Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling.

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Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M114.588764
P932PMC publication ID4148868
P698PubMed publication ID25035425

P50authorImran N. MungrueQ55909082
Thomas RutkowskiQ73255638
P2093author name stringRandal J Kaufman
Miklós Péterfy
Hui Z Mao
Javier A Gomez
Nicole Ehrhardt
Candy Bedoya
Diane DeZwaan-McCabe
P2860cites workCloning of a unique lipase from endothelial cells extends the lipase gene familyQ22009533
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alphaQ24322072
Endoplasmic reticulum stress: cell life and death decisions.Q24536108
A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteinsQ24541564
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemiaQ28118749
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
Combined lipase deficiency (cld): a lethal mutation on chromosome 17 of the mouseQ28509657
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumQ28512249
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulumQ28588244
Combined lipase deficiency in the mouse. Evidence of impaired lipase processing and secretionQ28590447
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene inductionQ28854565
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stressQ29615495
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
Transcriptional regulation of VEGF-A by the unfolded protein response pathwayQ33539754
Novel LMF1 nonsense mutation in a patient with severe hypertriglyceridemiaQ33644452
Mechanisms of lipase maturationQ33904125
Regulation of adipocyte developmentQ34324691
Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissueQ34486733
Lipase maturation factor 1 is required for endothelial lipase activity.Q34955884
Lipase maturation factor 1: a lipase chaperone involved in lipid metabolismQ35784094
Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in miceQ35870151
Transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and humansQ35903355
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Biochemistry and pathophysiology of intravascular and intracellular lipolysisQ36708030
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.Q36954378
Hepatic lipase maturation: a partial proteome of interacting factorsQ37190381
Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences.Q37352508
Lipase maturation factor 1: structure and role in lipase folding and assemblyQ37707896
How does protein misfolding in the endoplasmic reticulum affect lipid metabolism in the liver?Q38190781
Maturation of hepatic lipase. Formation of functional enzyme in the endoplasmic reticulum is the rate-limiting step in its secretionQ38347777
Mechanisms and clinical implications of hepatocyte lipoapoptosisQ39845029
Transcriptional repression of the prosurvival endoplasmic reticulum chaperone GRP78/BIP by E2F1Q39931621
Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers.Q40421034
Maturation of lipoprotein lipase in the endoplasmic reticulum. Concurrent formation of functional dimers and inactive aggregatesQ40756628
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretionQ40871524
cld and lec23 are disparate mutations that affect maturation of lipoprotein lipase in the endoplasmic reticulum.Q40912459
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stressQ42518206
Temporal clustering of gene expression links the metabolic transcription factor HNF4α to the ER stress-dependent gene regulatory networkQ42970598
Induction of endoplasmic reticulum-induced stress genes in Panc-1 pancreatic cancer cells is dependent on Sp proteinsQ46370605
Maturation of lipoprotein lipase. Expression of full catalytic activity requires glucose trimming but not translocation to the cis-Golgi compartmentQ46455577
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulumQ80935578
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-IIQ81144490
P433issue35
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)24417-24427
P577publication date2014-07-17
P1433published inJournal of Biological ChemistryQ867727
P1476titleLipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling
P478volume289

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cites work (P2860)
Q38816682Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis
Q38552126Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

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