Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress.

scientific article published on 24 January 2013

Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2337/DB12-1397
P932PMC publication ID3661626
P698PubMed publication ID23349482
P5875ResearchGate publication ID235371842

P50authorXiao-Yi ZengQ59681783
Hao WangQ59693997
Stanley ChanQ79859597
P2093author name stringMatthew J Watt
Ji-Ming Ye
Ruo-Qiong Sun
Zi-Heng Choong
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IKK-beta links inflammation to obesity-induced insulin resistanceQ29614285
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Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in miceQ30513404
Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in miceQ33553422
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Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistanceQ37105295
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humansQ37170824
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A ceramide-centric view of insulin resistanceQ38007631
Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistanceQ39388424
Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolismQ39928700
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.Q40701074
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitateQ42476162
Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.Q42508603
Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathwayQ42815451
PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasisQ43226732
Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: comparison with PPAR-gamma activationQ43555551
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscleQ43990155
Casitas b-lineage lymphoma-deficient mice are protected against high-fat diet-induced obesity and insulin resistanceQ46966521
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
insulin resistanceQ1053470
steatosisQ1365091
P304page(s)2095-2105
P577publication date2013-01-24
P1433published inDiabetesQ895262
P1476titleActivation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress
P478volume62

Reverse relations

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