Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice

scientific article published on 06 July 2018

Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41401-018-0016-8
P932PMC publication ID6289344
P698PubMed publication ID29980742

P50authorRoss VlahosQ87918648
Stephen R. RobinsonQ37828979
P2093author name stringJun Xu
Wen Tan
Songpei Li
Xiao-Yi Zeng
Ji-Ming Ye
Xiu Zhou
Ali Mahzari
P2860cites workLiver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.Q38311106
Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitusQ38319698
Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis.Q38669230
Repurposing Drugs to Target the Diabetes EpidemicQ38743445
Non-alcoholic fatty liver disease (NAFLD) prevalence and its metabolic associations in patients with type 1 diabetes and type 2 diabetesQ38833207
Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compoundsQ39310551
Effect of matrine on the expression of substance P receptor and inflammatory cytokines production in human skin keratinocytes and fibroblastsQ40139694
Role of unfolded protein response in lipogenesisQ41128321
Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat dietQ43177148
Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistanceQ43935456
PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegalyQ44295528
Protective effects of matrine against progression of high-fructose diet-induced steatohepatitis by enhancing antioxidant and anti-inflammatory defences involving Nrf2 translocationQ45345539
Restoration of autophagy alleviates hepatic ER stress and impaired insulin signalling transduction in high fructose-fed male miceQ46961307
Effects of fructose and glucose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans.Q51343064
Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.Q51497444
Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats.Q51620845
Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression.Q53013442
IRE1 impairs insulin signaling transduction of fructose-fed mice via JNK independent of excess lipid.Q55069645
Investigation of the role of SREBP-1c in the pathogenesis of HCV-related steatosisQ61895897
Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feedingQ63372079
HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interactionQ21145793
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetesQ24629052
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
Hepatitis C virus hijacks host lipid metabolismQ24652319
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysisQ28508851
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseQ29619334
The Sweet Path to Metabolic Demise: Fructose and Lipid SynthesisQ30249128
Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent modelQ34021867
Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance.Q34166238
Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice.Q34364516
Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetesQ34370610
Lipid-induced insulin resistance: unravelling the mechanismQ34370958
Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitisQ34436747
PPARδ agonists have opposing effects on insulin resistance in high fat-fed rats and mice due to different metabolic responses in muscleQ35005682
Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance.Q35016133
Radix Sophorae flavescentis for chronic hepatitis B: a systematic review of randomized trialsQ35207408
Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat.Q35680888
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetesQ35811523
Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream targetQ36016417
HSP72 protects against obesity-induced insulin resistanceQ36446531
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered miceQ36479005
Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress.Q36867522
Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assemblyQ36913366
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humansQ37170824
Physiologically based pharmacokinetics of matrine in the rat after oral administration of pure chemical and ACAPHAQ37188046
Dissociating fatty liver and diabetesQ38050214
De novo lipogenesis in health and disease.Q38210722
P433issue11
P304page(s)1753-1759
P577publication date2018-07-06
P1433published inActa Pharmacologica SinicaQ15749885
P1476titleRepurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice
P478volume39

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cites work (P2860)
Q61799706Effects of Radix Linderae extracts on a mouse model of diabetic bladder dysfunction in later decompensated phase
Q64093846Matrine Protects Against MCD-Induced Development of NASH via Upregulating HSP72 and Downregulating mTOR in a Manner Distinctive From Metformin
Q59330033Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway

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