Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice

scientific article published on 9 February 2012

Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.24783
P932PMC publication ID3319338
P698PubMed publication ID22095841
P5875ResearchGate publication ID51808036

P50authorStephen A. DuncanQ30512288
Krishna Rao MaddipatiQ57360345
P2093author name stringPaul Williams
Randal J Kaufman
Gregory Dyson
Chunbin Zhang
Guohui Wang
Kezhong Zhang
Xuebao Zhang
Ze Zheng
P2860cites workCREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expressionQ24291231
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory responseQ24304232
The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinomaQ24805822
Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectinsQ28217899
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factorQ28238069
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseQ29614930
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesionsQ33731663
A proposed model for the assembly of chylomicronsQ33783778
Proteolytic and lipolytic responses to starvationQ33997322
Fatty acid regulation of hepatic gene transcription.Q34463124
Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulinQ34610542
Prostaglandin catabolizing enzymesQ34998010
Quantitative assessment of atherosclerotic lesions in miceQ36456167
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered miceQ36479005
Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein HQ37280552
Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD).Q37281827
Progression of alcoholic and non-alcoholic steatohepatitis: common metabolic aspects of innate immune system and oxidative stressQ37819737
The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.Q38348083
Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cellsQ39834604
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolismQ41909224
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH.Q43106855
Hypertriglyceridemia Associated with Deficiency of Apolipoprotein C-IIQ46930868
Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet.Q46955928
ER stress signaling by regulated proteolysis of ATF6Q81604029
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectfatty acidQ61476
endoplasmic reticulumQ79927
P304page(s)1070-1082
P577publication date2012-02-09
P1433published inHepatologyQ15724398
P1476titleEndoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice
P478volume55

Reverse relations

cites work (P2860)
Q38871211Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid
Q36673609An orchestrated program regulating secretory pathway genes and cargos by the transmembrane transcription factor CREB-H.
Q37000389Bax Inhibitor-1 regulates hepatic lipid accumulation via ApoB secretion
Q42629530CIDE Family-Mediated Unique Lipid Droplet Morphology in White Adipose Tissue and Brown Adipose Tissue Determines the Adipocyte Energy Metabolism
Q37195626COX7AR is a Stress-inducible Mitochondrial COX Subunit that Promotes Breast Cancer Malignancy
Q41965207CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα.
Q42718227CREBH Couples Circadian Clock With Hepatic Lipid Metabolism
Q90167132CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms
Q51025282CREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis.
Q55137606CREBH Regulates Systemic Glucose and Lipid Metabolism.
Q37005595CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis
Q47214292Cell death-inducing DNA fragmentation factor A-like effector A and fat-specific protein 27β coordinately control lipid droplet size in brown adipocytes
Q89728169Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease
Q36754775Complexity of microRNA function and the role of isomiRs in lipid homeostasis.
Q40157473Critical role of CREBH-mediated induction of TGF-β2 by HCV infection in fibrogenic responses in hepatic stellate cells
Q41139952Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress.
Q46304887Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced Hepatic Steatosis in Mice.
Q35081048Diabetes mellitus is associated with hepatocellular carcinoma: a retrospective case-control study in hepatitis endemic area
Q58617286Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms
Q50968208ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis.
Q39364235Endoplasmic Reticulum Lipid Flux Influences Enterocyte Nuclear Morphology and Lipid-dependent Transcriptional Responses.
Q35821225Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes
Q37250797Endoplasmic reticulum factor ERLIN2 regulates cytosolic lipid content in cancer cells
Q33828303Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease
Q36729260Exposure to fine airborne particulate matter induces macrophage infiltration, unfolded protein response, and lipid deposition in white adipose tissue
Q35899007Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids
Q42237860GSK-3-mediated phosphorylation couples ER-Golgi transport and nuclear stabilization of the CREB-H transcription factor to mediate apolipoprotein secretion
Q52644448Genetic and Epigenetic Regulation in Nonalcoholic Fatty Liver Disease (NAFLD).
Q64252579Glucagon-Induced Acetylation of Energy-Sensing Factors in Control of Hepatic Metabolism
Q38789248Gluconeogenic signals regulate iron homeostasis via hepcidin in mice
Q41646513HBx induces the proliferation of hepatocellular carcinoma cells via AP1 over-expressed as a result of ER stress.
Q37098973Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression
Q42501673Hepatic BSCL2 (Seipin) Deficiency Disrupts Lipid Droplet Homeostasis and Increases Lipid Metabolism via SCD1 Activity.
Q58616116Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH
Q34873332Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH.
Q90364064Hepatocyte-specific Sirt6 deficiency impairs ketogenesis
Q36996099Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system
Q36951181ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis
Q36600595IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis
Q37061267Identification and characterization of cyclic AMP response element-binding protein H response element in the human apolipoprotein A5 gene promoter
Q47164817Inhalation Exposure to PM2.5 Counteracts Hepatic Steatosis in Mice Fed High-fat Diet by Stimulating Hepatic Autophagy.
Q50226931Insulin regulation of gluconeogenesis
Q87753980Interaction between stress responses and circadian metabolism in metabolic disease
Q37680190Intermittent selective clamping improves rat liver regeneration by attenuating oxidative and endoplasmic reticulum stress
Q37368738Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression.
Q34107296Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling.
Q49843619Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response
Q37594100Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21.
Q38291709Loss of Transcription Factor CREBH Accelerates Diet-Induced Atherosclerosis in Ldlr-/- Mice
Q36289536Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism.
Q59791398Maternal Protein Restriction Induces Alterations in Hepatic Unfolded Protein Response-Related Molecules in Adult Rat Offspring
Q95840450Mechanisms, regulation and functions of the unfolded protein response
Q39161263Micropatterned co-culture of hepatocyte spheroids layered on non-parenchymal cells to understand heterotypic cellular interactions
Q36386635Modulation Effect of Peroxisome Proliferator-Activated Receptor Agonists on Lipid Droplet Proteins in Liver
Q38760996Modulation of cAMP levels by high-fat diet and curcumin and regulatory effects on CD36/FAT scavenger receptor/fatty acids transporter gene expression.
Q38075862Molecular mechanisms of hypolipidemic effects of curcumin
Q36215429OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro
Q37505719Orphan nuclear receptor Errγ induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH.
Q30402192Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis.
Q64978042PCAF fine-tunes hepatic metabolic syndrome, inflammatory disease, and cancer.
Q35907138Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model.
Q35747483Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation
Q36063743Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets.
Q41583320Physiological/pathological ramifications of transcription factors in the unfolded protein response
Q92626349Regulation of hepatic autophagy by stress-sensing transcription factor CREBH
Q37352508Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences.
Q54397189Role of the unfolded protein response in organ physiology: lessons from mouse models.
Q49596452Sensing and signaling mechanisms linking dietary methionine restriction to the behavioral and physiological components of the response
Q38202500Signaling pathways from the endoplasmic reticulum and their roles in disease
Q38074493Targeting endoplasmic reticulum stress in metabolic disease
Q38132652Targeting the unfolded protein response in disease.
Q42970598Temporal clustering of gene expression links the metabolic transcription factor HNF4α to the ER stress-dependent gene regulatory network
Q91782825The Role of Mammalian Creb3-Like Transcription Factors in Response to Nutrients
Q41640752The SMAD Pathway Is Required for Hepcidin Response During Endoplasmic Reticulum Stress
Q30391726The effect of exposure to a high-fat diet on microRNA expression in the liver of blunt snout bream (Megalobrama amblycephala)
Q36062081The impact of the unfolded protein response on human disease
Q36004290The role of CREB-H transcription factor in triglyceride metabolism
Q38093057The role of the unfolded protein response in diabetes mellitus
Q42725767Toll-like Receptor (TLR) Signaling Interacts with CREBH to Modulate High-density Lipoprotein (HDL) in Response to Bacterial Endotoxin.
Q35085357Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis
Q64106408Transcriptional profiling of PPARα-/- and CREB3L3-/- livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα
Q46719881Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.
Q90080201Type I interferons and endoplasmic reticulum stress in health and disease
Q26748807Utilization of animal models to investigate non-alcoholic steatohepatitis-associated hepatocellular carcinoma
Q41553287Varicella-zoster virus glycoprotein expression differentially induces the unfolded protein response in infected cells
Q60916320Volatolomics in Bacterial Ecotoxicology, A Novel Method for Detecting Signatures of Pesticide Exposure?
Q39245270cAMP response element binding protein H mediates fenofibrate-induced suppression of hepatic lipogenesis
Q33654923β-Cryptoxanthin alleviates diet-induced nonalcoholic steatohepatitis by suppressing inflammatory gene expression in mice
Q36748405β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H.

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