| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2011PNAS..108.8885L |
| P356 | DOI | 10.1073/PNAS.1105564108 |
| P932 | PMC publication ID | 3102350 |
| P698 | PubMed publication ID | 21555585 |
| P5875 | ResearchGate publication ID | 51110785 |
| P50 | author | Gökhan Hotamışlıgil | Q6033455 |
| Laurie Glimcher | Q6501587 | ||
| Ann-Hwee Lee | Q124214884 | ||
| P2093 | author name string | Keely Heidtman | |
| P2860 | cites work | XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease | Q22252318 |
| Plasma cell differentiation requires the transcription factor XBP-1 | Q24291453 | ||
| XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 | ||
| Endoplasmic reticulum stress and the inflammatory basis of metabolic disease | Q24633352 | ||
| Signal integration in the endoplasmic reticulum unfolded protein response | Q27860577 | ||
| Proteasome inhibitors disrupt the unfolded protein response in myeloma cells | Q28155919 | ||
| Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes | Q28506402 | ||
| Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 | Q28507338 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands | Q28510479 | ||
| XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response | Q28585314 | ||
| The mammalian unfolded protein response | Q29547400 | ||
| Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls | Q29547730 | ||
| The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. | Q33300966 | ||
| The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells | Q33320542 | ||
| IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level | Q33707431 | ||
| A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse | Q33834161 | ||
| XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation | Q34345459 | ||
| Proinsulin and the genetics of diabetes mellitus | Q34977895 | ||
| Intersection of the unfolded protein response and hepatic lipid metabolism | Q34985745 | ||
| Endoplasmic reticulum stress and the development of diabetes: a review | Q35022174 | ||
| Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus | Q35552583 | ||
| XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. | Q36322684 | ||
| Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. | Q36393034 | ||
| Dense-core secretory granule biogenesis | Q36432227 | ||
| Regulated Ire1-dependent decay of messenger RNAs in mammalian cells | Q37309146 | ||
| Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells | Q37343526 | ||
| Hyperproinsulinemia is associated with increased beta cell demand after hemipancreatectomy in humans | Q37350440 | ||
| XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development | Q37377432 | ||
| XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum | Q39659690 | ||
| IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. | Q39814866 | ||
| Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes | Q40176269 | ||
| Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. | Q40236795 | ||
| The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells. | Q40581298 | ||
| Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice | Q42173352 | ||
| ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress | Q42518206 | ||
| Insulin, proinsulin, proinsulin:insulin ratio, and the risk of developing type 2 diabetes mellitus in women | Q44427238 | ||
| The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits | Q45052791 | ||
| Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets. | Q51006407 | ||
| Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects. | Q51025311 | ||
| Proinsulin as a marker for the development of NIDDM in Japanese-American men. | Q51590740 | ||
| Disproportionately increased proinsulin levels are associated with the insulin resistance syndrome. | Q51592496 | ||
| Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients. | Q51626329 | ||
| The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain development. | Q51899074 | ||
| PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. | Q52000258 | ||
| Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1 | Q80979487 | ||
| P433 | issue | 21 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 8885-8890 | |
| P577 | publication date | 2011-05-09 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion | |
| P478 | volume | 108 |
| Q38935432 | ATF6β regulates the Wfs1 gene and has a cell survival role in the ER stress response in pancreatic β-cells |
| Q33565839 | Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism |
| Q58122031 | Anti-diabetic Effect of Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3β and Inhibition of IRE1α-XBP1 Pathways |
| Q35881709 | Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis. |
| Q90707615 | Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes |
| Q60045810 | Bioluminescent reporter assay for monitoring ER stress in human beta cells |
| Q37373729 | Calcium signalling and ER stress in insulin resistance and atherosclerosis |
| Q38971267 | Cell Signaling and Stress Responses. |
| Q38241810 | Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview. |
| Q36604026 | Circadian control of β-cell function and stress responses |
| Q47813504 | Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response |
| Q39297443 | Cross-talk between the unfolded protein response and nuclear factor-κB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets |
| Q37582526 | Deficiency of the BiP cochaperone ERdj4 causes constitutive endoplasmic reticulum stress and metabolic defects |
| Q38261088 | Druggable sensors of the unfolded protein response |
| Q38558319 | ER stress and development of type 1 diabetes |
| Q47894399 | ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras. |
| Q58554232 | Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes |
| Q26827965 | Emerging functions of the unfolded protein response in immunity |
| Q39139204 | Endoplasmic Reticulum (ER) Stress and Endocrine Disorders. |
| Q89951520 | Endoplasmic Reticulum Stress Signaling in Cancer Cells |
| Q38385700 | Endoplasmic reticulum quality control in cancer: Friend or foe. |
| Q33828303 | Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease |
| Q26864238 | Endoplasmic reticulum stress and type 2 diabetes |
| Q38030876 | Endoplasmic reticulum stress in cardiometabolic disorders |
| Q57243233 | Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications |
| Q35288559 | Epithelial Xbp1 is required for cellular proliferation and differentiation during mammary gland development |
| Q64941368 | Exendin-4 protects INS-1 cells against palmitate-induced apoptosis through the IRE1α-Xbp1 signaling pathway. |
| Q92005094 | Exploration of a diversity of computational and statistical measures of association for genome-wide genetic studies |
| Q36796096 | Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes |
| Q47260586 | GRP94 is an Essential Regulator of Pancreatic β Cell Development, Mass and Function in Male Mice |
| Q41518068 | Genetic deficiency in neuronal peroxisomal fatty acid β-oxidation causes the interruption of dauer development in Caenorhabditis elegans |
| Q34314018 | Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer |
| Q35136628 | Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass. |
| Q61512382 | Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress |
| Q35213294 | Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress |
| Q41344802 | IER3IP1 deficiency leads to increased β-cell death and decreased β-cell proliferation |
| Q35204732 | IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis |
| Q52728755 | IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells. |
| Q55283549 | IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases. |
| Q35760821 | IRE1α activation protects mice against acetaminophen-induced hepatotoxicity |
| Q35868391 | IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis |
| Q26827218 | Innate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathway |
| Q36165645 | Insulin demand regulates β cell number via the unfolded protein response |
| Q64076341 | Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis |
| Q37512312 | Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity |
| Q27015015 | Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases |
| Q34380313 | Lack of XBP-1 impedes murine cytomegalovirus gene expression. |
| Q90668030 | Lessons from animal models of endocrine disorders caused by defects of protein folding in the secretory pathway |
| Q35082235 | Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. |
| Q29620447 | Mechanisms for insulin resistance: common threads and missing links |
| Q40088521 | Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes. |
| Q48152192 | Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes. |
| Q28393599 | Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment |
| Q36467006 | PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1. |
| Q36379500 | PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response. |
| Q27305957 | Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia |
| Q35799671 | Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes |
| Q54122859 | Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization. |
| Q28478056 | Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity |
| Q38209331 | Physiological roles of regulated Ire1 dependent decay |
| Q41583320 | Physiological/pathological ramifications of transcription factors in the unfolded protein response |
| Q36820961 | Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes |
| Q38704807 | Protein misfolding in the endoplasmic reticulum as a conduit to human disease |
| Q36418004 | Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation |
| Q64971224 | Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways. |
| Q45387412 | Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells |
| Q37352508 | Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences. |
| Q38153592 | Regulatory crosstalk within the mammalian unfolded protein response |
| Q34213205 | Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes |
| Q37976132 | Role of endoplasmic reticulum stress in metabolic disease and other disorders. |
| Q54397189 | Role of the unfolded protein response in organ physiology: lessons from mouse models. |
| Q38210545 | Role of the unfolded protein response in β cell compensation and failure during diabetes |
| Q54119551 | Scopoletin intervention in pancreatic endoplasmic reticulum stress induced by lipotoxicity. |
| Q90390291 | Sel1L-Hrd1 ER-associated degradation maintains β-cell identity via TGFβ signaling |
| Q91137776 | Serum biomarkers for diagnosis and prediction of type 1 diabetes |
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| Q38202500 | Signaling pathways from the endoplasmic reticulum and their roles in disease |
| Q36330343 | Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. |
| Q64965104 | Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes. |
| Q37568237 | Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes. |
| Q48708732 | Systemic effects of AGEs in ER stress induction in vivo |
| Q38852387 | Targeting ABL-IRE1α signaling spares ER-stressed pancreatic β cells to reverse autoimmune diabetes |
| Q38074493 | Targeting endoplasmic reticulum stress in metabolic disease |
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| Q89965531 | The Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities |
| Q92000954 | The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc |
| Q42858034 | The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells |
| Q35808715 | The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells. |
| Q26776377 | The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment |
| Q57792065 | The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress |
| Q37729757 | The diabetes gene Hhex maintains δ-cell differentiation and islet function |
| Q36062081 | The impact of the unfolded protein response on human disease |
| Q58185753 | The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo |
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| Q36314567 | The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis |
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| Q36744754 | Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function |
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| Q35822682 | Type 2 diabetes as a protein misfolding disease. |
| Q38490628 | Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition |
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| Q41997586 | Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish |
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