Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment

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Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-15-1570
P932PMC publication ID4854763
P698PubMed publication ID26979393

P50authorLaurie GlimcherQ6501587
Juan R Cubillos-RuizQ89307921
Sarah E BettigoleQ125299143
P2860cites workXBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
Lipid accumulation and dendritic cell dysfunction in cancerQ23912213
Plasma cell differentiation requires the transcription factor XBP-1Q24291453
A synthetic biology approach identifies the mammalian UPR RNA ligase RtcBQ24301555
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small moleculeQ24596804
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myelomaQ24598483
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myelomaQ24600346
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonucleaseQ24628936
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagyQ24655821
Ligand-independent activation of estrogen receptor alpha by XBP-1Q24678871
Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitorsQ27640568
Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease ActivityQ27702249
Proteasome inhibitors disrupt the unfolded protein response in myeloma cellsQ28155919
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell HomeostasisQ28389316
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritisQ28589300
An essential role in liver development for transcription factor XBP-1Q28593777
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineeringQ29615505
Molecular mechanisms of human IRE1 activation through dimerization and ligand bindingQ30404387
Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant gliomaQ30496396
Paneth cells as a site of origin for intestinal inflammation.Q30559414
IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin LevelQ33707431
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathwayQ33926690
Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells.Q34104084
The transcription factor XBP1 is selectively required for eosinophil differentiationQ34483620
Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.Q34572339
Nanomolecular targeting of dendritic cells for ovarian cancer therapyQ34663940
Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretionQ35008217
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.Q35041384
Ovarian cancer progression is controlled by phenotypic changes in dendritic cellsQ35826026
Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stressQ35879593
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagyQ35909430
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer.Q36643661
The role of X-box binding protein-1 in tumorigenicity.Q37553966
Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathwayQ37648367
Targeting the unfolded protein response in disease.Q38132652
Endoplasmic reticulum stress in immunityQ38286013
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimicQ38873500
Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survivalQ38996766
Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.Q40101179
Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell ViabilityQ41884011
Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancerQ46665995
Cytochemical and immunocytochemical characterization of blood cells and immunohistochemical analysis of spleen cells from 2 species of frog, Rana (Aquarana) catesbeiana and Xenopus laevisQ46669350
Trierixin, a novel Inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. 1. Taxonomy, fermentation, isolation and biological activitiesQ46965775
Quinotrierixin inhibited ER stress-induced XBP1 mRNA splicing through inhibition of protein synthesisQ83392806
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
P304page(s)2121-6
P577publication date2016-05-01
P1433published inClinical Cancer ResearchQ332253
P1476titleMolecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment
P478volume22

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cites work (P2860)
Q98778664Activation of unfolded protein response overcomes Ibrutinib resistance in diffuse large B-cell lymphoma
Q91738709Application of a New Multiplexed Array for Rapid, Sensitive, Simultaneous and Quantitative Assessment of Spliced and Unspliced XBP1
Q90129866Generation of in situ sequencing based OncoMaps to spatially resolve gene expression profiles of diagnostic and prognostic markers in breast cancer
Q42319225Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression
Q30252210Recent insights into the implications of metabolism in plasmacytoid dendritic cell innate functions: Potential ways to control these functions
Q47738152Role of the unfolded protein response in determining the fate of tumor cells and the promise of multi-targeted therapies
Q90080201Type I interferons and endoplasmic reticulum stress in health and disease
Q64883325Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells.

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