MicroRNA-7 facilitates the degradation of alpha-synuclein and its aggregates by promoting autophagy

scientific article published on 05 May 2018

MicroRNA-7 facilitates the degradation of alpha-synuclein and its aggregates by promoting autophagy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEULET.2018.05.009
P932PMC publication ID5990033
P698PubMed publication ID29738845

P50authorEunsung JunnQ85330559
P2093author name stringDoo Chul Choi
Savan Kabaria
Myungsik Yoo
P2860cites workalpha-Synuclein and neuronal cell deathQ21202835
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistanceQ24335999
Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153Q24633965
Mutation in the alpha-synuclein gene identified in families with Parkinson's diseaseQ27860459
MicroRNAs: small RNAs with a big role in gene regulationQ27860896
Dysregulation of autophagy and mitochondrial function in Parkinson's diseaseQ28071890
The roles of intracellular protein-degradation pathways in neurodegenerationQ28269322
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
Repression of alpha-synuclein expression and toxicity by microRNA-7.Q29542272
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementiaQ29547174
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's diseaseQ29547175
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagyQ29622819
Potential therapeutic applications of autophagyQ29622862
Differential development of neuronal physiological responsiveness in two human neural stem cell linesQ33285898
MicroRNA-7 protects against 1-methyl-4-phenylpyridinium-induced cell death by targeting RelA.Q34197681
Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implicationsQ34311607
Recent advances in the genetics and pathogenesis of Parkinson diseaseQ34502910
Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodiesQ34763209
The cast of molecular characters in Parkinson's disease: felons, conspirators, and suspectsQ35170991
Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates.Q35215169
MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell DeathQ35583229
Caught in the act: alpha-synuclein is the culprit in Parkinson's diseaseQ35594818
Parkinson diseaseQ36319286
Alternative α-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathologyQ36862730
Nilotinib Effects in Parkinson's disease and Dementia with Lewy bodiesQ37225128
MicroRNAs in neurodegenerative diseases and their therapeutic potential.Q37946984
Therapeutic potential of autophagy-enhancing agents in Parkinson's disease.Q38765856
The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's diseaseQ39136811
MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinomaQ39414132
Parkinson disease, LRRK2 and the endocytic-autophagic pathwayQ43273373
α-Synuclein Is Degraded by Both Autophagy and the ProteasomeQ44420467
Parkinson's diseaseQ56877819
Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson DiseaseQ57977634
P921main subjectautophagyQ288322
P304page(s)118-123
P577publication date2018-05-05
P1433published inNeuroscience LettersQ7002625
P1476titleMicroRNA-7 facilitates the degradation of alpha-synuclein and its aggregates by promoting autophagy
P478volume678

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cites work (P2860)
Q97423851Circular RNAs: Promising Molecular Biomarkers of Human Aging-Related Diseases via Functioning as an miRNA Sponge
Q64071921Epigenetic Analysis in Human Neurons: Considerations for Disease Modeling in PD
Q64085226Extracellular vesicles degradation pathway based autophagy lysosome pathway
Q64898499MicroRNAs: Game Changers in the Regulation of α-Synuclein in Parkinson's Disease.
Q64768819The role of the protein-RNA recognition code in neurodegeneration
Q92350333Trained Innate Immunity Not Always Amicable