Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

scientific article published on September 2009

Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/J.MOLCEL.2009.08.021
P8608Fatcat IDrelease_c53srwrfofd6noktdpkx3myofq
P932PMC publication ID3101568
P698PubMed publication ID19748352
P5875ResearchGate publication ID26806583

P50authorLaurie GlimcherQ6501587
P2093author name stringClaudio Hetz
P2860cites workCoupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stressQ24291026
Plasma cell differentiation requires the transcription factor XBP-1Q24291453
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsQ24298956
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress responseQ24303865
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alphaQ24310536
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeastQ24314476
AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress responseQ24314664
USP14 inhibits ER-associated degradation via interaction with IRE1alphaQ24314979
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alphaQ24320638
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alphaQ24322072
Autophagy suppresses tumorigenesis through elimination of p62Q24650670
One step at a time: endoplasmic reticulum-associated degradationQ24658302
Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nucleaseQ24805574
Divergent effects of PERK and IRE1 signaling on cell viabilityQ27438124
Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA SplicingQ27649529
The unfolded protein response signals through high-order assembly of Ire1Q27653139
Autophagy in the Pathogenesis of DiseaseQ27860558
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.Q27931697
Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteinsQ27932183
Comprehensive characterization of genes required for protein folding in the endoplasmic reticulumQ27937991
Proteasome inhibitors disrupt the unfolded protein response in myeloma cellsQ28155919
The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the GolgiQ28217040
Cell death: critical control pointsQ28240722
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasisQ28258427
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreasQ28505821
Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stressQ28506667
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiationQ28507769
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosisQ28588618
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stressQ28592598
ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulumQ37186859
The endoplasmic reticulum stress response in immunity and autoimmunityQ37231726
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorderQ38350959
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.Q39814866
Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular BakQ39865156
Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1.Q39917756
A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1.Q41854293
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stressQ42518206
Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.Q47942024
Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteinsQ50336381
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulumQ50336389
Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres.Q52178375
X-box binding protein 1 (XBP1) C--116G polymorphisms in bipolar disorders and age of onsetQ80495715
Translocation of Bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stress-induced apoptosisQ80795514
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
Genetics of bipolar disorderQ81010615
Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosisQ81507240
An essential role in liver development for transcription factor XBP-1Q28593777
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survivalQ28593963
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
The BCL-2 protein family: opposing activities that mediate cell deathQ29547380
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
Autophagy is activated for cell survival after endoplasmic reticulum stressQ29614485
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
Biological and chemical approaches to diseases of proteostasis deficiencyQ29616633
ER stress triggers apoptosis by activating BH3-only protein BimQ29617730
Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stressQ30164007
Evolutionarily conserved cytoprotection provided by Bax Inhibitor-1 homologs from animals, plants, and yeastQ31031519
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteinsQ33262919
A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathwayQ33475622
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.Q33777806
On the mechanism of sensing unfolded protein in the endoplasmic reticulumQ34230593
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationQ34345459
Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injuryQ34479417
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expressionQ34563098
Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expressionQ34631694
Messenger RNA targeting to endoplasmic reticulum stress signalling sites.Q34903088
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein responseQ35029280
BAX Inhibitor-1, an ancient cell death suppressor in animals and plants with prokaryotic relativesQ35838773
Regulatory roles of JNK in programmed cell deathQ35842920
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.Q36393034
Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetesQ36393503
Functionality of unspliced XBP1 is required to explain evolution of overlapping reading framesQ36620957
Bax Inhibitor-1 Is a pH-dependent regulator of Ca2+ channel activity in the endoplasmic reticulumQ36701864
ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damageQ36940021
Integrated endoplasmic reticulum stress responses in cancerQ37002431
The daily job of night killers: alternative roles of the BCL-2 family in organelle physiologyQ37031106
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagyQ37075287
Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stressQ37105304
The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegenerationQ37160833
The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cellsQ37181198
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)551-561
P577publication date2009-09-01
P1433published inMolecular CellQ3319468
P1476titleFine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome
P478volume35

Reverse relations

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