| P2093 | author name string | Dean M | |
| | Ali IU | |
| | Schriml LM | |
| P2860 | cites work | The lipid phosphatase activity of PTEN is critical for its tumor supressor function | Q22007981 |
| | DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours | Q24310338 |
| | Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. | Q42824933 |
| | Variant manifestation of Cowden disease in Japan: hamartomatous polyposis of the digestive tract with mutation of the PTEN gene | Q43218218 |
| | Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation | Q45345194 |
| | Mutations in the SMAD4/DPC4 gene in juvenile polyposis | Q45345229 |
| | Microsatellite instability in sporadic endometrial carcinoma | Q46250416 |
| | Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers | Q47709471 |
| | Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma | Q47712787 |
| | PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers | Q47720095 |
| | Distinct regions of allelic imbalance on chromosome 10q22-q26 in squamous cell carcinomas of the lung | Q47720136 |
| | PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas | Q47740646 |
| | Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma | Q47751177 |
| | Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas | Q47775705 |
| | PTEN/MMAC1/TEP1 involvement in primary prostate cancers. | Q47814101 |
| | Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas | Q47814647 |
| | PTEN and inherited hamartoma-cancer syndromes | Q47852476 |
| | p53 and PTEN gene mutations in gemistocytic astrocytomas | Q47895044 |
| | PTEN mutations in gliomas and glioneuronal tumors. | Q47995275 |
| | Germline mutations in PTEN are present in Bannayan-Zonana syndrome | Q48046915 |
| | Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations | Q48252490 |
| | Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles | Q48379390 |
| | The genetic basis of Cowden's syndrome: three novel mutations in PTEN/MMAC1/TEP1. | Q48463636 |
| | Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation | Q48555134 |
| | Alteration of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado. | Q53466245 |
| | Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades. | Q55477778 |
| | PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas. | Q55477977 |
| | PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies | Q57591287 |
| | High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice | Q58378937 |
| | The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 |
| | Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN | Q24322051 |
| | P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 |
| | PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 |
| | PTEN1 is frequently mutated in primary endometrial carcinomas | Q28250937 |
| | Phosphatases and tumorigenesis | Q28261948 |
| | Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 |
| | Pten is essential for embryonic development and tumour suppression | Q28509238 |
| | Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 |
| | Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems | Q28586004 |
| | Mutation in the mismatch repair gene Msh6 causes cancer susceptibility | Q28592583 |
| | The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway | Q28611339 |
| | Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome | Q29615538 |
| | New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway | Q29616144 |
| | PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells | Q33586807 |
| | Lhermitte-Duclos disease as a component of Cowden's syndrome. Case report and review of the literature | Q33588498 |
| | PTEN: a tumour suppressor that functions as a phospholipid phosphatase | Q33594251 |
| | The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway | Q33599964 |
| | Cowden syndrome and Lhermitte-Duclos disease in a family: a single genetic syndrome with pleiotropy? | Q33674349 |
| | Cowden syndrome | Q33675760 |
| | A gene for familial juvenile polyposis maps to chromosome 18q21.1. | Q34385458 |
| | p53 and APC gene mutations: software and databases | Q34622913 |
| | Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. | Q34742581 |
| | Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene | Q35063217 |
| | The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases. | Q35250021 |
| | Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis | Q35250337 |
| | Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression | Q36067596 |
| | In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma | Q36260162 |
| | Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas. | Q36619048 |
| | Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain | Q36818855 |
| | Identification of a novel PTEN mutation (L139X) in a patient with Cowden disease and Sjögren's syndrome. | Q37641635 |
| | Frameshift mutation: determinants of specificity | Q37794682 |
| | A tiger behind many doors: multiple genetic pathways to malignant glioma | Q40372189 |
| | The coordinated action of protein tyrosine phosphatases and kinases in cell signaling | Q40592852 |
| | Mechanisms and consequences of activation of protein kinase B/Akt | Q41751003 |
| | Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines | Q42818580 |
| P433 | issue | 22 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1922-1932 | |
| P577 | publication date | 1999-11-01 | |
| P1433 | published in | Journal of the National Cancer Institute | Q400279 |
| P1476 | title | Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity | |
| P478 | volume | 91 | |