| scholarly article | Q13442814 |
| P50 | author | Diego Rojas-Rivera | Q79257563 |
| P2093 | author name string | Claudio Hetz | |
| Estefanie Dufey | |||
| Denisse Sepúlveda | |||
| P2860 | cites work | Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress | Q22010800 |
| Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 | ||
| XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease | Q22252318 | ||
| Plasma cell differentiation requires the transcription factor XBP-1 | Q24291453 | ||
| XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 | ||
| Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response | Q24292966 | ||
| Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 | Q24293501 | ||
| The unfolded protein response: integrating stress signals through the stress sensor IRE1α | Q24293771 | ||
| ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats | Q24298956 | ||
| Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells | Q24299603 | ||
| Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53 | Q24300781 | ||
| Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress | Q24306658 | ||
| BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha | Q24310536 | ||
| Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast | Q24314476 | ||
| Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha | Q24322072 | ||
| Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. | Q24541469 | ||
| An integrated genomic analysis of human glioblastoma multiforme | Q24648860 | ||
| Autophagy suppresses tumorigenesis through elimination of p62 | Q24650670 | ||
| XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy | Q24655821 | ||
| IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response | Q24672592 | ||
| When ER stress reaches a dead end | Q26998580 | ||
| Endoplasmic reticulum stress in malignancy | Q27006434 | ||
| The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling | Q27008029 | ||
| Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis | Q27313877 | ||
| Divergent effects of PERK and IRE1 signaling on cell viability | Q27438124 | ||
| Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing | Q27649529 | ||
| The unfolded protein response signals through high-order assembly of Ire1 | Q27653139 | ||
| Signal integration in the endoplasmic reticulum unfolded protein response | Q27860577 | ||
| Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase | Q27938837 | ||
| Perk is essential for translational regulation and cell survival during the unfolded protein response | Q28140062 | ||
| IRE1α activation protects mice against acetaminophen-induced hepatotoxicity | Q35760821 | ||
| Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy | Q35909430 | ||
| The role of the unfolded protein response in tumour development: friend or foe? | Q35968425 | ||
| BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. | Q36000128 | ||
| The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis | Q36314567 | ||
| Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. | Q36330343 | ||
| Role of the unfolded protein response in cell death | Q36351719 | ||
| Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. | Q36364876 | ||
| Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. | Q36393034 | ||
| Comparison of mRNA localization and regulation during endoplasmic reticulum stress in Drosophila cells. | Q36490338 | ||
| Nonmuscle myosin IIB links cytoskeleton to IRE1α signaling during ER stress. | Q36540356 | ||
| Negative feedback by IRE1β optimizes mucin production in goblet cells | Q36637632 | ||
| ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo | Q36640055 | ||
| Defects in IRE1 enhance cell death and fail to degrade mRNAs encoding secretory pathway proteins in the Arabidopsis unfolded protein response. | Q36747723 | ||
| Activating transcription factor 4. | Q36805075 | ||
| MicroRNA-1291-mediated silencing of IRE1α enhances Glypican-3 expression. | Q36932880 | ||
| ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. | Q36954378 | ||
| Integrated endoplasmic reticulum stress responses in cancer | Q37002431 | ||
| X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function | Q37015048 | ||
| IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. | Q37091581 | ||
| ER-phagy: selective autophagy of the endoplasmic reticulum. | Q46683304 | ||
| Bcl-2-family proteins: the role of the BH3 domain in apoptosis | Q47686942 | ||
| Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum | Q50336389 | ||
| RNase domains determine the functional difference between IRE1alpha and IRE1beta. | Q50336397 | ||
| PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation. | Q51951390 | ||
| Activation of an unfolded protein response during differentiation of antibody-secreting B cells. | Q52113898 | ||
| Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. | Q52545083 | ||
| Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance. | Q53181684 | ||
| Role of the unfolded protein response in organ physiology: lessons from mouse models. | Q54397189 | ||
| Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast | Q28140422 | ||
| EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome | Q28142981 | ||
| Translational control is required for the unfolded protein response and in vivo glucose homeostasis | Q28204066 | ||
| IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA | Q28214814 | ||
| Cell death: critical control points | Q28240722 | ||
| Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice | Q28300013 | ||
| Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice | Q28359871 | ||
| Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP | Q28476029 | ||
| The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas | Q28505821 | ||
| Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload | Q28506232 | ||
| Regulated translation initiation controls stress-induced gene expression in mammalian cells | Q28506388 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands | Q28510479 | ||
| Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha | Q28512201 | ||
| CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum | Q28512249 | ||
| The transcription factor XBP-1 is essential for the development and survival of dendritic cells | Q28512302 | ||
| Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state | Q28572472 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| Mfn2 modulates the UPR and mitochondrial function via repression of PERK | Q28589398 | ||
| BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress | Q28592598 | ||
| Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival | Q28593963 | ||
| TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis | Q28594126 | ||
| ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals | Q28646129 | ||
| Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response | Q29547299 | ||
| The BCL-2 protein family: opposing activities that mediate cell death | Q29547380 | ||
| The unfolded protein response: from stress pathway to homeostatic regulation | Q29547396 | ||
| Autophagy and the Integrated Stress Response | Q29547398 | ||
| The mammalian unfolded protein response | Q29547400 | ||
| An integrated stress response regulates amino acid metabolism and resistance to oxidative stress | Q29547441 | ||
| Patterns of somatic mutation in human cancer genomes | Q29547841 | ||
| Autophagy is activated for cell survival after endoplasmic reticulum stress | Q29614485 | ||
| Mitochondria and cell death: outer membrane permeabilization and beyond | Q29615459 | ||
| Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress | Q29615495 | ||
| Mediators of endoplasmic reticulum stress-induced apoptosis | Q29615496 | ||
| IRE1 signaling affects cell fate during the unfolded protein response | Q29615502 | ||
| Quality control in the endoplasmic reticulum | Q29619929 | ||
| Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics | Q29620467 | ||
| Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress | Q30164007 | ||
| Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments | Q37124391 | ||
| Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. | Q37173956 | ||
| The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells | Q37181198 | ||
| Cytochrome c: functions beyond respiration | Q37196132 | ||
| Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma | Q37284612 | ||
| Regulated Ire1-dependent decay of messenger RNAs in mammalian cells | Q37309146 | ||
| Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability | Q37377347 | ||
| In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles | Q37394440 | ||
| Posttranscriptional regulation of PER1 underlies the oncogenic function of IREα. | Q37561026 | ||
| Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome | Q37596032 | ||
| Protein disulfide isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent association | Q37687467 | ||
| Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells | Q37811174 | ||
| Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat. | Q37814626 | ||
| Targeting the unfolded protein response in disease. | Q38132652 | ||
| TMBIM protein family: ancestral regulators of cell death | Q38190369 | ||
| Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases | Q38195215 | ||
| Getting RIDD of RNA: IRE1 in cell fate regulation | Q38198370 | ||
| The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells. | Q38309617 | ||
| Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. | Q38311676 | ||
| Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response | Q38845249 | ||
| Interaction of Nck1 and PERK phosphorylated at Y⁵⁶¹ negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content | Q39039522 | ||
| IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. | Q39422225 | ||
| XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum | Q39659690 | ||
| IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. | Q39814866 | ||
| Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak | Q39865156 | ||
| IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo. | Q40105547 | ||
| Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers. | Q40421034 | ||
| A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1. | Q41854293 | ||
| PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription | Q41888962 | ||
| UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. | Q42041480 | ||
| Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2 | Q42094437 | ||
| Activation of the unfolded protein response enhances motor recovery after spinal cord injury | Q42143560 | ||
| Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress | Q42163338 | ||
| A novel ER stress-independent function of the UPR in angiogenesis | Q42214059 | ||
| Addicted to secrete - novel concepts and targets in cancer therapy | Q42231665 | ||
| Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress | Q42451739 | ||
| ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress | Q42518206 | ||
| Autocrine control of glioma cells adhesion and migration through IRE1α-mediated cleavage of SPARC mRNA. | Q43811645 | ||
| A composite tissue‐engineered trachea using sheep nasal chondrocyte and epithelial cells | Q44425148 | ||
| ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response | Q46116386 | ||
| Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. | Q30465575 | ||
| Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma | Q30496396 | ||
| Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering | Q30496639 | ||
| Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits | Q30543820 | ||
| The double-stranded RNA-activated protein kinase PKR is dispensable for regulation of translation initiation in response to either calcium mobilization from the endoplasmic reticulum or essential amino acid starvation | Q31855270 | ||
| Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway | Q33264756 | ||
| Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance | Q33602496 | ||
| The ER stress transducer IRE1β is required for airway epithelial mucin production | Q33652759 | ||
| Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs | Q33654233 | ||
| Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance | Q33673551 | ||
| Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia | Q33694514 | ||
| IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level | Q33707431 | ||
| Regulation of basal cellular physiology by the homeostatic unfolded protein response | Q33886820 | ||
| XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway | Q33926690 | ||
| Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics | Q33986242 | ||
| XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages. | Q34047912 | ||
| P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling | Q34179244 | ||
| A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. | Q34202341 | ||
| On the mechanism of sensing unfolded protein in the endoplasmic reticulum | Q34230593 | ||
| Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury | Q34479417 | ||
| Direct association of unfolded proteins with mammalian ER stress sensor, IRE1β | Q34510834 | ||
| PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites | Q34541337 | ||
| Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression | Q34563098 | ||
| Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics | Q34841551 | ||
| Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein | Q34977917 | ||
| Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion | Q35008217 | ||
| The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response | Q35029280 | ||
| TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. | Q35041384 | ||
| The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response | Q35170906 | ||
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | endoplasmic reticulum | Q79927 |
| P304 | page(s) | C582-94 | |
| P577 | publication date | 2014-08-20 | |
| P1433 | published in | American Journal of Physiology - Cell Physiology | Q2227080 |
| P1476 | title | Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview | |
| P478 | volume | 307 |
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