Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly

scientific article

Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/JCM4040715
P932PMC publication ID4470163
P698PubMed publication ID26239352

P2093author name stringRobyn Cunard
P2860cites workAttenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory responseQ54651740
Mammalian Target of Rapamycin Pathway Blockade Slows Progression of Diabetic Kidney Disease in RatsQ59734510
A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant miceQ73303112
Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein responseQ74359929
Dysfunction of the ER chaperone BiP accelerates the renal tubular injuryQ80407859
Rapamycin prevents early steps of the development of diabetic nephropathy in ratsQ80726615
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulumQ80935578
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
Mouse models of diabetic nephropathyQ81056911
Modulation of AT-1R/CHOP-JNK-Caspase12 pathway by olmesartan treatment attenuates ER stress-induced renal apoptosis in streptozotocin-induced diabetic miceQ82235411
Renal protection by low dose irbesartan in diabetic nephropathy is paralleled by a reduction of inflammation, not of endoplasmic reticulum stressQ87086691
ER stress triggers MCP-1 expression through SET7/9-induced histone methylation in the kidneys of db/db miceQ87146747
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-betaQ22011091
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1Q22254333
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
Plasma cell differentiation requires the transcription factor XBP-1Q24291453
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell deathQ24298384
Knockout of toll-like receptor-2 attenuates both the proinflammatory state of diabetes and incipient diabetic nephropathyQ35143026
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stressesQ35169632
The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein responseQ35170906
p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasisQ35419603
Endoplasmic reticulum stress triggers autophagyQ35690087
IRE1α activation protects mice against acetaminophen-induced hepatotoxicityQ35760821
ER chaperone functions during normal and stress conditionsQ35885336
Wolcott-Rallison syndrome: a clinical and genetic study of three children, novel mutation in EIF2AK3 and a review of the literatureQ35895749
Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heartQ35898986
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viabilityQ35916071
Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetesQ36080882
Emerging role of autophagy in kidney function, diseases and agingQ36194753
Regulation of elongation phase of mRNA translation in diabetic nephropathy: amelioration by rapamycinQ36202808
Role of the unfolded protein response in cell deathQ36351719
CHOP deficiency results in elevated lipopolysaccharide-induced inflammation and kidney injuryQ36593043
Preconditioning with endoplasmic reticulum stress ameliorates mesangioproliferative glomerulonephritisQ36662140
Characterization of the R162W Kir7.1 mutation associated with snowflake vitreoretinopathyQ36699610
Switch between apoptosis and autophagy: radiation-induced endoplasmic reticulum stress?Q36766391
Activating transcription factor 4.Q36805075
Glucagon-Like Peptide-1 Analog Liraglutide Protects against Diabetic Cardiomyopathy by the Inhibition of the Endoplasmic Reticulum Stress PathwayQ36825702
Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.Q36870862
MicroRNA-1291-mediated silencing of IRE1α enhances Glypican-3 expression.Q36932880
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.Q36954378
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.Q37091581
From endoplasmic-reticulum stress to the inflammatory responseQ37225354
Effects of glucagon-like peptide-1 receptor agonists on renal functionQ37232679
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences.Q37352508
Danger signalling during cancer cell death: origins, plasticity and regulation.Q37381745
Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection.Q37418550
Regulation of the unfolded protein response by microRNAsQ37423378
Mammalian tribbles homologs at the crossroads of endoplasmic reticulum stress and Mammalian target of rapamycin pathwaysQ37481737
Endoplasmic reticulum (ER) stress and hypoxia response pathways interact to potentiate hypoxia-inducible factor 1 (HIF-1) transcriptional activity on targets like vascular endothelial growth factor (VEGF)Q37563444
Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactomeQ37596032
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress responseQ24303865
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-betaQ24305136
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alphaQ24310536
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formationQ24315723
Endoplasmic reticulum stress: cell life and death decisions.Q24536108
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small moleculeQ24596804
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myelomaQ24600346
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell deathQ24620548
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonucleaseQ24628936
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagyQ24655821
Emerging functions of the unfolded protein response in immunityQ26827965
Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injuryQ27330163
SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and toolsQ27499050
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Expression of wild-type and mutant forms of influenza hemagglutinin: the role of folding in intracellular transportQ27865283
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleusQ27930818
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndromeQ28142981
Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2Q28185092
Translational control is required for the unfolded protein response and in vivo glucose homeostasisQ28204066
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression programQ28216493
A molecular chaperone inducer protects neurons from ER stressQ28259344
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stressQ28306995
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient miceQ28359871
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreasQ28505821
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetesQ28506402
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
Wolcott-Rallison syndrome in two siblings with isolated central hypothyroidism.Q52115268
Protective effects of aliskiren and valsartan in mice with diabetic nephropathy.Q53034300
Manipulating the amyloid-beta aggregation pathway with chemical chaperones.Q53231251
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.Q53616050
VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress.Q54358936
GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases.Q54513292
Complement C5b-9 membrane attack complex increases expression of endoplasmic reticulum stress proteins in glomerular epithelial cellsQ44111663
MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis.Q44412861
Autophagy protects renal tubular cells against cyclosporine toxicityQ45069349
Acetaminophen attenuates obesity-related renal injury through ER-mediated stress mechanismsQ45298784
The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential.Q46021736
The protective effect of a newly developed molecular chaperone-inducer against mouse ischemic acute kidney injuryQ46140551
Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injuryQ46465778
A protective role of unfolded protein response in mouse ischemic acute kidney injury.Q46471252
Apoptosis induced by endoplasmic reticulum stress involved in diabetic kidney diseaseQ46639000
Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic miceQ46858582
Autophagy can repair endoplasmic reticulum stress damage of the passive Heymann nephritis model as revealed by proteomics analysisQ49195343
Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteinsQ50336381
Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling.Q50471195
Pleiotropic potential of dehydroxymethylepoxyquinomicin for NF-κB suppression via reactive oxygen species and unfolded protein response.Q50976778
Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP-triggered apoptosis via the inhibition of the IRE-α pathway.Q51326848
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathwayQ33926690
Humanized mouse models to study human diseasesQ33941638
Inflammation in diabetic kidney diseaseQ34023543
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.Q34024266
Tribbles homolog 3 attenuates mammalian target of rapamycin complex-2 signaling and inflammation in the diabetic kidneyQ34103431
P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signalingQ34179244
Regulation of podocyte survival and endoplasmic reticulum stress by fatty acidsQ34211573
Proteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte productQ34211611
Extensive translatome remodeling during ER stress response in mammalian cellsQ34264546
SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathwayQ34287569
Immunogenic cell death and DAMPs in cancer therapyQ34311701
Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.Q34324135
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationQ34345459
Chronic kidney disease: global dimension and perspectivesQ34347984
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expressionQ34563098
Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1.Q34575640
A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis.Q34596904
Suppression of XBP1S mediates high glucose-induced oxidative stress and extracellular matrix synthesis in renal mesangial cell and kidney of diabetic ratsQ34606527
Unraveling the mysteries of protein folding and misfoldingQ34820123
Metabolic stress promotes renal tubular inflammation by triggering the unfolded protein response.Q35064844
The transcription factor XBP-1 is essential for the development and survival of dendritic cellsQ28512302
Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cellsQ28535453
ACE-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic ratsQ28579167
mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathwayQ28583302
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein responseQ28589998
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
Regulation of glucose homeostasis through a XBP-1-FoxO1 interactionQ28592129
An essential role in liver development for transcription factor XBP-1Q28593777
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survivalQ28593963
3D tomography reveals connections between the phagophore and endoplasmic reticulumQ28610064
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagyQ29614479
Autophagy is activated for cell survival after endoplasmic reticulum stressQ29614485
Mediators of endoplasmic reticulum stress-induced apoptosisQ29615496
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteinsQ29620170
Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B.Q30425800
Proteinuria and hyperglycemia induce endoplasmic reticulum stressQ30484247
Role of mTOR in podocyte function and diabetic nephropathy in humans and miceQ30500731
Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cellsQ31080106
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein responseQ33264844
Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytesQ33353941
Transcriptional regulation of VEGF-A by the unfolded protein response pathwayQ33539754
BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein responseQ33631257
Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy.Q33633401
Epidermal growth factor receptor inhibition slows progression of diabetic nephropathy in association with a decrease in endoplasmic reticulum stress and an increase in autophagyQ33646704
Signal transduction from the endoplasmic reticulum to the cell nucleusQ33676889
IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin LevelQ33707431
Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammationQ33816297
The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetesQ33826388
A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouseQ33834161
Regulation of basal cellular physiology by the homeostatic unfolded protein responseQ33886820
Signalling pathways in the unfolded protein response: development from yeast to mammalsQ37622607
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2Q37622629
Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathwayQ37648367
Role of endoplasmic reticulum stress in apoptosis of differentiated mouse podocytes induced by high glucoseQ37685412
Control of NF-κB and inflammation by the unfolded protein responseQ37828515
Autophagy as a therapeutic target in diabetic nephropathyQ37949588
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signalingQ37996626
The intersecting roles of endoplasmic reticulum stress, ubiquitin- proteasome system, and autophagy in the pathogenesis of proteinuric kidney diseaseQ38068781
Endoplasmic reticulum stress signaling: the microRNA connectionQ38091632
Risk of metabolic complications in kidney transplantation after conversion to mTOR inhibitor: a systematic review and meta-analysisQ38242068
The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells.Q38309617
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress responseQ38326929
Febuxostat ameliorates diabetic renal injury in a streptozotocin-induced diabetic rat modelQ38436141
XBP-1 is a cell-nonautonomous regulator of stress resistance and longevityQ38681055
Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survivalQ38996766
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasomeQ39299566
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.Q39299575
PI3K/Akt pathway mediates high glucose-induced lipid accumulation in human renal proximal tubular cells via spliced XBP-1.Q39340361
Salubrinal, an eIF2α dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model.Q39535847
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging miceQ39812158
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.Q39814866
Endoplasmic reticulum stress induces autophagy in renal proximal tubular cellsQ39849425
Preventing oxidative stress: a new role for XBP1.Q39879215
Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1.Q39917756
Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II).Q40164655
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetesQ40176269
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosisQ40294776
ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicityQ40386955
Defective trafficking of nephrin missense mutants rescued by a chemical chaperoneQ40542258
Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cellsQ41157654
Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice.Q41786115
Measuring ER stress and the unfolded protein response using mammalian tissue culture systemQ41898554
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in miceQ41912848
Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signallingQ42045464
Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2Q42094437
Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stressQ42163338
TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1Q42365354
Endoplasmic reticulum stress and fungal pathogenesis convergeQ42408796
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stressQ42518206
Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stressQ42715752
The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death.Q42737440
Cannabinoid receptor 1 mediates palmitic acid-induced apoptosis via endoplasmic reticulum stress in human renal proximal tubular cells.Q43053240
Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: regulation of endoplasmic reticulum stress-oxidative activationQ43095387
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)715-40
P577publication date2015-01-01
P1433published inJournal of Clinical MedicineQ27724774
P1476titleEndoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly
P478volume4

Reverse relations

cites work (P2860)
Q46312225Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential
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Q91723087Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death
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Q39062870Inflammation, oxidative stress, apoptosis, and autophagy in diabetes mellitus and diabetic kidney disease: the Four Horsemen of the Apocalypse
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