PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis

scientific article published on July 2001

PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0002-9440(10)61702-6
P932PMC publication ID1850425
P698PubMed publication ID11438483

P50authorJ Gregory CairncrossQ114727084
Rebecca BetenskyQ42290664
P2093author name stringH Sasaki
D N Louis
Y Ino
M C Zlatescu
P2860cites workDMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumoursQ24310338
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor betaQ24310394
Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase IIQ24314310
Molecular analysis of mutations in the CSB (ERCC6) gene in patients with Cockayne syndromeQ24538671
Lack of DMBT1 expression in oesophageal, gastric and colon cancersQ24650252
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane associationQ27620298
PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.Q55476772
Molecular analysis of two putative tumour suppressor genes, PTEN and DMBT, which have been implicated in glioblastoma multiforme disease progression.Q55477358
Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades.Q55477778
Frequent inactivation of PTEN/MMAC1 in primary prostate cancerQ57240096
DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancerQ57326209
Frequency of homozygous deletion at p16/CDKN2 in primary human tumoursQ71721193
MTS1/CDKN2 gene mutations are rare in primary human astrocytomas with allelic loss of chromosome 9pQ72529989
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Alterations in the CSB gene in three Italian patients with the severe form of Cockayne syndrome (CS) but without clinical photosensitivityQ28141024
Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21Q28182048
ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genesQ28213725
MMAC1/PTEN mutations in primary tumor specimens and tumor cell linesQ28256046
A highly conserved processed PTEN pseudogene is located on chromosome band 9p21Q28273178
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predispositionQ28585729
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayQ29616144
Mutation nomenclature extensions and suggestions to describe complex mutations: a discussionQ29616531
The multiple roles of PTEN in tumor suppressionQ33849727
The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instabilityQ33883544
Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis.Q33942929
Chemotherapy for anaplastic oligodendroglioma. National Cancer Institute of Canada Clinical Trials GroupQ34059674
Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.Q34313328
Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridizationQ35787686
Deletion mapping of gliomas suggest the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q.Q36801269
A (CA)n dinucleotide repeat assay for evaluating loss of allelic heterozygosity in small and archival human brain tumor specimens.Q38487094
A tiger behind many doors: multiple genetic pathways to malignant gliomaQ40372189
Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancerQ40959040
Allelic deletion analyses of MMAC/PTEN and DMBT1 loci in gliomas: relationship to prognostic significance.Q44043105
PTEN gene mutations are seen in high-grade but not in low-grade gliomas.Q44846579
MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cellsQ45872881
Suppression of tumor growth in vivo by local and systemic 90K level increaseQ46143007
PTEN mutations in gliomas and glioneuronal tumors.Q47995275
Successful chemotherapy for recurrent malignant oligodendrogliomaQ48090619
Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtypeQ48144051
Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.Q48230264
Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlationsQ48252490
Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomasQ48374829
Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.Q48544624
Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q.Q48566471
Somatic mutations of PTEN in glioblastoma multiformeQ48618632
New deletion in low-grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26.Q48636243
Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomasQ48755711
Malignant astrocytomas with homozygous CDKN2/p16 gene deletions have higher Ki-67 proliferation indicesQ48910147
PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics.Q53427839
Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations.Q55476256
Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.Q55476495
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectoligodendrogliomaQ1318384
P304page(s)359-367
P577publication date2001-07-01
P1433published inThe American Journal of PathologyQ4744259
P1476titlePTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis
P478volume159

Reverse relations

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