Endoplasmic reticulum (ER) stress and hypoxia response pathways interact to potentiate hypoxia-inducible factor 1 (HIF-1) transcriptional activity on targets like vascular endothelial growth factor (VEGF)

scientific article published on 17 December 2013

Endoplasmic reticulum (ER) stress and hypoxia response pathways interact to potentiate hypoxia-inducible factor 1 (HIF-1) transcriptional activity on targets like vascular endothelial growth factor (VEGF) is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.507194
P932PMC publication ID3916539
P698PubMed publication ID24347168
P5875ResearchGate publication ID259353352

P50authorEthel R PereiraQ59489404
Karen FruddQ61312416
P2093author name stringLinda M Hendershot
Walid Awad
P2860cites workHypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cellsQ40725245
PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasisQ43226732
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.Q52173333
Regulation of tumor angiogenesis by oxygen-regulated protein 150, an inducible endoplasmic reticulum chaperone.Q55474365
Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlationQ73034285
Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein responseQ74359929
Bidirectional interaction between unfolded-protein-response key protein HSPA5 and estrogen signaling in human endometriumQ83574155
The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathwayQ24297372
The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanismQ24298728
Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alphaQ24301526
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1Q24316075
Hypoxia-inducible factors in physiology and medicineQ27013770
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Angiogenesis in cancer and other diseasesQ27861015
Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB siteQ28286400
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Angiogenesis in cancer, vascular, rheumatoid and other diseaseQ29547165
A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probesQ29615205
Oxygen sensing by HIF hydroxylasesQ29617806
Regulation of angiogenesis by hypoxia: role of the HIF systemQ29619187
Unfolded protein response regulation in keloid cells.Q30427140
Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant gliomaQ30496396
Transcriptional regulation of VEGF-A by the unfolded protein response pathwayQ33539754
Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein responseQ33686864
Preclinical models for neuroblastoma: establishing a baseline for treatmentQ33895108
Angiogenesis in wound healingQ33930565
mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1αQ34418791
In vivo expression of mammalian BiP ATPase mutants causes disruption of the endoplasmic reticulumQ34447105
Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cellsQ34732953
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stressesQ35169632
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stressQ35221396
Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent mannerQ35856898
The role of the unfolded protein response in tumour development: friend or foe?Q35968425
Transcriptional and posttranscriptional regulation of the proliferating cell nuclear antigen geneQ36714111
ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein responseQ36742493
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viabilityQ37377347
HIF-1α activation mediates resistance to anti-angiogenic therapy in neuroblastoma xenograftsQ39208364
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growthQ39470144
IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo.Q40105547
Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells.Q40353065
Role for casein kinase 2 in the regulation of HIF-1 activityQ40409384
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
endotheliumQ111140
hypoxiaQ105688
P304page(s)3352-3364
P577publication date2013-12-17
P1433published inJournal of Biological ChemistryQ867727
P1476titleEndoplasmic reticulum (ER) stress and hypoxia response pathways interact to potentiate hypoxia-inducible factor 1 (HIF-1) transcriptional activity on targets like vascular endothelial growth factor (VEGF)
P478volume289

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