ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis

scientific article published on 24 June 2013

ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...867234W
P356DOI10.1371/JOURNAL.PONE.0067234
P932PMC publication ID3691114
P698PubMed publication ID23826244
P5875ResearchGate publication ID245030283

P50authorRudolph LeibelQ7377432
Jay H. LefkowitchQ107128464
P2093author name stringElizabeth Watson
Charles A LeDuc
Kazuhisa Watanabe
Stuart G Fischer
Elizabeth J Millings
Maria Laura Cremona
P2860cites workEndoplasmic reticulum stress: cell life and death decisions.Q24536108
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONQ25939000
Endoplasmic reticulum stress and type 2 diabetesQ26864238
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation stateQ28278880
Correct homeostasis model assessment (HOMA) evaluation uses the computer programQ28290512
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to 14.5 days of gestationQ28513300
Molecular cloning of a lipolysis-stimulated remnant receptor expressed in the liverQ28570526
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in miceQ28586497
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survivalQ28593963
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene deliveryQ29615235
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathwayQ34128069
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesityQ34181503
A novel BAT3 sequence generated by alternative RNA splicing of exon 11B displays cell type-specific expression and impacts on subcellular localizationQ34256996
Sarco(endo)plasmic reticulum Ca 2+ -ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesityQ34320510
Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioningQ34511046
Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42Q34560844
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosisQ34609585
Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulinQ34610542
Genetic manipulations of fatty acid metabolism in beta-cells are associated with dysregulated insulin secretion.Q35022163
Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis.Q51375339
Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie dietQ57782515
A new recurrent chromosomal translocation t(3;11)(q13;q14) in myelodysplastic syndromes associated with overexpression of the ILDR1 geneQ59547371
Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistanceQ61993990
Blockade of intestinal lipoprotein clearance in rabbits injected with Triton WR 1339-ethyl oleateQ69144953
A time-dependent phase shift in the mammalian unfolded protein responseQ72997174
Endoplasmic reticulum Ca(2+) handling in excitable cells in health and diseaseQ35122788
Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance.Q35186665
Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formationQ35747483
Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in miceQ35870151
Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model.Q35907138
Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model.Q35992718
The impact of the unfolded protein response on human diseaseQ36062081
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodentsQ36183590
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistanceQ36583167
The genetic landscape of type 2 diabetes in miceQ36612875
Intermediate filament cytoskeleton of the liver in health and diseaseQ36661678
Endoplasmic reticulum stress: signaling the unfolded protein responseQ36844431
Fatty liver: a novel component of the metabolic syndromeQ36906553
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Membrane phospholipid synthesis and endoplasmic reticulum functionQ37308781
Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in miceQ37334591
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosisQ37465347
Insulin resistance in nonalcoholic fatty liver disease.Q37725021
Why does NAFLD predict type 2 diabetes?Q37856880
Role of endoplasmic reticulum stress in metabolic disease and other disorders.Q37976132
Reproducibility and accuracy of body composition assessments in mice by dual energy x-ray absorptiometry and time domain nuclear magnetic resonanceQ38353372
Analysis of the 'angulin' proteins LSR, ILDR1 and ILDR2--tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis.Q39226349
Identification of the cellular receptor of Clostridium spiroforme toxinQ39410820
LSR defines cell corners for tricellular tight junction formation in epithelial cellsQ39606199
Up-regulation of hepatic lipolysis stimulated lipoprotein receptor by leptin: a potential lever for controlling lipid clearance during the postprandial phaseQ39677679
Characterization of a novel immunoglobulin-like domain containing receptorQ40513291
Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and aQ40542044
Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT/enhancer-binding protein-homologous protein (CHOP/GADD153).Q40699167
Effect of cell type on the subcellular localization of the thyrotropin-releasing hormone receptorQ41113791
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stressQ42451739
Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH.Q43106855
Blood clearance rates of adenovirus type 5 in miceQ45871684
Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.Q45880303
Endoplasmic reticulum stress plays a central role in development of leptin resistanceQ46178586
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)e67234
P577publication date2013-06-24
P1433published inPLOS OneQ564954
P1476titleILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis
P478volume8

Reverse relations

cites work (P2860)
Q92802737A novel upstream transcription factor 1 target gene N4bp2l1 that regulates adipogenesis
Q41287621Angulin proteins ILDR1 and ILDR2 regulate alternative pre-mRNA splicing through binding to splicing factors TRA2A, TRA2B, or SRSF1
Q47957465Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus
Q91971036Genome-wide scan highlights the role of candidate genes on phenotypic plasticity for age at first calving in Nellore heifers
Q50066262ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.
Q54977679ILDR2 has a negligible role in hepatic steatosis.
Q50066281ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance.
Q92029371Kbtbd11 contributes to adipocyte homeostasis through the activation of upstream stimulatory factor 1
Q64375284Kbtbd11 gene expression in adipose tissue increases in response to feeding and affects adipocyte differentiation
Q36686168Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis
Q35998854RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome
Q46378953Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma

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