| scholarly article | Q13442814 |
| P50 | author | Michael Wigler | Q6835334 |
| Charis Eng | Q37385393 | ||
| P2093 | author name string | J Li | |
| N K Tonks | |||
| R Parsons | |||
| M P Myers | |||
| S I Wang | |||
| J P Stolarov | |||
| P2860 | cites work | Hyperexpression of mitogen-activated protein kinase in human breast cancer | Q37365431 |
| Cowden syndrome (multiple hamartoma syndrome). | Q40504443 | ||
| Protein tyrosine phosphatases take off. | Q41143264 | ||
| Biochemical characterization of a human band 4.1-related protein-tyrosine phosphatase, PTPH1. | Q41308546 | ||
| Allelotype of human malignant astrocytoma | Q48897234 | ||
| Bannayan-Riley-Ruvalcaba syndrome | Q67509446 | ||
| Protein phosphatases | Q71372651 | ||
| Cowden Syndrome | Q85527281 | ||
| Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo | Q24305924 | ||
| TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta | Q24310394 | ||
| Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases | Q24323070 | ||
| Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR | Q24556532 | ||
| Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. | Q24647903 | ||
| Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate | Q27730850 | ||
| Crystal structure of human protein tyrosine phosphatase 1B | Q27731235 | ||
| Crystal structure of the dual specificity protein phosphatase VHR | Q27732778 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
| PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth | Q28571339 | ||
| A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation | Q28581888 | ||
| MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo | Q29615244 | ||
| Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome | Q29615538 | ||
| Cowden syndrome and Lhermitte-Duclos disease in a family: a single genetic syndrome with pleiotropy? | Q33674349 | ||
| Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation | Q34050342 | ||
| Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene | Q34335557 | ||
| Comparative genomic analysis of tumors: detection of DNA losses and amplification | Q34816301 | ||
| 1002 protein phosphatases? | Q35237461 | ||
| The dual-specificity CLK kinase induces neuronal differentiation of PC12 cells | Q36668257 | ||
| Expression of 9E3 mRNA is associated with mitogenicity, phosphorylation, and morphological alteration in chicken embryo fibroblasts | Q36717089 | ||
| P433 | issue | 17 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Phosphatase and tensin homolog | Q416356 |
| protein dephosphorylation | Q14863383 | ||
| P304 | page(s) | 9052-9057 | |
| P577 | publication date | 1997-08-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | |
| P478 | volume | 94 |
| Q28583186 | 17 Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats |
| Q33965618 | 5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells |
| Q28585516 | A PTEN-like phosphatase with a novel substrate specificity |
| Q24632651 | A coding-independent function of gene and pseudogene mRNAs regulates tumour biology |
| Q24320313 | A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes |
| Q24336385 | A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast |
| Q92121461 | A meta-analysis of multiple matched aCGH/expression cancer datasets reveals regulatory relationships and pathway enrichment of potential oncogenes |
| Q44188511 | A new insight into structural and functional impact of single-nucleotide polymorphisms in PTEN gene |
| Q34099246 | A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells |
| Q36763145 | A recessive form of extreme macrocephaly and mild intellectual disability complements the spectrum of PTEN hamartoma tumour syndrome |
| Q29568319 | A role for nuclear PTEN in neuronal differentiation. |
| Q40184782 | A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth |
| Q44170741 | A tumor suppressor homolog, AtPTEN1, is essential for pollen development in Arabidopsis |
| Q34694344 | A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas |
| Q45869247 | Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo |
| Q34013783 | Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinase |
| Q36313185 | Akt-regulated pathways in prostate cancer |
| Q33740171 | Allele-specific tumor spectrum in pten knockin mice |
| Q48555134 | Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation |
| Q36622783 | Allelic loss of 10q23, the PTEN tumour suppressor gene locus, in Barrett's oesophagus-associated adenocarcinoma |
| Q36973814 | Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy |
| Q78201434 | Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis |
| Q40836678 | Alternative splicing of the human PTEN/MMAC1/TEP1 gene |
| Q40488966 | Amiloride augments TRAIL-induced apoptotic death by inhibiting phosphorylation of kinases and phosphatases associated with the P13K-Akt pathway |
| Q36790955 | An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias |
| Q60961798 | Analysis of PTEN expression and promoter methylation in Uyghur patients with mild type 2 diabetes mellitus |
| Q34729972 | Analysis of PTEN methylation patterns in soft tissue sarcomas by MassARRAY spectrometry |
| Q36618853 | Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma. |
| Q57591296 | Analysis of the PTEN gene in human meningiomas |
| Q38314871 | Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase |
| Q74428342 | Anti-phosphatases take the stage |
| Q36512334 | Antigen-induced Pten gene deletion in T cells exacerbates neuropathology in experimental autoimmune encephalomyelitis |
| Q36965370 | Applications of emerging molecular technologies in glioblastoma multiforme |
| Q41740974 | Assaying PTEN catalysis in vitro |
| Q77647988 | Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinomas and hyperplasias |
| Q57591248 | Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes |
| Q44350476 | BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels |
| Q28209463 | Biochemical signals and biological responses elicited by the focal adhesion kinase |
| Q35576526 | Brain tumours: classification and genes |
| Q35019216 | CREB is a novel nuclear target of PTEN phosphatase |
| Q58555035 | CRISPR-Cas9 human gene replacement and phenomic characterization in to understand the functional conservation of human genes and decipher variants of uncertain significance |
| Q41739799 | Cancer predisposition: where's the phosphate? |
| Q24295164 | Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function |
| Q36876219 | Capillary Isoelectric Focusing of Akt Isoforms Identifies Highly Dynamic Phosphorylation in Neuronal Cells and Brain Tissue |
| Q39400607 | Cell cycle arrest and apoptosis by expression of a novel TPIP (TPIP-C2) cDNA encoding a C2-domain in HEK-293 cells |
| Q34983621 | Cellular mechanisms targeted during astrocytoma progression |
| Q42739658 | Characterization of cryptic splicing in germline PTEN intronic variants in Cowden syndrome |
| Q89371453 | Cholesterol Peroxidation as a Special Type of Lipid Oxidation in Photodynamic Systems |
| Q34180660 | Combinatorial control of the specificity of protein tyrosine phosphatases |
| Q35882137 | Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy |
| Q101356242 | Comprehensive in silico mutational-sensitivity analysis of PTEN establishes signature regions implicated in pathogenesis of Autism Spectrum Disorders |
| Q90047400 | Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer |
| Q79098518 | Constipation, polyps, or cancer? let PTEN predict your future |
| Q36360863 | Correction of PTEN mutations in glioblastoma cell lines via AAV-mediated gene editing |
| Q36847305 | Cowden syndrome-related mutations in PTEN associate with enhanced proteasome activity |
| Q27620298 | Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association |
| Q35931063 | Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm |
| Q38885442 | Defective phosphoinositide metabolism in autism |
| Q33949063 | Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor |
| Q34373594 | Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities |
| Q35770177 | Development of novel targeted therapies in the treatment of malignant glioma |
| Q35586140 | Diagnosis of premalignant endometrial disease |
| Q33895317 | Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons |
| Q35915549 | Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development |
| Q35810225 | Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors |
| Q28203697 | Direct identification of PTEN phosphorylation sites |
| Q34658356 | Distinct expression profiles for PTEN transcript and its splice variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome. |
| Q38341405 | Doubles Game: Src-Stat3 versus p53-PTEN in Cellular Migration and Invasion |
| Q35435345 | Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines |
| Q40615729 | Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop. |
| Q40709512 | Downregulation of PTEN/MMAC/TEP1 expression in human prostate cancer cell line DU145 by growth stimuli |
| Q30829981 | Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway |
| Q29568322 | Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN. |
| Q53829615 | Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes. |
| Q42722759 | Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells |
| Q40268565 | Effects of cotransfection of antisense-EGFR and wild-type PTEN cDNA on human glioblastoma cells |
| Q44605250 | Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt. |
| Q40440548 | Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypox |
| Q37708388 | Establishment of a novel cellular model for myxofibrosarcoma heterogeneity |
| Q22253866 | Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2 |
| Q42701298 | Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors |
| Q43202044 | Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome |
| Q40152687 | Exogenous PTEN gene induces apoptosis in breast carcinoma cell line MDA468. |
| Q36179908 | Expression of PTEN, PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues |
| Q89998115 | Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling |
| Q39457088 | Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. |
| Q48154511 | Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines |
| Q34194118 | Functional analysis of the protein phosphatase activity of PTEN |
| Q48306512 | Functional and molecular analyses of 10q deletions in human gliomas |
| Q36325637 | Gene Expression and Correlation of Pten and Fabp4 in Liver, Muscle, and Adipose Tissues of Type 2 Diabetes Rats. |
| Q37955107 | Genetic alterations of PTEN in human melanoma |
| Q35117832 | Genetic alterations of human brain tumors as molecular prognostic factors |
| Q27666122 | Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITOR |
| Q37270416 | Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome. |
| Q26741013 | Genetic basis of Cowden syndrome and its implications for clinical practice and risk management |
| Q34783505 | Genetic insights into familial cancers-- update and recent discoveries |
| Q35757144 | Genetic pathways to primary and secondary glioblastoma |
| Q57720217 | Genetics of Pten Hamartoma Tumor Syndrome (PHTS) |
| Q44958045 | Genomic predictors of prostate cancer therapy outcomes |
| Q33681468 | Germline PTEN mutations in Cowden syndrome-like families. |
| Q36096600 | Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death |
| Q35700587 | Glutamate signaling to Ras-MAPK in striatal neurons: mechanisms for inducible gene expression and plasticity |
| Q90407605 | Gq/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR |
| Q36261980 | Growth stimulation of primary B cell precursors by the anti-phosphatase Sbf1. |
| Q36818855 | Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain |
| Q73410694 | Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues |
| Q47977695 | Higher plant tyrosine-specific protein phosphatases (PTPs) contain novel amino-terminal domains: expression during embryogenesis |
| Q35868041 | Highly penetrant hereditary cancer syndromes. |
| Q51825686 | Homozygous 10q23/PTEN deletion and its impact on outcome in glioblastoma: a prospective translational study on a uniformly treated cohort of adult patients. |
| Q41835165 | Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner |
| Q35435625 | Identification of PTEN mutations in metastatic melanoma specimens |
| Q45858964 | Identification of PTEN-related sequences in glioma cells and in non-neoplastic cell lines |
| Q24650927 | Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway |
| Q30884393 | Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4. |
| Q34109986 | Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation |
| Q38308779 | Immunohistochemical assessment of PTEN in vulvar cancer: best practices for tissue staining, evaluation, and clinical association. |
| Q61816328 | Impact of p85α Alterations in Cancer |
| Q55515829 | In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself. |
| Q36260162 | In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma |
| Q40838626 | Inactivation of MMAC1 in bladder transitional-cell carcinoma cell lines and specimens |
| Q48464018 | Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers |
| Q36067596 | Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression |
| Q34572332 | Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo |
| Q38744353 | Induction of Multidrug Resistance of Acute Myeloid Leukemia Cells by Cocultured Stromal Cells via Upregulation of the PI3K/Akt Signaling Pathway |
| Q35043420 | Induction of apoptosis in cancer: new therapeutic opportunities |
| Q92085285 | Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair |
| Q40173368 | Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN. |
| Q28344025 | Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells |
| Q37351516 | Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells |
| Q22253438 | Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase |
| Q98782026 | Lens fiber cell differentiation occurs independently of fibroblast growth factor receptor signaling in the absence of Pten |
| Q36899760 | Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin |
| Q24653934 | Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer |
| Q24797910 | Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor |
| Q77995588 | Loss of heterozygosity at 10q in tumors of the upper respiratory tract is associated with poor prognosis |
| Q36386464 | Loss of stromal androgen receptor leads to suppressed prostate tumourigenesis via modulation of pro-inflammatory cytokines/chemokines |
| Q40464853 | Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors. |
| Q24294392 | MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells |
| Q61818162 | Mathematical Modeling Highlights the Complex Role of AKT in TRAIL-Induced Apoptosis of Colorectal Carcinoma Cells |
| Q37917655 | MicroRNAs involved in the EGFR/PTEN/AKT pathway in gliomas |
| Q33771748 | Modulation of cellular apoptotic potential: contributions to oncogenesis |
| Q46396119 | Modulation of specific protein expression levels by PTEN: identification of AKAP121, DHFR, G3BP, Rap1, and RCC1 as potential targets of PTEN. |
| Q24290779 | Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B |
| Q36261402 | Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis |
| Q43955971 | Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity |
| Q40568043 | Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin |
| Q40895282 | Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia |
| Q55517824 | Mutation analysis of the PTEN / MMAC1 gene in Japanese patients with Cowden disease. |
| Q73008420 | Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract |
| Q73271272 | Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas |
| Q37642623 | Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas |
| Q47752292 | Mutational analysis of the TrkA gene in prostate cancer |
| Q33774967 | Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity |
| Q94521960 | Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity |
| Q36066328 | Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8. |
| Q28384823 | NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration |
| Q24630479 | Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein |
| Q28513537 | Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN |
| Q90597792 | Neurobehavioral phenotype of autism spectrum disorder associated with germline heterozygous mutations in PTEN |
| Q29616144 | New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway |
| Q38180461 | Non-receptor protein tyrosine kinases signaling pathways in normal and cancer cells |
| Q28393163 | Novel germline mutations in the PTEN tumour suppressor gene found in women with multiple cancers |
| Q28242514 | Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis |
| Q38652498 | Oncogenic PTEN functions and models in T-cell malignancies |
| Q35838821 | Oncogenic activation in prostate cancer progression and metastasis: Molecular insights and future challenges |
| Q24318882 | PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes |
| Q42085841 | PNUTS functions as a proto-oncogene by sequestering PTEN |
| Q92883870 | PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage |
| Q46395242 | PTEN Regulates Glucose Transporter Recycling by Impairing SNX27 Retromer Assembly |
| Q34202681 | PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control |
| Q92316075 | PTEN Tumor-Suppressor: The Dam of Stemness in Cancer |
| Q34180652 | PTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench |
| Q40188768 | PTEN and p16 genes as epigenetic biomarkers in oral squamous cell carcinoma (OSCC): a study on south Indian population |
| Q39900126 | PTEN and rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway |
| Q28217868 | PTEN associates with the vault particles in HeLa cells |
| Q35282160 | PTEN controls tumor-induced angiogenesis |
| Q39201094 | PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells |
| Q22254699 | PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1 |
| Q33765703 | PTEN gene and integrin signaling in cancer |
| Q55476772 | PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. |
| Q51597378 | PTEN gene: a model for genetic diseases in dermatology. |
| Q37139779 | PTEN in brain tumors |
| Q43701623 | PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression |
| Q92890429 | PTEN interacts with RNA polymerase II to dephosphorylate polymerase II C-terminal domain |
| Q42727150 | PTEN interacts with metal-responsive transcription factor 1 and stimulates its transcriptional activity |
| Q45904675 | PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer. |
| Q28239790 | PTEN is a protein tyrosine phosphatase for IRS1 |
| Q30360337 | PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7. |
| Q40125775 | PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney |
| Q28588309 | PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway |
| Q92286999 | PTEN modulates gene transcription by redistributing genome-wide RNA polymerase II occupancy |
| Q55475660 | PTEN mutation analysis in two genetic subtypes of high-grade oligodendroglial tumors. PTEN is only occasionally mutated in one of the two genetic subtypes. |
| Q34504165 | PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome |
| Q28482319 | PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development |
| Q34248383 | PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry |
| Q54674580 | PTEN promoter methylation and protein expression in normal early placentas and hydatidiform moles. |
| Q39388363 | PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity |
| Q28267704 | PTEN regulates cilia through Dishevelled |
| Q28202778 | PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow |
| Q27011088 | PTEN regulation of ERK1/2 signaling in cancer |
| Q40755882 | PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. |
| Q37270423 | PTEN signaling in brain: neuropathology and tumorigenesis. |
| Q35146572 | PTEN signaling pathways in melanoma |
| Q98164389 | PTEN suppresses epithelial-mesenchymal transition and cancer stem cell activity by downregulating Abi1 |
| Q54411913 | PTEN suppression promotes neurite development exclusively in differentiating PC12 cells via PI3‐kinase and MAP kinase signaling |
| Q78026206 | PTEN transcriptionally modulates c-myc gene expression in human breast carcinoma cells and is involved in cell growth regulation |
| Q40911230 | PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein. |
| Q39584451 | PTEN's regulation of VEGF and VEGFR1 expression and its clinical significance in myeloid leukemia |
| Q48548992 | PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3. |
| Q36753139 | PTEN, more than the AKT pathway |
| Q37955889 | PTEN-Associated Complexes: An Overview. |
| Q39247664 | PTEN/MAPK pathways play a key role in platelet-activating factor-induced experimental pulmonary tumor metastasis |
| Q73739349 | PTEN/MMAC1 in malignant melanoma and its importance for tumor progression |
| Q48203168 | PTEN/MMAC1 mutations in hepatocellular carcinomas |
| Q48190895 | PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors |
| Q33586807 | PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells |
| Q34540849 | PTEN: The down side of PI 3-kinase signalling. |
| Q37270432 | PTEN: a new guardian of the genome. |
| Q28203387 | PTEN: one gene, many syndromes |
| Q43104730 | PTEN: sometimes taking it off can be better than putting it on. |
| Q35203208 | PTEN: tumour suppressor, multifunctional growth regulator and more |
| Q57590810 | PTENHamartoma Tumor Syndrome |
| Q74290133 | Papillary carcinoma occurring within an adenomatous goiter of the thyroid gland in Cowden's disease |
| Q35925866 | Papillary renal cell carcinoma is associated with PTEN hamartoma tumor syndrome |
| Q40323743 | Peroxisome proliferator-activated receptor-gamma inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells |
| Q41529383 | Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury |
| Q30273891 | Pharmacological targeting of the mitochondrial phosphatase PTPMT1. |
| Q40972780 | Phenotypic analysis of human glioma cells expressing the MMAC1 tumor suppressor phosphatase |
| Q40854521 | Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells |
| Q40436436 | Phosphatase and Tensin Homolog Is a Growth Repressor of Both Rhizoid and Gametophore Development in the Moss Physcomitrella patens. |
| Q33864068 | Phosphatase and tensin homologue growth suppression without phosphatase |
| Q41164638 | Phosphatidylinositol 3-kinase signaling determines kidney size |
| Q64967349 | Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica. |
| Q38572786 | Phosphatidylinositolphosphate phosphatase activities and cancer |
| Q33862413 | Phosphoinositide phosphatases in cell biology and disease |
| Q27012953 | Phosphoinositides: tiny lipids with giant impact on cell regulation |
| Q40432782 | Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified. |
| Q24317335 | Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN |
| Q44467149 | Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions |
| Q24311116 | Physical association of GPR54 C-terminal with protein phosphatase 2A |
| Q40435447 | Phytoestrogen exposure elevates PTEN levels |
| Q24533977 | Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt |
| Q39652476 | Polymorphisms in Promoter Sequences of the p15 INK4B and PTEN Genes of Normal Japanese Individuals |
| Q27851999 | Predicting everolimus treatment efficacy in patients with advanced endometrial carcinoma: a GINECO group study. |
| Q30495389 | Prediction of sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements |
| Q40857263 | Profiling the downstream genes of tumor suppressor PTEN in lung cancer cells by complementary DNA microarray |
| Q43918868 | Promoter methylation and silencing of PTEN in gastric carcinoma |
| Q24613810 | Protean PTEN: form and function |
| Q42824933 | Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. |
| Q24604987 | Protein kinases and phosphatases in the control of cell fate |
| Q35146110 | Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation |
| Q53415824 | Protein tyrosine phosphatase epsilon increases the risk of mammary hyperplasia and mammary tumors in transgenic mice. |
| Q37638344 | Protein tyrosine phosphatases in glioma biology |
| Q24622527 | Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction |
| Q24677034 | PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration |
| Q34420665 | RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. |
| Q36009774 | Rapid isolation of cDNA by hybridization |
| Q40919390 | Rare-type mutations of MMAC1 tumor suppressor gene in human glioma cell lines and their tumors of origin |
| Q39540211 | Rat protein tyrosine phosphatase eta suppresses the neoplastic phenotype of retrovirally transformed thyroid cells through the stabilization of p27(Kip1). |
| Q33755023 | Redox Regulation of the Tumor Suppressor PTEN by Hydrogen Peroxide and Tert-Butyl Hydroperoxide |
| Q34623471 | Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets |
| Q37073431 | Redox regulation of interleukin-4 signaling |
| Q34827639 | Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteries |
| Q36643707 | Reduced PTEN expression in the pancreas overexpressing transforming growth factor-beta 1. |
| Q24653458 | Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway |
| Q34488136 | Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. |
| Q77342895 | Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN |
| Q44895310 | Regulation of hypoxia inducible factor-1 by nitric oxide in contrast to hypoxia in microvascular endothelium |
| Q35063217 | Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene |
| Q36995391 | Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium. |
| Q34724089 | Role of CXCL1 in tumorigenesis of melanoma. |
| Q42452984 | Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells |
| Q46098024 | S-nitrosylation of PTEN Invovled in ischemic brain injury in rat hippocampal CA1 region |
| Q36655495 | SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation |
| Q36830062 | Saturated Fatty Acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10. |
| Q74528947 | Severe Lhermitte-Duclos disease with unique germline mutation of PTEN |
| Q30494717 | Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells. |
| Q36301565 | Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. |
| Q38334794 | Signaling mechanisms regulating B-lymphocyte activation and tolerance |
| Q28141934 | Signalling through phosphoinositide 3-kinases: the lipids take centre stage |
| Q57591241 | Silencing of thePTENtumor-suppressor gene in anaplastic thyroid cancer |
| Q48379390 | Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles |
| Q34768898 | Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases |
| Q30391301 | Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer |
| Q39774233 | Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN. |
| Q35010842 | Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene |
| Q45881488 | Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN. |
| Q74608375 | Suppression of tumorigenicity and metastasis in B16F10 cells by PTEN/MMAC1/TEP1 gene |
| Q92957648 | Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers |
| Q37223362 | Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase |
| Q37713988 | TIEG1 deficiency confers enhanced myocardial protection in the infarcted heart by mediating the Pten/Akt signalling pathway |
| Q42061434 | TOPK and PTEN participate in CHFR mediated mitotic checkpoint |
| Q28364566 | TPIP: a novel phosphoinositide 3-phosphatase |
| Q51577103 | Tailor-Made Protein Tyrosine Phosphatases: In Vitro Site-Directed Mutagenesis of PTEN and PTPRZ-B. |
| Q28343581 | Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions |
| Q34432885 | Ten years of protein kinase B signalling: a hard Akt to follow |
| Q90215531 | The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells |
| Q91826180 | The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic Response |
| Q41715749 | The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity |
| Q36413227 | The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines |
| Q36396479 | The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway |
| Q33828931 | The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling |
| Q33599964 | The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway |
| Q42481082 | The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells |
| Q34229795 | The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models |
| Q93182694 | The PTEN⁻PI3K Axis in Cancer |
| Q37559086 | The Par-4/PTEN connection in tumor suppression |
| Q91114591 | The combination of PTEN deletion and 16p13.3 gain in prostate cancer provides additional prognostic information in patients treated with radical prostatectomy |
| Q35976355 | The complexity of PTEN: mutation, marker and potential target for therapeutic intervention |
| Q33816356 | The critical role of AKT2 in hepatic steatosis induced by PTEN loss |
| Q38274822 | The expression profile for the tumour suppressor gene PTEN and associated polymorphic markers |
| Q29615536 | The functions and regulation of the PTEN tumour suppressor |
| Q88955683 | The functions and regulation of the PTEN tumour suppressor: new modes and prospects |
| Q81241238 | The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans |
| Q28269344 | The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity |
| Q22007981 | The lipid phosphatase activity of PTEN is critical for its tumor supressor function |
| Q34770308 | The molecular and genetic basis of neurological tumours |
| Q39697902 | The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling |
| Q52431051 | The phosphatase PTPL1 is required for PTEN-mediated regulation of apical membrane size. |
| Q36150234 | The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions. |
| Q30156949 | The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation |
| Q34656554 | The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death |
| Q41840314 | The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN. |
| Q37123801 | The role and target potential of protein tyrosine phosphatases in cancer |
| Q27021287 | The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration |
| Q90669787 | The roles of S-nitrosylation and S-glutathionylation in Alzheimer's disease |
| Q40420028 | The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. |
| Q35225936 | The structure of phosphoinositide phosphatases: Insights into substrate specificity and catalysis |
| Q38809889 | The tumor suppressor PTEN has a critical role in antiviral innate immunity |
| Q24290417 | The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation |
| Q40884595 | The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes |
| Q40789651 | The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway |
| Q24317714 | The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate |
| Q22010498 | The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region |
| Q40601438 | The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif |
| Q40892936 | Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressor |
| Q28141881 | Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN |
| Q36256326 | Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways |
| Q64970166 | USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer. |
| Q39859883 | Upregulation of PTEN involved in scorpion venom-induced apoptosis in a lymphoma cell line |
| Q34320119 | VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. |
| Q28086901 | Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research |
| Q37847813 | Voltage-sensing phosphatase: its molecular relationship with PTEN. |
| Q102320357 | WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer |
| Q37588182 | WWP2 is an E3 ubiquitin ligase for PTEN. |
| Q38098152 | When Overgrowth Bumps Into Cancer: The PTEN-Opathies |
| Q51046620 | When overgrowth bumps into cancer: the PTEN-opathies. |
| Q38973879 | miR-106b is overexpressed in medulloblastomas and interacts directly with PTEN. |
| Q93147553 | miR-486 Promotes Capan-2 Pancreatic Cancer Cell Proliferation by Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) |
| Q91945636 | miRNA-186 Improves Sepsis Induced Renal Injury Via PTEN/PI3K/AKT/P53 Pathway |
| Q39545547 | α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells |
Search more.