| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2012PLoSO...730816R |
| P356 | DOI | 10.1371/JOURNAL.PONE.0030816 |
| P932 | PMC publication ID | 3280252 |
| P698 | PubMed publication ID | 22355328 |
| P5875 | ResearchGate publication ID | 221852116 |
| P50 | author | Stanley Chan | Q79859597 |
| Gregory J. Cooney | Q109947337 | ||
| Edward W. Kraegen | Q109947434 | ||
| Xiao-Yi Zeng | Q59681783 | ||
| Nigel Turner | Q42468712 | ||
| P2093 | author name string | Tristan J Iseli | |
| D Ross Laybutt | |||
| Ji-Ming Ye | |||
| Lu-Ping Ren | |||
| Ruo-Qiong Sun | |||
| P2860 | cites work | A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response | Q24305069 |
| Endoplasmic reticulum stress and the inflammatory basis of metabolic disease | Q24633352 | ||
| Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene | Q24681894 | ||
| Biochemistry and molecular cell biology of diabetic complications | Q28131781 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation | Q28510062 | ||
| Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance | Q28510149 | ||
| Atorvastatin prevents carbohydrate response element binding protein activation in the fructose-fed rat by activating protein kinase A | Q28571317 | ||
| Tissue-specific regulation of medium-chain acyl-CoA dehydrogenase gene by thyroid hormones in the developing rat | Q28574495 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver | Q28575499 | ||
| Measurement of rates of cholesterol synthesis using tritiated water | Q70767427 | ||
| Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus | Q43267910 | ||
| Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila | Q43978685 | ||
| PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly | Q44295528 | ||
| Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis | Q44598592 | ||
| Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients | Q44615824 | ||
| Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model | Q45157911 | ||
| 3',4'-Dihydroxyflavonol prevents diabetes-induced endothelial dysfunction in rat aorta. | Q46028228 | ||
| Chronic, in vivo, PPARalpha activation prevents lipid overload in rat liver induced by high fat feeding. | Q46031673 | ||
| Increase in liver antioxidant enzyme activities in non-alcoholic fatty liver disease | Q46702703 | ||
| Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action | Q46745033 | ||
| Casitas b-lineage lymphoma-deficient mice are protected against high-fat diet-induced obesity and insulin resistance | Q46966521 | ||
| Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats. | Q51620845 | ||
| Augmented resistance to oxidative stress in fatty rat livers induced by a short-term sucrose-rich diet. | Q54034617 | ||
| Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle | Q54986901 | ||
| Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes | Q29614548 | ||
| Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes | Q29615503 | ||
| The role of solution NMR in the structure determinations of VDAC-1 and other membrane proteins | Q30157173 | ||
| Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model | Q33998998 | ||
| Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model | Q34021867 | ||
| Diacylglycerol-mediated insulin resistance | Q34109119 | ||
| Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes | Q34300442 | ||
| Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats | Q34975588 | ||
| Intersection of the unfolded protein response and hepatic lipid metabolism | Q34985745 | ||
| The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. | Q35090215 | ||
| Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. | Q35101294 | ||
| The role of intramuscular lipid in insulin resistance | Q35178599 | ||
| Oxidative stress in nonalcoholic fatty liver disease: pathogenesis and antioxidant therapies | Q36025565 | ||
| Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver | Q36055803 | ||
| Molecular targets of diabetic cardiovascular complications | Q36198737 | ||
| Non-alcoholic steatohepatitis: from cell biology to clinical practice | Q36308129 | ||
| Mitochondrial glutathione: hepatocellular survival-death switch | Q36588190 | ||
| Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications | Q36617551 | ||
| Mitochondrial function in liver disease. | Q36664551 | ||
| Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism. | Q36807697 | ||
| Role of ChREBP in hepatic steatosis and insulin resistance. | Q36918305 | ||
| High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo | Q37087840 | ||
| GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice | Q37170811 | ||
| Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans | Q37170824 | ||
| Role of fatty acids in the pathogenesis of obesity and fatty liver: impact of bariatric surgery | Q37310304 | ||
| Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells | Q37364195 | ||
| Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids | Q37400725 | ||
| The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome | Q37724585 | ||
| Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism | Q39928700 | ||
| Endoplasmic reticulum stress promotes LIPIN2-dependent hepatic insulin resistance | Q41889666 | ||
| Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. | Q42033681 | ||
| ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver | Q42128898 | ||
| Diabetes of the liver: the link between nonalcoholic fatty liver disease and HFCS-55. | Q42450828 | ||
| Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway | Q42815451 | ||
| Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation | Q43003956 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | endoplasmic reticulum | Q79927 |
| insulin resistance | Q1053470 | ||
| steatosis | Q1365091 | ||
| preproinsulin | Q7240673 | ||
| P304 | page(s) | e30816 | |
| P577 | publication date | 2012-02-15 | |
| P1433 | published in | PLOS One | Q564954 |
| P1476 | title | Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance | |
| P478 | volume | 7 |
| Q35741908 | A 72-hour high fat diet increases transcript levels of the neuropeptide galanin in the dorsal hippocampus of the rat. |
| Q38609971 | A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance |
| Q36867522 | Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress. |
| Q28289130 | Adverse metabolic effects of dietary fructose: results from the recent epidemiological, clinical, and mechanistic studies |
| Q90146179 | Anti-inflammatory Property of AMP-activated Protein Kinase |
| Q33858526 | Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion. |
| Q37594114 | Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation |
| Q47863906 | Collective and experimental research project for master's students on the pathophysiology of obesity |
| Q38219740 | Developmental programming of obesity and insulin resistance: does mitochondrial dysfunction in oocytes play a role? |
| Q39044073 | Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD). |
| Q36119775 | Differential Responses of Plasma Adropin Concentrations To Dietary Glucose or Fructose Consumption In Humans |
| Q36392668 | Disparate metabolic response to fructose feeding between different mouse strains |
| Q36507547 | Docosahexaenoic Acid Ameliorates Fructose-Induced Hepatic Steatosis Involving ER Stress Response in Primary Mouse Hepatocytes |
| Q37220092 | Effect of BI-1 on insulin resistance through regulation of CYP2E1. |
| Q92702860 | Effects of Maternal Fructose Intake on Perinatal ER-Stress: A Defective XBP1s Nuclear Translocation Affects the ER-stress Resolution |
| Q42989310 | Elevated lipogenesis and diminished cholesterol synthesis in patients with hepatitis C viral infection compared to healthy humans |
| Q51714060 | Fructose supplementation worsens the deleterious effects of short-term high-fat feeding on hepatic steatosis and lipid metabolism in adult rats. |
| Q55062499 | Fucosylated chondroitin sulphate from Cusumaria frondosa mitigates hepatic endoplasmic reticulum stress and inflammation in insulin resistant mice. |
| Q34183986 | Hepatic FoxO1 acetylation is involved in oleanolic acid-induced memory of glycemic control: novel findings from Study 2. |
| Q33913097 | Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding |
| Q51736974 | High-Fructose Consumption Impairs the Redox System and Protein Quality Control in the Brain of Syrian Hamsters: Therapeutic Effects of Melatonin. |
| Q37701509 | High-refined-carbohydrate and high-fat diets induce comparable hepatic tumorigenesis in male mice |
| Q41661616 | Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity. |
| Q87038739 | Long-term taurine supplementation leads to enhanced hepatic steatosis, renal dysfunction and hyperglycemia in mice fed on a high-fat diet |
| Q64093846 | Matrine Protects Against MCD-Induced Development of NASH via Upregulating HSP72 and Downregulating mTOR in a Manner Distinctive From Metformin |
| Q89568436 | Metabolic effects of the dietary monosaccharides fructose, fructose-glucose, or glucose in mice fed a starch-containing moderate high-fat diet |
| Q47423998 | Modelling insulin resistance in rodents by alterations in diet. What have "high fat" and high calorie diets revealed? |
| Q37062751 | Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease |
| Q33814245 | Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish |
| Q36527942 | Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways |
| Q34364516 | Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice. |
| Q58783695 | PGC-1α in hepatic UPR during high-fat high-fructose diet and exercise training in mice |
| Q53813254 | Peripheral insulin resistance predicts liver damage in nondiabetic subjects with nonalcoholic fatty liver disease. |
| Q60301971 | Preconditioning lessens high fat induced metabolic syndrome along with markers of increased metabolic capacity in muscle and adipose tissue |
| Q64087511 | Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept |
| Q89450069 | Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice |
| Q34602496 | SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose |
| Q38971887 | Shifts in dietary carbohydrate-lipid exposure regulate expression of the non-alcoholic fatty liver disease-associated gene PNPLA3/adiponutrin in mouse liver and HepG2 human liver cells. |
| Q33599367 | Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice |
| Q54289083 | Similar changes in muscle lipid metabolism are induced by chronic high-fructose feeding and high-fat feeding in C57BL/J6 mice. |
| Q37446318 | The Mediation of Hepatic Lipogenesis Through Estrogens |
| Q37412003 | The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease |
| Q38351925 | The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling. |
| Q35084113 | Transcriptomic analysis of hepatic responses to testosterone deficiency in miniature pigs fed a high-cholesterol diet. |
| Q88609413 | Triggering and resolution of inflammation in NASH |
| Q42559592 | Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice |
| Q36616784 | What is the role of adiponectin in obesity related non-alcoholic fatty liver disease? |
| Q41195914 | eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet |
| Q58102109 | α-Linolenic acid prevents hepatic steatosis and improves glucose tolerance in mice fed a high-fat diet |
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