| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2008PNAS..10516314B |
| P356 | DOI | 10.1073/PNAS.0808517105 |
| P932 | PMC publication ID | 2570995 |
| P698 | PubMed publication ID | 18852460 |
| P5875 | ResearchGate publication ID | 23317668 |
| P50 | author | Craig B. Thompson | Q5180710 |
| Douglas R. Cavener | Q56489345 | ||
| P2093 | author name string | Christina Grigoriadou | |
| Ekaterina Bobrovnikova-Marjon | |||
| Georgia Hatzivassiliou | |||
| J. Alan Diehl | |||
| Margarita Romero | |||
| P2860 | cites work | Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress | Q24292499 |
| Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER | Q24305459 | ||
| Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes | Q24681212 | ||
| A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION | Q25939000 | ||
| Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B | Q27860731 | ||
| Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs | Q28115918 | ||
| PERK mediates cell-cycle exit during the mammalian unfolded protein response | Q28141519 | ||
| Translational control is required for the unfolded protein response and in vivo glucose homeostasis | Q28204066 | ||
| Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1 | Q28276509 | ||
| Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase | Q28296183 | ||
| Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2) | Q28305998 | ||
| Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function | Q28504899 | ||
| The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas | Q28505821 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival | Q28593963 | ||
| Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies | Q28611460 | ||
| The mammalian unfolded protein response | Q29547400 | ||
| Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF | Q29619663 | ||
| PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice | Q33295459 | ||
| ATP citrate lyase is an important component of cell growth and transformation | Q34432794 | ||
| The unfolding tale of the unfolded protein response | Q34486042 | ||
| Transcriptional regulation of metabolism | Q34511703 | ||
| Regulation of sterol synthesis in eukaryotes. | Q34657925 | ||
| Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: a link between a key cell proliferative pathway and membrane synthesis | Q34661758 | ||
| Mammary physiology and milk secretion | Q35111470 | ||
| Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis! | Q35749416 | ||
| Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2 | Q39315996 | ||
| Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice | Q39975807 | ||
| Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest | Q40246328 | ||
| Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression | Q40343371 | ||
| ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress | Q42518206 | ||
| Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis. | Q42832143 | ||
| Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. | Q45345766 | ||
| Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). | Q46626421 | ||
| Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine. | Q47313889 | ||
| SREBPs suppress IRS-2-mediated insulin signalling in the liver | Q47868873 | ||
| Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice. | Q48870288 | ||
| Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum | Q50336389 | ||
| PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation. | Q51951390 | ||
| PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. | Q52000258 | ||
| The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. | Q53579178 | ||
| Use of nile red for the rapid in situ quantitation of lipids on thin-layer chromatograms | Q69449116 | ||
| Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2 | Q80553475 | ||
| Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition | Q81347002 | ||
| P433 | issue | 42 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | adipocyte | Q357519 |
| Eukaryotic translation initiation factor 2A | Q21983243 | ||
| Eukaryotic translation initiation factor 2 alpha kinase 3 | Q21984224 | ||
| P304 | page(s) | 16314–16319 | |
| P577 | publication date | 2008-10-21 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation | |
| P478 | volume | 105 |
| Q89629318 | 1,25-hydroxyvitamin D3 decreases endoplasmic reticulum stress-induced inflammatory response in mammary epithelial cells |
| Q58591803 | 4-Phenylbutyric Acid Protects Ethanol-induced Damage in the Developing Mouse Brain |
| Q54199151 | AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response. |
| Q53795513 | Attenuation of Endoplasmic Reticulum Stress-Mediated Liver Damage by Mulberry Leaf Diet in Streptozotocin-Induced Diabetic Rats. |
| Q90151376 | Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway |
| Q42772839 | Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice |
| Q63246525 | Chewing the Fat: The Conserved Ability of DNA Viruses to Hijack Cellular Lipid Metabolism |
| Q33841075 | Chronic administration of brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reverses obesity induced by high-fat diet |
| Q33771982 | Circadian clock-coordinated hepatic lipid metabolism: only transcriptional regulation? |
| Q37087635 | Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue |
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| Q37784942 | Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes |
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| Q38989169 | Endoplasmic reticulum stress in the regulation of liver diseases: Involvement of Regulated IRE1α and β-dependent decay and miRNA. |
| Q33826820 | Endoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol trafficking |
| Q102211135 | Endoplasmic reticulum stress signals in the tumour and its microenvironment |
| Q36062468 | Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors |
| Q35288559 | Epithelial Xbp1 is required for cellular proliferation and differentiation during mammary gland development |
| Q35069547 | Eucommia ulmoides Oliver extract, aucubin, and geniposide enhance lysosomal activity to regulate ER stress and hepatic lipid accumulation |
| Q37426801 | Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been |
| Q42820703 | FFA‐Induced Adipocyte Inflammation and Insulin Resistance: Involvement of ER Stress and IKKβ Pathways |
| Q58709227 | Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer |
| Q37596032 | Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome |
| Q37432106 | GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase. |
| Q91751735 | GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury |
| Q37170811 | GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice |
| Q37535667 | Genetic deletion of Rheb1 in the brain reduces food intake and causes hypoglycemia with altered peripheral metabolism |
| Q39259539 | Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination. |
| Q37710429 | Impact of high cholesterol and endoplasmic reticulum stress on metabolic diseases: An updated mini-review |
| Q28236897 | Inflammation and cellular stress: a mechanistic link between immune-mediated and metabolically driven pathologies |
| Q46074650 | Inhibition of hepatocyte nuclear factor 1b induces hepatic steatosis through DPP4/NOX1-mediated regulation of superoxide |
| Q34985745 | Intersection of the unfolded protein response and hepatic lipid metabolism |
| Q36223912 | Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis. |
| Q54349322 | Ixeris dentata decreases ER stress and hepatic lipid accumulation through regulation of ApoB secretion. |
| Q27013858 | Lipid biology of breast cancer |
| Q53635269 | Lipopolysaccharide markedly changes glucose metabolism and mitochondrial function in the longissimus muscle of pigs. |
| Q38898700 | Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuries |
| Q38076705 | Minireview: endoplasmic reticulum stress: control in protein, lipid, and signal homeostasis. |
| Q38260582 | Molecular insights into the mechanisms of liver-associated diseases in early-lactating dairy cows: hypothetical role of endoplasmic reticulum stress |
| Q42801163 | Nck2, an unexpected regulator of adipogenesis |
| Q49358405 | Nonthermal plasma treated solution inhibits adipocyte differentiation and lipogenesis in 3T3-L1 preadipocytes via ER stress signal suppression |
| Q54701983 | Nutritional stimulation of milk protein yield of cows is associated with changes in phosphorylation of mammary eukaryotic initiation factor 2 and ribosomal s6 kinase 1. |
| Q39456761 | O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling. |
| Q35716234 | PDIA3 Knockdown Exacerbates Free Fatty Acid-Induced Hepatocyte Steatosis and Apoptosis |
| Q28397172 | PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development |
| Q36224716 | PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. |
| Q35192134 | PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment |
| Q36435206 | PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis |
| Q33977034 | PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage |
| Q36023300 | PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation |
| Q34671888 | PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection |
| Q89624072 | Pcsk9 knockout exacerbates diet-induced non-alcoholic steatohepatitis, fibrosis and liver injury in mice |
| Q35184903 | Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions |
| Q35907138 | Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model. |
| Q54586533 | Promastigote to amastigote differentiation of Leishmania is markedly delayed in the absence of PERK eIF2alpha kinase-dependent eIF2alpha phosphorylation. |
| Q36324486 | Protective Effects of Alisma orientale Extract against Hepatic Steatosis via Inhibition of Endoplasmic Reticulum Stress |
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| Q28577788 | Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver |
| Q36692569 | Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK |
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| Q38202220 | Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease. |
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| Q42980095 | Sustained upregulation of stearoyl-CoA desaturase in bovine mammary tissue with contrasting changes in milk fat synthesis and lipogenic gene networks caused by lipid supplements. |
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