Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease

scientific article

Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3748/WJG.V20.I7.1768
P3181OpenCitations bibliographic resource ID2962485
P932PMC publication ID3930975
P698PubMed publication ID24587654

P2093author name stringXue-Qun Zhang
P2860cites workCoupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stressQ24291026
TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liverQ24304147
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory responseQ24304232
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alphaQ24322072
Endoplasmic reticulum stress: cell life and death decisions.Q24536108
FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissueQ24643006
Atf4 regulates obesity, glucose homeostasis, and energy expenditureQ24648259
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosisQ28240946
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiationQ28507769
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stressQ28511471
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adultsQ29614911
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severityQ29614914
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stressQ29615495
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunitiesQ29617768
Epidemiology of alcoholic and nonalcoholic fatty liver disease in China.Q30352093
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stressQ42451739
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.Q43242090
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
Involvement of endoplasmic reticulum stress in insulin resistance and diabetesQ45127777
NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitisQ46802365
CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injuryQ46823993
Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective StudyQ51541188
Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance.Q53181684
Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers.Q53543252
Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis.Q54321919
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitisQ73735584
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver diseaseQ79788222
CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitisQ80229577
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosisQ81441036
ATF4 regulates lipid metabolism and thermogenesisQ82468721
Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat dietQ84966488
Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell deathQ33840334
Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.Q34148542
Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidationQ34512108
Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feedingQ34524224
Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma.Q34525065
The cell biology of the unfolded protein response.Q35085852
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stressesQ35169632
Cellular mechanism of insulin resistance in nonalcoholic fatty liver diseaseQ35239565
Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitisQ35490178
Endoplasmic reticulum stress in liver diseaseQ36031838
Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathwayQ36313774
Review: The role of insulin resistance in nonalcoholic fatty liver diseaseQ36591903
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implicationsQ36617551
ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylationQ36660203
C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitisQ36967242
Endoplasmic reticulum stress and liver injuryQ36989688
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight lossQ37105351
ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice.Q37132127
ATF6 modulates SREBP2-mediated lipogenesis.Q37260315
Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein responseQ37389501
Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidaseQ37456875
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2Q37622629
Insulin resistance in nonalcoholic fatty liver disease.Q37725021
Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver DiseaseQ37794163
The Role of Lipid Metabolism in the Pathogenesis of Alcoholic and Nonalcoholic Hepatic SteatosisQ37801599
Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implicationsQ37983300
Clinical Review: Nonalcoholic fatty liver disease: a novel cardiometabolic risk factor for type 2 diabetes and its complications.Q38072021
Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integrationQ38073952
NAFLD in Asia--as common and important as in the WestQ38086356
Nuclear factor (erythroid-derived 2)-like-2 factor (Nrf2), a key regulator of the antioxidant response to protect against atherosclerosis and nonalcoholic steatohepatitisQ38087926
Chromium alleviates glucose intolerance, insulin resistance, and hepatic ER stress in obese miceQ38292063
Endoplasmic reticulum stress leads to lipid accumulation through upregulation of SREBP-1c in normal hepatic and hepatoma cellsQ39148101
Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat modelQ39165020
Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell deathQ39912377
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
pathogenesisQ372016
liver diseaseQ929737
metabolic dysfunction–associated steatotic liver diseaseQ1546498
fatty liver diseaseQ6058862
P304page(s)1768-76
P577publication date2014-02-21
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleRole of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease
P478volume20

Reverse relations

cites work (P2860)
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