54570712
Attenuation of CHOP-mediated myocardial apoptosis in pressure-overloaded dominant negative p38α mitogen-activated protein kinase mice.Q54580126
Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosisQ54640151
Regulation of tumor angiogenesis by oxygen-regulated protein 150, an inducible endoplasmic reticulum chaperone.Q55474365
Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexesQ56565426
Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase ActivationQ57267080
Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytesQ64377708
Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitolQ67754688
Retention of mutant alpha(1)-antitrypsin Z in endoplasmic reticulum is associated with an autophagic responseQ73127387
The role of mitochondria in presynaptic calcium handling at a ribbon synapseQ73523712
Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein responseQ74359929
Cellular sensitization to cisplatin and carboplatin with decreased removal of platinum-DNA adduct by glucose-regulated stressQ77878619
Ca ion uptake by rat kidney mitochondria and its dependence on respiration and phosphorylationQ79434435
Cellular tolerance of prion protein PrP in yeast involves proteolysis and the unfolded protein responseQ79814435
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2Q80553475
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-IIQ81144490
Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6Q83118076
Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signalingQ83300064
C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammationQ83433872
Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liverQ83810163
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosisQ40002274
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cellsQ40128062
GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosisQ40144533
Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II).Q40164655
Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathyQ40176298
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.Q40179972
EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.Q40229528
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.Q40236795
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cellsQ40310345
The expression and functional characterization of sigma (sigma) 1 receptors in breast cancer cell linesQ40334631
ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicityQ40386955
The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity.Q40445820
Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress responseQ40500396
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.Q40519913
Manganese superoxide dismutase is induced by endoplasmic reticulum stress through IRE1-mediated nuclear factor (NF)-kappaB and AP-1 activation.Q40526557
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stressQ40527936
Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivoQ40534877
Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4.Q40595070
Molecular and cellular physiology of intracellular calcium storesQ40674713
Systematic probing of the environment of a translocating secretory protein during translocation through the ER membraneQ40792995
Calcium regulates the association between mitochondria and a smooth subdomain of the endoplasmic reticulumQ40854212
In vitro formation of the endoplasmic reticulum occurs independently of microtubules by a controlled fusion reactionQ40895705
Enzyme-membrane relationship in phenobarbital induction of synthesis of drug-metabolizing enzyme system and proliferation of endoplasmic membranesQ41078705
Hypersensitivity to DNA cross-linking agents associated with up-regulation of glucose-regulated stress protein GRP78.Q41078765
Mechanism of polypeptide translocation into the endoplasmic reticulumQ41239618
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.Q41256595
Protein translocation across the membrane of the endoplasmic reticulumQ41364028
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.Q41465002
Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytesQ41609588
Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signalsQ41700856
Protein translocation: tunnel visionQ41708899
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesisQ41791624
The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertensionQ41829078
Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth.Q41844309
X box-binding protein 1 regulates angiogenesis in human pancreatic adenocarcinomas.Q41859494
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
The endoplasmic reticulum.Q41939884
Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosisQ42004487
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Prion pathogenesis is independent of caspase-12.Q42068269
Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptakeQ42118696
Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in miceQ42173352
Axonopathy and transport deficits early in the pathogenesis of Alzheimer's diseaseQ42474769
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stressQ42518206
CREB3 subfamily transcription factors are not created equal: Recent insights from global analyses and animal models.Q42760035
Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulumQ42824803
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.Q42832143
ATF6 is important under both pathological and physiological states in the heartQ43104574
Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathwayQ43195284
Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overloadQ43207763
N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alphaQ43289215
Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signalingQ44267711
Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.Q44393459
Regular exercise is associated with a protective metabolic phenotype in the rat heartQ44856585
Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6.Q45010270
Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viabilityQ45101812
Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophyQ46534803
Gene expression profiling of the preclinical scrapie-infected hippocampusQ46578942
Cardiac fatty acid metabolism is preserved in the compensated hypertrophic rat heartQ46681807
ER-phagy: selective autophagy of the endoplasmic reticulum.Q46683304
Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.Q46742618
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expressionQ46955933
Functional characterization of Drosophila melanogaster PERK eukaryotic initiation factor 2alpha (eIF2alpha) kinase.Q47071973
Endoplasmic reticulum membrane tubules are distributed by microtubules in living cells using three distinct mechanismsQ47849817
Endoplasmic reticulum architecture: structures in flux.Q34684405
Functional coupling between ryanodine receptors, mitochondria and Ca(2+) ATPases in rat submandibular acinar cellsQ34692023
Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.Q34695923
A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasisQ34803685
Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activityQ34854373
ER calcium and Alzheimer's disease: in a state of fluxQ34966217
Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer diseaseQ34982214
Calcium dyshomeostasis and intracellular signalling in Alzheimer's diseaseQ34988301
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stressQ35041282
Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophyQ35045900
The endoplasmic reticulum: a multifunctional signaling organelleQ35051249
Mutant fibrinogen cleared from the endoplasmic reticulum via endoplasmic reticulum-associated protein degradation and autophagy: an explanation for liver diseaseQ35088205
Lipid transfer and signaling at organelle contact sites: the tip of the icebergQ35141334
Cholesterol at the endoplasmic reticulum: roles of the sigma-1 receptor chaperone and implications thereof in human diseasesQ35163209
T-tubule biogenesis and triad formation in skeletal muscle and implication in human diseasesQ35166273
PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachmentQ35192134
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stressQ35221396
PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolismQ35229188
Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress responseQ35233981
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.Q35551757
The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarctionQ35572373
Regulation of apoptosis by endoplasmic reticulum pathways.Q35591699
Organization of translocon complexes in ER membranesQ35594198
Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetesQ35641724
Endoplasmic reticulum stress triggers autophagyQ35690087
Expression profiling of pancreatic beta cells: glucose regulation of secretory and metabolic pathway genesQ35748146
Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagyQ35776381
Insulin receptor substrate proteins and diabetesQ35793714
Inositol 1,4,5-trisphosphate receptors as signal integratorsQ35799975
Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetesQ35838612
The role of the unfolded protein response in tumour development: friend or foe?Q35968425
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocationQ28510062
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaQ28512201
Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cellsQ28513964
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liverQ28577788
Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response: intracellular signaling of calcium stress in a cardiac myocyte model systemQ28578430
OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytesQ28580776
mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathwayQ28583302
ER-stress-inducible Herp, facilitates the degradation of immature nicastrinQ28586218
Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formationQ28587852
Reduction of spermatogenesis but not fertility in Creb3l4-deficient miceQ28588285
Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesisQ28591480
Regulation of glucose homeostasis through a XBP-1-FoxO1 interactionQ28592129
Gene-specific regulation by general translation factorsQ28611181
The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein responseQ28646118
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.Q33559643
Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscleQ33574066
BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein responseQ33631257
Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogsQ33654233
Stable binding of ATF6 to BiP in the endoplasmic reticulum stress responseQ33713564
Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivityQ33733839
Detergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum-mitochondria junctionQ33754855
Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stressQ33786940
PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosisQ33868451
Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathwayQ33891036
Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neuronsQ33966472
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damageQ33977034
Endoplasmic reticulum: ER stress regulates mitochondrial bioenergeticsQ33986242
SERCA pump isoforms: their role in calcium transport and diseaseQ34002326
Cholesterol, the central lipid of mammalian cellsQ34021021
Ryanodine receptors: structure, expression, molecular details, and function in calcium release.Q34024377
ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubulesQ34069992
β-AR blockers suppresses ER stress in cardiac hypertrophy and heart failureQ34071906
Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductaseQ34119006
Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16.Q34120076
ER calcium and the functions of intracellular organellesQ34132512
P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signalingQ34179244
Rab32 Modulates Apoptosis Onset and Mitochondria-associated Membrane (MAM) PropertiesQ34181492
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesisQ34192744
Ryanodine receptors/calcium release channels in heart failure and sudden cardiac deathQ34198372
IP(3) receptors: the search for structure.Q34313146
Activation of mitochondrial energy metabolism protects against cardiac failureQ34424919
The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondriaQ34455046
Herp regulates Hrd1-mediated ubiquitylation in a ubiquitin-like domain-dependent mannerQ34568352
Adenylate Kinase 2 Links Mitochondrial Energy Metabolism to the Induction of the Unfolded Protein ResponseQ34575683
Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.Q34582973
The oligomeric state of Derlin-1 is modulated by endoplasmic reticulum stressQ34622014
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complexQ34673344
P921main subjectendoplasmic reticulumQ79927
P304page(s)215-290
P577publication date2013-01-01
P1433published inInternational Review of Cell and Molecular BiologyQ26842011
P1476titleEndoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration
P478volume301

Reverse relations

cites work (P2860)
Q64117116A Ca-regulated deAMPylation switch in human and bacterial FIC proteins
Q38737988A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms.
Q96303232A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites
Q99555843Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer's Disease
Q51056596Activation of phospholipase C-γ1 and translocation of phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase contribute to GL-V9-induced apoptosis in human gastric cancer cells.
Q34528162Alteration in mitochondrial Ca(2+) uptake disrupts insulin signaling in hypertrophic cardiomyocytes.
Q92162437Alternative Mechanisms of mRNA Translation Initiation in Cellular Stress Response and Cancer
Q47706341Arsenite Induces Vascular Endothelial Cell Dysfunction by Activating IRE1α/XBP1s/HIF1α-Dependent ANGII Signaling
Q35016999Atorvastatin ameliorates myocardial ischemia/reperfusion injury through attenuation of endoplasmic reticulum stress-induced apoptosis
Q64232167Autophagy Intertwines with Different Diseases-Recent Strategies for Therapeutic Approaches
Q35201557Benzodiazepinone derivatives protect against endoplasmic reticulum stress-mediated cell death in human neuronal cell lines
Q38785855Bis(maltolato)oxovanadium(IV) (BMOV) Attenuates Apoptosis in High Glucose-Treated Cardiac Cells and Diabetic Rat Hearts by Regulating the Unfolded Protein Responses (UPRs).
Q41444351Bortezomib initiates endoplasmic reticulum stress, elicits autophagy and death in Echinococcus granulosus larval stage.
Q89134321CCPG1 is a noncanonical autophagy cargo receptor essential for reticulophagy and pancreatic ER proteostasis
Q47148501CSFV Infection Up-Regulates the Unfolded Protein Response to Promote Its Replication
Q33755195Calcium Dynamics Mediated by the Endoplasmic/Sarcoplasmic Reticulum and Related Diseases
Q91697989Characterization of the role of TMEM45A in cancer cell sensitivity to cisplatin
Q57455832Chromosomal instability causes sensitivity to protein folding stress and ATP depletion
Q38699105Chronic heart failure: Ca(2+), catabolism, and catastrophic cell death
Q97884039Chrysophanol Prevents Lipopolysaccharide-Induced Hepatic Stellate Cell Activation by Upregulating Apoptosis, Oxidative Stress, and the Unfolded Protein Response
Q92571554Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model
Q89440967Cyclin-dependent kinase inhibitors, roscovitine and purvalanol, induce apoptosis and autophagy related to unfolded protein response in HeLa cervical cancer cells
Q49399822Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains β-cell insulin secretion during inflammation
Q37688571Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells.
Q92955484Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myeloma
Q89522183Dexmedetomidine alleviates cisplatin‑induced acute kidney injury by attenuating endoplasmic reticulum stress‑induced apoptosis via the α2AR/PI3K/AKT pathway
Q60046993DiDang Tang Inhibits Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Oxygen Glucose Deprivation and Intracerebral Hemorrhage Through Blockade of the GRP78-IRE1/PERK Pathways
Q94553729Diagnostic and Prognostic Values of MANF Expression in Hepatocellular Carcinoma
Q55395234Differential Regulation of Toll-Like Receptor-Mediated Cytokine Production by Unfolded Protein Response.
Q28078536ER Stress-Mediated Signaling: Action Potential and Ca(2+) as Key Players
Q38946303ER stress and impaired autophagy flux in neuronal degeneration and brain injury.
Q59357354ER stress regulating protein phosphatase 2A-B56γ, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes
Q91520867EZH2 is overexpressed in transitional preplasmablasts and is involved in human plasma cell differentiation
Q89536675Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model
Q49718773Effect of Roux-en-Y gastric bypass on liver mitochondrial dynamics in a rat model of obesity
Q38637432Effect of endoplasmic reticulum stress inhibition on hyperoxaluria-induced oxidative stress: influence on cellular ROS sources
Q30401167Endocrine Imbalance Associated With Proteome Changes in Diabetes
Q54980775Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt Activation.
Q64258921Endoplasmic Reticulum Stress and Unfolded Protein Response in Breast Cancer: The Balance between Apoptosis and Autophagy and Its Role in Drug Resistance
Q38557011Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease
Q40051888Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites.
Q38890572Endoplasmic reticulum stress causes autophagy and apoptosis leading to cellular redistribution of the autoantigens Ro/Sjögren's syndrome-related antigen A (SSA) and La/SSB in salivary gland epithelial cells.
Q58288164Endoplasmic reticulum stress in ischemic and nephrotoxic acute kidney injury
Q28084110Endoplasmic reticulum stress in periimplantation embryos
Q38257120Endoplasmic reticulum stress is the crossroads of autophagy, inflammation, and apoptosis signaling pathways and participates in liver fibrosis
Q26776032Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment
Q92188423Epigenetic loss of the endoplasmic reticulum-associated degradation inhibitor SVIP induces cancer cell metabolic reprogramming
Q36870797Evaluation of energy metabolism and calcium homeostasis in cells affected by Shwachman-Diamond syndrome
Q52690230Exercise Mitigates Alcohol Induced Endoplasmic Reticulum Stress Mediated Cognitive Impairment through ATF6-Herp Signaling.
Q90750116Exercise protects against diabetic cardiomyopathy by the inhibition of the endoplasmic reticulum stress pathway in rats
Q64913901Exploring Cellular Stress Response and Chaperones.
Q47834894Fibroblast growth factor 2 induces proliferation and distribution of G2 /M phase of bovine endometrial cells involving activation of PI3K/AKT and MAPK cell signaling and prevention of effects of ER stress
Q46606929Fisetin induces apoptosis and endoplasmic reticulum stress in human non-small cell lung cancer through inhibition of the MAPK signaling pathway
Q64244254Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis
Q90042573Genome-wide effects of social status on DNA methylation in the brain of a cichlid fish, Astatotilapia burtoni
Q42023856Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1α/X box-binding protein-1 pathway
Q52314492Glaucoma pathogenesis and neurotrophins: Focus on the Molecular and Genetic basis for Therapeutic prospects.
Q64248817Glycosylation Profile of the Transferrin Receptor in Gestational Iron Deficiency and Early-Onset Severe Preeclampsia
Q42011853HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma.
Q58089566Hepatitis C virus downregulates ubiquitin conjugating enzyme E2S expression to prevent proteasomal degradation of NS5A, leading to host cells more sensitive to DNA damage
Q37192552High-Fat Diet Induces Oxidative Stress and MPK2 and HSP83 Gene Expression in Drosophila melanogaster.
Q47338427How stress contributes to autoimmunity-lessons from Sjögren's syndrome
Q49953037Hypoxic regulation of the expression of cell proliferation related genes in U87 glioma cells upon inhibition of ire1 signaling enzyme
Q92173192IRE1α modulates ER and mitochondria crosstalk
Q93267893Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes
Q92891433Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats
Q89707828Inorganic polyphosphate controls cyclophilin B-mediated collagen folding in osteoblast-like cells
Q89820629Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases
Q38789346Interplay between steroid hormone activation of the unfolded protein response and nuclear receptor action.
Q46915803Involvement of mitochondrial dysfunction and ER-stress in the physiopathology of equine osteochondritis dissecans (OCD).
Q38216863Iron, oxidative stress, and redox signaling in the cardiovascular system
Q47097021Is osteoporosis an autoimmune mediated disorder?
Q28551099Kaempferol Inhibits Endoplasmic Reticulum Stress-Associated Mucus Hypersecretion in Airway Epithelial Cells And Ovalbumin-Sensitized Mice
Q37534269Links between ER stress and autophagy in plants
Q92195093Mechanisms of obesity-induced metabolic and vascular dysfunctions
Q55406400Metabolic Reprogramming and the Recovery of Physiological Functionality in 3D Cultures in Micro-Bioreactors.
Q33757346Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway.
Q39198755Modulation of AβPP and GSK3β by Endoplasmic Reticulum Stress and Involvement in Alzheimer's Disease.
Q92538749Molecular Insight Into the IRE1α-Mediated Type I Interferon Response Induced by Proteasome Impairment in Myeloid Cells of the Brain
Q35377710Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development
Q55429735Neuritin Attenuates Neuronal Apoptosis Mediated by Endoplasmic Reticulum Stress In Vitro.
Q35016962New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cells
Q33731804New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets
Q58797541Novel roles for scleraxis in regulating adult tenocyte function
Q37607813Of yeast, mice and men: MAMs come in two flavors.
Q37711952Ophiobolin A, a sesterpenoid fungal phytotoxin, displays different mechanisms of cell death in mammalian cells depending upon the cancer cell origin
Q91847366Osteochondritis dissecans (OCD) in Horses - Molecular Background of its Pathogenesis and Perspectives for Progenitor Stem Cell Therapy
Q90260610Oxidative Stress in Pulmonary Fibrosis
Q35716234PDIA3 Knockdown Exacerbates Free Fatty Acid-Induced Hepatocyte Steatosis and Apoptosis
Q91582462PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes
Q98612725Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations
Q57064753Phagocytosis influences the intracellular survival of via the endoplasmic reticulum stress response
Q36863681Phemindole, a Synthetic Di-indole Derivative Maneuvers the Store Operated Calcium Entry (SOCE) to Induce Potent Anti-Carcinogenic Activity in Human Triple Negative Breast Cancer Cells.
Q38764734Phenotype and natural history of variant late infantile ceroid-lipofuscinosis 5.
Q39282297Phenylbutyrate and β-cell function: contribution of histone deacetylases and ER stress inhibition.
Q90080205Preface: Endoplasmic reticulum in health and disease
Q37839078Proteomic analysis of the Simkania-containing vacuole: the central role of retrograde transport
Q90470351Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos
Q34344097Purple perilla extracts allay ER stress in lipid-laden macrophages
Q30239820Reactive oxygen species-mediated unfolded protein response pathways in preimplantation embryos
Q89473746Retrograde signaling mediates an adaptive survival response to endoplasmic reticulum stress in Saccharomyces cerevisiae
Q37195781Review: retinal degeneration: focus on the unfolded protein response.
Q64052546Right place, right time: localisation and assembly of the NLRP3 inflammasome
Q26853645Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease
Q89379684Rosiglitazone rescues human neural stem cells from amyloid-beta induced ER stress via PPARγ dependent signaling
Q39169425Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology.
Q28078342Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease
Q92188838Sestrin2: Its Potential Role and Regulatory Mechanism in Host Immune Response in Diseases
Q93061499Sleep, Aging, and Cellular Health: Aged-Related Changes in Sleep and Protein Homeostasis Converge in Neurodegenerative Diseases
Q28082709Stress responses from the endoplasmic reticulum in cancer
Q53776619Targeting multidrug-resistant ovarian cancer through estrogen receptor α dependent ATP depletion caused by hyperactivation of the unfolded protein response.
Q64255905Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes
Q41525295The Networks of Genes Encoding Palmitoylated Proteins in Axonal and Synaptic Compartments Are Affected in PPT1 Overexpressing Neuronal-Like Cells
Q90597572The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases
Q54997182The Selective Autophagy Receptor Optineurin in Crohn's Disease.
Q38726766The calmodulin antagonist W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride) inhibits DENV infection in Huh-7 cells.
Q92772619The cellular basis of fetal endoplasmic reticulum stress and oxidative stress in drug-induced neurodevelopmental deficits
Q92389875The endoplasmic reticulum unfolded protein response varies depending on the affected region of the tissue but independently from the source of stress
Q64082977The interactome of a family of potential methyltransferases in HeLa cells
Q48269589The potent effect of mycolactone on lipid membranes.
Q38836989The unfolded protein response: mechanisms and therapy of neurodegeneration
Q38946790Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy.
Q46418471Thiamine deficiency induces endoplasmic reticulum stress and oxidative stress in human neurons derived from induced pluripotent stem cells
Q89736832Thioridazine Induces Cardiotoxicity via Reactive Oxygen Species-Mediated hERG Channel Deficiency and L-Type Calcium Channel Activation
Q37529613Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells
Q92880942Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes
Q90446620Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia
Q36349949Unfolded protein response-induced dysregulation of calcium homeostasis promotes retinal degeneration in rat models of autosomal dominant retinitis pigmentosa
Q38931035Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms
Q92822477Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism
Q64072323Wolbachia endosymbionts subvert the endoplasmic reticulum to acquire host membranes without triggering ER stress
Q42331869Δ2-Troglitazone promotes cytostatic rather than pro-apoptotic effects in breast cancer cells cultured in high serum conditions

Search more.