The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding

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The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/J.PRETEYERES.2014.12.001
P3181OpenCitations bibliographic resource ID3221737
P932PMC publication ID4339403
P698PubMed publication ID25529848
P5875ResearchGate publication ID270653522

P2093author name stringMaulasri Bhatta
Joshua J. Wang
Sarah X. Zhang
Jacey H. Ma
Steven J. Fliesler
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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein responseQ24292966
The unfolded protein response: integrating stress signals through the stress sensor IRE1αQ24293771
The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanismQ24298728
XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activationQ24304996
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cellsQ24309442
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Endoplasmic reticulum stress and inflammationQ26825586
The unfolded protein response and diabetic retinopathyQ27000603
ER stress-induced cell death mechanismsQ27027638
ER stress and apoptosis: a new mechanism for retinal cell deathQ27690757
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
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Roles of molecular chaperones in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD)Q28255326
Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injuryQ28286412
Isolation of putative progenitor endothelial cells for angiogenesisQ28302884
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An aryl hydrocarbon receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2Q28393127
Transcriptional regulation of VEGFA by the endoplasmic reticulum stress transducer OASIS in ARPE-19 cellsQ28485361
An essential role for frizzled 5 in mammalian ocular developmentQ28511042
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculatureQ28511517
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P58(IPK) inhibition of endoplasmic reticulum stress in human retinal capillary endothelial cells in vitro.Q36724620
ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein responseQ36742493
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αB-crystallin, an effector of unfolded protein response, confers anti-VEGF resistance to breast cancer via maintenance of intracrine VEGF in endothelial cellsQ36838575
Promise of endothelial progenitor cell for treatment of diabetic retinopathyQ36839005
Endoplasmic reticulum stress in disease pathogenesisQ36842308
Endoplasmic reticulum structure and interconnections with other organellesQ36932847
TCF7L2 variation and proliferative diabetic retinopathyQ37015022
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Amino acid deprivation promotes tumor angiogenesis through the GCN2/ATF4 pathwayQ37061049
Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cellsQ37101882
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stressQ42518206
Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis.Q42559927
T-cadherin attenuates the PERK branch of the unfolded protein response and protects vascular endothelial cells from endoplasmic reticulum stress-induced apoptosis.Q43067380
Characterization and comparison of bone marrow and peripheral blood mononuclear cells used for cellular therapy in critical leg ischaemia: towards a new cellular productQ43427303
Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathyQ43442147
Mobilization of endothelial progenitor cells in patients with acute myocardial infarctionQ43636896
Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways.Q44198462
Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion.Q44198738
Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in diseaseQ44429660
Retinal pigment epithelium cells produce VEGF in response to oxidized phospholipids through mechanisms involving ATF4 and protein kinase CK2.Q44672901
Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6.Q45010270
Are linear regression techniques appropriate for analysis when the dependent (outcome) variable is not normally distributed?Q45179675
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.Q45345766
Sequence variation of Epstein-Barr virus (EBV) BZLF1 gene in EBV-associated gastric carcinomas and nasopharyngeal carcinomas in Northern ChinaQ45367015
Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stressQ45865568
Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions.Q45948477
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein responseQ46116386
Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression.Q46184567
Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes.Q46404558
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosisQ46434986
Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus.Q46464366
Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' diseaseQ46554065
Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.Q46742618
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.Q46900500
Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1.Q48134071
Oxygen and the growth and development of retinal vessels. In vivo and in vitro studies. The XX Francis I. Proctor Lecture.Q48563093
The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner.Q50504743
Regression of vessels in the tunica vasculosa lentis is initiated by coordinated endothelial apoptosis: a role for vascular endothelial growth factor as a survival factor for endothelium.Q52182121
Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice.Q52545083
GM-CSF induces cyclin D1 expression and proliferation of endothelial progenitor cells via PI3K and MAPK signaling.Q53060904
Cigarette smoke extract induces prolonged endoplasmic reticulum stress and autophagic cell death in human umbilical vein endothelial cells.Q53240368
Paracrine factors secreted by endothelial progenitor cells prevent oxidative stress-induced apoptosis of mature endothelial cells.Q53336156
XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress.Q53676823
Monocyte chemotactic protein-induced protein (MCPIP) promotes inflammatory angiogenesis via sequential induction of oxidative stress, endoplasmic reticulum stress and autophagy.Q54495622
Effect of neurotrophin-4 on endoplasmic reticulum stress-related neuronal apoptosis in diabetic and high glucose exposed rat retinas.Q54573507
Regulation of tumor angiogenesis by oxygen-regulated protein 150, an inducible endoplasmic reticulum chaperone.Q55474365
Visceral Adipose Tissue-derived Serine Proteinase Inhibitor Inhibits Apoptosis of Endothelial Cells as a Ligand for the Cell-Surface GRP78/Voltage-dependent Anion Channel ComplexQ58366278
Retinopathy of prematurityQ60439193
Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitorsQ62590334
Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia–reperfusion injury in ratsQ63285823
Identification of ribophorins in rough microsomal membranes from different organs of several speciesQ70369583
Development of astrocytes and their relation to blood vessels in fetal monkey retinaQ71812759
A time-dependent phase shift in the mammalian unfolded protein responseQ72997174
Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factorsQ73075799
Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptorQ73226153
Experimental approach to the pathogenesis of retrolental fibroplasia. I. Changes of the eye induced by exposure of newborn mice to concentrated oxygenQ73706796
Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structuresQ78570627
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetesQ82097295
Interleukin-8 is associated with circulating CD133+ progenitor cells in acute myocardial infarctionQ82458639
Assessment of gelatinase and tumor necrosis factor-α level in the vitreous and serum of patients with Eales disease: role of inflammation-mediated angiogenesis in the pathogenesis of Eales diseaseQ83586166
Intravitreal anti-VEGF therapy blocks inflammatory cell infiltration and re-entry into the circulation in retinal angiogenesisQ84283942
Retinopathy of prematurityQ85171792
[Endoplasmic reticulum stress and angiogenesis]Q95453574
Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrolQ95795941
Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factorQ28567494
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Cloning of mammalian Ire1 reveals diversity in the ER stress responsesQ28587224
Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in miceQ28590550
An essential role in liver development for transcription factor XBP-1Q28593777
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein responseQ28611502
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
Mediators of endoplasmic reticulum stress-induced apoptosisQ29615496
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluidQ29617640
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunitiesQ29617768
Hematopoiesis: an evolving paradigm for stem cell biologyQ29619676
Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature developmentQ30434991
The mouse retina as an angiogenesis modelQ30495106
Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant gliomaQ30496396
Computer-aided quantification of retinal neovascularization.Q30577340
The endoplasmic reticulum: a cytochemist's view (a review)Q33322587
Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseasesQ33517638
alphaB-crystallin regulation of angiogenesis by modulation of VEGF.Q33519880
Diabetes mellitus induces bone marrow microangiopathyQ33521433
Transcriptional regulation of VEGF-A by the unfolded protein response pathwayQ33539754
7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formationQ33610630
Nutrient sensing and inflammation in metabolic diseasesQ33623354
Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein responseQ33686864
Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularizationQ33870103
The role of oxygen availability in embryonic development and stem cell functionQ33876311
7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo.Q33921301
The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow nicheQ33925176
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathwayQ33926690
Endoplasmic reticulum stress and the unfolded protein responses in retinal degenerationQ34005691
Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stressesQ34012817
Role of connective tissue growth factor in the retinal vasculature during development and ischemiaQ34039271
Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of lifeQ34090125
Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degenerationQ34116399
Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironmentQ34140841
Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flowQ37176759
Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathyQ37214899
From endoplasmic-reticulum stress to the inflammatory responseQ37225354
Protein folding includes oligomerization - examples from the endoplasmic reticulum and cytosolQ37235421
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapiesQ37285838
Animal models of diabetic retinopathy: summary and comparisonQ37304677
Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosisQ37310184
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.Q37363053
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viabilityQ37377347
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesiclesQ37394440
Oxidized phospholipids in the macula increase with age and in eyes with age-related macular degenerationQ37402200
The role of molecular chaperones in human misfolding diseasesQ37459598
Endoplasmic reticulum (ER) stress and hypoxia response pathways interact to potentiate hypoxia-inducible factor 1 (HIF-1) transcriptional activity on targets like vascular endothelial growth factor (VEGF)Q37563444
Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactomeQ37596032
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2Q37622629
XBP1: the last two decadesQ37649065
HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo.Q37661142
The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington diseaseQ37663855
Persistent hyperplastic primary vitreous: congenital malformation of the eye.Q37679315
Recent developments in the treatment of age-related macular degenerationQ37679956
VEGF-A: a critical regulator of blood vessel growthQ37694868
Diabetes, hyperglycemia and accelerated atherosclerosis: evidence supporting a role for endoplasmic reticulum (ER) stress signalingQ37720770
Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell NicheQ37777514
Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularizationQ37777653
Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases.Q37804462
Endoplasmic reticulum stress as a therapeutic target in cardiovascular diseaseQ37804650
Treatment of diabetic retinopathy with anti-VEGF drugsQ37806321
Developmental and pathological angiogenesisQ37901035
Mechanisms of ER stress-induced apoptosis in atherosclerosisQ37957844
From oxygen to erythropoietin: relevance of hypoxia for retinal development, health and diseaseQ37959651
Targeting endoplasmic reticulum stress for cancer therapyQ37971758
Mechanism of inflammation in age-related macular degenerationQ38064846
Organelle plasticity and interactions in cholesterol transport and steroid biosynthesis.Q38068026
Mechanisms and management of retinopathy of prematurityQ38069895
The eIF2α kinases: their structures and functionsQ38077051
The ageing haematopoietic stem cell compartmentQ38098875
The Role of Endoplasmic Reticulum Stress in the Progression of AtherosclerosisQ34141006
Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization.Q34161139
Characterization of a Mouse Model of Hyperglycemia and Retinal NeovascularizationQ34254645
Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling.Q34314109
eIF-2 kinases: regulators of general and gene-specific translation initiationQ34318608
Transcriptional control of B-cell developmentQ34547226
Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1.Q34575640
Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization.Q34581539
7-Ketocholesterol induces inflammation and angiogenesis in vivo: a novel rat modelQ34586643
The critical role of GRP78 in physiologic and pathologic stress.Q34594217
7-ketocholesterol accumulates in ocular tissues as a consequence of aging and is present in high levels in drusenQ34624421
Protein kinase C and alcohol addiction.Q34637120
The multifaceted von Hippel-Lindau tumour suppressor proteinQ34660062
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoformsQ34787725
A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasisQ34803685
Familial exudative vitreoretinopathy and related retinopathiesQ34905378
Endothelial progenitor cell biology in disease and tissue regenerationQ35069503
Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration.Q35105102
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stressesQ35169632
Cellular mechanisms in retinal vascular developmentQ35174073
Expression of endoplasmic reticulum stress-related factors in the retinas of diabetic ratsQ35195608
Blockade of NADPH oxidase restores vasoreparative function in diabetic CD34+ cellsQ35221390
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stressQ35221396
Unfolded protein response is required in nu/nu mice microvasculature for treating breast tumor with tunicamycinQ35309992
Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progressionQ35552863
Endoplasmic reticulum stress-related factors protect against diabetic retinopathyQ35607313
Hemangioblasts, angioblasts, and adult endothelial cell progenitorsQ35618193
Cholesterol biosynthesis and regulation: role of peroxisomes.Q35624454
Intermittent but not constant high glucose induces ER stress and inflammation in human retinal pericytesQ35627455
N-linked protein glycosylation in the endoplasmic reticulumQ38113312
Noninfectious immune-mediated uveitis and ocular inflammationQ38171373
Network Motifs in JNK Signaling.Q38172167
Inflammation in age-related macular degeneration.Q38199024
Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetesQ38294227
Genetic difference in susceptibility to the blood-retina barrier breakdown in diabetes and oxygen-induced retinopathyQ38585087
Crucial role for endoplasmic reticulum stress during megakaryocyte maturationQ39081993
Pyridoxal phosphatase: cytochemical localization in GERL and other organelles of rat neuronsQ39222592
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.Q39299575
Mild endoplasmic reticulum stress promotes retinal neovascularization via induction of BiP/GRP78.Q39356067
Lipid transport function of lipoproteins in blood plasmaQ39510264
IGF-I is critical for normal vascularization of the human retinaQ39607676
Origin of endothelial progenitors in human postnatal bone marrowQ39737487
Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78.Q39749582
GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomibQ39807121
IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo.Q40105547
Cholesterol transport between cells and body fluids. Role of plasma lipoproteins and the plasma cholesterol esterification system.Q40328388
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.Q40519913
Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4.Q40595070
Activation of endoplasmic reticulum stress by hyperglycemia is essential for Müller cell-derived inflammatory cytokine production in diabetesQ40666660
Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress.Q40714649
The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flowQ40857641
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.Q40883590
Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurityQ41292409
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retinaQ41457604
Retinal neovascularisation: early contributions of Professor Michaelson and recent observationsQ41543765
X box-binding protein 1 regulates angiogenesis in human pancreatic adenocarcinomas.Q41859494
Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stressQ41876098
Bruch's membrane and choroidal macrophages in early and advanced age-related macular degenerationQ42463987
The unfolded protein response is an important regulator of inflammatory genes in endothelial cellsQ42500350
P407language of work or nameEnglishQ1860
P921main subjectprotein foldingQ847556
P304page(s)111-31
P577publication date2015-03-01
P1433published inProgress in Retinal and Eye ResearchQ15760062
P1476titleThe unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding
P478volume45

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