Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function

scientific article published on 20 January 2016

Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M115.685750
P932PMC publication ID4813565
P698PubMed publication ID26792861

P2093author name stringMichele A Battle
Jason C Mills
Haiyan Wang
Fumihiko Urano
Claes B Wollheim
Benjamin D Moore
Heiyong Lo
Min Jung
Ramon U Jin
P2860cites workA gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)Q22003951
Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein HQ37280552
XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell developmentQ37377432
Cav1.2 and Cav1.3 are differentially coupled to glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion in the pancreatic beta-cell line INS-1.Q37416435
Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium.Q37451902
Calcium efflux from the endoplasmic reticulum leads to β-cell deathQ37594059
Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensorQ37700695
A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the youngQ38296057
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cellsQ38331321
XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic ReticulumQ39659690
Calcium-induced calcium release in neuronesQ41000747
Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1.Q41841514
Measuring ER stress and the unfolded protein response using mammalian tissue culture systemQ41898554
Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis.Q43116152
Adenoviral gene transfer into isolated pancreatic isletsQ43274911
The measurement of insulin secretion from isolated rodent islets of Langerhans.Q45979037
Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cellsQ46868194
Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitationQ47404772
Autoregulation of the HAC1 gene is required for sustained activation of the yeast unfolded protein responseQ47981105
Molecular genetics and phenotypic characteristics of MODY caused by hepatocyte nuclear factor 4α mutations in a large European collectionQ57920428
Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretionQ74248211
Genetic analysis of HNF4A polymorphisms in Caucasian-American type 2 diabetesQ81580501
A protocol for islet isolation from mouse pancreasQ84817750
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans developmentQ24292104
RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturationQ24293415
Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 geneQ24561549
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small moleculeQ24596804
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cellsQ24658399
IRE1-independent gain control of the unfolded protein responseQ24798921
First measurement of the rate for the inclusive radiative penguin decay b-->s gammaQ27349109
A new generation of Ca2+ indicators with greatly improved fluorescence propertiesQ27860793
Organization and partial sequence of the hepatocyte nuclear factor-4 alpha/MODY1 gene and identification of a missense mutation, R127W, in a Japanese family with MODYQ28250071
Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cellsQ28259615
Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)Q28298538
Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cellsQ28507247
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretionQ28513687
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasisQ28591211
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouseQ29620355
Mapping of HNF4alpha target genes in intestinal epithelial cellsQ33504399
Mulan: multiple-sequence local alignment and visualization for studying function and evolutionQ33596324
A Phos-tag-based approach reveals the extent of physiological endoplasmic reticulum stressQ33641274
Sarco(endo)plasmic reticulum Ca 2+ -ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesityQ34320510
Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liverQ34694228
Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretionQ35008217
The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein responseQ35170906
Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult miceQ35801944
Modulating sarco(endo)plasmic reticulum Ca2+ ATPase 2 (SERCA2) activity: cell biological implications.Q36232527
Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarraysQ36635201
Scaling factors: transcription factors regulating subcellular domainsQ36953736
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)6146-6157
P577publication date2016-01-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleTranscriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function
P478volume291

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cites work (P2860)
Q38989169Endoplasmic reticulum stress in the regulation of liver diseases: Involvement of Regulated IRE1α and β-dependent decay and miRNA.
Q90225387HNF4a transcription is a target of trichloroethylene toxicity in the embryonic mouse heart
Q38762525Hepatocyte nuclear factor 4α is required for cell differentiation and homeostasis in the adult mouse gastric epithelium
Q50021474Patterning the gastrointestinal epithelium to confer regional-specific functions
Q90564951Proliferation and Differentiation of Gastric Mucous Neck and Chief Cells During Homeostasis and Injury-induced Metaplasia
Q92759022Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases
Q60922840The role of lineage specifiers in pancreatic ductal adenocarcinoma
Q50152905Trichloroethylene perturbs HNF4a expression and activity in the developing chick heart.

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