Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

scientific article published on 03 March 2016

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.METABOL.2016.02.014
P932PMC publication ID4931958
P698PubMed publication ID26997538

P2093author name stringArun J Sanyal
Sophie C Cazanave
Bubu A Banini
Manoela Mota
P2860cites workPioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitisQ24625697
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.Q24815740
Carbohydrate intake and nonalcoholic fatty liver disease: fructose as a weapon of mass destructionQ26991952
Fructose as a key player in the development of fatty liver diseaseQ27014596
Recent insights on the role of cholesterol in non-alcoholic fatty liver diseaseQ28082693
Clinical utility of LC3 and p62 immunohistochemistry in diagnosis of drug-induced autophagic vacuolar myopathies: a case-control studyQ28482758
A lipidomic analysis of nonalcoholic fatty liver disease.Q44931121
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
Hepatospecific effects of fructose on c-jun NH2-terminal kinase: implications for hepatic insulin resistanceQ44938048
Poly(ADP‐ribose) polymerase 1 is involved in glucose toxicity through SIRT1 modulation in HepG2 hepatocytesQ44965464
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathwayQ44967749
No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trialQ44997998
Role of p53 in the cellular response following oleic acid accumulation in Chang liver cellsQ46718232
Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitisQ46751757
Hepatocyte autophagy is linked to C/EBP-homologous protein, Bcl2-interacting mediator of cell death, and BH3-interacting domain death agonist gene expressionQ50216534
Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection.Q50448712
Changes in insulin action, triglycerides, and lipid composition during sucrose feeding in rats.Q51578666
Hepatic inflammation induced by high-fructose diet is associated with altered 11βHSD1 expression in the liver of Wistar rats.Q52646591
Statin use and non-alcoholic steatohepatitis in at risk individuals.Q53504568
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.Q53555710
A high fructose diet affects the early steps of insulin action in muscle and liver of rats.Q54050337
Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent.Q54334813
Fatty acid transporters involved in the palmitate and oleate induced insulin resistance in primary rat hepatocytesQ62034066
Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1Q71743266
Comparison of the effects of sucrose and fructose on insulin action and glucose toleranceQ72997993
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosisQ82677113
Ursodeoxycholyl lysophosphatidylethanolamide improves steatosis and inflammation in murine models of nonalcoholic fatty liver diseaseQ83067058
Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fas activation in Bak/Bax-deficient miceQ83677023
Hepatic NAD salvage pathway is enhanced in mice on a high-fat dietQ85274225
Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trialQ85319932
Endoplasmic reticulum stress and Nrf2 repression in circulating cells of type 2 diabetic patients without the recommended glycemic goalsQ86298171
Standard short-term diet ameliorates the lipid profile altered by a fructose-rich diet in ratsQ87069709
Downregulating SOCS3 with siRNA ameliorates insulin signaling and glucose metabolism in hepatocytes of IUGR rats with catch-up growthQ87369430
Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitisQ40960591
Effects of inhibitors of key enzymes of sphingolipid metabolism on insulin-induced glucose uptake and glycogen synthesis in liver cells of old ratsQ41261653
Individual CLA Isomers, c9t11 and t10c12, Prevent Excess Liver Glycogen Storage and Inhibit Lipogenic Genes Expression Induced by High-Fructose Diet in Rats.Q41459356
Circulating phospholipid profiling identifies portal contribution to NASH signature in obesityQ41755444
Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH modelQ41761778
Attenuation of oxidative stress, inflammation and insulin resistance by allium sativum in fructose-fed male ratsQ41932791
Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytesQ41985780
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stressQ42148009
Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicityQ42409618
Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturaseQ42563412
Sirt1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat dietQ42701630
Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed miceQ42717472
Oxidative stress induced by high-glucose diet in liver of C57BL/6J mice and its underlying mechanismQ43136171
Insulin resistance induced by high-fructose diet potentiates carbon tetrachloride hepatotoxicityQ43183517
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalitiesQ43552270
Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver diseaseQ44037507
Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitisQ44697151
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosisQ28547365
Mediators of endoplasmic reticulum stress-induced apoptosisQ29615496
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseQ29619334
Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.Q33420360
Linoleate appears to protect against palmitate-induced inflammation in Huh7 cellsQ33684205
Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell deathQ33840334
High fat diet induced hepatic steatosis and insulin resistance: Role of dysregulated ceramide metabolismQ33896110
Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance.Q34166238
Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.Q34206288
Ceramides and glucosylceramides are independent antagonists of insulin signalingQ34384118
Recent advances in the development of farnesoid X receptor agonistsQ34464043
The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicityQ34512981
Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetesQ34594406
Bax inhibition protects against free fatty acid-induced lysosomal permeabilizationQ34665604
Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trialQ35031127
Fluvastatin attenuates hepatic steatosis-induced fibrogenesis in rats through inhibiting paracrine effect of hepatocyte on hepatic stellate cellsQ35107757
Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques.Q35123226
Proteomic analysis of liver mitochondria from rats with nonalcoholic steatohepatitisQ35159970
Adipogenic changes of hepatocytes in a high-fat diet-induced fatty liver mice model and non-alcoholic fatty liver disease patientsQ35228266
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.Q35551757
New evidence for the role of ceramide in the development of hepatic insulin resistanceQ35551917
Death receptor 5 signaling promotes hepatocyte lipoapoptosisQ35604362
Liver injury and fibrosis induced by dietary challenge in the Ossabaw miniature SwineQ35610499
Intermittent but not constant high glucose induces ER stress and inflammation in human retinal pericytesQ35627455
Retracted: Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose DietQ35670773
Hepatic oxidative stress in fructose-induced fatty liver is not caused by sulfur amino acid insufficiencyQ35671121
Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver diseaseQ35904142
Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosisQ35939383
Role of ceramides in nonalcoholic fatty liver diseaseQ36129432
Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitisQ36243417
Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathwaysQ36421523
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domainsQ36712468
Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in miceQ36723099
Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress.Q36867522
Omega 3 - Omega 6: What is right for the liver?Q36942356
A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitisQ37189403
Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver diseaseQ37405640
The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver diseaseQ37412003
Bcl-2 family on guard at the ER.Q37412841
Mcl-1 degradation during hepatocyte lipoapoptosisQ37431628
JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosisQ37446730
Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytesQ37625425
c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver.Q37643931
The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicityQ37680167
The role of fructose in the pathogenesis of NAFLD and the metabolic syndromeQ37724585
Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological roleQ37887977
Interaction domains of p62: a bridge between p62 and selective autophagyQ38093208
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.Q38172752
Biomarkers of liver cell deathQ38177569
Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulationQ38323405
Fructose containing sugars modulate mRNA of lipogenic genes ACC and FAS and protein levels of transcription factors ChREBP and SREBP1c with no effect on body weight or liver fat.Q38329583
Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.Q38356462
Islet β-cell failure in type 2 diabetes--Within the network of toxic lipidsQ38406600
Cell death induced by endoplasmic reticulum stress.Q38639996
Fructose induces mitochondrial dysfunction and triggers apoptosis in skeletal muscle cells by provoking oxidative stress.Q38882240
All-trans retinoic acid induces p53-depenent apoptosis in human hepatocytes by activating p14 expression via promoter hypomethylationQ38892523
Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicityQ38911401
Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosisQ39000961
Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitisQ39005663
Liquid fructose down-regulates liver insulin receptor substrate 2 and gluconeogenic enzymes by modifying nutrient sensing factors in ratsQ39032673
CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosisQ39709114
Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosisQ39731721
Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytesQ39885259
Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolismQ39928700
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytesQ40064603
Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosisQ40108223
Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activityQ40146370
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cellsQ40313352
Oxysterols induce mitochondrial impairment and hepatocellular toxicity in non-alcoholic fatty liver diseaseQ40438293
P433issue8
P921main subjectmetabolic dysfunction–associated steatotic liver diseaseQ1546498
fatty liver diseaseQ6058862
P304page(s)1049-1061
P577publication date2016-03-03
P1433published inMetabolismQ15764354
P1476titleMolecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease
P478volume65

Reverse relations

cites work (P2860)
Q89634074A Network-Based Bioinformatics Approach to Identify Molecular Biomarkers for Type 2 Diabetes that Are Linked to the Progression of Neurological Diseases
Q55503094Apoptosis and non-alcoholic fatty liver diseases.
Q92258134Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome
Q55379918Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease.
Q61798368Association of TM6SF2 rs58542926 gene polymorphism with the risk of non-alcoholic fatty liver disease and colorectal adenoma in Chinese Han population
Q89701777Bergamot Polyphenols Improve Dyslipidemia and Pathophysiological Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease
Q92635735Bile Acid and Fibroblast Growth Factor 19 Regulation in Obese Diabetics, and Non-Alcoholic Fatty Liver Disease after Sleeve Gastrectomy
Q90596865Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol
Q53685192Caspases in metabolic disease and their therapeutic potential.
Q55250531Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats.
Q90595521DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism
Q47871089Dapagliflozin and Empagliflozin Ameliorate Hepatic Dysfunction Among Chinese Subjects with Diabetes in Part Through Glycemic Improvement: A Single-Center, Retrospective, Observational Study
Q58590774Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects
Q55456504Endoplasmic Reticulum Stress in Metabolic Disorders.
Q64996877Epidemiology of nonalcoholic steatohepatitis and hepatocellular carcinoma.
Q83226128Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity
Q33743274Fat content, fatty acid pattern and iron content in livers of turkeys with hepatic lipidosis.
Q92932318Foie gras and liver regeneration: a fat dilemma
Q47311472G-Protein-Coupled Estrogen Receptor (GPER) and Sex-Specific Metabolic Homeostasis
Q37454201Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress/GSK-3-mediated mitochondrial pathway
Q38794320Hepatic Steatosis Accompanies Pulmonary Alveolar Proteinosis
Q58123798Hepatoprotective and Antioxidant Activities of Oil from Baru Almonds ( Vog.) in a Preclinical Model of Lipotoxicity and Dyslipidemia
Q91283915Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis
Q89697924In Steatotic Cells, ATP-Citrate Lyase mRNA Is Efficiently Translated through a Cap-Independent Mechanism, Contributing to the Stimulation of De Novo Lipogenesis
Q92993317Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study
Q40979699Linarin Enriched Extract Attenuates Liver Injury and Inflammation Induced by High-Fat High-Cholesterol Diet in Rats
Q57792139Liraglutide protects against glucolipotoxicity-induced RIN-m5F β-cell apoptosis through restoration of PDX1 expression
Q54946966Liraglutide reduces hepatic glucolipotoxicity‑induced liver cell apoptosis through NRF2 signaling in Zucker diabetic fatty rats.
Q90648223Maternal obesity leads to long-term altered levels of plasma ceramides in the offspring as revealed by a longitudinal lipidomic study in children
Q59443140Mechanisms of NAFLD development and therapeutic strategies.
Q46288090Melatonin application in targeting oxidative-induced liver injuries: A review
Q55258217Metabolic risk factors are associated with non-hepatitis B non-hepatitis C hepatocellular carcinoma in Taiwan, an endemic area of chronic hepatitis B.
Q57807657Molecular pathways of nonalcoholic fatty liver disease development and progression
Q57114860New Aspects of Lipotoxicity in Nonalcoholic Steatohepatitis
Q50957769Non-Alcoholic Fatty Liver Disease.
Q90416246Nonalcoholic Fatty Liver Disease
Q33855157Nonalcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, Natural History, Diagnosis, and Current Treatment Options.
Q92407746Pathogenesis of NASH: The Impact of Multiple Pathways
Q58705640Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches
Q100994726Perspectives on youth-onset nonalcoholic fatty liver disease
Q64987284Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure.
Q90750222Potential Therapeutic Application of Estrogen in Gender Disparity of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Q48184818Protective Effect of Meretrix meretrix Oligopeptides on High-Fat-Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice
Q89221428Protective effects of Tat-DJ-1 protein against streptozotocin-induced diabetes in a mice model
Q90396914Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
Q91526348Sodium fluorocitrate having inhibitory effect on fatty acid uptake ameliorates high fat diet-induced non-alcoholic fatty liver disease in C57BL/6J mice
Q38655651Stable isotope-based flux studies in nonalcoholic fatty liver disease
Q48144949Steatosis caused by experimental periodontitis is reversible after removal of ligature in rats
Q96229752The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease
Q100994717The metabolic basis of nonalcoholic steatohepatitis
Q90205939Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source
Q64988176Transcriptional Repression of CYP3A4 by Increased miR-200a-3p and miR-150-5p Promotes Steatosis in vitro.
Q49331156Translating scientific discovery: the need for preclinical models of nonalcoholic steatohepatitis
Q51761242p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes the Medicine.

Search more.