| scholarly article | Q13442814 |
| P50 | author | M. Flint Beal | Q67409129 |
| P2093 | author name string | Bobby Thomas | |
| Rebecca Banerjee | |||
| P2860 | cites work | Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease | Q21136406 |
| ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B) | Q24294908 | ||
| PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 | Q24297155 | ||
| PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy | Q24299149 | ||
| Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism | Q24309753 | ||
| Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy | Q24311582 | ||
| Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling | Q24313304 | ||
| Parkin is recruited selectively to impaired mitochondria and promotes their autophagy | Q24317471 | ||
| Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission | Q24320327 | ||
| Hereditary early-onset Parkinson's disease caused by mutations in PINK1 | Q24337084 | ||
| LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing | Q24597817 | ||
| Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments | Q24633947 | ||
| Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy | Q24646352 | ||
| Rapamycin fed late in life extends lifespan in genetically heterogeneous mice | Q24647805 | ||
| Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability | Q24648173 | ||
| XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy | Q24655821 | ||
| Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy | Q24683089 | ||
| Autophagy fights disease through cellular self-digestion | Q27860902 | ||
| TOR, a central controller of cell growth | Q27933354 | ||
| Chaperone-mediated autophagy markers in Parkinson disease brains | Q28115026 | ||
| Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease | Q28261987 | ||
| Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1 | Q28300820 | ||
| Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations | Q28506710 | ||
| The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice | Q28591283 | ||
| Trinucleotide Repeat Disorders | Q29038716 | ||
| Autophagy: process and function | Q29547296 | ||
| Autophagy: from phenomenology to molecular understanding in less than a decade | Q29614174 | ||
| Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy | Q29614178 | ||
| Plasma membrane contributes to the formation of pre-autophagosomal structures | Q29614494 | ||
| Mitochondria supply membranes for autophagosome biogenesis during starvation | Q29614495 | ||
| Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum | Q29614500 | ||
| Autophagy gone awry in neurodegenerative diseases | Q29614849 | ||
| PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy | Q29616005 | ||
| S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury | Q29616550 | ||
| Autophagy in health and disease: a double-edged sword | Q29618103 | ||
| PINK1-dependent recruitment of Parkin to mitochondria in mitophagy | Q29620567 | ||
| Potential therapeutic applications of autophagy | Q29622862 | ||
| Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. | Q30437121 | ||
| Regulation of amyloid precursor protein processing by the Beclin 1 complex | Q33608732 | ||
| Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases | Q33613123 | ||
| Parkinson's disease: from molecular pathways in disease to therapeutic approaches | Q33644302 | ||
| Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy | Q33670282 | ||
| Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease | Q33814719 | ||
| Rapamycin extends maximal lifespan in cancer-prone mice | Q33816255 | ||
| Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis | Q33840243 | ||
| A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease | Q33871331 | ||
| A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease | Q34073879 | ||
| Clearing the brain's amyloid cobwebs | Q34099588 | ||
| A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model. | Q34165508 | ||
| Dynein mutations impair autophagic clearance of aggregate-prone proteins | Q34429194 | ||
| Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. | Q34552031 | ||
| Clinical trials for neuroprotection in ALS. | Q34618907 | ||
| Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. | Q34626231 | ||
| Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease. | Q34740278 | ||
| Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease | Q36320351 | ||
| Lithium induces autophagy by inhibiting inositol monophosphatase | Q36321015 | ||
| Chaperone-mediated autophagy in aging and disease | Q36510519 | ||
| Does autophagy contribute to cell death? | Q36549462 | ||
| A century-old debate on protein aggregation and neurodegeneration enters the clinic | Q36628151 | ||
| Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients | Q36778260 | ||
| Cell death modalities: classification and pathophysiological implications | Q36790543 | ||
| Autophagy, amyloidogenesis and Alzheimer disease | Q37011121 | ||
| Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins | Q37039531 | ||
| Autophagy: principles and significance in health and disease | Q37330775 | ||
| Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps | Q37376117 | ||
| Autophagy, lithium, and amyotrophic lateral sclerosis | Q37554121 | ||
| Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes | Q37606853 | ||
| Chaperone-mediated autophagy in health and disease | Q37660666 | ||
| Pathology of protein synthesis and degradation systems in ALS. | Q37681655 | ||
| The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). | Q39689378 | ||
| Novel targets for Huntington's disease in an mTOR-independent autophagy pathway | Q41978909 | ||
| Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism. | Q42066100 | ||
| Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells | Q42423397 | ||
| Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation | Q42472879 | ||
| Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. | Q42941899 | ||
| Mitochondrial abnormalities in Alzheimer's disease. | Q43581697 | ||
| Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy | Q44406691 | ||
| α-Synuclein Is Degraded by Both Autophagy and the Proteasome | Q44420467 | ||
| Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein | Q45296862 | ||
| Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts | Q45296864 | ||
| Rapamycin alleviates toxicity of different aggregate-prone proteins | Q45299514 | ||
| Studies on brain biopsies of patients with Huntington's chorea | Q45300907 | ||
| Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. | Q45301281 | ||
| Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. | Q45303665 | ||
| A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy | Q45306898 | ||
| Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition. | Q48298684 | ||
| Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer's disease. | Q48304039 | ||
| Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. | Q53263789 | ||
| Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. | Q53369656 | ||
| Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS. | Q54792092 | ||
| The Lysosome | Q55037468 | ||
| Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium | Q57201203 | ||
| Altered macroautophagy in the spinal cord of SOD1 mutant mice | Q80496792 | ||
| Increased autophagy in transgenic mice with a G93A mutant SOD1 gene | Q80774356 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | autophagy | Q288322 |
| neurodegeneration | Q1755122 | ||
| P304 | page(s) | 541-549 | |
| P577 | publication date | 2010-10-12 | |
| P1433 | published in | Trends in Neurosciences | Q3538443 |
| P1476 | title | Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications | |
| P478 | volume | 33 |
| Q36777200 | A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation |
| Q33689169 | AMPK activation--protean potential for boosting healthspan |
| Q60322779 | Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease |
| Q34693311 | Activation of mTOR ameliorates fragile X premutation rCGG repeat-mediated neurodegeneration |
| Q50871143 | Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation. |
| Q42277252 | Adenoviral expression of TDP-43 and FUS genes and shRNAs for protein degradation pathways in rodent motoneurons in vitro and in vivo |
| Q38737652 | Adoptive Autophagy Activation: a Much-Needed Remedy Against Chemical Induced Neurotoxicity/Developmental Neurotoxicity |
| Q35935083 | Aggregation of MBP in chronic demyelination |
| Q41703924 | Association between two α-2-macroglobulin gene polymorphisms and Parkinson's disease: a meta-analysis |
| Q34827331 | Atg4b-dependent autophagic flux alleviates Huntington's disease progression |
| Q36907208 | Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein. |
| Q34096364 | Autophagic induction of amyotrophic lateral sclerosis-linked Cu/Zn superoxide dismutase 1 G93A mutant in NSC34 cells |
| Q34163170 | Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats |
| Q38029001 | Autophagy and Its Comprehensive Impact on ALS. |
| Q38287906 | Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia |
| Q34287719 | Autophagy of mitochondria: a promising therapeutic target for neurodegenerative disease |
| Q38888410 | Autophagy potentially protects against 2,3,7,8-tetrachlorodibenzo-p-Dioxin induced apoptosis in SH-SY5Y cells |
| Q40941779 | Autophagy protects against de novo formation of the [PSI+] prion in yeast |
| Q37686246 | Bioenergetic medicine |
| Q38770543 | Bioenergetics and metabolism: a bench to bedside perspective |
| Q90714628 | Cadmium results in accumulation of autophagosomes-dependent apoptosis through activating Akt-impaired autophagic flux in neuronal cells |
| Q89862560 | Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex |
| Q34770689 | Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neurons |
| Q42922923 | Current Evidence for a Role of Neuropeptides in the Regulation of Autophagy. |
| Q90186667 | DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis |
| Q44617144 | Decreased expression of lysosomal alpha-galactosiase A gene in sporadic Parkinson's disease. |
| Q37200313 | Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15 |
| Q37690389 | Diet-induced obesity impairs spermatogenesis: a potential role for autophagy |
| Q33736536 | Downregulation of MicroRNA-193b-3p Promotes Autophagy and Cell Survival by Targeting TSC1/mTOR Signaling in NSC-34 Cells |
| Q48194110 | Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice |
| Q64262571 | Histone deacetylase 4 protects from denervation and skeletal muscle atrophy in a murine model of amyotrophic lateral sclerosis |
| Q41465422 | Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in a transgenic mouse model of amyotrophic lateral sclerosis. |
| Q37938694 | How can we improve clinical trials in amyotrophic lateral sclerosis? |
| Q36714243 | Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease |
| Q36954995 | Increased generation of cyclopentenone prostaglandins after brain ischemia and their role in aggregation of ubiquitinated proteins in neurons |
| Q33818093 | Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction |
| Q37891848 | Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation |
| Q45118902 | Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation |
| Q35501802 | Linking RNA Dysfunction and Neurodegeneration in Amyotrophic Lateral Sclerosis |
| Q33878853 | MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis. |
| Q41415748 | Managing intracellular transport |
| Q37043326 | Membrane trafficking in neuronal maintenance and degeneration. |
| Q37299382 | Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson's Disease via Autophagy and Mitochondrial ROS Clearance |
| Q64875418 | MicroRNA-7 facilitates the degradation of alpha-synuclein and its aggregates by promoting autophagy |
| Q54942358 | Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson's Disease? |
| Q51737103 | Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics. |
| Q38081388 | Monitoring autophagy in the treatment of protein aggregate diseases: steps toward identifying autophagic biomarkers |
| Q55344929 | Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy. |
| Q38042565 | Neuronal autophagy in cerebral ischemia |
| Q38112078 | Neuronal autophagy: self-eating or self-cannibalism in Alzheimer's disease |
| Q38683881 | Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review |
| Q30537554 | Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession |
| Q37989403 | Non-classical membrane trafficking processes galore |
| Q37210083 | Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model. |
| Q42705625 | Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway |
| Q34571566 | Peroxisome proliferator-activated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury |
| Q52608079 | Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation. |
| Q37641524 | Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson's disease model |
| Q35241298 | Proteomics in neurodegenerative diseases: Methods for obtaining a closer look at the neuronal proteome |
| Q39350772 | Rapid generation of mitochondrial superoxide induces mitochondrion-dependent but caspase-independent cell death in hippocampal neuronal cells that morphologically resembles necroptosis |
| Q89819694 | Real-state of autophagy signaling pathway in neurodegenerative disease; focus on multiple sclerosis |
| Q38329808 | Recent advances in autophagy-based neuroprotection |
| Q41196900 | Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease |
| Q37563505 | Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy |
| Q35958359 | Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases |
| Q34566305 | Role of D-Limonene in autophagy induced by bergamot essential oil in SH-SY5Y neuroblastoma cells |
| Q47143422 | Scrambled eggs: Proteomic portraits and novel biomarkers of egg quality in zebrafish (Danio rerio). |
| Q38108575 | Sirtuins' modulation of autophagy |
| Q64069168 | Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications |
| Q41930602 | Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage |
| Q35294409 | Suppressed autophagy flux in skeletal muscle of an amyotrophic lateral sclerosis mouse model during disease progression |
| Q42220038 | The effects of Brazilian green propolis that contains flavonols against mutant copper-zinc superoxide dismutase-mediated toxicity |
| Q38349925 | The emerging role of acid sphingomyelinase in autophagy |
| Q38006955 | The many faces of mitochondrial autophagy: making sense of contrasting observations in recent research |
| Q37999796 | The role of autophagy in Parkinson's disease. |
| Q38532744 | The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases |
| Q27000356 | The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration |
| Q41740088 | Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson's Disease |
| Q35837162 | Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta₂₅₋₃₅ via the Autophagy Pathway |
| Q51154268 | Unconventional Protein Secretion in Animal Cells. |
| Q90433673 | Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain |
| Q38828092 | Upregulation of cell surface estrogen receptor alpha is associated with the mitogen-activated protein kinase/extracellular signal-regulated kinase activity and promotes autophagy maturation |
| Q48578193 | cPKCγ-Modulated Autophagy in Neurons Alleviates Ischemic Injury in Brain of Mice with Ischemic Stroke Through Akt-mTOR Pathway |
| Q46636484 | mTOR inhibition by rapamycin protects against deltamethrin-induced apoptosis in PC12 Cells |
| Q92817095 | p-Coumaric Acid Has Protective Effects against Mutant Copper-Zinc Superoxide Dismutase 1 via the Activation of Autophagy in N2a Cells |
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