XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

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XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy is …
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scholarly articleQ13442814

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P356DOI10.1101/GAD.1830709
P8608Fatcat IDrelease_j5l6j6bainbo5khf4rqesnau3u
P3181OpenCitations bibliographic resource ID1741565
P932PMC publication ID2758741
P698PubMed publication ID19762508
P5875ResearchGate publication ID26820096

P50authorLaurie GlimcherQ6501587
Ana María CuervoQ19766132
Robert H BrownQ76762027
P2093author name stringClaudio Hetz
Soledad Matus
Peter Thielen
Roberta Kiffin
Gabriela Martinez
Melissa Nassif
Felipe Court
P2860cites workXBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesQ23757358
Plasma cell differentiation requires the transcription factor XBP-1Q24291453
Role of EDEM in the release of misfolded glycoproteins from the calnexin cycleQ24296412
The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERADQ24297892
Fine structure of the autophagosome.Q53482258
Degradation of Amyotrophic Lateral Sclerosis-linked Mutant Cu,Zn-Superoxide Dismutase Proteins by Macroautophagy and the ProteasomeQ56777088
The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosisQ80352679
Increased autophagy in transgenic mice with a G93A mutant SOD1 geneQ80774356
Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic miceQ80786193
Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosisQ80838012
Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell deathQ81439746
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosisQ24299487
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alphaQ24310536
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome markerQ24633015
Misfolded proteins partition between two distinct quality control compartmentsQ24651093
Autophagy in the Pathogenesis of DiseaseQ27860558
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Autophagy fights disease through cellular self-digestionQ27860902
Induction of autophagy and inhibition of tumorigenesis by beclin 1Q28131718
Suppression of basal autophagy in neural cells causes neurodegenerative disease in miceQ28131756
Loss of autophagy in the central nervous system causes neurodegeneration in miceQ28131804
The roles of intracellular protein-degradation pathways in neurodegenerationQ28269322
Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosisQ28277961
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1Q28300820
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPSQ28306195
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in miceQ28591283
ALS: a disease of motor neurons and their nonneuronal neighborsQ29618000
Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS modelQ34596280
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viabilityQ35916071
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.Q36393034
Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALSQ36491424
Molecular biology of amyotrophic lateral sclerosis: insights from geneticsQ36573336
The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegenerationQ37160833
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.Q38947838
ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.Q39888991
VAPB interacts with and modulates the activity of ATF6.Q40014767
Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis.Q40059458
Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II).Q40164655
Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.Q40254780
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicityQ42042260
Schwann cell to axon transfer of ribosomes: toward a novel understanding of the role of glia in the nervous system.Q44461978
A role for motoneuron subtype-selective ER stress in disease manifestations of FALS miceQ46070173
Protective role of autophagy in neonatal hypoxia-ischemia induced brain injuryQ46400463
Closed head injury induces upregulation of Beclin 1 at the cortical site of injury.Q48820012
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectnervous systemQ9404
amyotrophic lateral sclerosisQ206901
autophagyQ288322
P304page(s)2294-306
P577publication date2009-10-01
P1433published inGenes & DevelopmentQ1524533
P1476titleXBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
P478volume23

Reverse relations

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