scholarly article | Q13442814 |
review article | Q7318358 |
P356 | DOI | 10.1016/J.SEMCDB.2005.03.009 |
P698 | PubMed publication ID | 15896987 |
P50 | author | Bradly Wouters | Q30528131 |
Marianne Koritzinsky | Q55299160 | ||
Costas Koumenis | Q56559519 | ||
Twan van den Beucken | Q89115527 | ||
Michaël G Magagnin | Q114431378 | ||
Diane Fels | Q114431401 | ||
P2860 | cites work | Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 |
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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery | Q24302549 | ||
4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family | Q24318361 | ||
REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species | Q24321795 | ||
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function | Q24324452 | ||
Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia | Q24524140 | ||
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha | Q24540258 | ||
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex | Q24559347 | ||
A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation | Q24650753 | ||
Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival | Q24653078 | ||
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway | Q24672316 | ||
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TSC2 mediates cellular energy response to control cell growth and survival | Q27860970 | ||
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR | Q28115142 | ||
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family | Q28119190 | ||
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling | Q28131740 | ||
Perk is essential for translational regulation and cell survival during the unfolded protein response | Q28140062 | ||
Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis | Q28200184 | ||
Translational control is required for the unfolded protein response and in vivo glucose homeostasis | Q28204066 | ||
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells | Q28204697 | ||
Internal ribosome entry sites in eukaryotic mRNA molecules | Q28205551 | ||
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins | Q28207283 | ||
The AMP-activated protein kinase cascade--a unifying system for energy control | Q28239257 | ||
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase | Q28244045 | ||
Exploiting tumour hypoxia in cancer treatment | Q28264146 | ||
The LKB1 tumor suppressor negatively regulates mTOR signaling | Q28272728 | ||
Upstream and downstream of mTOR | Q28277365 | ||
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase | Q28296183 | ||
Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase | Q28299534 | ||
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels | Q28586348 | ||
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent | Q28593855 | ||
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response | Q29547299 | ||
Hypoxia--a key regulatory factor in tumour growth | Q29547318 | ||
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress | Q29547441 | ||
Initiation of translation in prokaryotes and eukaryotes | Q29618237 | ||
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours | Q29618396 | ||
Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators | Q29618401 | ||
Molecular mechanisms of translation initiation in eukaryotes | Q29619902 | ||
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap | Q29620550 | ||
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway | Q29620730 | ||
Transient inhibition of protein synthesis induces expression of proto-oncogenes and stimulates resting cells to enter the cell cycle | Q41263722 | ||
Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction | Q41491288 | ||
Activation of the heat shock transcription factor by hypoxia in normal and tumor cell lines in vivo and in vitro | Q41645510 | ||
Internal initiation of translation mediated by the 5′ leader of a cellular mRNA | Q41665812 | ||
The intraischemic and early reperfusion changes of protein synthesis in the rat brain. eIF-2 alpha kinase activity and role of initiation factors eIF-2 alpha and eIF-4E. | Q42449340 | ||
Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis | Q42607636 | ||
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation | Q42796185 | ||
Changes in RNA in relation to growth of the fibroblast. III. Posttranscriptional regulation of mRNA formation in resting and growing cells | Q42833316 | ||
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis | Q44851701 | ||
Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing | Q45040826 | ||
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation | Q47070662 | ||
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size | Q47211341 | ||
Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes | Q47421825 | ||
Role of the heat-shock response in the life and death of proteins. | Q47824004 | ||
Stress-induced inhibition of protein synthesis initiation: modulation of initiation factor 2 and guanine nucleotide exchange factor activities following transient cerebral ischemia in the rat. | Q48291280 | ||
Disturbances of calcium homeostasis within the endoplasmic reticulum may contribute to the development of ischemic-cell damage | Q48902327 | ||
The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation | Q49107927 | ||
The genetic basis of tuberous sclerosis. | Q51991180 | ||
The effect of protein degradation on cellular growth characteristics | Q53585486 | ||
Enhancement of IRES-Mediated Translation of the c-myc and BiP mRNAs by the Poly(A) Tail Is Independent of Intact eIF4G and PABP | Q57397535 | ||
Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway | Q59080908 | ||
Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements | Q62819809 | ||
Cellular growth and metabolic adaptations to nutrient stress environments in tumor microregions | Q69491062 | ||
Oxygen effects in radiobiology | Q70557887 | ||
Ultrastructural localization of phosphorylated eIF2alpha [eIF2alpha(P)] in rat dorsal hippocampus during reperfusion | Q73133012 | ||
Expression of TNF-alpha by herpes simplex virus-infected macrophages is regulated by a dual mechanism: transcriptional regulation by NF-kappa B and activating transcription factor 2/Jun and translational regulation through the AU-rich region of the | Q74321530 | ||
Isolation of translationally controlled mRNAs by differential screening. | Q30652256 | ||
TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway | Q31858969 | ||
Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. | Q33558752 | ||
Translational control: the cancer connection | Q33601620 | ||
Eukaryotic initiation factor eIF2. | Q33601625 | ||
Translation initiation: adept at adapting | Q33740230 | ||
Activation of the heat shock transcription factor by hypoxia in mammalian cells | Q33746641 | ||
Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia | Q33772948 | ||
Highly conserved RNA sequences that are sensors of environmental stress | Q33781775 | ||
Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis | Q33933174 | ||
Evolution of human hypoxia tolerance physiology | Q33940686 | ||
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression | Q33968465 | ||
Role of the heat shock response and molecular chaperones in oncogenesis and cell death | Q34052682 | ||
Tuberous sclerosis: from tubers to mTOR. | Q34173640 | ||
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy | Q34306865 | ||
Mammalian TOR: a homeostatic ATP sensor | Q34519173 | ||
LKB1, a protein kinase regulating cell proliferation and polarity | Q34534892 | ||
Transcriptional and translational control in the Mammalian unfolded protein response | Q34762452 | ||
von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays | Q34784862 | ||
Translational control in the endoplasmic reticulum stress response | Q35001600 | ||
The unfolded protein response | Q35105972 | ||
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses | Q35169632 | ||
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family | Q35234179 | ||
Starting the protein synthesis machine: eukaryotic translation initiation. | Q35591866 | ||
Targeting hypoxia tolerance in cancer | Q35741480 | ||
Tuberous sclerosis complex: from Drosophila to human disease. | Q35753172 | ||
Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes | Q35839675 | ||
Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. | Q35909879 | ||
Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins | Q35917778 | ||
Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2. | Q35964633 | ||
Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection | Q36307005 | ||
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response | Q36322641 | ||
Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray | Q36667026 | ||
Activating transcription factor 4 is translationally regulated by hypoxic stress | Q37349289 | ||
Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. | Q37354077 | ||
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells | Q37388595 | ||
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2 | Q37622629 | ||
4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase | Q37628904 | ||
Stress-induced gene expression requires programmed recovery from translational repression | Q39735685 | ||
IRESdb: the Internal Ribosome Entry Site database | Q39790137 | ||
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth | Q40424038 | ||
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. | Q40519913 | ||
Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells | Q40618812 | ||
A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. | Q40643741 | ||
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling | Q40711462 | ||
Translational control in development: a perspective | Q40716826 | ||
Tumor Hypoxia and Heterogeneity: Challenges and Opportunities for the Future | Q40953722 | ||
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome | Q41022988 | ||
Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k. | Q41106936 | ||
P433 | issue | 4-5 | |
P921 | main subject | hypoxia | Q105688 |
P304 | page(s) | 487-501 | |
P577 | publication date | 2005-08-01 | |
P1433 | published in | Seminars in Cell & Developmental Biology | Q14330411 |
P1476 | title | Control of the hypoxic response through regulation of mRNA translation | |
P478 | volume | 16 |
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Q40254110 | Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway |
Q30483779 | An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. |
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Q24304179 | Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control |
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Q36877199 | Gene regulation under low oxygen: holding your breath for transcription. |
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Q36423955 | Human cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78, which is required for virion assembly |
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Q82253873 | Hypoxia regulates the production and activity of glucose transporter-1 and indoleamine 2,3-dioxygenase in monocyte-derived endothelial-like cells: possible relevance to infantile haemangioma pathogenesis |
Q35155445 | Hypoxia-induced energy stress regulates mRNA translation and cell growth |
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Q39026199 | Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism |
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Q41525858 | Peroxisome Proliferator-Activated Receptor -β/δ, -γ Agonists and Resveratrol Modulate Hypoxia Induced Changes in Nuclear Receptor Activators of Muscle Oxidative Metabolism |
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Q37064617 | Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates |
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Q38844063 | Role of Stro1+/CD44+ stem cells in myometrial physiology and uterine remodeling during pregnancy |
Q47654911 | Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL. |
Q35746325 | Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro |
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Q39157751 | The efficacy of CHK1 inhibitors is not altered by hypoxia, but is enhanced after reoxygenation |
Q40341867 | The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation. |
Q40385787 | The hypoxic proteome is influenced by gene-specific changes in mRNA translation |
Q49309709 | The integrated stress response in hypoxia-induced diffuse white matter injury |
Q33510814 | The l1-l2 regularization framework unmasks the hypoxia signature hidden in the transcriptome of a set of heterogeneous neuroblastoma cell lines |
Q33876311 | The role of oxygen availability in embryonic development and stem cell function |
Q50802617 | The translational repressor 4E-BP mediates hypoxia-induced defects in myotome cells. |
Q26852080 | The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding |
Q64244241 | Translating the Hypoxic Response-the Role of HIF Protein Translation in the Cellular Response to Low Oxygen |
Q34546985 | Translational control of collagen prolyl 4-hydroxylase-alpha(I) gene expression under hypoxia. |
Q36503783 | Translational repression during chronic hypoxia is dependent on glucose levels |
Q47273498 | Trophoblast lineage specification, differentiation and their regulation by oxygen tension |
Q37515791 | Tumor hypoxia as a modifier of DNA strand break and cross-link repair. |
Q36839790 | Tumor hypoxia, DNA repair and prostate cancer progression: new targets and new therapies |
Q36394344 | Type I interferons mediate pancreatic toxicities of PERK inhibition |
Q37736757 | Unravelling the biology of human papillomavirus (HPV) related tumours to enhance their radiosensitivity. |
Q48535751 | Up-Regulation of the Excitatory Amino Acid Transporters EAAT1 and EAAT2 by Mammalian Target of Rapamycin. |
Q43247883 | Variation in gene expression profiles of human monocytic U937 cells exposed to various fluxes of nitric oxide |
Q38365693 | mTOR activity under hypoxia |
Q34418791 | mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α |
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