The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.

scientific article published on 14 September 2011

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E11-06-0510
P932PMC publication ID3216664
P698PubMed publication ID21917591
P5875ResearchGate publication ID51643153

P50authorJeanette N. McClintickQ56055103
Tracy G. AnthonyQ54457113
P2093author name stringRonald C Wek
Sheree A Wek
Brian F Teske
Judy K Cundiff
Piyawan Bunpo
P2860cites workCoupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factorQ73967308
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulumQ80935578
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-IIQ81144490
Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibitionQ81347002
That which does not kill me makes me stronger: adapting to chronic ER stressQ81405125
ER stress signaling by regulated proteolysis of ATF6Q81604029
Methods for analyzing eIF2 kinases and translational control in the unfolded protein responseQ83296083
ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligaseQ24290903
Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein responseQ24290935
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stressQ24292499
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory responseQ24304232
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
Divergent effects of PERK and IRE1 signaling on cell viabilityQ27438124
The structure of the PERK kinase domain suggests the mechanism for its activationQ27667715
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteinsQ27932183
Regulation of translation initiation in eukaryotes: mechanisms and biological targetsQ28111696
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to GolgiQ28141775
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndromeQ28142981
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
More powerful procedures for multiple significance testingQ28255714
Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneityQ28268714
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreasQ28505821
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiationQ28507769
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress responseQ28508156
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumQ28512249
PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liverQ28593775
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survivalQ28593963
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene inductionQ28854565
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
The mammalian unfolded protein responseQ29547400
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
Proteasome inhibitors: valuable new tools for cell biologistsQ29620573
SNARE Protein Structure and FunctionQ30336208
eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memoryQ30586619
PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in miceQ33295459
BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein responseQ33631257
Regulation of basal cellular physiology by the homeostatic unfolded protein responseQ33886820
Molecular symbiosis of CHOP and C/EBP beta isoform LIP contributes to endoplasmic reticulum stress-induced apoptosisQ33963803
PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathwayQ34024253
Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16.Q34120076
Wolcott-Rallison syndromeQ34148057
On the mechanism of sensing unfolded protein in the endoplasmic reticulumQ34230593
Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J miceQ35740930
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress responseQ36322641
Endoplasmic reticulum stress signaling in diseaseQ36610455
Translational control and the unfolded protein responseQ36924278
Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2.Q36948959
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cellsQ37388595
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesiclesQ37394440
GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.Q37432106
XBP1: the last two decadesQ37649065
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress responseQ38326929
Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response.Q38346445
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Role of vesicle-associated syntaxin 5 in the assembly of pre-Golgi intermediatesQ41064399
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stressQ42451739
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stressQ42518206
Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stressQ42952040
Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6.Q45010270
Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viabilityQ45101812
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.Q45345766
Beta testing the antioxidant function of eIF2alpha phosphorylation in diabetes prevention.Q45936856
PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.Q52000258
P433issue22
P921main subjectendoplasmic reticulumQ79927
P304page(s)4390-4405
P577publication date2011-09-14
P1433published inMolecular Biology of the CellQ2338259
P1476titleThe eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
P478volume22

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