PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer (scientific article (publication date: 28 March 1997))

cites work (P2860)

Q49788344	"Researching the Research" in Prostate Cancer: A Comparative Bibliometric Analysis of the Top 100 Cited Articles in the Field of Prostate Cancer
Q36510818	'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis
Q47399921	10q25.3 (DMBT1) copy number changes in astrocytoma grades II and IV.
Q91583253	11C-Labeled Pictilisib (GDC-0941) as a Molecular Tracer Targeting Phosphatidylinositol 3-Kinase (PI3K) for Breast Cancer Imaging
Q37167731	3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer.
Q33965618	5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells
Q37549908	5q- myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing actin dynamics.
Q38325322	7q deletion mapping and expression profiling in uterine fibroids.
Q35869429	A 39-bp deletion polymorphism in PTEN in African American individuals: implications for molecular diagnostic testing
Q39769697	A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells
Q40182646	A New Case of the Rare 10q22.3q23.2 Microdeletion Flanked by Low-Copy Repeats 3/4.
Q34099246	A Novel Human TPIP Splice-Variant (TPIP-C2) mRNA, Expressed in Human and Mouse Tissues, Strongly Inhibits Cell Growth in HeLa Cells
Q36227148	A PTEN translational isoform has PTEN-like activity
Q46946333	A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors
Q36887707	A Prospective Investigation of PTEN Loss and ERG Expression in Lethal Prostate Cancer
Q28292188	A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival
Q28079929	A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.
Q37814798	A Tale of Tailless
Q34694344	A Unique Spectrum of Somatic PIK3CA (p110α) Mutations Within Primary Endometrial Carcinomas
Q24795510	A candidate metastasis-associated DNA marker for ductal mammary carcinoma
Q34065944	A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene.
Q24647081	A census of human cancer genes
Q88869540	A chimeric protein PTEN-L-p53 enters U251 cells to repress proliferation and invasion
Q98303321	A compendium of mutational cancer driver genes
Q35534634	A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development
Q74404380	A direct interaction between oncogenic Ha-Ras and phosphatidylinositol 3-kinase is not required for Ha-Ras-dependent transformation of epithelial cells
Q44237684	A diverse family of inositol 5-phosphatases playing a role in growth and development in Dictyostelium discoideum
Q24336385	A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast
Q37696203	A four-gene signature predicts survival in clear-cell renal-cell carcinoma
Q48119280	A genotype of the polymorphic DNA repair gene MGMT is associated with de novo glioblastoma
Q53395186	A hypothesis about tumour development and the clinical features of hereditary breast cancers
Q34056402	A membrane capture assay for lipid kinase activity
Q39626176	A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts.
Q40978920	A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer
Q39666296	A mutant form of PTEN linked to autism
Q35747677	A neuroendocrine/small cell prostate carcinoma xenograft-LuCaP 49
Q40556578	A new human cell line, PDSS-26, from poorly differentiated synovial sarcoma, with unique chromosomal anomalies
Q54354412	A novel class of PTEN protein in Arabidopsis displays unusual phosphoinositide phosphatase activity and efficiently binds phosphatidic acid
Q36437601	A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men.
Q24651885	A novel germline mutation of PTEN associated with brain tumours of multiple lineages
Q73292721	A novel germline mutation of the PTEN/MMAC1 gene in a patient with Cowden disease
Q39430738	A novel imidazopyridine analogue as a phosphatidylinositol 3-kinase inhibitor against human breast cancer
Q33904287	A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line
Q34089314	A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells.
Q39116000	A novel o-naphtoquinone inhibits N-cadherin expression and blocks melanoma cell invasion via AKT signaling
Q36322321	A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast
Q42959293	A novel selective small-molecule PI3K inhibitor is effective against human multiple myeloma in vitro and in vivo
Q37392640	A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell
Q33685619	A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
Q37214332	A phase II study evaluating the toxicity and efficacy of single-agent temsirolimus in chemotherapy-naïve castration-resistant prostate cancer
Q37308576	A phase-1, open-label, single-dose study of the pharmacokinetics of buparlisib in subjects with mild to severe hepatic impairment.
Q39093102	A phosphatase-independent gain-of-function mutation in PTEN triggers aberrant cell growth in astrocytes through an autocrine IGF-1 loop.
Q28305284	A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.
Q52430809	A protocol for custom CRISPR Cas9 donor vector construction to truncate genes in mammalian cells using pcDNA3 backbone
Q29568319	A role for nuclear PTEN in neuronal differentiation.
Q28366259	A role of tensin in skeletal-muscle regeneration
Q40184782	A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth
Q33707181	A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation
Q82954448	A solid phase extraction-liquid chromatographic–tandem mass spectrometry method for determination of concentrations of GDC-0941, a small molecule class I phosphatidylinositide 3-kinase inhibitor, to support clinical development
Q52370966	A streamlined workflow for single-cells genome-wide copy-number profiling by low-pass sequencing of LM-PCR whole-genome amplification products
Q48666856	A study on promoter methylation of PTEN in sporadic breast cancer patients from North India
Q33934322	A survey of homozygous deletions in human cancer genomes
Q38116265	A systems biology analysis of autophagy in cancer therapy
Q44170741	A tumor suppressor homolog, AtPTEN1, is essential for pollen development in Arabidopsis
Q35201003	A unified nomenclature and amino acid numbering for human PTEN.
Q47825566	A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers.
Q35996719	ABT-737 Synergizes with Bortezomib to Induce Apoptosis, Mediated by Bid Cleavage, Bax Activation, and Mitochondrial Dysfunction in an Akt-Dependent Context in Malignant Human Glioma Cell Lines
Q34106554	AKT/PKB Phosphorylation of p21Cip/WAF1 Enhances Protein Stability of p21Cip/WAF1 and Promotes Cell Survival
Q39255027	AKT/PKB Signaling: Navigating the Network
Q46574533	AKT1(E17K) in human solid tumours
Q35169608	AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers
Q36413704	AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf, and TSC1/TSC2.
Q38997227	ANXA7-GTPase as Tumor Suppressor: Mechanisms and Therapeutic Opportunities
Q35853239	ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells
Q36851633	ATP modulates PTEN subcellular localization in multiple cancer cell lines.
Q132126026	Aberrant Promoter Methylation of PTEN Gene among Indian Patients with Oral Squamous Cell Carcinoma
Q55163735	Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.
Q24658269	Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas
Q84425492	Aberrant promoter methylation and inactivation of PTEN gene in cervical carcinoma from Indian population
Q38161369	Aberrant signaling pathways in glioma.
Q64974623	Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt/β-catenin signaling.
Q52537916	Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers
Q35861043	Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice
Q30439629	Absence of AKT1 mutations in glioblastoma
Q24291245	Absence of PPP2R1A mutations in Wilms tumor
Q43516654	Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats
Q54442337	Abundant expression of mTOR kinase in salivary gland tumors – potentials as therapy target?
Q41020572	Accumulation of genetic alterations and their significance in each primary human cancer and cell line
Q38320448	Acetylated Sp1 inhibits PTEN expression through binding to PTEN core promoter and recruitment of HDAC1 and promotes cancer cell migration and invasion
Q36733736	Achieving specificity in Akt signaling in cancer
Q35787692	Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter
Q36969866	Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis
Q39559213	Activated PI3K signaling as an endogenous inducer of p53 in human cancer
Q36945898	Activation of AKT negatively regulates the pro-apoptotic function of death-associated protein kinase 3 (DAPK3) in prostate cancer
Q34443746	Activation of miR-21 by STAT3 induces proliferation and suppresses apoptosis in nasopharyngeal carcinoma by targeting PTEN gene
Q24294831	Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
Q35642171	Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.
Q24792135	Activation of synovial fibroblasts in rheumatoid arthritis: lack of Expression of the tumour suppressor PTEN at sites of invasive growth and destruction
Q24613036	Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a
Q33511579	Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models
Q26830671	Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis
Q40146202	Adenoviral-mediated PTEN expression radiosensitizes non-small cell lung cancer cells by suppressing DNA repair capacity
Q40591981	Adenoviral-mediated PTEN transgene expression sensitizes Bcl-2-expressing prostate cancer cells to radiation
Q44647433	Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells
Q38757962	Adenovirus-mediated co-expression of ING4 and PTEN cooperatively enhances their antitumor activity in human hepatocellular carcinoma cells
Q45869247	Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo
Q34013783	Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinase
Q30426125	Advances in the genetics of glioblastoma: are we reaching critical mass?
Q37255151	Advancing precision medicine for prostate cancer through genomics
Q30273930	Age-dependent expression of Pten and Smad4 genes in the urogenital system of Wistar rats
Q36663043	Aging of the brain, neurotrophin signaling, and Alzheimer's disease: is IGF1-R the common culprit?
Q34196216	Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the Children's Oncology Group
Q40816815	Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology
Q24304442	Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
Q36917074	Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
Q64054222	Akt inhibitor SC66 promotes cell sensitivity to cisplatin in chemoresistant ovarian cancer cells through inhibition of COL11A1 expression
Q37415110	Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor
Q39451375	Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.
Q36313185	Akt-regulated pathways in prostate cancer
Q54513779	Akt/PKB activation in gastric carcinomas correlates with clinicopathologic variables and prognosis.
Q33740171	Allele-specific tumor spectrum in pten knockin mice
Q40969242	Alleletyping of an oligodendrocyte-type-2 astrocyte lineage derive from a human glioblastoma multiforme
Q48555134	Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation
Q39836086	Allelic loss at PTEN locus leads to progression of colorectal carcinoma among North Indian patients
Q84912254	Allelic loss of 10q23.3, the PTEN gene locus in cervical carcinoma from Northern Indian population
Q45585418	Allelic loss of chromosome 4q21 approximately 23 associates with hepatitis B virus-related hepatocarcinogenesis and elevated alpha-fetoprotein
Q57205409	Allelic loss of chromosome 4q21?23 associates with hepatitis B virus-related hepatocarcinogenesis and elevated alpha-fetoprotein
Q73316223	Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype
Q42860747	Allelic loss on chromosome 10q in human lung cancer: association with tumour progression and metastatic phenotype
Q78757756	Allelic loss on chromosomes 2q, 3p and 21q: possibly a poor prognostic factor in oral squamous cell carcinoma
Q77359632	Allelic losses at 1p, 9q, 10q, 14q, and 22q in the progression of aggressive meningiomas and undifferentiated meningeal sarcomas
Q74480207	Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types
Q28186818	Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate
Q36973814	Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy
Q41162185	Alteration of cellular metabolism in cancer cells and its therapeutic prospects
Q51072877	Alteration of the E-cadherin/β-catenin complex predicts poor response to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment
Q78201434	Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis
Q28284845	Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer
Q45974630	Altering PI3K-Akt signalling in zebrafish embryos affects PTEN phosphorylation and gastrulation.
Q90570508	Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs
Q47915665	Alternative splicing of the Drosophila PTEN gene
Q40836678	Alternative splicing of the human PTEN/MMAC1/TEP1 gene
Q39961330	An AKT activity threshold regulates androgen-dependent and androgen-independent PSA expression in prostate cancer cell lines
Q34432869	An Integrated Physical and Genetic Map Spanning Chromosome Band 10q24
Q48239804	An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
Q35750105	An essential role for protein synthesis in oncogenic cellular transformation
Q39836235	An evaluation of the anti-neoplastic activity of curcumin in prostate cancer cell lines.
Q36790955	An inducible knock-out mouse to model cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias
Q24648860	An integrated genomic analysis of human glioblastoma multiforme
Q38656675	An update on the current pharmacotherapy for endometrial cancer
Q47914352	Analysis of APCL, a brain-specific adenomatous polyposis coli homologue, for mutations and expression in brain tumors
Q34729972	Analysis of PTEN Methylation Patterns in Soft Tissue Sarcomas by MassARRAY Spectrometry
Q37431681	Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex
Q36942597	Analysis of PTEN expression in large intestine polyps and its relation to the recognized histopathological and clinical risk factors for cancer development in this location
Q52543055	Analysis of PTEN/MMAC1 alteration in neuroblastoma
Q39308117	Analysis of bypass signaling in EGFR pathway and profiling of bypass genes for predicting response to anticancer EGFR tyrosine kinase inhibitors
Q41111171	Analysis of gene expression profiles associated with glioma progression
Q36830940	Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression
Q38280971	Analysis of intracellular PTEN signaling and secretion
Q36618853	Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma.
Q74234504	Analysis of the DMBT1 gene in carcinomas of the respiratory tract
Q57591296	Analysis of the PTEN gene in human meningiomas
Q38314871	Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase
Q24601008	Analysis of the genome to personalize therapy for melanoma
Q39210166	Analysis of the interplay between methylation and expression reveals its potential role in cancer aetiology
Q57651388	Analyzing phosphoinositides and their interacting proteins
Q46641516	Anaplastic astrocytomas: biology and treatment
Q34444942	Androgen Receptor Signaling in Androgen-Refractory Prostate Cancer
Q90266952	Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer
Q26799813	Androgen deprivation of prostate cancer: Leading to a therapeutic dead end
Q34283623	Androgen metabolism in prostate cancer: from molecular mechanisms to clinical consequences
Q40598904	Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells
Q33922894	Animal models of melanoma: recent advances and future prospects
Q35564020	Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.
Q73693654	Antagonism between PTEN/MMAC1/TEP-1 and androgen receptor in growth and apoptosis of prostatic cancer cells
Q42974266	Anti-androgen resistance in prostate cancer cells chronically induced by interleukin-1β.
Q74428342	Anti-phosphatases take the stage
Q34568628	Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in (12) V-Ha-Ras transgenic mouse glioma model
Q37203000	Antitumor Activity of NVP-BKM120—A Selective Pan Class I PI3 Kinase Inhibitor Showed Differential Forms of Cell Death Based on p53 Status of Glioma Cells
Q33597685	Antitumor effect of novel small chemical inhibitors of Snail-p53 binding in K-Ras-mutated cancer cells
Q59566807	Application of differential cDNA screening techniques to the identification of unique gene expression in tumours and lymphocytes
Q36965370	Applications of emerging molecular technologies in glioblastoma multiforme
Q37783931	Approaches and limitations of phosphatidylinositol-3-kinase pathway activation status as a predictive biomarker in the clinical development of targeted therapy
Q91716361	Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs
Q37768769	Array CGH as a potential predictor of radiocurability in intermediate risk prostate cancer
Q51673156	Assessment of PTEN-associated vascular malformations in a patient with Bannayan-Riley-Ruvalcaba syndrome
Q77647988	Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinomas and hyperplasias
Q35761550	Association between Cowden syndrome and Lhermitte-Duclos disease: report of two cases and review of the literature
Q91593491	Association between PTEN and clinical-pathological features of osteosarcoma
Q57022565	Association of ERG/PTEN status with biochemical recurrence after radical prostatectomy for clinically localized prostate cancer
Q58572361	Association of PTEN expression with liver function and inflammatory changes in patients with liver cancer after chemotherapy
Q36464903	Association of PTEN gene polymorphisms with liver cancer risk
Q34446051	Association of PTEN genetic polymorphisms with atherosclerotic cerebral infarction in the Han Chinese population
Q24323057	Association of SET domain and myotubularin-related proteins modulates growth control
Q48373067	Association of loss of heterozygosity and PTEN gene abnormalities with paraclinical, clinical modalities and survival time of glioma patients in Malaysia
Q40615998	Association of the polymorphisms in the 5′‐untranslated region of PTEN gene with type 2 diabetes in a Japanese population
Q21093282	Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance
Q39367212	Attenuation of PTEN perturbs genomic stability via activation of Akt and down‐regulation of Rad51 in human embryonic kidney cells
Q36101188	Autism spectrum disorders: from genes to neurobiology
Q30742805	Autistic-Like Traits and Cerebellar Dysfunction in Purkinje Cell PTEN Knock-Out Mice
Q47561660	Autoimmunity checkpoints as therapeutic targets in B cell malignancies
Q36654185	Autophagic pathways as new targets for cancer drug development
Q37087035	Autophagy defects suggested by low levels of autophagy activator MAP1S and high levels of autophagy inhibitor LRPPRC predict poor prognosis of prostate cancer patients
Q35232272	Autophagy regulation in cancer development and therapy
Q88090511	B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies
Q37566231	BAD: undertaker by night, candyman by day.
Q39073672	BAG5 regulates PTEN stability in MCF-7 cell line
Q57292305	BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
Q64935151	BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancer.
Q26822064	Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder
Q57720202	Bannayan-Riley-Ruvalcaba Syndrome
Q35566202	Bannayan-Riley-Ruvalcaba syndrome: further delineation of the phenotype and management of PTEN mutation-positive cases.
Q35801259	Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice
Q36825199	Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma
Q38074874	Bergmann Glia Function in Granule Cell Migration During Cerebellum Development
Q34356308	Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer
Q36384467	Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
Q37735950	Bilateral Triple-Negative Invasive Breast Cancer with a BRCA2 Mutation, and Glioblastoma: A Case Report and Literature Review
Q45961245	Biochemical and biological characterization of tumor-associated mutations of p110alpha.
Q28209463	Biochemical signals and biological responses elicited by the focal adhesion kinase
Q48712580	Biologic tumor behavior in pilocytic astrocytomas
Q34444274	Biological mechanisms of glioma invasion and potential therapeutic targets
Q34405013	Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation
Q26825496	Biomarkers for glioma immunotherapy: the next generation
Q45289825	Biomarkers for prostate cancer: who will benefit from local treatment, who harbors occult systemic disease and who needs treatment at all?
Q34321332	Bisperoxovanadium compounds are potent PTEN inhibitors.
Q33901504	Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs
Q34495274	Bone Marrow Biopsy: RNA Isolation with Expression Profiling in Men with Metastatic Castration-resistant Prostate Cancer—Factors Affecting Diagnostic Success
Q50000036	Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit+ cardiac stem cells from oxidative injury through the PTEN/PI3K/Akt axis.
Q40726891	Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor
Q39762403	Brain Tumor Genetic Modification Yields Increased Resistance to Paclitaxel in Physical Confinement.
Q58491157	Brain Tumours
Q35576526	Brain tumours: classification and genes
Q77139593	Breast and Prostate Cancer: An Analysis of Common Epidemiological, Genetic, and Biochemical Features*
Q55003868	Breast cancer associated germline structural variants harboring small noncoding RNAs impact post-transcriptional gene regulation.
Q36108626	Breast cancer susceptibility and the DNA damage response
Q27851446	Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling
Q47963126	Broad spectrum of neuropsychiatric phenotypes associated with white matter disease in PTEN hamartoma tumor syndrome
Q40016930	Broadening of transgenic adenocarcinoma of the mouse prostate (TRAMP) model to represent late stage androgen depletion independent cancer
Q36844293	Building a hit list for the fight against metastatic castration resistant prostate cancer
Q38290374	C. elegans as a model to study PTEN's regulation and function
Q39147514	CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth
Q58555035	CRISPR-Cas9 human gene replacement and phenomic characterization in to understand the functional conservation of human genes and decipher variants of uncertain significance
Q26769907	CRISPR/Cas9 and cancer targets: future possibilities and present challenges
Q36562166	CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc
Q28391721	CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation
Q48095864	Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation
Q45166166	Caenorhabditis elegans PIAK, a phospholipid-independent kinase that activates the AKT/PKB survival kinase
Q90380782	Calcitonin receptor is required for T-antigen-induced prostate carcinogenesis
Q34425717	Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2.
Q39912728	Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A.
Q64899590	Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides.
Q33704062	Cancer cell metabolism: its relevance to cancer treatment
Q34962407	Cancer gene discovery in mouse and man.
Q34710694	Cancer genomics
Q41739799	Cancer predisposition: Where's the phosphate?
Q36618198	Cancer risk in close relatives of women with early-onset breast cancer--a population-based incidence study
Q38249099	Cancer systems biology: embracing complexity to develop better anticancer therapeutic strategies
Q36553683	Cancer-associated genodermatoses: a personal history
Q48111016	Candidate glioblastoma development gene identification using concordance between copy number abnormalities and gene expression level changes.
Q36347094	Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT.
Q35799783	Capturing the Molecular and Biological Diversity of High-Grade Astrocytoma in Genetically Engineered Mouse Models
Q35715762	Carcinoma of the prostate: inherited susceptibility, somatic gene defects and androgen receptors
Q38721782	Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia
Q33721897	Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to Akt
Q34633364	Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway
Q37511752	Cause and consequences of genetic and epigenetic alterations in human cancer.
Q39451271	Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide
Q36220879	Cell Signals Influencing Hepatic Fibrosis
Q34537642	Cell metabolism in the regulation of programmed cell death
Q39947712	Cellular commitment to reentry into the cell cycle after stalled DNA is determined by site-specific phosphorylation of Chk1 and PTEN.
Q34983621	Cellular mechanisms targeted during astrocytoma progression
Q26863333	Cellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressor
Q36512624	Central regulation of metabolism by protein tyrosine phosphatases
Q39467245	Chamaejasmine Inactivates Akt To Trigger Apoptosis in Human HEp-2 Larynx Carcinoma Cells
Q36345855	Changes in the transcriptome of bovine ovarian cortex during follicle activation in vitro
Q41914832	Changing histopathological diagnostics by genome-based tumor classification
Q39742541	Characterisation of the PTEN inhibitor VO-OHpic
Q41000308	Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization
Q38699761	Characterization of a novel p110β-specific inhibitor BL140 that overcomes MDV3100-resistance in castration-resistant prostate cancer cells
Q52691347	Characterization of aptamer-mediated gene delivery system for liver cancer therapy
Q40815452	Characterization of chromosome aberrations associated with soft-tissue leiomyosarcomas by twenty-four-color karyotyping and comparative genomic hybridization analysis
Q36426477	Characterization of the Functional Domains of a Mammalian Voltage-Sensitive Phosphatase
Q39709408	Characterization of the potency of epidermal growth factor (EGFR)-DNA targeting combi-molecules containing a hydrolabile carbamate at the 3-position of the triazene chain
Q52590901	Chemical probes and drug leads from advances in synthetic planning and methodology.
Q73795992	Chemiluminescence assay of serum alkaline phosphatase and phosphoprotein phosphatases
Q40018845	Chemosensitization of endometrial cancer cells through AKT inhibition involves FOXO1.
Q38388784	Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma Multiforme
Q35746558	Chromosomal Rainbows detect Oncogenic Rearrangements of Signaling Molecules in Thyroid Tumors
Q57781636	Chromosomal abnormalities and microsatellite instability in sporadic endometrial cancer
Q48419001	Chromosomal abnormalities in human glioblastomas: gain in chromosome 7p correlating with loss in chromosome 10q.
Q33781119	Chromosomal and genomic changes in lung cancer
Q73147272	Chromosomal imbalances in small cell carcinomas of the urinary bladder
Q35201471	Chromosome aberrations in solid tumors
Q38258642	Chronic Chlorpyrifos Exposure Does Not Promote Prostate Cancer in Prostate Specific PTEN Mutant Mice
Q31149230	Chronic oxidative stress increases growth and tumorigenic potential of MCF-7 breast cancer cells
Q64055205	Chronic prostatitis alters the prostatic microenvironment and accelerates preneoplastic lesions in C57BL/6 mice
Q48014444	Circulating levels of PTEN and KLLN in papillary thyroid carcinoma: can they be considered as novel diagnostic biomarkers?
Q28551950	Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice
Q30523962	Class II formin targeting to the cell cortex by binding PI(3,5)P(2) is essential for polarized growth.
Q36313163	Class reunion: PTEN joins the nuclear crew.
Q37871915	Clinical activity of mammalian target of rapamycin inhibitors in solid tumors
Q24685731	Clinical and experimental progression of a new model of human prostate cancer and therapeutic approach
Q38515841	Clinical efficacy of mTOR inhibitors in solid tumors: a systematic review
Q73666921	Clinical, pathological and genetic features of women at high familial risk of breast cancer undergoing prophylactic mastectomy
Q31026243	Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocelular carcinoma
Q24290385	Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member
Q38964512	Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines
Q29615606	Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
Q46710025	Coalterations of p53 and PTEN tumor suppressor genes in non–small cell lung carcinoma patients
Q42353638	Combination effects of sorafenib with PI3K inhibitors under hypoxia in colorectal cancer
Q39804055	Combination gene therapy with PTEN and EGFR siRNA suppresses U251 malignant glioma cell growth in vitro and in vivo
Q48112869	Combination of all-trans retinoic acid and interferon-gamma suppressed PI3K/Akt survival pathway in glioblastoma T98G cells whereas NF-kappaB survival signaling in glioblastoma U87MG cells for induction of apoptosis
Q37701569	Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors
Q34180660	Combinatorial control of the specificity of protein tyrosine phosphatases
Q28728155	Combined Phosphatase and Tensin Homolog (PTEN) Loss and Fatty Acid Synthase (FAS) Overexpression Worsens the Prognosis of Chinese Patients with Hepatocellular Carcinoma
Q34880928	Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K
Q36107116	Combined haploinsufficiency and genetic control of the G2/M checkpoint in irradiated cells.
Q44080704	Common chromosomal aberrations detected by array comparative genomic hybridization in specialized stromal tumors of the prostate
Q37200911	Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.
Q28276866	Commonly occurring loss and mutation of theMXI1 gene in prostate cancer
Q55477117	Comparative molecular genetic profiles of anaplastic astrocytomas/glioblastomas multiforme and their subsequent recurrences.
Q36578820	Comparison of Glioblastomas and Brain Metastases using Dynamic Contrast-Enhanced Perfusion MRI
Q35039874	Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas
Q77790149	Complementary biobank of rodent tissue samples to study the effect of World Trade Center exposure on cancer development
Q34438555	Complete loss of PTEN protein expression correlates with shorter time to brain metastasis and survival in stage IIIB/C melanoma patients with BRAFV600 mutations
Q89387405	Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer
Q47142338	Comprehensive genomic analysis of Oesophageal Squamous Cell Carcinoma reveals clinical relevance
Q33757319	Concurrent BRAF and PTEN mutations in melanoma of unknown origin presenting as a breast mass
Q34632753	Conditional ablation of Pten in osteoprogenitors stimulates FGF signaling
Q34581012	Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development
Q34545106	Conditional deletion of the Pten gene in the mouse prostate induces prostatic intraepithelial neoplasms at early ages but a slow progression to prostate tumors
Q34158700	Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme
Q41266999	Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes
Q43747246	Conserved synteny between the Fugu and human PTEN locus and the evolutionary conservation of vertebrate PTEN function
Q35788734	Considerations when analyzing the methylation status of PTEN tumor suppressor gene
Q79098518	Constipation, polyps, or cancer? let PTEN predict your future
Q43761459	Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer
Q40234083	Construction and expression of human PTEN tumor suppressor gene recombinant adenovirus vector
Q34750104	Contactin-1 reduces E-cadherin expression via activating AKT in lung cancer.
Q35141779	Contribution of stem cells and differentiated cells to epidermal tumours
Q37109227	Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.
Q34979483	Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
Q35021348	Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma therapies
Q36129275	Control of the hypoxic response through regulation of mRNA translation.
Q33422870	Cooperation of Mtmr8 with PI3K regulates actin filament modeling and muscle development in zebrafish
Q34338564	Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis
Q37096504	Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer
Q81811800	Correlation between loss of PTEN expression and PKB/AKT phosphorylation in hepatocellular carcinoma
Q37593968	Correlation of NEDD4-1 and PTEN expression with the invasive capacity of pituitary adenomas
Q37269614	Counteracting the activation of pAkt by inhibition of MEK/Erk inhibition reduces actin disruption-mediated apoptosis in PTEN-null PC3M prostate cancer cell lines
Q37267670	Coupling between the voltage-sensing and phosphatase domains of Ci-VSP.
Q42230567	Coupling of Ci-VSP Modules Requires a Combination of Structure and Electrostatics within the Linker
Q90478449	Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity
Q85527281	Cowden Syndrome
Q35739261	Cowden Syndrome with a Novel Germline PTEN Mutation and an Unusual Clinical Course
Q73245498	Cowden disease and Lhermitte Duclos disease, markers of breast carcinoma: report of two patients
Q38240785	Cowden syndrome: recognizing and managing a not-so-rare hereditary cancer syndrome
Q36456939	Cowden syndrome: report of a case with immunohistochemical analysis and review of the literature.
Q34098308	Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis
Q47158122	Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations.
Q37767357	Critical molecular pathways in cancer stem cells of chronic myeloid leukemia
Q46082313	Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries
Q42944792	Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.
Q28083118	Cross Talk between Two Antioxidant Systems, Thioredoxin and DJ-1: Consequences for Cancer
Q36236802	Crosstalk between Nrf2 and Notch signaling.
Q38181338	Crosstalk between kinases and Nedd4 family ubiquitin ligases.
Q35048965	Crosstalking between androgen and PI3K/AKT signaling pathways in prostate cancer cells
Q27642841	Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome
Q27640282	Crystal structure of an inactive Akt2 kinase domain
Q27620298	Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
Q38242086	Current clinical regulation of PI3K/PTEN/Akt/mTOR signalling in treatment of human cancer
Q34539833	Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines.
Q38465671	Cytogenetically balanced translocations are associated with focal copy number alterations
Q83904431	Cytogenomic aberrations associated with prostate cancer
Q36724548	Cytoplasmic PTEN protein loss distinguishes intraductal carcinoma of the prostate from high-grade prostatic intraepithelial neoplasia
Q24536178	DBC2, a candidate for a tumor suppressor gene involved in breast cancer
Q24310338	DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours
Q35753414	DNA Copy Number Changes in Development and Progression in Leiomyosarcomas of Soft Tissues
Q33733232	DNA copy number losses in human neoplasms
Q28182054	DOCK4, a GTPase activator, is disrupted during tumorigenesis
Q30371703	Deciphering the impact of somatic mutations in exon 20 and exon 9 of PIK3CA gene in breast tumors among Indian women through molecular dynamics approach.
Q34158474	Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer.
Q38702978	Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD.
Q39641817	Deep Genetic Connection Between Cancer and Developmental Disorders
Q39841592	Defective expression of polarity protein PAR-3 gene (PARD3) in esophageal squamous cell carcinoma
Q36703783	Defining biomarkers to predict sensitivity to PI3K/Akt/mTOR pathway inhibitors in breast cancer
Q43947306	Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT,p16(INK4A), and p19(ARF) genes in nasopharyngeal carcinoma
Q51996177	Deletion 10q23.2-q23.33 in a patient with gastrointestinal juvenile polyposis and other features of a Cowden-like syndrome
Q28591535	Deletion of Leucine Zipper Tumor Suppressor 2 (Lzts2) Increases Susceptibility to Tumor Development
Q47198022	Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
Q90705867	Deletion of ptn1, a PTEN/TEP1 Orthologue, in Ustilago maydis Reduces Pathogenicity and Teliospore Development
Q73672434	Deletion ofPTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease
Q34283491	Delivery of cell cycle genes to block astrocytoma growth
Q36107160	Delivery systems and molecular targets of mechanism-based therapies for GBM.
Q39723322	Denaturing high performance liquid chromatography (DHPLC) used in the detection of germline and somatic mutations
Q24658292	Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms
Q28073195	Deregulated MicroRNAs in Biliary Tract Cancer: Functional Targets and Potential Biomarkers
Q28468683	Deriving Cell Lines from Zebrafish Embryos and Tumors
Q33949063	Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor
Q57138539	Design, synthesis, and evaluation of 4,5,6,7-tetrahydrobenzo[]thiazole-based novel dual kinase inhibitors of CK2 and GSK3β
Q39975443	Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer.
Q40660977	Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer.
Q35356484	Detailed characterization of alterations of chromosomes 7, 9, and 10 in glioblastomas as assessed by single-nucleotide polymorphism arrays.
Q33852849	Detecting low penetrance genes in cancer: the way ahead
Q55475202	Detection of PTEN nonsense mutation and psiPTEN expression in central nervous system high-grade astrocytic tumors by a yeast-based stop codon assay.
Q43860454	Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10.
Q28117749	Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis
Q37633952	Deubiquitylation and stabilization of PTEN by USP13
Q41818669	Developing a Novel Embryo-Larval Zebrafish Xenograft Assay to Prioritize Human Glioblastoma Therapeutics.
Q35949604	Developing genetically engineered mouse models to study tumor suppression
Q37164106	Development of a novel mouse glioma model using lentiviral vectors
Q35184864	Development of a peptide-drug conjugate for prostate cancer therapy.
Q39939547	Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.
Q35770177	Development of novel targeted therapies in the treatment of malignant glioma
Q39641050	Different expression patterns of pAkt, NF‐κB and cyclin D1 proteins during the invasion process of head and neck squamous cell carcinoma: an in vitro approach
Q38967191	Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: apoptotic bodies, microvesicles, and exosomes
Q31045942	Different pattern of loss of heterozygosity among endocervical-type adenocarcinoma, endometrioid-type adenocarcinoma and adenoma malignum of the uterine cervix
Q40394198	Differential PTEN protein expression profiles in superficial versus invasive bladder cancers.
Q35915549	Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development
Q39226426	Differential effects of exogenous and autocrine growth hormone on LNCaP prostate cancer cell proliferation and survival
Q34435501	Differential expression of PTEN in hepatic tissue and hepatic stellate cells during rat liver fibrosis and its reversal
Q33813843	Differential expression of p42.3 in low- and high-grade gliomas
Q24319742	Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages
Q35810225	Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors
Q34370353	Differential sensitization of different prostate cancer cells to apoptosis.
Q34093068	Differentiation therapy of human cancer: basic science and clinical applications
Q40469795	Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi.
Q28203697	Direct identification of PTEN phosphorylation sites
Q34152841	Discovering Tumor Suppressor Genes Through Genome-Wide Copy Number Analysis
Q38760518	Discovery Proteomics Identifies a Molecular Link between the Coatomer Protein Complex I and Androgen Receptor-dependent Transcription
Q27674784	Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer
Q35742439	Discrete functions of GSK3α and GSK3β isoforms in prostate tumor growth and micrometastasis
Q38160495	Disruption of prostate epithelial differentiation pathways and prostate cancer development
Q34602712	Dissociated Primary Human Prostate Cancer Cells Coinjected with the Immortalized Hs5 Bone Marrow Stromal Cells Generate Undifferentiated Tumors in NOD/SCID-γ Mice
Q33843299	Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility
Q34460872	Distinct and Overlapping Functions of Insulin and IGF-I Receptors
Q55477778	Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades
Q42737245	Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice
Q83853850	Diverse antiapoptotic signaling pathways activated by vasoactive intestinal polypeptide, epidermal growth factor, and phosphatidylinositol 3-kinase in prostate cancer cells converge on BAD
Q83223368	Do DNA copy number changes differentiate uterine from non-uterine leiomyosarcomas and predict metastasis?
Q34119182	Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination?
Q39392236	Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development
Q37007270	Dose-Dependent Protective Effect of Bisperoxovanadium against Acute Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury
Q59238491	Double primary cancers of the breast and thyroid in women: molecular analysis and genetic implications
Q35435345	Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines
Q40090115	Down-regulation of Stat3 induces apoptosis of human glioma cell: a potential method to treat brain cancer.
Q40615729	Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.
Q28360348	Downregulation of Akt1 inhibits anchorage-independent cell growth and induces apoptosis in cancer cells
Q34831381	Downregulation of PTEN at Corneal Wound Sites Accelerates Wound Healing through Increased Cell Migration
Q44801430	Downregulation of PTEN expression in psoriatic lesions
Q40709512	Downregulation of PTEN/MMAC/TEP1 expression in human prostate cancer cell line DU145 by growth stimuli
Q33253913	Downregulation of RUNX3 and TES by hypermethylation in glioblastoma
Q34787109	Downregulation of TES by hypermethylation in glioblastoma reduces cell apoptosis and predicts poor clinical outcome
Q38910285	Downregulation of TPTE2P1 Inhibits Migration and Invasion of Gallbladder Cancer Cells
Q38844346	Downregulation of key regulatory proteins in androgen dependent prostate tumor cells by oncolytic reovirus
Q64930094	Downregulation of microRNA‑21 expression inhibits proliferation, and induces G1 arrest and apoptosis via the PTEN/AKT pathway in SKM‑1 cells.
Q34639532	Driver Mutations in Melanoma: Lessons Learned From Bench-to-Bedside Studies
Q35839783	Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking.
Q90103140	Drosophila melanogaster as a Model System for Human Glioblastomas
Q35566228	Drosophila melanogaster as a model system for human brain cancers
Q30829981	Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
Q35705897	Dual inhibition of phosphatidylinositol 3‐kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin
Q53829615	Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes.
Q48394985	Dynamics of genetic alterations associated with glioma recurrence
Q36089140	Dysphagia and Neck Swelling in a Case of Undiagnosed Lhermitte-Duclos Disease and Cowden Syndrome.
Q30436220	Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis
Q36712707	Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism
Q40528326	E17K substitution in AKT1 in prostate cancer
Q39917232	E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway
Q91694680	EGFR mutation: novel prognostic factor associated with immune infiltration in lower-grade glioma; an exploratory study
Q37284242	EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors
Q24299669	EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK
Q39258956	ER-activating ability of breast cancer stromal fibroblasts is regulated independently of alteration of TP53 and PTEN tumor suppressor genes
Q38681610	ERG expression in prostate cancer: biological relevance and clinical implication
Q38354820	Early gene activation in chronic leukemic B lymphocytes induced toward a plasma cell phenotype
Q50444489	Early malignant transformation of a petroclival meningothelial meningioma
Q40444732	Effect of 7-hydroxystaurosporine on glioblastoma cell invasion and migration
Q39210082	Effect of PTEN Antisense Oligonucleotide on Oesophageal Squamous Cell Carcinoma Cell Lines
Q40850887	Effect of PTEN Gene Mutations and Environmental Risk Factors on the Progression and Prognosis of Bladder Cancer.
Q64271866	Effect of PTEN loss on metabolic reprogramming in prostate cancer cells
Q44577628	Effect of adenovirus-mediated PTEN gene on ulcerative colitis-associated colorectal cancer
Q36381071	Effect of aging and dietary salt and potassium intake on endothelial PTEN (Phosphatase and tensin homolog on chromosome 10) function
Q39687681	Effect of wild type PTEN gene on proliferation and invasion of multiple myeloma
Q43138169	Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice
Q34583094	Effects and mechanisms of silibinin on human hepatoma cell lines
Q38748416	Effects of PTEN gene silencing on invasion and EMT in oral squamous carcinoma Tca8113 cells
Q39294497	Effects of PTEN inhibition on regulation of tau phosphorylation in an okadaic acid‐induced neurodegeneration model
Q40133649	Effects of SHIP-1 on MMP2 secretion and invasion of SR3Y1 cells
Q40268565	Effects of cotransfection of antisense-EGFR and wild-type PTEN cDNA on human glioblastoma cells
Q36943601	Effects of indomethacin on expression of PTEN tumour suppressor in human cancers
Q52614688	Effects of isoliquiritigenin on ovarian cancer cells
Q57470956	Effects of the tumor suppressor PTEN on biological behaviors of activated pancreatic stellate cells in pancreatic fibrosis
Q92143276	Efficacy of PI3K inhibitors in advanced breast cancer
Q47281756	Efficient Generation of Somatic Cell Nuclear Transfer-Competent Porcine Cells with Mutated Alleles at Multiple Target Loci by Using CRISPR/Cas9 Combined with Targeted Toxin-Based Selection System
Q34460262	Efficient inhibition of human glioma development by RNA interference-mediated silencing of PAK5
Q35640263	Elevated PI3K signaling drives multiple Breast Cancer subtypes
Q42176783	Elucidating the mechanism of miRNA-214 in the regulation of gingival carcinoma
Q39544217	Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN
Q35123575	Endocrine-resistant breast cancer: Underlying mechanisms and strategies for overcoming resistance
Q35084786	Endocrine-responsive breast cancer and strategies for combating resistance
Q39846920	Endogenous tumor suppression mediated by PTEN involves survivin gene silencing.
Q36790454	Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis
Q88654113	Endothelial Akt1 loss promotes prostate cancer metastasis via β-catenin-regulated tight-junction protein turnover
Q40509977	Enhanced cell growth inhibition following PTEN nonviral gene transfer using polyethylenimine and photochemical internalization in endometrial cancer cells
Q48454996	Enhanced phosphorylation of PTEN in rat brain after transient middle cerebral artery occlusion
Q40412834	Enhanced radiation damage of tumor vasculature by mTOR inhibitors
Q27824772	Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.
Q45885573	Enhanced tumor suppression by adenoviral PTEN gene therapy combined with cisplatin chemotherapy in small-cell lung cancer
Q40371796	Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in PTEN-deficient cancer cells
Q37403650	Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases
Q24310260	EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt
Q33993779	EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.
Q37105532	Epidemiology and surveillance of hepatocellular carcinoma
Q37886638	Epidermal Growth Factor Receptor Vaccination for Glioblastoma Multiforme
Q36458742	Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy
Q37381874	Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity
Q50527200	Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor
Q35745799	Epigenetic PTEN silencing in malignant melanomas without PTEN mutation
Q37830385	Epigenetic aberrations during oncogenesis.
Q38319591	Epigenetic alterations in cancer and personalized cancer treatment
Q46244569	Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation
Q28391921	Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?
Q38735060	Epstein-Barr Virus (EBV)-BamHI-A Rightward Transcript (BART)-6 and Cellular MicroRNA-142 Synergistically Compromise Immune Defense of Host Cells in EBV-Positive Burkitt Lymphoma.
Q35479646	ErbB3 Ablation Impairs PI3K/Akt-Dependent Mammary Tumorigenesis
Q42268831	Esophageal Adenocarcinoma-Derived Extracellular Vesicle MicroRNAs Induce a Neoplastic Phenotype in Gastric Organoids
Q35164689	Esophageal cancer in a family with hamartomatous tumors and germline PTEN frameshift and SMAD7 missense mutations
Q34280493	Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis
Q37360125	Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis
Q55477684	Establishing human glioma-derived cell lines.
Q40891163	Establishment and characterization of a human cell line from paediatric cerebellar glioblastoma multiforme
Q43845131	Establishment and characterization of nine human brain tumor cell lines
Q39132853	Establishment of a Chinese bladder cancer cell line (T921) with high metastatic activity
Q37708388	Establishment of a novel cellular model for myxofibrosarcoma heterogeneity
Q48192678	Establishment of two glioma cell lines from two surgical specimens obtained at different times from the same individual
Q37442718	Estrogen partially down-regulates PTEN to prevent apoptosis in VSC4.1 motoneurons following exposure to IFN-gamma
Q36557541	Eukaryotic initiation factor 2B and its role in alterations in mRNA translation that occur under a number of pathophysiological and physiological conditions
Q92200712	Evaluation of PTEN and CD4+FOXP3+ T cell expressions as diagnostic and predictive factors in endometrial cancer: A case control study
Q56928438	Evaluation of germline PTEN mutations in endometrial cancer patients
Q22253866	Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
Q42701298	Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors
Q35813677	Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns
Q90719450	Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults
Q38734366	Evolving Molecular Genetics of Glioblastoma
Q28374576	Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies
Q36618879	Exclusion of a major role for the PTEN tumour-suppressor gene in breast carcinomas
Q43202044	Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome
Q24616117	Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
Q33358687	Exon expression arrays as a tool to identify new cancer genes
Q64912972	Exosomal miRNA-107 induces myeloid-derived suppressor cell expansion in gastric cancer.
Q30392471	Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesis
Q47883924	Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer
Q36611435	Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing
Q29615120	Exploiting the PI3K/AKT pathway for cancer drug discovery
Q92171674	Expression Profiles of the Phosphatase and Tensin Homolog (PTEN), CDH1, and CDH2 Genes, and the Cell Membrane Protein, CD133, in the Ishikawa Human Endometrial Adenocarcinoma Cell Line
Q42951206	Expression and clinical significance of mTOR and PTEN in non-small cell lung cancer
Q77879703	Expression and prognostic significance of PTEN product protein in patients with esophageal squamous cell carcinoma
Q73437715	Expression and significance of new tumor suppressor gene PTEN in primary liver cancer
Q82846340	Expression levels of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and focal adhesion kinase in patients with multiple myeloma and their relationship to clinical stage and extramedullary infiltration
Q51799708	Expression of FAK and PTEN in bronchioloalveolar carcinoma and lung adenocarcinoma
Q36976151	Expression of Lewis y antigen and integrin αv, β3 in ovarian cancer and their relationship with chemotherapeutic drug resistance
Q36261565	Expression of NF-κB and PTEN in primary epithelial ovarian carcinoma and the correlation with chemoresistance
Q36502768	Expression of PTEN and KAI1 tumor suppressor genes in pancreatic carcinoma and its association with different pathological factors
Q33275157	Expression of PTEN and mTOR in sacral chordoma and association with poor prognosis
Q49103729	Expression of PTEN and phosphorylated Akt in human cholesteatoma epithelium
Q74234906	Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivo
Q79249861	Expression of PTEN in renal cell carcinoma and its relation to tumor behavior and growth
Q58616333	Expression of PTEN, Androgen Receptor, HER2/neu, Cytokeratin 5/6, Estrogen Receptor-Beta, HMGA2, and PLAG1 in Salivary Duct Carcinoma
Q36179908	Expression of PTEN, PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues
Q45869005	Expression of PTEN-long mediated by CRISPR/Cas9 can repress U87 cell proliferation.
Q83012129	Expression of PTTG1 and PTEN in endometrial carcinoma: correlation with tumorigenesis and progression
Q37720098	Expression of miR‑26a exhibits a negative correlation with HMGA1 and regulates cancer progression by targeting HMGA1 in lung adenocarcinoma cells
Q33879264	Expression of the DMBT1 gene is frequently suppressed in human lung cancer
Q21136078	Expression of versican 3'-untranslated region modulates endogenous microRNA functions
Q28577689	Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors
Q92044740	FAM35A/SHLD2/RINN2: A Novel Determinant of DSB Repair Pathway Choice and Genome Stability in Cancer
Q40368462	FAS associated phosphatase (FAP-1) blocks apoptosis of astrocytomas through dephosphorylation of FAS.
Q90481635	FGD1 promotes tumor progression and regulates tumor immune response in osteosarcoma via inhibiting PTEN activity
Q35021334	FHIT: from gene discovery to cancer treatment and prevention
Q28204251	FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer
Q39994736	FOXO3a mediates the androgen-dependent regulation of FLIP and contributes to TRAIL-induced apoptosis of LNCaP cells
Q47317248	Familial Adenomatous Polyposis (FAP) and Other Polyposis Syndromes
Q88371763	Familial Syndromes Involving Meningiomas Provide Mechanistic Insight Into Sporadic Disease
Q37409748	FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model.
Q24317761	Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development
Q28509303	Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2
Q35940296	Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System
Q24792470	Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis
Q57541406	Finding biomarkers of resistance to targeted cancer therapies
Q54633363	Fine allelotyping of Erbb2-induced mammary tumors in mice reveals multiple discontinuous candidate regions of tumor-suppressor loci.
Q48615715	Fine mapping of a region of common deletion on chromosome arm 10p in human glioma
Q36006472	Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis
Q91728282	Fine-tuning AKT kinase activity through direct lysine methylation
Q34626967	First-in-human study of CH5132799, an oral class I PI3K inhibitor, studying toxicity, pharmacokinetics, and pharmacodynamics, in patients with metastatic cancer
Q33761221	Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth
Q37383459	Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progression
Q52542857	Focal adhesion kinase (FAK) phosphorylation is not required for genistein-induced FAK-beta-1-integrin complex formation
Q26797287	Focus on PTEN Regulation
Q39457088	Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.
Q24797933	Formin homology 2 domains occur in multiple contexts in angiosperms
Q37288553	Formins: emerging players in the dynamic plant cell cortex
Q49065989	Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma.
Q48154511	Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines
Q38445188	Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma
Q36740152	Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer
Q34507972	Frequent loss of 9p21 (p16(INK4A)) and other genomic imbalances in human malignant fibrous histiocytoma
Q35842249	Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas
Q53401422	Frequent loss of heterozygosity at the 19p13.3 locus without LKB1/STK11 mutations in human carcinoma metastases to the brain
Q52910001	Frequent loss of heterozygosity on chromosomes 4, 12 and 19 in radiation-induced lymphomas in mice
Q27852227	Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers
Q39732683	Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma
Q37531067	Friend or foe: role of E-cadherin in prostate cancer metastasis
Q30397539	Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells
Q48306512	Functional and molecular analyses of 10q deletions in human gliomas
Q34935982	Functional cloning of a tumor suppressor gene, TSLC1, in human non-small cell lung cancer
Q40811004	Functional evidence for the presence of tumor suppressor gene on chromosome 10p15 in human prostate cancers
Q33744696	Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc
Q47724155	Functional involvement of PTP-U2L in apoptosis subsequent to terminal differentiation of monoblastoid leukemia cells
Q64053269	Functional role of SGK3 in PI3K/Pten driven liver tumor development
Q37891467	Functional roles of the phosphatidylinositol 3-kinases (PI3Ks) signaling in the mammalian ovary
Q33956911	Functional studies of the mammalian Sac1 phosphoinositide phosphatase
Q37158111	GGAP2/PIKE-a directly activates both the Akt and nuclear factor-kappaB pathways and promotes prostate cancer progression.
Q33919758	GLI1 Confers Profound Phenotypic Changes upon LNCaP Prostate Cancer Cells That Include the Acquisition of a Hormone Independent State
Q42834476	GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN.
Q35683214	Gab2 regulates the migratory behaviors and E-cadherin expression via activation of the PI3K pathway in ovarian cancer cells
Q33599177	Gastrointestinal polyposis syndromes
Q22003889	Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains
Q35974781	Gene expression in breastmilk cells is associated with maternal and infant characteristics.
Q83641832	Gene of the month: PTEN
Q78676814	Gene therapy for pancreatic cancer
Q24804867	Gene therapy in rheumatoid arthritis: how to target joint destruction?
Q35143797	Genes and pathways driving glioblastomas in humans and murine disease models
Q35772604	Genes differentially expressed in prostate cancer
Q24679438	Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility
Q34178906	Genes that regulate metastasis and angiogenesis
Q42850964	Genetic Pathways of Colorectal Carcinogenesis Rarely Involve thePTEN and LKB1 Genes Outside the Inherited Hamartoma Syndromes
Q34345248	Genetic Variations in a PTEN/AKT/mTOR Axis and Prostate Cancer Risk in a Chinese Population
Q36618884	Genetic aberrations in glioblastoma multiforme: translocation of chromosome 10 in an O-2A-like cell line
Q24806121	Genetic alterations and in vivo tumorigenicity of neurospheres derived from an adult glioblastoma
Q34984218	Genetic alterations associated with adult diffuse astrocytic tumors
Q46425566	Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice
Q35753171	Genetic alterations in hormone-refractory recurrent prostate carcinomas
Q35782991	Genetic alterations in prostate cancer
Q37955107	Genetic alterations of PTEN in human melanoma
Q35117832	Genetic alterations of human brain tumors as molecular prognostic factors
Q55477922	Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade
Q36184584	Genetic and biochemical alterations in non-small cell lung cancer
Q35130695	Genetic and cytogenetic analyses of breast cancer yield different perspectives of a complex disease
Q36021580	Genetic and hypoxic regulation of angiogenesis in gliomas
Q53364708	Genetic derangements in the tumor suppressor gene PTEN in endometrial precancers as prognostic markers for cancer development: a population-based study from northern Norway with long-term follow-up
Q34109485	Genetic factors in ovarian carcinoma
Q34783505	Genetic insights into familial cancers-- update and recent discoveries
Q35757144	Genetic pathways to primary and secondary glioblastoma
Q33836065	Genetic predisposition to breast cancer: a surgical perspective
Q51661724	Genetic profile of PTEN gene in Indian oral squamous cell carcinoma primary tumors
Q48471291	Genetic sub-types of human malignant astrocytoma correlate with survival
Q38191462	Genetic unraveling of colorectal cancer
Q33836807	Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
Q48958932	Genetic variation in AKT1, PTEN and the 8q24 locus, and the risk of testicular germ cell tumor
Q34332175	Genetically engineered mouse models of PI3K signaling in breast cancer
Q36429488	Genetically engineered murine models of prostate cancer: insights into mechanisms of tumorigenesis and potential utility
Q26865248	Genetically modified mouse models for the study of nonalcoholic fatty liver disease
Q41667932	Genetics of Pediatric Central Nervous System Tumors
Q57720217	Genetics of Pten Hamartoma Tumor Syndrome (PHTS)
Q33959675	Genetics of hereditary colon cancer - a basis for prevention?
Q36563659	Genetics of melanoma
Q34480154	Genetics of nervous system tumors
Q33723275	Genetics of prostate cancer
Q35447362	Genetics of skin appendage neoplasms and related syndromes
Q92873349	Genome sequencing analysis of a family with a child displaying severe abdominal distention and recurrent hypoglycemia
Q35375811	Genome-wide approaches for cancer gene discovery.
Q40667885	Genome-wide screening for complete genetic loss in prostate cancer by comparative hybridization onto cDNA microarrays
Q45183732	Genome-wide search for loss of heterozygosity in Chinese patients with sporadic colorectal cancer
Q82452891	Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway
Q40363836	Genome-wide two-locus interaction analysis identifies multiple epistatic SNP pairs that confer risk of prostate cancer: A cross-population study.
Q55689982	Genomic Deletion at 10q23 in Prostate Cancer: More Than PTEN Loss?
Q35571452	Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers
Q77513470	Genomic organization of the canine p53 gene and its mutational status in canine mammary neoplasia
Q36003157	Genomic research and prostate cancer: what does it offer us?
Q34175539	Germ line mutations associated with breast cancer susceptibility
Q33905657	Germline Inactivation of PTEN and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway Cause Human Lhermitte-Duclos Disease in Adults
Q47759113	Germline Mutations of the PTEN/MMAC1 Gene in Japanese Patients with Cowden Disease
Q33681468	Germline PTEN mutations in Cowden syndrome-like families.
Q41010238	Germline RECQL mutations are associated with breast cancer susceptibility
Q73892577	Germline mutation screening of the STK11/LKB1 gene in familial breast cancer with LOH on 19p
Q48046915	Germline mutations in PTEN are present in Bannayan-Zonana syndrome
Q44173483	Germline mutations in the PTEN gene in Israeli patients with Bannayan-Riley-Ruvalcaba syndrome and women with familial breast cancer
Q29615538	Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
Q37602543	Glioblastoma Multiforme Oncogenomics and Signaling Pathways
Q27691826	Glioblastoma genetics: in rapid flux
Q35920513	Glioblastoma--a moving target.
Q35752307	Glioblastomas on the move
Q34423421	Glioma cell growth inhibition following photochemical internalization enhanced non‐viral PTEN gene transfection
Q34366431	Glioma models
Q33378368	Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor, and both can be maintained long-term in vitro.
Q34186001	Gliomagenesis: genetic alterations and mouse models
Q35116828	Glucose metabolism measured by [¹⁸F]fluorodeoxyglucose positron emission tomography is independent of PTEN/AKT status in human colon carcinoma cells
Q35700587	Glutamate signaling to Ras-MAPK in striatal neurons: mechanisms for inducible gene expression and plasticity
Q48311582	Granular Cell Astrocytomas Show a High Frequency of Allelic Loss but are not a Genetically Defined Subset
Q92002414	Grb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response
Q34534169	Green Tea Polyphenols Induce p53-Dependent and p53-Independent Apoptosis in Prostate Cancer Cells through Two Distinct Mechanisms
Q36261980	Growth stimulation of primary B cell precursors by the anti-phosphatase Sbf1
Q36818855	Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain
Q33560795	Growth suppression of human lung cancer cells and implanted tumors by adenovirus-mediated transfer of the PTEN gene
Q34086208	Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.
Q39687743	H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3
Q38795844	HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies.
Q34230195	HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells
Q39970929	HIF-1 alpha: a key survival factor for serum-deprived prostate cancer cells
Q34438274	HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling
Q42325792	HO-1-STAT3 axis in mouse liver ischemia/reperfusion injury: regulation of TLR4 innate responses through PI3K/PTEN signaling
Q24654006	Hamartomatous polyposis syndromes
Q33194830	Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse
Q33944717	Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
Q35794584	Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma
Q40338078	Heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin potentiates the radiation response of tumor cells grown as monolayer cultures and spheroids by inducing apoptosis
Q34380511	Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
Q40811083	Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.
Q39657506	Hereditary Breast Cancer: The Era of New Susceptibility Genes
Q56928447	Hereditary breast cancer
Q36978755	Hereditary breast cancer in the Han Chinese population.
Q37199029	Hereditary breast cancer: new genetic developments, new therapeutic avenues
Q34977063	Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management
Q35029059	Heritable colorectal cancer syndromes: recognition and preventive management
Q73410694	Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues
Q36515688	Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability
Q26739125	Hidden association of Cowden syndrome, PTEN mutation and meningioma frequency
Q58378937	High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
Q51721747	High levels of Phosphatase and Tensin Homolog Expression Predict Favorable Prognosis in Patients with Non-small Cell Lung Cancer.
Q39611034	High resolution ArrayCGH and expression profiling identifies PTPRD and PCDH17/PCH68 as tumor suppressor gene candidates in laryngeal squamous cell carcinoma.
Q40979749	High-density screen of human tumor cell lines for homozygous deletions of loci on chromosome arm 8p.
Q36645878	High-resolution genome-wide allelotype analysis identifies loss of chromosome 14q as a recurrent genetic alteration in astrocytic tumours
Q36497083	High-throughput mutational analysis of the human cancer genome
Q30802898	High-throughput screening of effective siRNAs from RNAi libraries delivered via bacterial invasion
Q37457770	Higher methylation intensity induced by EBV LMP1 via NF-κB/DNMT3b signaling contributes to silencing of PTEN gene
Q36309407	Highly expressed UNC119 promotes hepatocellular carcinoma cell proliferation through Wnt/β-catenin signaling and predicts a poor prognosis
Q35868041	Highly penetrant hereditary cancer syndromes.
Q33276186	Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression
Q38908331	Histone deacetylases function as a novel potential therapeutic target for cancer
Q51825686	Homozygous 10q23/PTEN deletion and its impact on outcome in glioblastoma: a prospective translational study on a uniformly treated cohort of adult patients
Q77470732	Homozygous and frequent deletion of proximal 8p sequences in human prostate cancers: Identification of a potential tumor suppressor gene site
Q40582553	Homozygous deletion and expression of PTEN and DMBT1 in human primary neuroblastoma and cell lines
Q41055353	Homozygous deletion and frequent allelic loss of the 21q11.1-q21.1 region including theANA gene in human lung carcinoma
Q40795397	Homozygous deletion in a neuroblastoma cell line defined by a high-density STS map spanning human chromosome band 1p36.
Q52827239	Homozygous deletion of the PTEN tumor-suppressor gene is not a feature in oral squamous cell carcinoma.
Q37287417	Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
Q98563186	Hsa_circ_0007494 suppresses prostate cancer progression via miR-616/PTEN axis
Q22242264	Human Cancer Syndromes: Clues to the Origin and Nature of Cancer
Q53643234	Human alveolar macrophages are deficient in PTEN. The role of endogenous oxidants
Q37482150	Human cancers converge at the HIF-2alpha oncogenic axis.
Q73466868	Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase
Q34360616	Human prostate cancer risk factors
Q83970146	Hypertonicity activates GSK3beta in tumor cells
Q33924693	Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
Q24648948	IDH1 and IDH2 mutations in gliomas
Q40874616	IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation
Q92215465	IGFBP-2 in cervical cancer development
Q34215333	IKBKE Protein Activates Akt Independent of Phosphatidylinositol 3-Kinase/PDK1/mTORC2 and the Pleckstrin Homology Domain to Sustain Malignant Transformation
Q36335722	IL-15 regulates migration, invasion, angiogenesis and genes associated with lipid metabolism and inflammation in prostate cancer
Q92684050	ILF2 promotes anchorage independence through direct regulation of PTEN
Q28592943	Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN
Q35435625	Identification of PTEN mutations in metastatic melanoma specimens
Q45858964	Identification of PTEN-related sequences in glioma cells and in non-neoplastic cell lines
Q77132678	Identification of a 100-kb region of common allelic loss on chromosome bands 10q25-q26 in human endometrial cancer
Q24650927	Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
Q53391340	Identification of a gene frequently mutated in prostate tumors
Q48099795	Identification of a gene on human chromosome 8q11 that is differentially expressed during prostate-cancer progression
Q77786561	Identification of a homozygous deletion at 8p12-21 in a human prostate cancer xenograft
Q73305484	Identification of a novel PTEN intronic deletion in Li-Fraumeni syndrome and its effect on RNA processing
Q37641635	Identification of a novel PTEN mutation (L139X) in a patient with Cowden disease and Sjögren's syndrome.
Q40577939	Identification of a novel candidate gene, CASC2, in a region of common allelic loss at chromosome 10q26 in human endometrial cancer
Q30736967	Identification of a novel gene NCRMS on chromosome 12q21 with differential expression between rhabdomyosarcoma subtypes
Q24293578	Identification of a novel inhibitor of differentiation-1 (ID-1) binding partner, caveolin-1, and its role in epithelial-mesenchymal transition and resistance to apoptosis in prostate cancer cells
Q27748273	Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design
Q41657305	Identification of a subset of human non-small cell lung cancer patients with high PI3Kβ and low PTEN expression, more prevalent in squamous cell carcinoma
Q34168243	Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas
Q33771011	Identification of epigenetic interactions between miRNA and DNA methylation associated with gene expression as potential prognostic markers in bladder cancer
Q39901210	Identification of genes that exhibit changes in expression on the 8p chromosomal arm by the Systematic Multiplex RT-PCR (SM RT-PCR) and DNA microarray hybridization methods.
Q38348824	Identification of genetic pathways activated by the androgen receptor during the induction of proliferation in the ventral prostate gland.
Q40166005	Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array
Q45398491	Identification of host range mutants of myxoma virus with altered oncolytic potential in human glioma cells
Q38657057	Identification of novel prostate cancer drivers using RegNetDriver: a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network
Q34459725	Identifying breast cancer risk loci by global differential allele-specific expression (DASE) analysis in mammary epithelial transcriptome
Q37181138	Identifying candidate genes involved in brain tumor formation
Q47584260	Identifying radiographic specificity for phosphatase and tensin homolog and epidermal growth factor receptor changes: a quantitative analysis of glioblastomas
Q36977078	Immune-mediated signaling in intestinal goblet cells via PI3-kinase- and AKT-dependent pathways
Q41541275	Immunoexcitatory mechanisms in glioma proliferation, invasion and occasional metastasis
Q40485163	Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities
Q53532887	Immunohistochemical detection of phosphorylated Akt, PI3K, and PTEN in ameloblastic tumors
Q35788322	Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
Q42519161	Immunohistochemical heterogeneity of breast carcinomas negative for estrogen receptors, progesterone receptors and Her2/neu (basal-like breast carcinomas).
Q92714699	Impact of next-generation sequencing (NGS) for primary endocrine resistance in breast cancer patients
Q28344344	Impaired FHIT expression characterizes serous ovarian carcinoma
Q37855206	Importance of PI3-kinase pathway in response/resistance to aromatase inhibitors
Q91656496	In Vivo Detection of Circulating Tumor Cells in High-Risk Non-Metastatic Prostate Cancer Patients Undergoing Radiotherapy
Q37080378	In depth evaluation of the prognostic and predictive utility of PTEN immunohistochemistry in colorectal carcinomas: performance of three antibodies with emphasis on intracellular and intratumoral heterogeneity
Q37589232	In human retinoblastoma Y79 cells okadaic acid-parthenolide co-treatment induces synergistic apoptotic effects, with PTEN as a key player.
Q55515829	In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself.
Q34747123	In situ detection of phospholipid and phosphoinositide metabolism
Q30444938	In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms
Q36894883	In vitro and in vivo antitumor effects of the Egyptian scorpion Androctonus amoreuxi venom in an Ehrlich ascites tumor model.
Q36260162	In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma
Q40838626	Inactivation of MMAC1 in bladder transitional-cell carcinoma cell lines and specimens
Q50752792	Inactivation of PTEN is associated with a low p27Kip1 protein expression in breast carcinoma
Q77340398	Inactivation of the PTEN tumor suppressor gene is associated with increased angiogenesis in clinically localized prostate carcinoma
Q36067596	Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
Q48464018	Inactivation of thePTEN/MMAC1/TEP1 gene in human lung cancers
Q35597950	Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations
Q45883628	Increase of Fatty Acid Oxidation and VLDL Assembly and Secretion Overexpression of PTEN in Cultured Hepatocytes of Newborn Calf
Q40877541	Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression
Q45097925	Increased Gastric Cancer Risk withPTENIVS4 Polymorphism in a Turkish Population
Q37388842	Increased concentrations of fructose 2,6-bisphosphate contribute to the Warburg effect in phosphatase and tensin homolog (PTEN)-deficient cells.
Q34572332	Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo
Q37332423	Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro
Q35043420	Induction of apoptosis in cancer: new therapeutic opportunities
Q38355691	Induction of gene encoding FABP4 in Pten-null keratinocytes.
Q90448698	Infantile macrocephaly and multiple subcutaneous lipomas diagnosed with PTEN hamartoma tumor syndrome: A case report
Q37322631	Infiltrating macrophages promote prostate tumorigenesis via modulating androgen receptor-mediated CCL4-STAT3 signaling.
Q28259645	Infrequent Genetic Alterations of the PTEN/MMAC1 Gene in Japanese Patients with Primary Cancers of the Breast, Lung, Pancreas, Kidney, and Ovary
Q48506220	Infrequent Mutations in the PTEN/MMAC1 Gene among Primary Breast Cancers
Q26772947	Inherited PTEN mutations and the prediction of phenotype
Q33813980	Inherited genetic predisposition in breast cancer. A population-based perspective
Q48766603	Inherited macrocephaly-hamartoma syndromes
Q35250337	Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis
Q36277422	Inherited polyposis syndromes: molecular mechanisms, clinicopathology, and genetic testing
Q40623335	Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells.
Q35238068	Inhibition of Cyclin-Dependent Kinase Phosphorylation of FOXO1 and Prostate Cancer Cell Growth by a Peptide Derived from FOXO1
Q28144746	Inhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs)
Q34734532	Inhibition of FOXO1/3 promotes vascular calcification
Q40896708	Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene
Q40443893	Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.
Q39900003	Inhibition of LPS-induced cyclooxygenase 2 and nitric oxide production by transduced PEP-1-PTEN fusion protein in Raw 264.7 macrophage cells
Q36080383	Inhibition of Mycobacterial Infection by the Tumor Suppressor PTEN
Q37508608	Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence
Q41468431	Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors
Q34043823	Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer
Q35816378	Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells
Q37743533	Inhibition of STAT3 signaling blocks obesity-induced mammary hyperplasia in a mouse model
Q33306169	Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line
Q40685493	Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
Q40173368	Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN.
Q28344025	Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells
Q34608329	Inhibition of mTOR in kidney cancer
Q90630048	Inhibition of miR-19a partially reversed the resistance of colorectal cancer to oxaliplatin via PTEN/PI3K/AKT pathway
Q39283520	Inhibition of microRNA-21 increases radiosensitivity of esophageal cancer cells through phosphatase and tensin homolog deleted on chromosome 10 activation
Q28576729	Inhibition of neuronal phenotype by PTEN in PC12 cells
Q40615155	Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias
Q41971722	Inhibition of transfected PTEN on human colon cancer
Q35440540	Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System.
Q73243689	Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells
Q39979496	Insights into the structural specificity of the cytotoxicity of 3-deoxyphosphatidylinositols
Q54639986	Insulin Receptor Substrate Regulation of Phosphoinositide 3-Kinase
Q35720774	Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer
Q39495112	Insulin-Like Growth Factor–Type 1 Receptor Inhibitor NVP-AEW541 Enhances Radiosensitivity of PTEN Wild-Type but Not PTEN-Deficient Human Prostate Cancer Cells
Q35880328	Insulin-like growth factor binding protein 2 promotes glioma development and progression
Q31807473	Insulin-like growth factor binding protein 5 and type-1 insulin-like growth factor receptor are differentially regulated during apoptosis in cerebellar granule cells
Q35869171	Insulin-like growth factor factor binding protein-2 is a novel mediator of p53 inhibition of insulin-like growth factor signaling
Q42493873	Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival.
Q31033699	Insulin‐like Growth Factor Binding Protein 2: Gene Expression Microarrays and the Hypothesis‐generation Paradigm
Q37213805	Integrated analysis of breast cancer cell lines reveals unique signaling pathways
Q24649562	Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers
Q35863493	Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma
Q36092726	Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer
Q34122822	Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer.
Q64883453	Integrating Combinatorial Lipid Nanoparticle and Chemically Modified Protein for Intracellular Delivery and Genome Editing.
Q28117650	Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
Q36678492	Integrative Analysis of miRNA and inflammatory gene expression after acute particulate matter exposure.
Q36019387	Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10
Q37643449	Integrin signaling aberrations in prostate cancer.
Q34047231	Integrin-linked kinase (ILK): a "hot" therapeutic target
Q35998768	Integrin-linked kinase: a cancer therapeutic target unique among its ILK.
Q37182177	Integrins in prostate cancer progression
Q37351516	Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells
Q43798744	Interaction of cisplatin, paclitaxel and adriamycin with the tumor suppressor PTEN
Q99634967	Interaction of the Hippo Pathway and Phosphatases in Tumorigenesis
Q22253438	Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase
Q30437740	Interactions between PTEN and receptor tyrosine kinase pathways and their implications for glioma therapy
Q30866782	Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer
Q92799574	Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells
Q55394781	Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice.
Q36164945	Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy
Q92646030	Intracranial ganglioglioma co-existing with breast cancer
Q54750794	Intratumoral Heterogeneity in Microsatellite Alterations in BRCA1 and PTEN Regions in Sporadic Colorectal Cancer
Q36088788	Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: mechanisms and clinical implications
Q38840489	Investigating a signature of temozolomide resistance in GBM cell lines using metabolomics
Q90064802	Investigation of PTEN promoter methylation in ameloblastoma
Q41749107	Investigation of genetic alterations associated with the grade of astrocytic tumor by comparative genomic hybridization
Q55475713	Investigation of germline PTEN, p53, p16(INK4A)/p14(ARF), and CDK4 alterations in familial glioma.
Q34184917	Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.
Q41838197	Involvement of Phosphoinositide 3-Kinase and PTEN Protein in Mechanism of Activation of TRPC6 Protein in Vascular Smooth Muscle Cells
Q33757441	Involvement of the PTEN-AKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia.
Q46176330	Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells.
Q37073819	Irs2 inactivation suppresses tumor progression in Pten+/- mice
Q36410440	Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?
Q37829953	Is prenatal myo‐inositol deficiency a mechanism of CNS injury in galactosemia?
Q39941689	Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion
Q55476524	Isolation and characterization of glioblastoma-associated homozygously deleted DNA fragments from chromosomal region 9p21 suggests involvement of multiple tumour suppressor genes.
Q36132632	JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.
Q41551496	KIF7 attenuates prostate tumor growth through LKB1-mediated AKT inhibition
Q28393007	KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1α accumulation
Q35079842	KSHV microRNAs mediate cellular transformation and tumorigenesis by redundantly targeting cell growth and survival pathways
Q37972666	Keratinocyte Stem Cells and the Targets for Nonmelanoma Skin Cancer†
Q36255926	Keratoacanthoma of the Lip: Activation of the mTOR Pathway, Tumor Suppressor Proteins, and Tumor Senescence
Q132730853	Key roles of ubiquitination in regulating critical regulators of cancer stem cell functionality
Q36535351	Killin is a p53-regulated nuclear inhibitor of DNA synthesis
Q38275382	Kinases, tails and more: regulation of PTEN function by phosphorylation
Q34558936	Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathways
Q24802990	Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells
Q50075102	Knockdown of lncRNA CCAT2 inhibits endometrial cancer cells growth and metastasis via sponging miR-216b
Q54296417	Knockdown of zinc finger protein X-linked inhibits prostate cancer cell proliferation and induces apoptosis by activating caspase-3 and caspase-9
Q36944808	L-Aminoacyl-triazine derivatives are isoform-selective PI3Kβ inhibitors that target non-conserved Asp862 of PI3Kβ
Q40762476	LAPSER1: a novel candidate tumor suppressor gene from 10q24.3
Q36316549	LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis
Q35131658	LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin
Q50421113	LZTS2 promoter hypermethylation: a potential biomarker for the diagnosis and prognosis of laryngeal squamous cell carcinoma.
Q24650252	Lack of DMBT1 expression in oesophageal, gastric and colon cancers
Q37690067	Lack of an additive effect between the deletions of Klf5 and Nkx3-1 in mouse prostatic tumorigenesis
Q73679882	Lack of deletions of the PTEN/MMAC1 and MXI1 loci in renal cell carcinoma by interphase cytogenetics
Q35745808	Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter
Q30652017	Laser capture microdissection: beyond functional genomics to proteomics
Q97531620	Leflunomide triggers synthetic lethality in PTEN-deficient prostate cancer
Q79974795	Leiomyosarcoma of the breast: a pathologic and comparative genomic hybridization study of two cases
Q34976249	Lentiviruses with trastuzumab bound to their envelopes can target and kill prostate cancer cells
Q37939073	Lessons from a decade of integrating cancer copy number alterations with gene expression profiles
Q37330814	Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer
Q44645813	Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells
Q40257851	Lhermitte-Duclos disease and Cowden's syndrome. Report of two cases
Q34399490	Lhermitte-Duclos disease is a clinical manifestation of Cowden's syndrome
Q35844528	Lifelong accumulation of bone in mice lacking Pten in osteoblasts
Q41298549	Ligands of the peroxisome proliferator-activated receptor γ inhibit hepatoce llular carcinoma cell proliferation
Q28258080	Limatin (LIMAB1), an Actin-Binding LIM Protein, Maps to Mouse Chromosome 19 and Human Chromosome 10q25, a Region Frequently Deleted in Human Cancers
Q73283461	Limiting the location of a putative human prostate cancer tumor suppressor gene at chromosome 13q14.3.
Q28201487	Limiting the location of putative human prostate cancer tumor suppressor genes on chromosome 18q
Q74826238	Linkage and association of CYP17 gene in hereditary and sporadic prostate cancer
Q33942901	Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo
Q38186042	Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy.
Q44199808	Lipid Nanoparticles Improve Activity of Single-Stranded siRNA and Gapmer Antisense Oligonucleotides in Animals
Q35096682	Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial
Q37224466	Liver diseases and metabolic syndrome
Q48505182	LncRNA Gas5 acts as a ceRNA to regulate PTEN expression by sponging miR-222-3p in papillary thyroid carcinoma
Q57476011	LncRNA MEG3 impacts proliferation, invasion, and migration of ovarian cancer cells through regulating PTEN
Q36223500	LncRNA-GAS5 induces PTEN expression through inhibiting miR-103 in endometrial cancer cells
Q33988959	Long intergenic non-coding RNAs (LincRNAs) identified by RNA-seq in breast cancer
Q57591277	Long-chain L 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency does not appear to be the primary cause of lipid myopathy in patients with Bannayan-Riley-Ruvalcaba syndrome (BRRS)
Q39685947	Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT, ERK and STAT5 signaling via epigenetic silencing of the PTEN gene
Q27026704	Long-term temozolomide might be an optimal choice for patient with multifocal glioblastoma, especially with deep-seated structure involvement: a case report and literature review
Q42413905	Loss and reduced expression of PTEN correlate with advanced-stage gastric carcinoma
Q24539769	Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity
Q55456954	Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate.
Q37627634	Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers
Q35586422	Loss of PLZF expression in prostate cancer by immunohistochemistry correlates with tumor aggressiveness and metastasis
Q92859253	Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression
Q74054452	Loss of PTEN expression is associated with metastatic disease in patients with endometrial carcinoma
Q28145476	Loss of PTEN facilitates HIF-1-mediated gene expression
Q35764742	Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer
Q27851755	Loss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of the temozolomide era.
Q28388722	Loss of PTEN permits CXCR4-mediated tumorigenesis through ERK1/2 in prostate cancer cells
Q38975182	Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A₂α via AKT in prostate cancer cells
Q24653934	Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer
Q35935634	Loss of Pten Disrupts the Thymic Epithelium and Alters Thymic Function
Q40597735	Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines
Q24797910	Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor
Q48101895	Loss of chromosome 10 in glioblastoma: relation to proliferation and angiogenesis
Q41877426	Loss of chromosome 10 is an independent prognostic factor in high-grade gliomas
Q28367455	Loss of expression of human spectrin src homology domain binding protein 1 is associated with 10p loss in human prostatic adenocarcinoma
Q43675669	Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer
Q37883145	Loss of heterozygosity analysis in malignant gliomas.
Q34493845	Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence
Q77995588	Loss of heterozygosity at 10q in tumors of the upper respiratory tract is associated with poor prognosis
Q44945301	Loss of heterozygosity at 7q31.1 and 12p13-12 in advanced prostate cancer
Q34382719	Loss of heterozygosity on 10q23.3 and mutation of tumor suppressor gene PTEN in gastric cancer and precancerous lesions
Q22010806	Loss of heterozygosity on 8p in prostate cancer implicates a role for dematin in tumor progression
Q55476215	Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas.
Q53388588	Loss of heterozygosity on chromosome 10q is associated with earlier onset sporadic colorectal adenocarcinoma
Q47193299	Loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in malays with malignant glioma.
Q55475127	Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma.
Q33633647	Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis
Q37322384	Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma
Q36386464	Loss of stromal androgen receptor leads to suppressed prostate tumourigenesis via modulation of pro‐inflammatory cytokines/chemokines
Q40464853	Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors.
Q53390981	Loss of tumor suppressor protein PTEN during renal carcinogenesis
Q35728921	Low expression of phosphatase and tensin homolog in clear‑cell renal cell carcinoma contributes to chemoresistance through activating the Akt/HDM2 signaling pathway
Q74095463	Low frequency of genetic lesions in Wilms tumors by representational difference analysis
Q35151381	Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN.
Q38044174	Lysophospholipid receptor activation of RhoA and lipid signaling pathways
Q24294392	MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells
Q90292063	MAGI-2 downregulation: a potential predictor of tumor progression and early recurrence in Han Chinese patients with prostate cancer
Q55495010	MALAT1: A long non-coding RNA highly associated with human cancers.
Q36923130	MED12 mutations in human diseases
Q36117367	MET and PTEN gene copy numbers and Ki-67 protein expression associate with pathologic complete response in ERBB2-positive breast carcinoma patients treated with neoadjuvant trastuzumab-based therapy
Q45872881	MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells
Q64094161	MTA2-mediated inhibition of PTEN leads to pancreatic ductal adenocarcinoma carcinogenicity
Q33836755	MYC Deregulation in Primary Human Cancers.
Q33667340	MYC oncogenes and human neoplastic disease
Q34991267	MYC-xing it up with PIK3CA mutation and resistance to PI3K inhibitors: summit of two giants in breast cancers
Q21245465	Main roads to melanoma
Q33329722	Major copy proportion analysis of tumor samples using SNP arrays
Q48422991	Malignant glioma: Should chemotherapy be overthrown by experimental treatments?
Q26744387	Malignant gliomas: old and new systemic treatment approaches
Q35096127	Mammalian neural stem-cell renewal: nature versus nurture
Q37195644	Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies
Q39111556	Mannan-Conjugated Adenovirus Enhanced Gene Therapy Effects on Murine Hepatocellular Carcinoma Cells in Vitro and in Vivo
Q36277846	Mannan-modified Ad5-PTEN treatment combined with docetaxel improves the therapeutic effect in H22 tumor-bearing mice
Q77310406	Mapping an Endometrial Cancer Tumor Suppressor Gene at 10q25 and Development of a Bacterial Clone Contig for the Consensus Deletion Interval
Q30303987	Mapping of genetic deletions on the long arm of chromosome 4 in human esophageal adenocarcinomas
Q39443467	Mapping of homozygous deletions in verified esophageal adenocarcinoma cell lines and xenografts
Q24598640	Markers of resistance to anti-EGFR therapy in colorectal cancer
Q61818162	Mathematical Modeling Highlights the Complex Role of AKT in TRAIL-Induced Apoptosis of Colorectal Carcinoma Cells
Q39115959	Matrine Activates PTEN to Induce Growth Inhibition and Apoptosis in V600EBRAF Harboring Melanoma Cells
Q47584016	Mechanism of resistance to endocrine therapy in breast cancer: the important role of PI3K/Akt/mTOR in estrogen receptor-positive, HER2-negative breast cancer
Q92629967	Mechanisms and significance of therapy-induced and spontaneous senescence of cancer cells
Q38221717	Mechanisms involved in attenuated cardio-protective role of ischemic preconditioning in metabolic disorders.
Q42378747	Mechanisms of Androgen-Independent Prostate Cancer
Q37018652	Mechanisms of disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors
Q28213888	Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells
Q37451135	Mechanisms of resistance to EGFR inhibitors in head and neck cancer
Q36589865	Mechanisms of resistance to endocrine therapy in breast cancer: focus on signaling pathways, miRNAs and genetically based resistance.
Q35096583	Mechanistic Analysis of a DNA Damage-Induced, PTEN-Dependent Size Checkpoint in Human Cells
Q28189724	Mechanistic studies on protein tyrosine phosphatases
Q35033761	Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids
Q33822119	Melanoma: Stem cells, sun exposure and hallmarks for carcinogenesis, molecular concepts and future clinical implications
Q24290802	Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions
Q34002994	Mesenchymal migration as a therapeutic target in glioblastoma
Q38936250	Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.
Q34031701	Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Q34419460	Metabolism and proliferation share common regulatory pathways in cancer cells
Q38034126	Metastasis suppressors in human benign prostate, intraepithelial neoplasia, and invasive cancer: their prospects as therapeutic agents
Q40285593	Metformin Has a Positive Therapeutic Effect on Prostate Cancer in Patients With Type 2 Diabetes Mellitus
Q34103053	Methylation analysis of the phosphates and tensin homologue on chromosome 10 gene (PTEN) in multiple myeloma
Q43728392	Methylation and mutational analysis of p27(kip1) in prostate carcinoma
Q24795636	Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma
Q38725879	MiR-200a acts as an oncogene in colorectal carcinoma by targeting PTEN.
Q92987907	MiR-21 promotes pterygium cell proliferation through the PTEN/AKT pathway
Q37028111	MiR-214 regulate gastric cancer cell proliferation, migration and invasion by targeting PTEN
Q93023246	MiR-4465 directly targets PTEN to inhibit AKT/mTOR pathway-mediated autophagy
Q35148037	MiR-486 regulates lactation and targets the PTEN gene in cow mammary glands
Q33994744	MicroRNA and HER2-overexpressing cancer
Q37069474	MicroRNA involvement in brain tumors: from bench to bedside
Q54284943	MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN.
Q38731400	MicroRNA-152 Targets Phosphatase and Tensin Homolog to Inhibit Apoptosis and Promote Cell Migration of Nasopharyngeal Carcinoma Cells
Q33607585	MicroRNA-155-5p promotes hepatocellular carcinoma progression by suppressing PTEN through the PI3K/Akt pathway
Q35945582	MicroRNA-1908 functions as a glioblastoma oncogene by suppressing PTEN tumor suppressor pathway
Q38752746	MicroRNA-19b Mediates Lung Epithelial-Mesenchymal Transition via Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase in Response to Mechanical Stretch
Q50027068	MicroRNA-203 inhibits long noncoding RNA HOTAIR and regulates tumorigenesis through epithelial-to-mesenchymal transition pathway in renal cell carcinoma.
Q34436329	MicroRNA-20b promotes cell growth of breast cancer cells partly via targeting phosphatase and tensin homologue (PTEN).
Q64233019	MicroRNA-20b promotes proliferation of H22 hepatocellular carcinoma cells by targeting PTEN
Q38180409	MicroRNA-21 is a novel promising target in cancer radiation therapy
Q38761376	MicroRNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer
Q38802466	MicroRNA-21 promotes proliferation, invasion and suppresses apoptosis in human osteosarcoma line MG63 through PTEN/Akt pathway
Q39147368	MicroRNA-21 regulates the migration and invasion of a stem-like population in hepatocellular carcinoma
Q39560767	MicroRNA-221 and -222 Regulate Radiation Sensitivity by Targeting the PTEN Pathway
Q39000398	MicroRNA-221 targeting PI3-K/Akt signaling axis induces cell proliferation and BCNU resistance in human glioblastoma
Q36304803	MicroRNA-26b Modulates the NF-κB Pathway in Alveolar Macrophages by Regulating PTEN.
Q34991208	MicroRNA-27a distinguishes glioblastoma multiforme from diffuse and anaplastic astrocytomas and has prognostic value
Q35742539	MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation
Q36580396	MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis
Q89475347	MicroRNA-498 promotes proliferation and migration by targeting the tumor suppressor PTEN in breast cancer cells
Q92839542	MicroRNA-590-5p promotes cell survival in endometrioid endometrial cancer by suppressing tumor suppressor PTEN
Q35550210	MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A
Q37917655	MicroRNAs involved in the EGFR/PTEN/AKT pathway in gliomas
Q52605201	MicroRNA‑142‑5p modulates breast cancer cell proliferation and apoptosis by targeting phosphatase and tensin homolog
Q38682456	Microarray analysis of copy-number variations and gene expression profiles in prostate cancer
Q48102903	Microarray analysis of gliomas reveals chromosomal position-associated gene expression patterns and identifies potential immunotherapy targets.
Q88746661	Microfluidics in Malignant Glioma Research and Precision Medicine
Q59465999	Microfluidics: Rapid Diagnosis for Breast Cancer
Q73104112	Microsatellite analysis at 10q25-q26 in Sardinian patients with sporadic endometrial carcinoma: identification of specification patterns of genetic alteration
Q57781643	Microsatellite instability and mutation analysis of candidate genes in unselected sardinian patients with endometrial carcinoma
Q55475900	Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene.
Q40782081	Microsatellite instability in human mammary epithelial cells transformed by heavy ions
Q34566436	Migration and invasion in brain neoplasms
Q35011051	Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.
Q33896844	Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer
Q35057157	MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer
Q98158679	Model-based optimization of combination protocols for irradiation-insensitive cancers
Q38245726	Modeling cutaneous squamous carcinoma development in the mouse
Q38280833	Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model
Q37053034	Modeling prostate cancer in mice: limitations and opportunities
Q51610397	Modelling and analysis of an ensemble of eukaryotic translation initiation models
Q39020269	Modulation of VEGF receptor 2 signaling by protein phosphatases
Q33771748	Modulation of cellular apoptotic potential: contributions to oncogenesis
Q40119094	Modulation of intracellular signaling pathways to induce apoptosis in prostate cancer cells
Q34792974	Modulation of protein kinase signaling by protein phosphatases and inhibitors
Q46396119	Modulation of specific protein expression levels by PTEN: identification of AKAP121, DHFR, G3BP, Rap1, and RCC1 as potential targets of PTEN.
Q28069538	Modulation, Plasticity and Pathophysiology of the Parallel Fiber-Purkinje Cell Synapse
Q26865240	Molecular Alterations during Progression of Prostate Cancer to Androgen Independence
Q39210492	Molecular Dissection of AKT Activation in Lung Cancer Cell Lines
Q37065742	Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation.
Q55981792	Molecular Genetics of Gastroenteropancreatic Neuroendocrine Tumours
Q44528135	Molecular Pathways: PI3K Pathway Targets in Triple-Negative Breast Cancers
Q38850598	Molecular Pathways: Targeting the PI3K Pathway in Cancer-BET Inhibitors to the Rescue
Q35104265	Molecular abnormalities and correlations with tumor response and outcome in glioma patients
Q54438321	Molecular alterations of EGFR and PTEN in prostate cancer: association with high-grade and advanced-stage carcinomas
Q38307065	Molecular analysis of PTEN and MXI1 in primary bladder carcinoma
Q35196655	Molecular and genetic prognostic factors of prostate cancer
Q34098586	Molecular aspects of multiple myeloma.
Q34481493	Molecular biology and cellular physiology of refractoriness to androgen ablation therapy in advanced prostate cancer
Q36478640	Molecular biology of human gliomas
Q77224978	Molecular biology of lung cancer
Q24610335	Molecular biology of lung cancer: clinical implications
Q34569440	Molecular biology of lung cancer: clinical implications.
Q34480160	Molecular biology of nervous system tumors
Q38092784	Molecular biology of normal melanocytes and melanoma cells
Q76402656	Molecular biology of prostate cancer
Q24290371	Molecular characterization of human tensin
Q35746144	Molecular characterization of pancreatic serous microcystic adenomas: evidence for a tumor suppressor gene on chromosome 10q.
Q44771919	Molecular characterization of uterine clear cell carcinoma
Q26822717	Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date
Q37010879	Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer.
Q38392332	Molecular classification of gastric adenocarcinoma: translating new insights from the cancer genome atlas research network
Q41872534	Molecular classification of the inherited hamartoma polyposis syndromes: clearing the muddied waters
Q34080737	Molecular cytogenetics of prostate cancer
Q35740772	Molecular damage in cancer: an argument for mTOR-driven aging
Q41019659	Molecular definition of chromosome translocations involving 10q24 and 19q13 in human malignant glioma cells
Q35786956	Molecular genetic alterations in radiation-induced astrocytomas
Q24671002	Molecular genetic analysis of ependymal tumors. NF2 mutations and chromosome 22q loss occur preferentially in intramedullary spinal ependymomas
Q40390047	Molecular genetic evidence supporting a novel human hepatocellular carcinoma tumor suppressor locus at 13q12.11.
Q31039228	Molecular genetics of human prostate cancer.
Q58136321	Molecular genetics of prostate cancer
Q37972706	Molecular genetics of prostate cancer: emerging appreciation of genetic complexity
Q48514271	Molecular markers of prognosis in astrocytic tumors
Q38129574	Molecular mechanisms of HPV induced carcinogenesis in head and neck
Q37601178	Molecular mechanisms of necrosis in glioblastoma: the role of glutamate excitotoxicity
Q34558134	Molecular mechanisms of prostate cancer
Q37354089	Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy
Q35065032	Molecular pathogenesis and prognostic factors in endometrial carcinoma
Q36021558	Molecular pathogenesis of astrocytic tumours
Q33793308	Molecular pathogenesis of lung cancer
Q34684170	Molecular pathogenesis of pancreatic cancer
Q36155104	Molecular pathology of non-small-cell lung cancer
Q40740686	Molecular pathways: PI3K pathway phosphatases as biomarkers for cancer prognosis and therapy
Q38264216	Molecular pathways: intercellular PTEN and the potential of PTEN restoration therapy
Q34410331	Molecular physiology of the tensin brotherhood of integrin adaptor proteins
Q33883602	Molecular profiling of clinical tissue specimens: feasibility and applications
Q30660744	Molecular profiling of clinical tissues specimens: feasibility and applications
Q37350203	Molecular profiling of oligodendrogliomas: impact on prognosis, treatment, and future directions
Q24797310	Molecular responses to hypoxia in tumor cells
Q35789183	Molecular targets of omega 3 and conjugated linoleic Fatty acids - "micromanaging" cellular response.
Q35538323	Molecular techniques and prostate cancer diagnostic
Q37997543	Molecular testing in melanoma
Q37269832	Monitoring phosphorylation of the pyruvate dehydrogenase complex.
Q33882146	Monitoring the development of xenograft triple-negative breast cancer models using diffusion-weighted magnetic resonance imaging.
Q34952032	Monosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas.
Q36798747	Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation
Q37968973	Morphologic Manifestations of Gene-Specific Molecular Alterations (“Genetic Addictions”) in Mouse Models of Disease
Q43955971	Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity
Q38998265	Mouse Models of Breast Cancer Share Amplification and Deletion Events with Human Breast Cancer
Q24318884	Mouse PRL-2 and PRL-3, Two Potentially Prenylated Protein Tyrosine Phosphatases Homologous to PRL-1
Q33739279	Mouse models for colorectal cancer
Q33739296	Mouse models of prostate cancer
Q36810717	Multicenter Phase II Study of Neoadjuvant Lapatinib and Trastuzumab With Hormonal Therapy and Without Chemotherapy in Patients With Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Cancer: TBCRC 006
Q34019748	Multicenter breast cancer collaborative registry.
Q35194754	Multicenter phase II trial of the heat shock protein 90 inhibitor, retaspimycin hydrochloride (IPI-504), in patients with castration-resistant prostate cancer
Q48426668	Multicentric glioblastoma multiforme in a patient with BRCA-1 invasive breast cancer
Q37302554	Multidisciplinary surgical management of Cowden syndrome: Report of a case.
Q92906114	Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions
Q41903586	Multiple deleted regions on the long arm of chromosome 6 in astrocytic tumours
Q22009077	Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19
Q42096081	Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias
Q33915992	Multiple roles and therapeutic implications of Akt signaling in cancer.
Q37286664	Multiplex Gene Expression Profiling of 16 Target Genes in Neoplastic and Non-Neoplastic Canine Mammary Tissues Using Branched-DNA Assay
Q33714209	Muscle-specific Pten deletion protects against insulin resistance and diabetes
Q64923497	Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis.
Q40410776	Mutant PIK3CA promotes cell growth and invasion of human cancer cells
Q40568043	Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin
Q40895282	Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia
Q43199043	Mutation analysis of aryl hydrocarbon receptor interacting protein (AIP) gene in colorectal, breast, and prostate cancers
Q55517824	Mutation analysis of the PTEN / MMAC1 gene in Japanese patients with Cowden disease.
Q73911344	Mutation analysis of the PTEN gene in uveal melanoma cell lines
Q73008420	Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract
Q78206096	Mutation analysis of the putative tumor suppression gene PTEN/MMAC1 in sporadic breast cancer
Q73271272	Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas
Q40941698	Mutation and deletion analysis of GFR alpha-1, encoding the co-receptor for the GDNF/RET complex, in human brain tumours
Q35745875	Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells
Q39711051	Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN
Q36619048	Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas.
Q28586004	Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
Q47709471	Mutation of thePTENTumor Suppressor Gene Is Not a Feature of Ovarian Cancers
Q39626053	Mutational Analysis of the PTEN Gene and Its Effects in Esophageal Squamous Cell Carcinoma
Q38363342	Mutational analysis of ETV6 in prostate carcinoma
Q48252490	Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations
Q37642623	Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas
Q47752292	Mutational analysis of the TrkA gene in prostate cancer
Q47751177	Mutational analysis of thePTEN gene in head and neck squamous cell carcinoma
Q33774967	Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity
Q36591365	Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias
Q33681476	Mutations of PTEN in patients with Bannayan-Riley-Ruvalcaba phenotype
Q64951424	Mutations of the MAPK/TSC/mTOR pathway characterize periventricular glioblastoma with epithelioid SEGA-like morphology–morphological and therapeutic implications.
Q38402828	Mutations of the human interferon alpha-2b gene in brain tumor patients exposed to different environmental conditions
Q64379477	Mutual Contribution of Pten and Estrogen to Endometrial Carcinogenesis in a PtenloxP/loxP Mouse Model
Q39688384	Mutual interaction and reciprocal down-regulation between c-met and insulin receptor substrate-1.
Q40013923	Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression
Q38311476	Mxi1 is a potential cellular target of carcinogens and frequently mutated in experimental rat tumors and tumor cell lines
Q28188728	Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells
Q94521960	Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity
Q35608097	Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation
Q36317685	Myocardial ischemic post-conditioning attenuates ischemia reperfusion injury via PTEN/Akt signal pathway
Q92207064	Myosin 1b Regulates Nuclear AKT Activation by Preventing Localization of PTEN in the Nucleus
Q22254632	Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate
Q36066328	Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8
Q24292919	NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN
Q36108761	NF-kB in development and progression of human cancer
Q35256204	NHERFs, NEP, MAGUKs, and more: interactions that regulate PTEN.
Q60948295	NQO1 Is Regulated by PTEN in Glioblastoma, Mediating Cell Proliferation and Oxidative Stress
Q59130214	NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts
Q35063769	NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/mTOR phosphorylation
Q24646237	NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
Q39459665	Na(+)/H(+) Exchanger Regulatory Factor 1 (NHERF1) Is Required for the Estradiol-Dependent Increase of Phosphatase and Tensin Homolog (PTEN) Protein Expression
Q91893133	Nanoparticle-mediated intratumoral inhibition of miR-21 for improved survival in glioblastoma
Q98612773	Nanotechnology-Based Targeting of mTOR Signaling in Cancer
Q34611577	Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis
Q35848387	Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN.
Q28513537	Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
Q46886399	Neonatal estrogenic exposure suppresses PTEN-related endometrial carcinogenesis in recombinant mice
Q30536784	Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKCα Invasive Signaling Axis
Q24644868	Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes
Q31148172	Network-constrained regularization and variable selection for analysis of genomic data
Q37534591	Neural stem cells in the developing and adult brains
Q27303158	Neuregulin promotes incomplete autophagy of prostate cancer cells that is independent of mTOR pathway inhibition
Q38178068	Neurobiology of autism gene products: towards pathogenesis and drug targets.
Q74243364	Neurologic Surgery
Q89477351	Neuropsychopathology of Autism Spectrum Disorder: Complex Interplay of Genetic, Epigenetic, and Environmental Factors
Q41596501	Neurotrophin signal transduction in medulloblastoma
Q38604713	New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway
Q38000457	New insights in the activity of voltage sensitive phosphatases
Q33822465	New insights into acute lung injury
Q29616144	New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
Q37851994	New phosphatidylinositol 3-kinase inhibitors for cancer
Q37853198	New targeted therapies for gastric cancer
Q37304241	No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer
Q42218359	Nongenomic Mechanisms of PTEN Regulation
Q26799880	Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis
Q47220398	Notoginsenoside R7 suppresses cervical cancer via PI3K/PTEN/Akt/mTOR signaling
Q50304163	Novel PTEN germline mutation in a family with mild phenotype: Difficulties in genetic counseling
Q37826349	Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumors
Q38112184	Novel approaches to glioma drug design and drug screening.
Q36901964	Novel dual-color immunohistochemical methods for detecting ERG-PTEN and ERG-SPINK1 status in prostate carcinoma
Q28393163	Novel germline mutations in the PTEN tumour suppressor gene found in women with multiple cancers
Q90465608	Novel insight into the function of tankyrase
Q28242514	Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis
Q54497843	Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
Q57591227	Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma
Q38878518	Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure
Q42076186	Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation
Q91152079	Nuclear receptor HNF4α performs a tumor suppressor function in prostate cancer via its induction of p21-driven cellular senescence
Q33714405	Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function.
Q39238259	Nucleophosmin/B26 regulates PTEN through interaction with HAUSP in acute myeloid leukemia
Q34707834	Odontogenic ameloblast-associated protein (ODAM) inhibits growth and migration of human melanoma cells and elicits PTEN elevation and inactivation of PI3K/AKT signaling
Q35064223	On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)
Q91743043	Oncogene inference optimization using constraint-based modelling incorporated with protein expression in normal and tumour tissues
Q38652498	Oncogenic PTEN functions and models in T-cell malignancies
Q38379348	Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies
Q37708804	Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer
Q28284802	Oncogenic mutations of PIK3CA in human cancers
Q52044871	Ontogeny of phosphoinositide 3-kinase signaling in developing heart: effect of acute beta-adrenergic stimulation
Q38360847	Opposite regulation of myc and p21waf1 transcription by STAT3 proteins
Q40343052	Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo
Q33406279	Oscillations of the p53-Akt network: implications on cell survival and death
Q39871570	Osteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells characterized by multiplex kinase activity profiling
Q35368205	Our changing view of the genomic landscape of cancer
Q33236931	Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner
Q38017732	Overcoming treatment resistance in HER2-positive breast cancer: potential strategies.
Q55404029	Overexpressing TPTE2 (TPIP), a homolog of the human tumor suppressor gene PTEN, rescues the abnormal phenotype of the PTEN-/- mutant.
Q54978052	Overexpression of G Protein-Coupled Receptor Kinase 6 (GRK6) Is Associated with Progression and Poor Prognosis of Papillary Thyroid Carcinoma.
Q93111131	Overexpression of PTEN may increase the effect of pemetrexed on A549 cells via inhibition of the PI3K/AKT/mTOR pathway and carbohydrate metabolism
Q36591929	Overexpression of cyclin B1 antagonizes chemotherapeutic-induced apoptosis through PTEN/Akt pathway in human esophageal squamous cell carcinoma cells
Q36500377	Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation.
Q22253161	Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression
Q40500190	Overexpression of the Wilms' tumor gene W T1 in primary astrocytic tumors
Q38581928	Overview of Genetically Engineered Mouse Models of Papillary and Anaplastic Thyroid Cancers: Enabling Translational Biology for Patient Care Improvement
Q34360248	Overview of the biochemical and genetic processes in malignant mesothelioma.
Q24322705	P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
Q39891650	P53 and PTEN expression contribute to the inhibition of EGFR downstream signaling pathway by cetuximab.
Q36948641	PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression
Q40453259	PAX6 suppresses growth of human glioblastoma cells.
Q37290801	PCR-SSCP-DNA sequencing method in detecting PTEN gene mutation and its significance in human gastric cancer
Q24300933	PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
Q41809036	PHLPP-1 negatively regulates Akt activity and survival in the heart
Q49388808	PHLPP1 mediates melanoma metastasis suppression through repressing AKT2 activation.
Q24625894	PHLiPPing the switch on Akt and protein kinase C signaling
Q33738762	PI(3,4)P2 plays critical roles in the regulation of focal adhesion dynamics of MDA-MB-231 breast cancer cells
Q30080017	PI3K and cancer: lessons, challenges and opportunities
Q24338724	PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
Q33933626	PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib
Q37039348	PI3K signaling in glioma--animal models and therapeutic challenges
Q38004656	PI3K signaling in the regulation of branching morphogenesis
Q54527804	PI3K signalling: the path to discovery and understanding
Q38206682	PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance
Q37520558	PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells.
Q35898353	PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis
Q34131044	PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: modulation by PTEN
Q35980515	PI3K/AKT signaling and systemic autoimmunity
Q38217651	PI3K/AKT signaling pathway and cancer: an updated review
Q38239229	PI3K/Akt/mTOR signaling in medullary thyroid cancer: a promising molecular target for cancer therapy
Q28383083	PI3K/PTEN signaling in angiogenesis and tumorigenesis
Q23914949	PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis
Q39717036	PI3K/PTEN/Akt pathway status affects the sensitivity of high-grade glioma cell cultures to the insulin-like growth factor-1 receptor inhibitor NVP-AEW541.
Q37032524	PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects
Q37808385	PI3Kinase signaling in glioblastoma
Q28395725	PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells
Q37563404	PIASxα ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase
Q92443760	PIK3CA Gene Mutations in Solid Malignancies: Association with Clinicopathological Parameters and Prognosis
Q33610437	PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer
Q28609463	PIP3 pathway in regulatory T cells and autoimmunity
Q24318882	PIR1, a Novel Phosphatase That Exhibits High Affinity to RNA·Ribonucleoprotein Complexes
Q54478528	PK-PD modeling of combination efficacy effect from administration of the MEK inhibitor GDC-0973 and PI3K inhibitor GDC-0941 in A2058 xenografts.
Q42085841	PNUTS Functions as a Proto-Oncogene by Sequestering PTEN
Q41818544	PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells
Q40114074	PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation
Q55234431	PTEN / MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas.
Q33940647	PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase
Q33874805	PTEN C-terminal deletion causes genomic instability and tumor development
Q47654647	PTEN Gene Induces Cell Invasion and Migration via Regulating AKT/GSK-3β/β-Catenin Signaling Pathway in Human Gastric Cancer
Q64235738	PTEN Genetic and Epigenetic Alterations Define Distinct Subgroups in North Indian Breast Cancer Patients
Q37378282	PTEN Inhibits Cell Proliferation, Promotes Cell Apoptosis, and Induces Cell Cycle Arrest via Downregulating the PI3K/AKT/hTERT Pathway in Lung Adenocarcinoma A549 Cells.
Q37832338	PTEN Level in Tumor Suppression: How Much Is Too Little?
Q39401816	PTEN Loss as Determined by Clinical-grade Immunohistochemistry Assay Is Associated with Worse Recurrence-free Survival in Prostate Cancer
Q92883870	PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage
Q38720395	PTEN Plays Dual Roles As a Tumor Suppressor in Osteosarcoma Cells
Q38759310	PTEN Promotes Dopaminergic Neuronal Differentiation Through Regulation of ERK-Dependent Inhibition of S6K Signaling in Human Neural Stem Cells
Q40765673	PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy
Q46395242	PTEN Regulates Glucose Transporter Recycling by Impairing SNX27 Retromer Assembly
Q51114244	PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition
Q34202681	PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control
Q92316075	PTEN Tumor-Suppressor: The Dam of Stemness in Cancer
Q34196262	PTEN action in leukaemia dictated by the tissue microenvironment
Q38843254	PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition
Q27824857	PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer
Q39592426	PTEN ameliorates high glucose-induced lipid deposits through regulating SREBP-1/FASN/ACC pathway in renal proximal tubular cells
Q38048884	PTEN and Melanomagenesis
Q36378575	PTEN and NEDD4 in Human Breast Carcinoma
Q38629644	PTEN and PI3K/AKT in non-small-cell lung cancer.
Q45864098	PTEN and TRAIL genes loaded zein nanoparticles as potential therapy for hepatocellular carcinoma
Q28218655	PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease
Q34180652	PTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench
Q40607696	PTEN and myotubularins: families of phosphoinositide phosphatases
Q34514602	PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation
Q33681342	PTEN and prostate cancer
Q37259680	PTEN and the PI3-kinase pathway in cancer
Q92459709	PTEN arginine methylation by PRMT6 suppresses PI3K-AKT signaling and modulates pre-mRNA splicing
Q24555751	PTEN as an effector in the signaling of antimigratory G protein-coupled receptor
Q28217868	PTEN associates with the vault particles in HeLa cells
Q36452913	PTEN at a glance
Q52661710	PTEN at the interface of immune tolerance and tumor suppression.
Q34133079	PTEN augments SPARC suppression of proliferation and inhibits SPARC-induced migration by suppressing SHC-RAF-ERK and AKT signaling.
Q40736882	PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway
Q39689621	PTEN breast cancer susceptibility: a matter of dose
Q30434033	PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity
Q35282160	PTEN controls tumor-induced angiogenesis
Q36278234	PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer
Q39644716	PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors
Q35553313	PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability
Q34518277	PTEN deficiency mediates a reciprocal response to IGFI and mTOR inhibition
Q24801835	PTEN deficiency: a role in mammary carcinogenesis
Q54504570	PTEN deletion and concomitant c-Myc activation do not lead to tumor formation in pancreatic beta cells.
Q38315381	PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin
Q38915989	PTEN deletion potentiates invasion of colorectal cancer spheroidal cells through 3D Matrigel
Q36506366	PTEN encoding product: a marker for tumorigenesis and progression of gastric carcinoma
Q33968441	PTEN expression causes feedback upregulation of insulin receptor substrate 2
Q81484682	PTEN expression in clear cell adenocarcinoma of the ovary
Q46452179	PTEN expression in ovine granulosa cells increases during terminal follicular growth
Q74141759	PTEN expression is maintained in sporadic colorectal tumours
Q22254699	PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1
Q34942330	PTEN function in mammalian cell size regulation
Q24528114	PTEN function: how normal cells control it and tumour cells lose it
Q38198345	PTEN function: the long and the short of it.
Q39076276	PTEN functions as a melanoma tumor suppressor by promoting host immune response
Q40404987	PTEN functions by recruitment to cytoplasmic vesicles
Q33765703	PTEN gene and integrin signaling in cancer
Q39640325	PTEN gene mutations correlate to poor prognosis in glioma patients: a meta-analysis
Q40508012	PTEN gene targeting reveals a radiation-induced size checkpoint in human cancer cells
Q55476772	PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.
Q51597378	PTEN gene: a model for genetic diseases in dermatology.
Q74026971	PTEN germ-line mutations in juvenile polyposis coli
Q92569890	PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around
Q37139779	PTEN in brain tumors
Q90441646	PTEN in propofol-induced insulin resistance in mouse primary hepatocytes
Q50168053	PTEN in the maintenance of genome integrity: From DNA replication to chromosome segregation
Q35070903	PTEN increases autophagy and inhibits the ubiquitin-proteasome pathway in glioma cells independently of its lipid phosphatase activity
Q35661819	PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.
Q43701623	PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression
Q34409067	PTEN inhibition enhances neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells
Q34228582	PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migration
Q24315949	PTEN inhibits BMI1 function independently of its phosphatase activity
Q44737517	PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells
Q36211287	PTEN inhibits macrophage polarization from M1 to M2 through CCL2 and VEGF-A reduction and NHERF-1 synergism
Q34364654	PTEN interacts with histone H1 and controls chromatin condensation
Q92560338	PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription
Q45904675	PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer.
Q28239790	PTEN is a protein tyrosine phosphatase for IRS1
Q35746631	PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis
Q33608760	PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice
Q42016344	PTEN is involved in modulation of vasculogenesis in early chick embryos
Q28565184	PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression
Q30415350	PTEN knockdown alters dendritic spine/protrusion morphology, not density
Q58724002	PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis
Q90392045	PTEN loss activates a functional AKT/CXCR4 signaling axis to potentiate tumor growth and lung metastasis in human osteosarcoma cells
Q41907553	PTEN loss and ERG protein expression are infrequent in prostatic ductal adenocarcinomas and concurrent acinar carcinomas
Q37856722	PTEN loss in the continuum of common cancers, rare syndromes and mouse models.
Q37116576	PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling
Q30360337	PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7.
Q40125775	PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney
Q28588309	PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
Q92286999	PTEN modulates gene transcription by redistributing genome-wide RNA polymerase II occupancy
Q40639993	PTEN modulates insulin-like growth factor II (IGF-II)-mediated signaling; the protein phosphatase activity of PTEN downregulates IGF-II expression in hepatoma cells
Q64379300	PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects
Q55475660	PTEN mutation analysis in two genetic subtypes of high-grade oligodendroglial tumors. PTEN is only occasionally mutated in one of the two genetic subtypes.
Q34504165	PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome
Q53300858	PTEN mutation spectrum in breast cancers and breast hyperplasia
Q79772653	PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations
Q35747653	PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers
Q57591147	PTEN mutations are common in sporadic microsatellite stable colorectal cancer
Q48731942	PTEN mutations in malignant gliomas and their relation with meningeal gliomatosis
Q28482319	PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development
Q34248383	PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry
Q37527357	PTEN opposes negative selection and enables oncogenic transformation of pre-B cells
Q54653566	PTEN overexpression attenuates angiogenic processes of endothelial cells by blockade of endothelin-1/endothelin B receptor signaling
Q34796595	PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium
Q37606460	PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress
Q26995683	PTEN plasticity: how the taming of a lethal gene can go too far
Q53804306	PTEN polymorphisms contribute to clinical outcomes of advanced lung adenocarcinoma patients treated with platinum-based chemotherapy
Q54674580	PTEN promoter methylation and protein expression in normal early placentas and hydatidiform moles.
Q38398970	PTEN protein expression in malignant pleural mesothelioma
Q38738670	PTEN protein loss by immunostaining: analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients
Q39176925	PTEN proteoforms in biology and disease
Q35188319	PTEN reconstitution alters glioma responses to c-Met pathway inhibition.
Q54447341	PTEN reduces cuff-induced neointima formation and proinflammatory cytokines
Q34232438	PTEN redundancy: overexpressing lpten, a homolog of Dictyostelium discoideum ptenA, the ortholog of human PTEN, rescues all behavioral defects of the mutant ptenA-
Q28540547	PTEN regulates BCRP/ABCG2 and the side population through the PI3K/Akt pathway in chronic myeloid leukemia
Q45834365	PTEN regulates matrix synthesis in adult human chondrocytes under oxidative stress
Q36497447	PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).
Q28202778	PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow
Q24321834	PTEN regulation by Akt-EGR1-ARF-PTEN axis
Q27011088	PTEN regulation of ERK1/2 signaling in cancer
Q30459697	PTEN regulation of local and long-range connections in mouse auditory cortex.
Q37530158	PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in mice
Q39615005	PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts
Q40755882	PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway.
Q51012340	PTEN sequence analysis in endometrial hyperplasia and endometrial carcinoma in Slovak women
Q37270423	PTEN signaling in brain: neuropathology and tumorigenesis.
Q35146572	PTEN signaling pathways in melanoma
Q50117668	PTEN silencing enhances neuronal proliferation and differentiation by activating PI3K/Akt/GSK3β pathway in vitro
Q36713508	PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma
Q98164389	PTEN suppresses epithelial-mesenchymal transition and cancer stem cell activity by downregulating Abi1
Q78026206	PTEN transcriptionally modulates c-myc gene expression in human breast carcinoma cells and is involved in cell growth regulation
Q24303571	PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
Q28181035	PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms
Q40911230	PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.
Q50977901	PTEN, Longevity and Age-Related Diseases
Q28115966	PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
Q48548992	PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3.
Q42811887	PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells
Q42816027	PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes
Q42911804	PTEN, here, there, everywhere
Q36753139	PTEN, more than the AKT pathway
Q36733630	PTEN, the Achilles' heel of myocardial ischaemia/reperfusion injury?
Q47604204	PTEN-L promotes type I interferon responses and antiviral immunity
Q36861839	PTEN-deficient cancers depend on PIK3CB.
Q34016861	PTEN-deficient tumors depend on AKT2 for maintenance and survival
Q91739141	PTEN-knockdown disrupts the morphology, growth pattern and function of Nthy-Ori 3-1 cells by downregulating PAX8 expression
Q38407414	PTEN-mediated AKT activation contributes to the reduced apoptosis among Indian oral squamous cell carcinoma patients.
Q48889007	PTEN-mediated Akt activation in human neocortex during prenatal development
Q37698905	PTEN-mediated ERK1/2 inhibition and paradoxical cellular proliferation following Pnck overexpression
Q34438439	PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1
Q36646490	PTEN/MMAC1 expression in melanoma resection specimens
Q73739349	PTEN/MMAC1 in malignant melanoma and its importance for tumor progression
Q48203168	PTEN/MMAC1 mutations in hepatocellular carcinomas
Q48190895	PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors
Q33586807	PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells
Q37382416	PTEN/PI3K and MAPK signaling in protection and pathology following CNS injuries
Q38268858	PTEN/PI3K/Akt/VEGF signaling and the cross talk to KRIT1, CCM2, and PDCD10 proteins in cerebral cavernous malformations
Q28250937	PTEN1 is frequently mutated in primary endometrial carcinomas
Q39377876	PTEN: A potential prognostic marker in virus-induced hepatocellular carcinoma.
Q35087328	PTEN: Multiple Functions in Human Malignant Tumors
Q43104730	PTEN: Sometimes Taking It Off Can Be Better than Putting It On
Q34540849	PTEN: The down side of PI 3-kinase signalling.
Q90429880	PTEN: Tumor Suppressor and Metabolic Regulator
Q37216319	PTEN: a default gate-keeping tumor suppressor with a versatile tail
Q37270432	PTEN: a new guardian of the genome.
Q60595469	PTEN: a new twist on β-catenin?
Q34327837	PTEN: a newly identified regulator of neuronal differentiation
Q38406254	PTEN: a yin-yang master regulator protein in health and disease
Q28203387	PTEN: one gene, many syndromes
Q35203208	PTEN: tumour suppressor, multifunctional growth regulator and more
Q35870626	PTENless means more.
Q28238905	PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism
Q37733825	PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription
Q46051852	Pancreas-specific Pten deficiency causes partial resistance to diabetes and elevated hepatic AKT signaling
Q49936958	Parkin in Parkinson's Disease and Cancer: a Double-Edged Sword
Q35870069	Partial PTEN deletion is linked to poor prognosis in breast cancer
Q36056424	Pathobiology of brain metastases
Q34160157	Pathogenesis of colorectal cancer
Q55110010	Pathology of hereditary breast cancer.
Q37996214	Pathology: Commonly Monitored Glioblastoma Markers: EFGR, EGFRvIII, PTEN, and MGMT
Q39671200	Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors
Q37284256	Pediatric glioblastomas: a histopathological and molecular genetic study
Q33680045	Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3
Q28258611	Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase
Q26766292	Pharmacodynamic Biomarker Development for PI3K Pathway Therapeutics
Q35574952	Pharmacogenetic candidate genes for melanoma
Q34978420	Pharmacological profiling of kinase dependency in cell lines across triple-negative breast cancer subtypes
Q27853324	Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors
Q64236597	Phase I study of alpelisib (BYL719), an α-specific PI3K inhibitor, in Japanese patients with advanced solid tumors
Q38406496	Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors
Q37641248	Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02
Q45850976	Phase II trial of RAD001 and bicalutamide for castration-resistant prostate cancer
Q90292840	Phase Ib study of the MEK inhibitor cobimetinib (GDC-0973) in combination with the PI3K inhibitor pictilisib (GDC-0941) in patients with advanced solid tumors
Q33834813	Phenotype vs genotype in the evolution of astrocytic brain tumors
Q37852615	Phenotype-genotype correlation in familial breast cancer
Q40972780	Phenotypic analysis of human glioma cells expressing the MMAC1 tumor suppressor phosphatase
Q40854521	Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells
Q35432463	Phenotypic findings of Cowden syndrome and Bannayan-Zonana syndrome in a family associated with a single germline mutation in PTEN
Q51014452	Phosphatase and Tensin Homolog Deficiency and Resistance to Trastuzumab and Chemotherapy
Q40436436	Phosphatase and Tensin Homolog Is a Growth Repressor of Both Rhizoid and Gametophore Development in the Moss Physcomitrella patens.
Q39612578	Phosphatase and Tensin Homolog Reconstruction and Vascular Endothelial Growth Factor Knockdown Synergistically Inhibit the Growth of Glioblastoma
Q35235757	Phosphatase and Tensin Homolog on Chromosome 10 Is Phosphorylated in Primary Effusion Lymphoma and Kaposi's Sarcoma
Q26784590	Phosphatase and Tensin Homologue: Novel Regulation by Developmental Signaling
Q37638254	Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?
Q46709687	Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis
Q36943633	Phosphatase and tensin homologue deleted on chromosome 10
Q37364696	Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis
Q34699422	Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair
Q61718783	Phosphatases: Their Roles in Cancer and Their Chemical Modulators
Q35504084	Phosphatases: the new brakes for cancer development?
Q34316184	Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis.
Q41164638	Phosphatidylinositol 3-kinase signaling determines kidney size
Q37116110	Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
Q40725486	Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear beta-catenin accumulation
Q34203861	Phosphatidylinositol 3-kinase: the oncoprotein
Q39635280	Phosphatidylinositol 3‐kinase affects mitochondrial function in part through inducing peroxisome proliferator‐activated receptor γ coactivator‐1β expression
Q33823535	Phosphatidylinositol 4,5-bisphosphate-specific AKT1 is oncogenic
Q64967349	Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica.
Q38572786	Phosphatidylinositolphosphate phosphatase activities and cancer
Q37992006	Phosphoinositide 3-Kinases—A Historical Perspective
Q37003826	Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers
Q34481485	Phosphoinositide 3-kinase inhibition in cancer treatment
Q36346828	Phosphoinositide 3-kinase: from viral oncoprotein to drug target
Q39260815	Phosphoinositide binding to the substrate regulates susceptibility to proteolysis by calpain.
Q33862413	Phosphoinositide phosphatases in cell biology and disease
Q35163916	Phosphoinositide signaling disorders in human diseases
Q38053947	Phosphoinositides in Insulin Action and Diabetes
Q27861051	Phosphoinositides in cell regulation and membrane dynamics
Q27022953	Phosphoinositides: Key modulators of energy metabolism
Q27012953	Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Q39036639	Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate
Q36544734	Phosphorylation and inactivation of PTEN at residues Ser380/Thr382/383 induced by Helicobacter pylori promotes gastric epithelial cell survival through PI3K/Akt pathway
Q40456737	Phosphorylation of both EGFR and ErbB2 is a reliable predictor of prostate cancer cell proliferation in response to EGF.
Q40432782	Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.
Q49335104	Phosphorylation of phosphatase and tensin homolog induced by Helicobacter pylori promotes cell invasion by activation of focal adhesion kinase
Q34101673	Phosphorylation of the PTEN Tail Acts as an Inhibitory Switch by Preventing Its Recruitment into a Protein Complex
Q22254305	Phosphorylation of the PTEN tail regulates protein stability and function
Q36998831	Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis
Q36427519	Phosphotyrosine recognition domains: the typical, the atypical and the versatile
Q36924388	Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling
Q39947431	Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study
Q37660266	Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation
Q36681273	Pleuropulmonary blastoma: cytogenetic and spectral karyotype analysis
Q38899532	Pnck overexpression in HER-2 gene-amplified breast cancer causes Trastuzumab resistance through a paradoxical PTEN-mediated process
Q36693272	Poly(Adenosine Diphosphate–Ribose) Polymerase Inhibitors in Cancer Treatment
Q34981637	Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth
Q48925401	Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas
Q35431613	Polymorphisms in PTEN in breast cancer families
Q39652476	Polymorphisms in Promoter Sequences of the p15 INK4B and PTEN Genes of Normal Japanese Individuals
Q33733210	Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer
Q33997970	Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx
Q37059129	Portrait of PTEN: messages from mutant mice.
Q41865417	Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production
Q37270440	Post-translational regulation of PTEN.
Q34210447	Postoperative radiotherapy of astrocytomas
Q39682060	Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP
Q37783617	Potential role of PI3K inhibitors in the treatment of breast cancer.
Q30383801	Prediction of functionally significant single nucleotide polymorphisms [SNPs] in PTEN tumor suppressor gene: An in silico approach.
Q40414575	Predictors of participation in clinical and psychosocial follow-up of the kConFab breast cancer family cohort
Q28140543	Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome
Q36791086	Primary extraosseous Ewing sarcoma of the lung in children
Q45352484	Primary squamous cell carcinoma of the endometrium unrelated to human papilloma virus: a molecular study.
Q43680908	Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance
Q43920629	Proapoptotic and antiapoptotic markers in cutaneous T-cell lymphoma skin infiltrates and lymphomatoid papulosis
Q78845346	Profiling of differential expression of messenger RNA in normal, benign, and metastatic prostate cell lines
Q40857263	Profiling the downstream genes of tumor suppressor PTEN in lung cancer cells by complementary DNA microarray
Q34048106	Progesterone reverses the mesenchymal phenotypes of basal phenotype breast cancer cells via a membrane progesterone receptor mediated pathway
Q48749343	Prognosis in human glioblastoma based on expression of ligand growth hormone-releasing hormone, pituitary-type growth hormone-releasing hormone receptor, its splicing variant receptors, EGF receptor and PTEN genes
Q47155578	Prognostic Value of Molecular Markers and Implication for Molecular Targeted Therapies in Nasopharyngeal Carcinoma: An Update in an Era of New Targeted Molecules Development
Q90226704	Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing Perspectives
Q36816038	Prognostic biomarkers in renal cell carcinoma
Q31062346	Prognostic factors for anaplastic astrocytomas
Q37636833	Prognostic role of phospho-PRAS40 (Thr246) expression in gastric cancer
Q48520102	Prognostic value of loss of heterozygosity around three candidate tumor suppressor genes on chromosome 10q in astrocytomas
Q35601956	Programmed cell death and survival pathways in prostate cancer cells.
Q92179695	Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis
Q37143657	Progress in the pathogenesis and genetics of Parkinson's disease
Q53431081	Progress in understanding the molecular pathogenesis of human lung cancer
Q38811268	Proliferative lesion of anogenital mammary-like glands in the setting of Cowden syndrome: case report and review of the literature
Q43918868	Promoter methylation and silencing of PTEN in gastric carcinoma
Q80403566	Promoter methylation of the PTEN gene is a common molecular change in breast cancer
Q42129357	Promoter region methylation and loss of protein expression of PTEN and significance in cervical cancer
Q41970534	Prospective, high-throughput molecular profiling of human gliomas
Q47149516	Prostate Cancer Imaging and Biomarkers Guiding Safe Selection of Active Surveillance
Q38731643	Prostate Cancer Stem Cells and Nanotechnology: A Focus on Wnt Signaling
Q38314252	Prostate cancer cells use genetic and epigenetic mechanisms for progression to androgen independence.
Q34707619	Prostate cancer genomics
Q27014810	Prostate cancer genomics by high-throughput technologies: genome-wide association study and sequencing analysis
Q48334691	Prostate-specific PTen deletion in mice activates inflammatory microRNA expression pathways in the epithelium early in hyperplasia development.
Q34090705	Prostatic expression of hensin, a protein implicated in epithelial terminal differentiation
Q24613810	Protean PTEN: form and function
Q39264728	Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma
Q54280898	Protective effect of berberine against myocardial ischemia reperfusion injury: role of Notch1/Hes1-PTEN/Akt signaling
Q64245074	Protein Phosphatases-A Touchy Enemy in the Battle Against Glioblastomas: A Review
Q37282349	Protein expression of PTEN, insulin-like growth factor I receptor (IGF-IR), and lethal prostate cancer: a prospective study
Q42824933	Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
Q36727225	Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells
Q37814680	Protein kinase signaling networks in cancer
Q24604987	Protein kinases and phosphatases in the control of cell fate
Q41679383	Protein tyrosine kinases and cancer
Q53415824	Protein tyrosine phosphatase epsilon increases the risk of mammary hyperplasia and mammary tumors in transgenic mice
Q37094068	Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease
Q41739061	Protein-Tyrosine Phosphatases: Biological Function, Structural Characteristics, and Mechanism of Catalysis
Q33692154	Protein-tyrosine phosphatases in development
Q39002801	Proteomics analyses of prostate cancer cells reveal cellular pathways associated with androgen resistance
Q34066409	Protocol for PTEN expression by immunohistochemistry in formalin-fixed paraffin-embedded human breast carcinoma
Q39882765	Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells.
Q36764870	PtdIns-4,5-P2 as a potential therapeutic target for pathologic angiogenesis
Q42984934	Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity
Q38442957	Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated β-Catenin Signaling
Q48305468	Pten facilitates epiblast epithelial polarization and proamniotic lumen formation in early mouse embryos
Q38280829	Pten function in zebrafish: anything but a fish story
Q42253687	Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer
Q28509238	Pten is essential for embryonic development and tumour suppression
Q37595166	Pten is necessary for the quiescence and maintenance of adult muscle stem cells.
Q47198015	Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease
Q34707865	Pten signaling in gliomas
Q74063881	Pten, a candidate tumor suppressor gene, maps to mouse Chromosome 19
Q42125233	Pten, a protean tumor suppressor
Q47843523	PtenDeletion in Adult Hippocampal Neural Stem/Progenitor Cells Causes Cellular Abnormalities and Alters Neurogenesis
Q37032400	Ptena and ptenb genes play distinct roles in zebrafish embryogenesis.
Q27347612	Ptenb mediates gastrulation cell movements via Cdc42/AKT1 in zebrafish
Q53665221	Putative tumor-suppressor gene regions responsible for radiation lymphomagenesis in F1 mice with different p53 status
Q47100175	QSKL protects against myocardial apoptosis on heart failure via PI3K/Akt-p53 signaling pathway
Q43636650	Questioning the role of selected somatic PIK3C2B mutations in squamous non-small cell lung cancer oncogenesis
Q34420665	RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.
Q96302844	RAS-targeted therapies: is the undruggable drugged?
Q34117879	RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells
Q36939659	RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes
Q44559392	RETRACTED: Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src.
Q32884571	RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation
Q35185336	ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells
Q34189695	RRM1-induced metastasis suppression through PTEN-regulated pathways
Q48792418	Rab5 and Ndfip1 are involved in Pten ubiquitination and nuclear trafficking
Q39144903	Radiation-induced upregulation of telomerase activity escapes PI3-kinase inhibition in two malignant glioma cell lines.
Q24312999	Rak functions as a tumor suppressor by regulating PTEN protein stability and function
Q33608830	Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples
Q89729975	Rapamycin inhibits B-cell activating factor (BAFF)-stimulated cell proliferation and survival by suppressing Ca2+-CaMKII-dependent PTEN/Akt-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells
Q43099344	Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
Q36009774	Rapid isolation of cDNA by hybridization
Q40919390	Rare-type mutations of MMAC1 tumor suppressor gene in human glioma cell lines and their tumors of origin
Q55477300	Ras activation in astrocytomas and neurofibromas.
Q39540211	Rat protein tyrosine phosphatase eta suppresses the neoplastic phenotype of retrovirally transformed thyroid cells through the stabilization of p27(Kip1).
Q30952801	Rat testicular myotubularin, a protein tyrosine phosphatase expressed by Sertoli and germ cells, is a potential marker for studying cell-cell interactions in the rat testis
Q36997524	Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatment
Q35758482	Rb1 and Pten Co-Deletion in Osteoblast Precursor Cells Causes Rapid Lipoma Formation in Mice
Q38722705	Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance
Q92090098	Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway
Q42518946	Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner
Q33426848	Real-time imaging of HIF-1alpha stabilization and degradation
Q41052994	Rearrangement of the Long Arm of Chromosome 10 in the Prostate Adenocarcinoma Cell Line LNCaP
Q93147363	Recent Findings in the Regulation of Programmed Death Ligand 1 Expression
Q34232481	Recent advances in melanoma research
Q38552555	Recent advances in the molecular genetics of cancer. Second joint conference of the American Association of Cancer Research and the European Association of Cancer Research, Oxford, 9-12 September 1997.
Q91890909	Recent progress in mapping the emerging landscape of the small-cell lung cancer genome
Q36542256	Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs.
Q52608306	Reconstructing the molecular life history of gliomas
Q73459814	Recurrent allelic deletions of chromosome arms 15q and 16q in human small cell lung carcinomas
Q44236054	Recurrent allelic imbalance at the rat Pten locus in DMBA-induced fibrosarcomas
Q34477787	Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.
Q36415676	Redox-Sensitive Oxidation and Phosphorylation of PTEN Contribute to Enhanced Activation of PI3K/Akt Signaling in Rostral Ventrolateral Medulla and Neurogenic Hypertension in Spontaneously Hypertensive Rats
Q34694605	Reduced Dose and Intermittent Treatment with Lapatinib and Trastuzumab for Potent Blockade of the HER Pathway in HER2/neu-Overexpressing Breast Tumor Xenografts
Q36643707	Reduced PTEN expression in the pancreas overexpressing transforming growth factor-beta 1.
Q45099758	Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen
Q39361510	Reduced expression of PTEN and increased PTEN phosphorylation at residue Ser380 in gastric cancer tissues: A novel mechanism of PTEN inactivation
Q39652589	Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells.
Q47669969	Reduction of PTEN and p27kip1 expression correlates with tumor grade in prostate cancer. Analysis in radical prostatectomy specimens and needle biopsies
Q35032366	Regulation of FOXO protein stability via ubiquitination and proteasome degradation
Q24653458	Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
Q29568316	Regulation of GABAA receptors by fragile X mental retardation protein
Q40816834	Regulation of Id2 gene expression by the insulin-like growth factor I receptor requires signaling by phosphatidylinositol 3-kinase.
Q36047109	Regulation of PI 3-K, PTEN, p53, and mTOR in Malignant and Benign Tumors Deficient in Tuberin
Q42276895	Regulation of PTEN expression by the SWI/SNF chromatin-remodelling protein BRG1 in human colorectal carcinoma cells.
Q37113710	Regulation of PTEN expression in intestinal epithelial cells by c-Jun NH2-terminal kinase activation and nuclear factor-kappaB inhibition
Q28586804	Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis
Q28646911	Regulation of PTEN transcription by p53
Q43666441	Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells
Q37256999	Regulation of T-cell responses by PTEN
Q34428555	Regulation of Translation via TOR Signaling: Insights from Drosophila melanogaster
Q55475411	Regulation of brain fatty acid-binding protein expression by differential phosphorylation of nuclear factor I in malignant glioma cell lines.
Q77342895	Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN
Q34117899	Regulation of death receptor-mediated apoptosis pathways
Q33672286	Regulation of glioma migration and invasion via modification of Rap2a activity by the ubiquitin ligase Nedd4-1.
Q37979774	Regulation of intracellular signalling through cysteine oxidation by reactive oxygen species
Q34257074	Regulation of phosphatase and tensin homolog on chromosome 10 in response to hypoxia
Q35756915	Regulation of sensitivity to TRAIL by the PTEN tumor suppressor.
Q36328536	Regulation of the cell cycle by focal adhesion kinase
Q35063217	Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene
Q33672445	Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth.
Q39271041	Regulation of the tumor suppressor PTEN by SUMO.
Q47691876	Regulation of the tumor suppressor PTEN by natural anticancer compounds
Q43683238	Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt.
Q82182829	Regulation, Role, and Targeting of Akt in Cancer
Q36439912	Regulators of gene expression as biomarkers for prostate cancer
Q41213948	Regulatory Role of Redox Balance in Determination of Neural Precursor Cell Fate.
Q79936859	Relationship between PTEN and VEGF expression and clinicopathological characteristics in HCC
Q48413426	Relationship between PTEN gene expression and differentiation of human glioma
Q35140496	Relationships between PTEN gene mutations and prognosis in glioma: a meta-analysis
Q35123025	Relevance and therapeutic possibility of PTEN-long in renal cell carcinoma
Q46903118	Reply to niermeijer
Q28207115	Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation
Q74397205	Research: the track record justifies expanded support
Q35591518	Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: mechanisms and clinical implications
Q30438487	Restoration of PTEN expression alters the sensitivity of prostate cancer cells to EGFR inhibitors
Q40509159	Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle
Q90253669	Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA
Q34171717	Resveratrol Inhibits Inflammatory Responses via the Mammalian Target of Rapamycin Signaling Pathway in Cultured LPS-Stimulated Microglial Cells
Q38839803	Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer
Q36995391	Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium.
Q36727409	Retinoblastoma and Phosphate and Tensin Homolog Tumor Suppressors: Impact on Ductal Carcinoma In Situ Progression
Q33570393	Retracted: Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway
Q24611142	Retroviral oncogenes: a historical primer
Q40019071	Reversal of multidrug resistance and inhibition of phosphorylation of AKT in human ovarian cancer cell line by wild-type PTEN gene
Q50854927	Reversible oxidation of PRL family protein-tyrosine phosphatases
Q33771160	Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma
Q37776605	Review of the complexities of the PI3K/mTOR pathway presages similar handling of other critical topics
Q28082973	Review on molecular and chemopreventive potential of nimbolide in cancer
Q38100279	Rho-associated coiled-coil kinase (ROCK) signaling and disease
Q46674979	Ribozymes targeting serine/threonine kinase Akt1 sensitize cells to anticancer drugs
Q48187608	Risk of malignant brain tumor as a second primary is significantly reduced after treatment of breast cancer
Q35077315	Risk of severe diarrhea with dual anti-HER2 therapies: a meta-analysis
Q37375389	Rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
Q41220222	Role of IGF-1/IGF-1R in regulation of invasion in DU145 prostate cancer cells
Q24324261	Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth
Q42452984	Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells
Q79095314	Role of PTEN and MMP‐7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma
Q37325482	Role of PTEN in modulation of ADP-dependent signaling pathways in vascular endothelial cells
Q41463056	Role of PTEN-Akt-CREB Signaling Pathway in Nervous System impairment of Rats with Chronic Arsenite Exposure
Q38115245	Role of Phosphatidylinositol 3,4,5-Trisphosphate in Cell Signaling
Q38613831	Role of Protein Tyrosine Phosphatases in Plants
Q35169570	Role of Pten in leukemia stem cells
Q24657979	Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells
Q26747419	Role of Redox Status in Development of Glioblastoma
Q37071045	Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma
Q34978001	Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal
Q38143834	Role of inositol poly-phosphatases and their targets in T cell biology
Q39460820	Role of phosphoinositide 3-kinase in the aggressive tumor growth of HT1080 human fibrosarcoma cells
Q37960021	Role of signaling transduction pathways in development of castration-resistant prostate cancer
Q91977334	Role of the PI3K/AKT pathway and PTEN in otitis media
Q38153615	Role of the PTEN signaling pathway in autism spectrum disorder
Q92372937	Role of the RAB7 Protein in Tumor Progression and Cisplatin Chemoresistance
Q37127301	Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications
Q37414125	Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress
Q40494536	Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells
Q42355766	Roles of Polo-like kinase 3 in suppressing tumor angiogenesis.
Q36477469	Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.
Q28754549	Roots of angiosperm formins: the evolutionary history of plant FH2 domain-containing proteins
Q40494567	Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP.
Q37857744	S-phase-coupled apoptosis in tumor suppression
Q37123127	SAHA-induced loss of tumor suppressor Pten gene promotes thyroid carcinogenesis in a mouse model
Q100490939	SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN
Q36934463	SGK3 is associated with estrogen receptor expression in breast cancer
Q34629544	SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer
Q53118754	SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells
Q53414968	SK&F 96365 induces apoptosis and autophagy by inhibiting Akt–mTOR signaling in A7r5 cells
Q24293490	SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation
Q59808132	SLC25A22 Promotes Proliferation and Metastasis of Osteosarcoma Cells via the PTEN Signaling Pathway
Q37714736	SNP rs10248565 in HDAC9 as a novel genomic aberration biomarker of lung adenocarcinoma in non-smoking women
Q34261684	SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT
Q38837458	SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.
Q35343534	STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells
Q37550760	STAT3 regulation of glioblastoma pathogenesis.
Q33914389	Sac phosphatase domain proteins.
Q35669138	Safety and efficacy of everolimus in adult patients with neuroendocrine tumors
Q36949192	Sample type bias in the analysis of cancer genomes
Q42801709	Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization
Q39215680	Screening of candidate tumor-suppressor genes in 3p21.3 and investigation of the methylation of gene promoters in oral squamous cell carcinoma
Q35173049	Searching for the gatekeeper oncogene of prostate cancer
Q34206082	Senescent cells and their secretory phenotype as targets for cancer therapy.
Q41413210	Serum microRNA-17 functions as a prognostic biomarker in osteosarcoma
Q90225264	Sestrins as a Therapeutic Bridge between ROS and Autophagy in Cancer
Q30494717	Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells.
Q36301565	Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.
Q28248532	Shc3 affects human high-grade astrocytomas survival
Q24309044	Should individual PI3 kinase isoforms be targeted in cancer?
Q42715939	Side-effects of resveratrol in HepG2 cells: Reduced pten and increased bcl-xl mRNA expression
Q39458668	Sigma1 Pharmacology in the Context of Cancer
Q38943216	Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer
Q42524777	Signal transduction through the T cell receptor is dynamically regulated by balancing kinase and phosphatase activities
Q36027381	Signaling mechanisms for regulation of chemotaxis
Q38747573	Signaling pathways as therapeutic targets in biliary tract cancer.
Q38194093	Signals controlling un-differentiated states in embryonic stem and cancer cells: role of the phosphatidylinositol 3' kinase pathway
Q39737975	Signatures of mutation and selection in the cancer genome
Q64257573	Significance of PTEN Mutation in Cellular Process, Prognosis, and Drug Selection in Clear Cell Renal Cell Carcinoma
Q33868072	Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer
Q57591241	Silencing of thePTENtumor-suppressor gene in anaplastic thyroid cancer
Q33687282	Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer.
Q33678607	Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth
Q64121699	Single Cell Profiling Reveals PTEN Overexpression in Influenza-Specific B cells in Aging HIV-infected individuals on Anti-retroviral Therapy
Q36429478	Single nucleotide polymorphism: a new risk factor for endometrial cancer?
Q47156618	Single nucleotide polymorphisms rs701848 and rs2735343 in PTEN increases cancer risks in an Asian population
Q36469802	Single nucleotide polymorphisms: early diagnosis and risk assessment in genitourinary malignancy
Q52356988	Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors.
Q42813355	Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit
Q33306309	Small molecule regulators of autophagy identified by an image-based high-throughput screen
Q34071777	SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer
Q36113311	Sodium iodide symporter and phosphatase and tensin homolog deleted on chromosome ten expression in cholangiocarcinoma analysis with clinicopathological parameters
Q48379390	Somatic Mutations of the PTEN/MMAC1 Gene in Fifteen Japanese Endometrial Cancers: Evidence for Inactivation of Both Alleles
Q36617723	Somatic mutation of PTEN in bladder carcinoma
Q73035204	Somatic mutation of the PTEN/MMAC1 gene in breast cancers with microsatellite instability
Q28141888	Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma
Q73501431	Somatic mutations and genetic polymorphisms of the PPP1R3 gene in patients with several types of cancers
Q34482374	Somatic mutations of PIK3R1 promote gliomagenesis
Q77470719	Somatic mutations of thePTEN tumor suppressor gene in sporadic follicular thyroid tumors
Q77519093	Some neoplasms and some hamartomatous syndromes: genetic considerations
Q46170145	Sonic Hedgehog Signaling in Thyroid Cancer
Q37388961	Spatiotemporal Dynamics of Phosphorylation in Lipid Second Messenger Signaling
Q74274255	Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus
Q31538849	Src homology 2-containing inositol 5-phosphatase 1 binds to the multifunctional docking site of c-Met and potentiates hepatocyte growth factor-induced branching tubulogenesis.
Q42379044	Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
Q37588308	Status of PI3K inhibition and biomarker development in cancer therapeutics
Q55212706	Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN.
Q38899337	Stromal cells of endometrial carcinoma promotes proliferation of epithelial cells through the HGF/c-Met/Akt signaling pathway
Q38498355	Structural and genic characterization of stable genomic regions in breast cancer: relevance to chemotherapy.
Q37218678	Structural comparisons of class I phosphoinositide 3-kinases
Q30391301	Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer
Q45143602	Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines
Q28257290	Superdomains in the protein structure hierarchy: The case of PTP-C2
Q44415199	Suppression of LNCaP prostate cancer xenograft tumors by a prostate‐specific protein tyrosine phosphatase, prostatic acid phosphatase
Q40557650	Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN.
Q35010842	Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene
Q45881488	Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN
Q61811539	Suppression of miR-21-3p enhances TRAIL-mediated apoptosis in liver cancer stem cells by suppressing the PI3K/Akt/Bad cascade via regulating PTEN
Q28181613	Suppression of the cell proliferation and invasion phenotypes in glioma cells by the LGI1 gene
Q35172239	Supratentorial grade II astrocytoma: biological features and clinical course
Q36832185	Survival factor NFIL3 restricts FOXO-induced gene expression in cancer
Q35545780	Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer
Q39215791	Synergistic effects of histone deacetylase inhibitor in combination with mTOR inhibitor in the treatment of prostate carcinoma
Q57364534	Synergy in tumor suppression by direct interaction of Neutral Endopeptidase with PTEN
Q36768641	Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae
Q82037526	Synthesis of GSK3β mimetic inhibitors of Akt featuring a novel extended dipeptide surrogate
Q92957648	Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
Q36967232	Systematic analysis of the PTEN 5' leader identifies a major AUU initiated proteoform
Q100958576	Systematic investigation of promoter substitutions resulting from somatic intrachromosomal structural alterations in diverse human cancers
Q40503025	Systematic multiplex polymerase chain reaction and reverse transcription-polymerase chain reaction analyses of changes in copy number and expression of proto-oncogenes and tumor suppressor genes in cancer tissues and cell lines
Q34491046	Systemic lupus erythematosus and B-cell hematologic neoplasm
Q57185252	T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
Q27938872	TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation
Q41790357	TET1-mediated different transcriptional regulation in prostate cancer
Q39943672	TGFbeta modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells
Q38901670	TGFβ-induced phosphorylation of Par6 promotes migration and invasion in prostate cancer cells
Q24677033	THE CROONIAN LECTURE 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease
Q41872025	TIGAR, TIGAR, burning bright.
Q26999359	TLX: A master regulator for neural stem cell maintenance and neurogenesis
Q42061434	TOPK and PTEN participate in CHFR mediated mitotic checkpoint
Q33705275	TR4 nuclear receptor functions as a tumor suppressor for prostate tumorigenesis via modulation of DNA damage/repair system
Q28548386	TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response
Q34482821	TRAIL/Apo-2L: Mechanisms and Clinical Applications in Cancer
Q42510422	TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells
Q34658958	TSC2 deficiency increases PTEN via HIF1alpha
Q36956724	Tackling EGFR signaling with TACE antagonists: a rational target for metalloprotease inhibitors in cancer
Q35927501	Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors
Q57327189	Targeted Genomic Screen Reveals Focal Long Non-Coding RNA Copy Number Alterations in Cancer Cell Lines
Q90599256	Targeted Next-Generation Sequencing Identifies Actionable Targets in Estrogen Receptor Positive and Estrogen Receptor Negative Endometriod Endometrial Cancer
Q40268278	Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma
Q27652488	Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
Q37956110	Targeted therapies: how personal should we go?
Q28382812	Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway
Q27852012	Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models
Q33750719	Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas
Q64254413	Targeting PI3K in cancer: mechanisms and advances in clinical trials
Q29617685	Targeting PI3K signalling in cancer: opportunities, challenges and limitations
Q38369369	Targeting PTEN using small molecule inhibitors
Q33554884	Targeting PTPs with small molecule inhibitors in cancer treatment
Q37718461	Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo
Q36184185	Targeting a common collaborator in cancer development
Q45885528	Targeting and killing of prostate cancer cells using lentiviral constructs containing a sequence recognized by translation factor eIF4E and a prostate-specific promoter.
Q36326247	Targeting cancer by binding iron: Dissecting cellular signaling pathways
Q37068767	Targeting genomic alterations in squamous cell lung cancer
Q37766475	Targeting mTOR in cancer: renal cell is just a beginning
Q39224420	Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma.
Q27022941	Targeting oncogenic ALK and MET: a promising therapeutic strategy for glioblastoma
Q36995054	Targeting prostate cancer based on signal transduction and cell cycle pathways.
Q39074281	Targeting protein kinase-b3 (akt3) signaling in melanoma
Q37132788	Targeting the Mammalian Target of Rapamycin (mTOR) in Cancer Therapy: Lessons from Past and Future Perspectives
Q37265126	Targeting the PI3-kinase/Akt/mTOR signaling pathway
Q38019609	Targeting the PI3K Pathway for Cancer Therapy
Q24647554	Targeting the PI3K signaling pathway in cancer
Q37975242	Targeting the PI3K signaling pathway in cancer therapy
Q37353968	Targeting the PI3K-AKT-mTOR signaling network in cancer
Q35571372	Targeting the PI3K-Akt pathway in human cancer: rationale and promise
Q26829652	Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies
Q36742629	Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations
Q35584560	Targeting the Phosphatidylinositol 3-Kinase Signaling Pathway in Breast Cancer
Q40154931	Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.
Q29615809	Targeting the phosphoinositide 3-kinase pathway in cancer
Q33558141	Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies
Q38157714	Targeting the protein-protein interaction between IRS1 and mutant p110α for cancer therapy
Q35563110	Targeting tumor cells by enhancing radiation sensitivity
Q36776310	Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases
Q44412390	Temporal variations in protein tyrosine kinase activity in leukaemic cells: response to all-trans retinoic acid
Q36497352	Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma
Q34302014	Tensin is potentially involved in extracellular matrix production in mesangial cells
Q24530395	Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration
Q35971862	The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis
Q36313171	The Akt of translational control
Q46845226	The Akt pathway in human breast cancer: a tissue-array-based analysis
Q36313193	The Akt/PKB pathway: molecular target for cancer drug discovery
Q40862061	The Akt/protein kinase B-dependent anti-apoptotic pathway and the mitogen-activated protein kinase cascade are alternatively activated in human glioblastoma multiforme
Q35469548	The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells
Q38166599	The Biological Role of PI3K Pathway in Lung Cancer
Q41730297	The Biology of Inherited Disorders of the Gastrointestinal Tract Part I: Gastrointestinal Disorders
Q28611339	The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
Q35939892	The Chaperone-assisted E3 Ligase C Terminus of Hsc70-interacting Protein (CHIP) Targets PTEN for Proteasomal Degradation
Q39043141	The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB.
Q21735922	The DNA sequence and comparative analysis of human chromosome 10
Q43848062	The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling
Q90663773	The FOXO's Advantages of Being a Family: Considerations on Function and Evolution
Q57113379	The Genomics of Prostate Cancer: A Historic Perspective
Q48317607	The Genomics of Prostate Cancer: emerging understanding with technologic advances
Q53596358	The HIV protease and PI3K/Akt inhibitor nelfinavir does not improve the curative effect of fractionated irradiation in PC-3 prostate cancer in vitro and in vivo
Q39199039	The High Mobility Group A proteins contribute to thyroid cell transformation by regulating miR-603 and miR-10b expression
Q38160734	The Interactions of microRNA and Epigenetic Modifications in Prostate Cancer
Q41715749	The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity
Q47920723	The Molecular Genetics of Endocrine Tumours
Q36137883	The Optimization of Soluble PTEN Expression in Escherichia coli
Q40507359	The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells
Q24632283	The PI3K pathway as drug target in human cancer
Q89586588	The PI3K pathway impacts stem gene expression in a set of glioblastoma cell lines
Q33770769	The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors
Q36413227	The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines
Q36137628	The PTEN Tumor Suppressor Forms Homodimers in Solution.
Q46025791	The PTEN inhibitor bisperoxovanadium enhances myelination by amplifying IGF-1 signaling in rat and human oligodendrocyte progenitors.
Q36396479	The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway
Q40805561	The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity
Q33828931	The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling
Q55341284	The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia.
Q34825957	The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network
Q34828662	The PTEN-PI3K pathway: of feedbacks and cross-talks
Q33599964	The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
Q24531835	The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
Q34229795	The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models
Q93182694	The PTEN⁻PI3K Axis in Cancer
Q37559086	The Par-4/PTEN connection in tumor suppression
Q83463374	The Protective Effect of Cu/Zn-SOD Against Oxidative Stress After PTEN Deletion
Q35208824	The RAS signal transduction pathway and its role in radiation sensitivity
Q34605237	The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia
Q41957358	The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord.
Q34106285	The Role of B-RAF Mutations in Melanoma and the Induction of EMT via Dysregulation of the NF-κB/Snail/RKIP/PTEN Circuit
Q38011345	The Role of IMiDs Alone or in Combination in Prostate Cancer
Q38121538	The Role of PTEN in β-Cell Growth
Q36289377	The Role of Semaphorins and Their Receptors in Gliomas
Q40744469	The SH2-containing inositol 5-phosphatase (SHIP)-1 is implicated in the control of cell-cell junction and induces dissociation and dispersion of MDCK cells
Q47620321	The Smad4/PTEN Expression Pattern Predicts Clinical Outcomes in Colorectal Adenocarcinoma
Q28507365	The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
Q28258708	The TriTryp phosphatome: analysis of the protein phosphatase catalytic domains
Q93081350	The Use of Genetically Engineered Mouse Models for Studying the Function of Mutated Driver Genes in Pancreatic Cancer
Q38482991	The acetyl-CoA carboxylase enzyme: a target for cancer therapy?
Q38370773	The activity of the androgen receptor variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way.
Q36758478	The akt kinase: molecular determinants of oncogenicity
Q40596882	The alteration of PTEN tumor suppressor expression and its association with the histopathological features of human primary hepatocellular carcinoma
Q41871255	The annual incidence of DiGeorge/velocardiofacial syndrome
Q39149568	The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells
Q33986252	The aryl hydrocarbon receptor (AhR) inhibits vanadate-induced vascular endothelial growth factor (VEGF) production in TRAMP prostates
Q37261822	The association of PTEN hypermethylation and breast cancer: a meta-analysis
Q26778641	The associations between Parkinson's disease and cancer: the plot thickens
Q91114591	The combination of PTEN deletion and 16p13.3 gain in prostate cancer provides additional prognostic information in patients treated with radical prostatectomy
Q34116818	The complexes of mammalian target of rapamycin.
Q35976355	The complexity of PTEN: mutation, marker and potential target for therapeutic intervention
Q47158683	The component formula of Salvia miltiorrhiza and Panax ginseng induces apoptosis and inhibits cell invasion and migration through targeting PTEN in lung cancer cells.
Q34103628	The contradictions of the insulin-like growth factor 1 receptor
Q58588298	The contrary functions of lncRNA HOTAIR/miR-17-5p/PTEN axis and Shenqifuzheng injection on chemosensitivity of gastric cancer cells
Q30365726	The determinants of head and neck cancer: Unmasking the PI3K pathway mutations
Q39051595	The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells
Q29615650	The development of androgen-independent prostate cancer
Q36158532	The differential diagnosis of familial lentiginosis syndromes
Q47215309	The eIF4E2-Directed Hypoxic Cap-Dependent Translation Machinery Reveals Novel Therapeutic Potential for Cancer Treatment
Q34187693	The effects of short-term genistein intervention on prostate biomarker expression in patients with localised prostate cancer before radical prostatectomy
Q29547302	The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Q94571981	The expression change of OTUD3-PTEN signaling axis in glioma cells
Q38274822	The expression profile for the tumour suppressor gene PTEN and associated polymorphic markers
Q28540259	The expression profile of phosphatidylinositol in high spatial resolution imaging mass spectrometry as a potential biomarker for prostate cancer
Q38148036	The function, mechanisms, and role of the genes PTEN and TP53 and the effects of asbestos in the development of malignant mesothelioma: a review focused on the genes' molecular mechanisms
Q29615536	The functions and regulation of the PTEN tumour suppressor
Q88955683	The functions and regulation of the PTEN tumour suppressor: new modes and prospects
Q39365663	The functions of tumor suppressor PTEN in innate and adaptive immunity
Q38088812	The future of targeted therapy approaches in melanoma.
Q28391635	The future role of personalized medicine in the treatment of glioblastoma multiforme
Q33536033	The genetic basis of breast cancer and its clinical implications
Q35190150	The genetics of malignant melanoma: lessons from mouse and man.
Q29614700	The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Q24617949	The genomic complexity of primary human prostate cancer
Q33883544	The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability
Q36892321	The hepatocyte growth factor antagonist NK4 inhibits indoleamine-2,3-dioxygenase expression via the c-Met-phosphatidylinositol 3-kinase-AKT signaling pathway
Q37805099	The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival
Q54112403	The impact of phosphatases on proliferative and survival signaling in cancer
Q22253881	The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis
Q34771536	The interplay of NR4A receptors and the oncogene-tumor suppressor networks in cancer
Q35447328	The lentiginoses: cutaneous markers of systemic disease and a window to new aspects of tumourigenesis
Q28588665	The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development
Q34906624	The linker pivot in Ci-VSP: the key to unlock catalysis
Q22007981	The lipid phosphatase activity of PTEN is critical for its tumor supressor function
Q24627306	The mTOR Signalling Pathway in Human Cancer
Q34886859	The mTOR signaling pathway as a treatment target for intracranial neoplasms
Q38809660	The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer.
Q30165214	The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migration.
Q42414110	The membrane targeted apoptosis modulators erucylphosphocholine and erucylphosphohomocholine increase the radiation response of human glioblastoma cell lines in vitro
Q42700734	The miR-486-5p plays a causative role in prostate cancer through negative regulation of multiple tumor suppressor pathways
Q34376079	The mitochondrial transporter SLC25A43 is frequently deleted and may influence cell proliferation in HER2-positive breast tumors
Q34770308	The molecular and genetic basis of neurological tumours
Q37290512	The molecular genetics of breast cancer and targeted therapy
Q47919422	The molecular genetics of central nervous system tumors
Q36659339	The molecular pathogenesis of head and neck squamous cell carcinoma
Q24652181	The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells.
Q33756968	The next wave: protein tyrosine phosphatases enter T cell antigen receptor signalling
Q38716615	The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.
Q34234737	The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
Q79635149	The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells
Q39697902	The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling
Q33906083	The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer.
Q29547860	The phosphatidylinositol 3-Kinase AKT pathway in human cancer
Q37454384	The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.
Q35684114	The physics of cancer: the role of physical interactions and mechanical forces in metastasis
Q37452295	The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
Q54791332	The presence of candidate tumor suppressor gene loci at chromosome 3p for oral squamous cell carcinomas.
Q24297392	The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
Q36476282	The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: miR-21 and promoter methylation
Q43276275	The protein tyrosine phosphatase receptor D, a broadly inactivated tumor suppressor regulating STAT function.
Q53386350	The random development of LOH on chromosome 9q in superficial bladder cancers
Q47103987	The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors
Q38090432	The regulatory roles of phosphatases in cancer
Q28075211	The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia
Q35250021	The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases.
Q37270446	The role of PTEN signaling perturbations in cancer and in targeted therapy
Q33774170	The role of PTEN tumor suppressor pathway staining in carcinoma in situ of the bladder.
Q37476789	The role of autophagy in sensitizing malignant glioma cells to radiation therapy
Q39030291	The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme
Q36695220	The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions
Q27021287	The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration
Q38271374	The role of polycomb repressive complexes in biliary tract cancer.
Q38055432	The role of promoter hypermethylation in fibroblast activation and fibrogenesis
Q40796029	The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line
Q37929371	The role of the phosphatidylinositol 3-kinase (PI3K) pathway in the development and treatment of uterine cancer
Q37270420	The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey
Q37889525	The skeleton: a multi-functional complex organ. New insights into osteoblasts and their role in bone formation: the central role of PI3Kinase
Q40420028	The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN.
Q43232449	The spectrum of vascular anomalies in patients with PTEN mutations: implications for diagnosis and management
Q27649316	The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
Q35225936	The structure of phosphoinositide phosphatases: Insights into substrate specificity and catalysis
Q42824022	The suitability and application of a GFP-actin fusion protein for long-term imaging of the organization and dynamics of the cytoskeleton in mammalian cells
Q28070264	The therapeutic potential of targeting the PI3K pathway in pediatric brain tumors
Q28141335	The transmembrane protein tyrosine phosphatase RPTPsigma modulates signaling of the epidermal growth factor receptor in A431 cells
Q38809889	The tumor suppressor PTEN has a critical role in antiviral innate immunity
Q48362692	The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells
Q24290417	The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation
Q40884595	The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes
Q40789651	The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
Q37465437	The tumor suppressor protein PTEN inhibits rat hepatic stellate cell activation
Q24317714	The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
Q22010498	The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region
Q24650856	The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization
Q58704993	The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten
Q39262217	Therapeutic Strategies for Targeting Ras Proteins
Q34061302	Therapeutic potential of targeting the oncogenic SHP2 phosphatase
Q38111449	Therapeutic targeting of EGFR-activated metabolic pathways in glioblastoma
Q27852764	Therapeutic targeting of cancers with loss of PTEN function
Q38042938	Therapeutic targeting of the phosphatidylinositol 3-kinase signaling pathway: novel targeted therapies and advances in the treatment of colorectal cancer
Q26749115	Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment
Q36629722	Thioredoxin and Thioredoxin Target Proteins: From Molecular Mechanisms to Functional Significance
Q36368481	Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells
Q39026764	Traditional Approaches to Molecular Genetic Analysis
Q40892936	Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressor
Q28141881	Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN
Q33558545	Transcriptional repression by RB-E2F and regulation of anchorage-independent survival
Q35154249	Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression
Q40243334	Transforming growth factor-beta promotes invasion in tumorigenic but not in nontumorigenic human prostatic epithelial cells.
Q90428516	Translation deregulation in human disease
Q49471057	Translational Advances in the Field of Pulmonary Hypertension. From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs
Q24813788	Treating breast cancer through novel inhibitors of the phosphatidylinositol 3'-kinase pathway
Q36191321	Treating metastatic soft-tissue or bone sarcomas - potential role of ridaforolimus
Q83787893	Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer
Q89666682	Triple-high expression of phosphatase and tensin homolog (PTEN), estrogen receptor (ER) and progesterone receptor (PR) may predict favorable prognosis for patients with Type I endometrial carcinoma
Q38259322	Triple-negative breast cancer: investigating potential molecular therapeutic target
Q24313221	Triplet Repeat-Containing Ribosomal Protein L14 Gene in Immortalized Human Endothelial Cell Line (t-HUE4)
Q41722868	Tumor Suppressing Pathways
Q38831320	Tumor Suppressors in Zebrafish: From TP53 to PTEN and Beyond
Q36143751	Tumor spectrum, tumor latency and tumor incidence of the Pten-deficient mice
Q40817321	Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway
Q35016068	Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau.
Q36256326	Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways
Q30479470	Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions
Q24618747	Tumor suppressors: enhancers or suppressors of regeneration?
Q34549952	Tumorigenesis facilitated by Pten deficiency in the skin: evidence of p53-Pten complex formation on the initiation phase
Q39402722	Tumour suppressor PTEN enhanced enzyme activity of GPx, SOD and catalase by suppression of PI3K/AKT pathway in non-small cell lung cancer cell lines
Q33939124	Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line
Q90391286	Tumour-intrinsic resistance to immune checkpoint blockade
Q33670203	Two MAD tails: what the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network
Q79803734	Two faces of PTEN
Q27315422	Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling
Q35788293	Tyrosine kinases expressed in vivo by human prostate cancer bone marrow metastases and loss of the type 1 insulin-like growth factor receptor
Q39377739	USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells
Q64970166	USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer.
Q24292946	Ubiquitination regulates PTEN nuclear import and tumor suppression
Q47300620	Ultra high-speed sorting
Q34694707	Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry
Q42211716	Unbiased identification of substrates of protein tyrosine phosphatase ptp-3 in C. elegans
Q92322223	Uncovering missed indels by leveraging unmapped reads
Q42712366	Understanding the stereospecific interactions of 3-deoxyphosphatidylinositol derivatives with the PTEN phosphatase domain
Q35763142	Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase.
Q37046419	Upregulated TRIM29 promotes proliferation and metastasis of nasopharyngeal carcinoma via PTEN/AKT/mTOR signal pathway
Q28114928	Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model
Q38322081	Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma
Q39859883	Upregulation of PTEN involved in scorpion venom-induced apoptosis in a lymphoma cell line
Q39260908	Upregulation of miR-153 promotes cell proliferation via downregulation of the PTEN tumor suppressor gene in human prostate cancer
Q43826002	Vanadate disrupts mammary gland development in whole organ culture
Q35889659	Variants on the promoter region of PTEN affect breast cancer progression and patient survival
Q33112684	Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism
Q49706476	Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells
Q42542192	Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia
Q24296637	Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation
Q28086901	Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research
Q21129281	Voltage-Controlled Enzymes: The New JanusBifrons
Q37847813	Voltage-Sensing Phosphatase: Its Molecular Relationship With PTEN
Q38991113	Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.
Q53810668	WWP2 is a physiological ubiquitin ligase for phosphatase and tensin homolog (PTEN) in mice
Q37588182	WWP2 is an E3 ubiquitin ligase for PTEN
Q39168132	What Is New in the miRNA World Regarding Osteosarcoma and Chondrosarcoma?
Q38098152	When Overgrowth Bumps Into Cancer: The PTEN-Opathies
Q51046620	When overgrowth bumps into cancer: the PTEN-opathies
Q53208402	Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma
Q27012684	Will kinase inhibitors make it as glioblastoma drugs?
Q28078957	Will targeting PI3K/Akt/mTOR signaling work in hematopoietic malignancies?
Q38125302	X-ray crystallography and NMR as tools for the study of protein tyrosine phosphatases
Q39268465	Xenotransplanted Human Prostate Carcinoma (DU145) Cells Develop into Carcinomas and Cribriform Carcinomas: Ultrastructural Aspects
Q47844055	Xq27-28 deletions in prostate carcinoma
Q39442177	ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo
Q47073952	Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development.
Q82623062	[Advances in molecular biology and their application in the diagnosis and treatment of melanoma]
Q84778493	[Translational approaches in cancer stem cell research]
Q21134582	arrayMap: a reference resource for genomic copy number imbalances in human malignancies
Q27649203	c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations
Q33956988	c-Myc target genes involved in cell growth, apoptosis, and metabolism
Q34438708	cMET Activation and EGFR-Directed Therapy Resistance in Triple-Negative Breast Cancer
Q34433952	dmGWAS: dense module searching for genome-wide association studies in protein-protein interaction networks
Q30160821	grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice
Q54546623	mTOR and PTEN expression in non-small cell lung cancer: analysis by real-time fluorescence quantitative polymerase chain reaction and immunohistochemistry
Q28268516	mTOR and cancer therapy
Q40407116	mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma
Q36919646	mTOR signalling in human cancer
Q37288437	miR-101 inhibits glioma cell invasion via the downregulation of COX-2.
Q46272050	miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages
Q40082134	miR-148a-3p overexpression contributes to glomerular cell proliferation by targeting PTEN in lupus nephritis
Q47380679	miR-20b promotes cellular proliferation and migration by directly regulating phosphatase and tensin homolog in prostate cancer
Q37359807	miR-21 Reduces Hydrogen Peroxide-Induced Apoptosis in c-kit+ Cardiac Stem Cells In Vitro through PTEN/PI3K/Akt Signaling.
Q42135508	miR-21 increases c-kit+ cardiac stem cell proliferation in vitro through PTEN/PI3K/Akt signaling
Q47140406	miR-21 is involved in transforming growth factor β1-induced chemoresistance and invasion by targeting PTEN in breast cancer
Q49852741	miR-21a negatively modulates tumor suppressor genes PTEN and miR-200c and further promotes the transformation of M2 macrophages
Q33856653	miR-34a functions as a tumor suppressor modulating EGFR in glioblastoma multiforme
Q38803162	miR-367 promotes proliferation and invasion of hepatocellular carcinoma cells by negatively regulating PTEN.
Q98159092	miR-494 promotes progression of retinoblastoma via PTEN through PI3K/AKT signaling pathway
Q35770894	miR-494-3p Regulates Cellular Proliferation, Invasion, Migration, and Apoptosis by PTEN/AKT Signaling in Human Glioblastoma Cells
Q43416243	miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma.
Q38735816	miR-543 is up-regulated in gefitinib-resistant non-small cell lung cancer and promotes cell proliferation and invasion via phosphatase and tensin homolog
Q40328958	miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN).
Q93140672	miR-92a-3p promotes the proliferation, migration and invasion of esophageal squamous cell cancer by regulating PTEN
Q100386591	miRNA-216 knockdown has effects to suppress osteosarcoma via stimulating PTEN
Q64113722	miRNA-221 promotes cutaneous squamous cell carcinoma progression by targeting PTEN
Q90438534	microRNA-875-5p plays critical role for mesenchymal condensation in epithelial-mesenchymal interaction during tooth development
Q54765421	p53 and PTEN/MMAC1 mutational analysis of the small-intestinal cancer.
Q39820138	p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.
Q33558237	sCNAphase: using haplotype resolved read depth to genotype somatic copy number alterations from low cellularity aneuploid tumors
Q39545547	α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells
Q47625421	δ-Tocopherol inhibits the development of prostate adenocarcinoma in prostate specific Pten-/- mice
Q50943486	“Immunocytochemical expression of P53, PTEN, FAS (CD95), P16INK4A and HPV L1 major capsid proteins in ThinPrep cervical samples with squamous intraepithelial lesions”

P356	DOI	10.1126/SCIENCE.275.5308.1943
P3181	OpenCitations bibliographic resource ID	168581
P698	PubMed publication ID	9072974
P5875	ResearchGate publication ID	14139778

P2093	author name string	J Li
		L Rodgers
		R Parsons
		B Tycko
		S H Bigner
		S Bose
		M H Wigler
		M Ittmann
		D Liaw
		S I Wang
		C Yen
		B C Giovanella
		J Puc
		H Hibshoosh
		K Podsypanina
		C Miliaresis
		R McCombie
P433	issue	5308
P407	language of work or name	English	Q1860
P921	main subject	brain	Q1073
		prostate cancer	Q181257
P304	page(s)	1943-7
P577	publication date	1997-03-28
P1433	published in	Science	Q192864
P1476	title	PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
P478	volume	275

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

scientific article (publication date: 28 March 1997)

Reverse relations