| scholarly article | Q13442814 |
| P50 | author | Thomas Rutkowski | Q73255638 |
| P2093 | author name string | D Thomas Rutkowski | |
| P2860 | cites work | SIRT1 negatively regulates the mammalian target of rapamycin | Q21142655 |
| Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 | ||
| CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression | Q24291231 | ||
| Roles of CHOP/GADD153 in endoplasmic reticulum stress | Q24302185 | ||
| Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response | Q24304232 | ||
| A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response | Q24305069 | ||
| Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway | Q24537844 | ||
| The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma | Q24805822 | ||
| The unfolded protein response: the dawn of a new field | Q26777462 | ||
| Energy metabolism in the liver | Q26996783 | ||
| Alcoholic and non-alcoholic steatohepatitis | Q27000153 | ||
| The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis | Q27319729 | ||
| The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307) | Q28139056 | ||
| Pathways for protein disulphide bond formation | Q28141294 | ||
| Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance | Q28244602 | ||
| Hepatocellular carcinoma: epidemiology and molecular carcinogenesis | Q28306363 | ||
| Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes | Q28506402 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum | Q28509611 | ||
| The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation | Q28510062 | ||
| XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands | Q28510479 | ||
| Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish | Q28539163 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver | Q28577788 | ||
| Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance | Q61993990 | ||
| Effect of fatty acids on physical properties of microsomes from isolated perfused rat liver | Q71180972 | ||
| Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis | Q73700066 | ||
| Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis | Q73735584 | ||
| Acetaminophen induces ER dependent signaling in mouse liver | Q79505704 | ||
| CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis | Q80229577 | ||
| Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis | Q81441036 | ||
| C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation | Q83433872 | ||
| Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liver | Q83810163 | ||
| Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses | Q84654008 | ||
| Assays for induction of the unfolded protein response and selective activation of the three major pathways | Q86984959 | ||
| Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis | Q37164215 | ||
| GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice | Q37170811 | ||
| Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H | Q37280552 | ||
| Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability | Q37377347 | ||
| SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease | Q37463911 | ||
| LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition | Q37469224 | ||
| The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy | Q37519318 | ||
| Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. | Q37703451 | ||
| GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN. | Q37714508 | ||
| The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology | Q37860033 | ||
| Calcium signaling around Mitochondria Associated Membranes (MAMs). | Q37937074 | ||
| Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications | Q37983300 | ||
| The endoplasmic reticulum-mitochondria connection: one touch, multiple functions. | Q38161252 | ||
| XBP1s Is an Anti-lipogenic Protein | Q38291938 | ||
| METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction. | Q38297313 | ||
| Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice | Q38354947 | ||
| The antioxidant machinery of the endoplasmic reticulum: Protection and signaling | Q38368254 | ||
| Cell death induced by endoplasmic reticulum stress. | Q38639996 | ||
| Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction | Q38732966 | ||
| Protein quality control at the endoplasmic reticulum | Q38981679 | ||
| C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis | Q36967242 | ||
| Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity | Q36981204 | ||
| Endoplasmic reticulum stress and liver injury | Q36989688 | ||
| mTOR couples cellular nutrient sensing to organismal metabolic homeostasis | Q37097444 | ||
| Peroxisome proliferator-activated receptor alpha acts as a mediator of endoplasmic reticulum stress-induced hepatocyte apoptosis in acute liver failure. | Q37120406 | ||
| Divergent Roles of IRS (Insulin Receptor Substrate) 1 and 2 in Liver and Skeletal Muscle | Q39277642 | ||
| Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome | Q39299566 | ||
| IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. | Q39299575 | ||
| BCL-2 family: integrating stress responses at the ER to control cell demise | Q39378629 | ||
| Detection and quantification of endoplasmic reticulum stress in living cells using the fluorescent compound, Thioflavin T. | Q39405623 | ||
| Activation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein | Q39550327 | ||
| Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells | Q39616452 | ||
| Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator-Activated Receptor α. | Q39748140 | ||
| Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases cAMP-stimulated hepatic gluconeogenesis via inhibition of CREB. | Q39761357 | ||
| Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice | Q39975807 | ||
| Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis | Q40002274 | ||
| Real-time detection and continuous monitoring of ER stress in vitro and in vivo by ES-TRAP: evidence for systemic, transient ER stress during endotoxemia. | Q40249855 | ||
| Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells | Q40313352 | ||
| Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2. | Q40966919 | ||
| Regulation of VLDL synthesis and secretion in the liver. | Q41173128 | ||
| eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet | Q41195914 | ||
| Role for the endoplasmic reticulum stress sensor IRE1α in liver regenerative responses | Q41628812 | ||
| Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish | Q41764630 | ||
| The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis | Q41791624 | ||
| Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing. | Q41811106 | ||
| Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice | Q41825121 | ||
| The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis | Q41904044 | ||
| Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy | Q41912442 | ||
| UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. | Q42041480 | ||
| Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling | Q42045464 | ||
| ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development | Q42199386 | ||
| ER Stress-induced Inflammasome Activation Contributes to Hepatic Inflammation and Steatosis | Q42355577 | ||
| ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress | Q42518206 | ||
| CREBH Couples Circadian Clock With Hepatic Lipid Metabolism | Q42718227 | ||
| Temporal clustering of gene expression links the metabolic transcription factor HNF4α to the ER stress-dependent gene regulatory network | Q42970598 | ||
| Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice | Q43076742 | ||
| Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. | Q43106855 | ||
| Circadian clock-coordinated 12 Hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liver | Q43194435 | ||
| Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER. | Q44317091 | ||
| Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome | Q44385945 | ||
| Involvement of endoplasmic reticulum stress in insulin resistance and diabetes | Q45127777 | ||
| Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor | Q45200756 | ||
| Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease | Q45308989 | ||
| The Unfolded Protein Response and Cell Fate Control | Q46394895 | ||
| CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury | Q46823993 | ||
| Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice. | Q46857277 | ||
| A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease | Q47073806 | ||
| Role of the unfolded protein response in determining the fate of tumor cells and the promise of multi-targeted therapies | Q47738152 | ||
| Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice. | Q48448374 | ||
| Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet | Q50082945 | ||
| Activation of the Unfolded Protein Response by Lipid Bilayer Stress. | Q50540191 | ||
| ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis. | Q50968208 | ||
| CREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis. | Q51025282 | ||
| Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress. | Q51188275 | ||
| Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes. | Q51346281 | ||
| Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress. | Q53654532 | ||
| Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice. | Q54327674 | ||
| In vivo imaging of the spatiotemporal activity of the eIF2 -ATF4 signaling pathway: Insights into stress and related disorders | Q57174327 | ||
| Cytosolic NADP(+)-dependent isocitrate dehydrogenase. Isolation of rat cDNA and study of tissue-specific and developmental expression of mRNA | Q28580849 | ||
| Fibroblast growth factor 21 is induced by endoplasmic reticulum stress | Q28581415 | ||
| Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction | Q28592129 | ||
| An essential role in liver development for transcription factor XBP-1 | Q28593777 | ||
| ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals | Q28646129 | ||
| Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression | Q28818754 | ||
| Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response | Q29547299 | ||
| The unfolded protein response: from stress pathway to homeostatic regulation | Q29547396 | ||
| An integrated stress response regulates amino acid metabolism and resistance to oxidative stress | Q29547441 | ||
| Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes | Q29615503 | ||
| Mitofusin 2 tethers endoplasmic reticulum to mitochondria | Q29619861 | ||
| Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. | Q30488194 | ||
| Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering | Q30496639 | ||
| Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner | Q30701525 | ||
| Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins | Q33262919 | ||
| A highly sensitive assay for monitoring the secretory pathway and ER stress | Q33288966 | ||
| ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity | Q33492751 | ||
| Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish | Q33814245 | ||
| A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse | Q33834161 | ||
| BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K | Q33838482 | ||
| Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response | Q33838972 | ||
| Liver regeneration | Q33870218 | ||
| BiP availability distinguishes states of homeostasis and stress in the endoplasmic reticulum of living cells | Q33907006 | ||
| Necroptosis: the release of damage-associated molecular patterns and its physiological relevance | Q34035754 | ||
| FoxO1 links hepatic insulin action to endoplasmic reticulum stress | Q34132566 | ||
| A blast from the past: clearance of apoptotic cells regulates immune responses. | Q34162195 | ||
| Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity | Q34181503 | ||
| Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis | Q34192744 | ||
| Sarco(endo)plasmic reticulum Ca 2+ -ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity | Q34320510 | ||
| Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity | Q34449244 | ||
| Hepatic ANGPTL3 regulates adipose tissue energy homeostasis | Q34490931 | ||
| Deciphering B-ZIP transcription factor interactions in vitro and in vivo | Q34507956 | ||
| The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex | Q34673344 | ||
| Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis. | Q34790153 | ||
| Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver | Q34813321 | ||
| Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells | Q34836604 | ||
| Ca2+ signaling and calcium binding chaperones of the endoplasmic reticulum | Q35051255 | ||
| CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model | Q35067403 | ||
| Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis | Q35204677 | ||
| Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism | Q35378742 | ||
| p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis | Q35419603 | ||
| The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. | Q35551757 | ||
| Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation. | Q35612368 | ||
| Apoptosis: the nexus of liver injury and fibrosis. | Q35651666 | ||
| Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice | Q35709954 | ||
| CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis | Q35717788 | ||
| IRE1α activation protects mice against acetaminophen-induced hepatotoxicity | Q35760821 | ||
| Sustained activation of PPARα by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice | Q35790318 | ||
| Inhibition of fatty acid oxidation enhances oxidative protein folding and protects hepatocytes from endoplasmic reticulum stress | Q35790896 | ||
| Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice | Q35870151 | ||
| Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis | Q35887283 | ||
| Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum. | Q35895318 | ||
| Chronic inflammation, immune escape, and oncogenesis in the liver: a unique neighborhood for novel intersections | Q36055039 | ||
| Attenuating the endoplasmic reticulum stress response improves functional recovery after spinal cord injury | Q36082154 | ||
| Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet | Q36114917 | ||
| Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents | Q36183590 | ||
| ER stress induces NLRP3 inflammasome activation and hepatocyte death. | Q36293033 | ||
| Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. | Q36330343 | ||
| Overview of animal models of obesity. | Q36351868 | ||
| Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet | Q36382065 | ||
| The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism | Q36497151 | ||
| C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver | Q36596344 | ||
| IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis | Q36600595 | ||
| Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver | Q36635369 | ||
| Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains | Q36712468 | ||
| Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis | Q36746670 | ||
| Differential control of the CCAAT/enhancer-binding protein beta (C/EBPbeta) products liver-enriched transcriptional activating protein (LAP) and liver-enriched transcriptional inhibitory protein (LIP) and the regulation of gene expression during the | Q36825517 | ||
| Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes | Q36861224 | ||
| Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress. | Q36867522 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 356-378 | |
| P577 | publication date | 2018-01-23 | |
| P1433 | published in | FEBS Journal | Q1388041 |
| P1476 | title | Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response | |
| P478 | volume | 286 |
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