Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress

scientific article published on 14 July 2010

Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E09-02-0133
P932PMC publication ID2929991
P698PubMed publication ID20631254

P2093author name stringTakashi Sato
Kazutoshi Mori
Keisuke Yamamoto
Seiichi Oyadomari
Tetsuya Okada
Akihiro Harada
Kazuna Takahara
P2860cites workMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-betaQ22011091
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein responseQ24290935
Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein responseQ24534422
Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein responseQ24548363
Nonalcoholic fatty liver diseaseQ24555779
The blind men 'see' the elephant-the many faces of fatty liver diseaseQ24654991
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.Q24815740
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONQ25939000
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Protein synthesis upon acute nutrient restriction relies on proteasome functionQ40336957
The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid compositionQ40705151
Degradation of newly synthesized apolipoprotein B-100 in a pre-Golgi compartmentQ41728130
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stressQ42518206
Developmental changes of synapsin I subcellular localization in rat cerebellar neuronsQ48849020
Regulated Co-translational ubiquitination of apolipoprotein B100. A new paradigm for proteasomal degradation of a secretory proteinQ56971926
Intrahepatic assembly of very low density lipoproteins. Rate of transport out of the endoplasmic reticulum determines rate of secretionQ69447815
The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-lifeQ69543027
CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in miceQ80142989
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulumQ80935578
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradationQ28131669
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcriptionQ28287446
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathwaysQ28365886
Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overloadQ28506232
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
Dynamic and regulated association of caveolin with lipid bodies: modulation of lipid body motility and function by a dominant negative mutantQ28581882
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein responseQ28611502
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
The mammalian unfolded protein responseQ29547400
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controlsQ29547730
Steatohepatitis: a tale of two "hits"?Q29547771
Lipid droplets: a unified view of a dynamic organelleQ29614467
Molecular mediators of hepatic steatosis and liver injuryQ29616709
Molecular chaperones and protein quality controlQ29617795
Protein disulfide isomerase: the multifunctional redox chaperone of the endoplasmic reticulumQ33794232
Tripartite management of unfolded proteins in the endoplasmic reticulumQ33941135
A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.Q34202341
Activation of mammalian unfolded protein response is compatible with the quality control system operating in the endoplasmic reticulumQ34358672
Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidationQ34512108
Mechanisms of non-alcoholic steatohepatitisQ34554507
Retro-translocation of proteins from the endoplasmic reticulum into the cytosolQ34627241
Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteinsQ34634838
HRD gene dependence of endoplasmic reticulum-associated degradationQ34711814
Pathogenesis of steatohepatitisQ34983506
Nonalcoholic steatohepatitis: what we know in the new millenniumQ34993711
HSP47 as a collagen-specific molecular chaperone: function and expression in normal mouse developmentQ35676791
The role of p58IPK in protecting the stressed endoplasmic reticulumQ35949048
Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis.Q36366205
Mouse models in non-alcoholic fatty liver disease and steatohepatitis research.Q36377266
Diversity of endotoxin and its impact on pathogenesisQ36585994
PPARalpha and dyslipidemiaQ36866428
Nonalcoholic fatty liver disease and mitochondrial dysfunctionQ37054354
Transcriptional regulation of peroxisome proliferator-activated receptors and liver X receptors.Q37074308
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
P433issue17
P921main subjectendoplasmic reticulumQ79927
pharmacologyQ128406
steatosisQ1365091
knockout mouseQ1364740
P304page(s)2975-2986
P577publication date2010-07-14
P1433published inMolecular Biology of the CellQ2338259
P1476titleInduction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress
P478volume21

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