The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity

scientific article published on January 2000

The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1027098741
P356DOI10.1038/SJ.ONC.1203288
P698PubMed publication ID10644997
P5875ResearchGate publication ID12669552

P2093author name stringRoth RA
Tomlinson MG
Bolen JB
Nakatani K
Herbst R
Morimoto AM
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domainQ22009089
Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinaseQ24314398
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinaseQ24682825
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Regulation of phosphoinositide-specific phospholipase C isozymesQ28240477
PTEN1 is frequently mutated in primary endometrial carcinomasQ28250937
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteinsQ28569131
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndromeQ29615538
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cellsQ33586807
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathwayQ33599964
Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.Q33869038
The akt kinase: molecular determinants of oncogenicityQ36758478
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domainQ36818855
Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis.Q40939773
Inhibition of phospholipase C-gamma1 activation blocks glioma cell motility and invasion of fetal rat brain aggregatesQ40968600
Phenotypic analysis of human glioma cells expressing the MMAC1 tumor suppressor phosphataseQ40972780
Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathwayQ40986827
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.Q41063499
Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicityQ41067663
Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progressionQ41109515
Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell lineQ41491473
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.Q42824933
Germline mutations in PTEN are present in Bannayan-Zonana syndromeQ48046915
Signal transduction for proliferation of glioma cells in vitro occurs predominantly through a protein kinase C-mediated pathwayQ49111454
Lipid-Regulated Kinases: Some Common Themes at LastQ57903715
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceQ58378937
Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signalingQ77195331
Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transductionQ77686452
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)200-209
P577publication date2000-01-01
P1433published inOncogeneQ1568657
P1476titleThe MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity
P478volume19

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cites work (P2860)
Q34629975An increase in integrin-linked kinase non-canonically confers NF-κB-mediated growth advantages to gastric cancer cells by activating ERK1/2.
Q28138260Cell-substrate interactions and signaling through ILK
Q22254461Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation
Q48158087Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines.
Q36379951Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane
Q34301995ILKAP regulates ILK signaling and inhibits anchorage-independent growth
Q33762935Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.
Q35676234Integrin signaling and mammary cell function
Q34429805Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes
Q34047231Integrin-linked kinase (ILK): a "hot" therapeutic target
Q28567387Integrin-linked kinase is a positive mediator of L6 myoblast differentiation
Q40766267Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-kappa B-dependent manner
Q34792920Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties
Q35998768Integrin-linked kinase: a cancer therapeutic target unique among its ILK.
Q37409706MDA-9/syntenin is a key regulator of glioma pathogenesis
Q24673182Mechanotransduction in skeletal muscle
Q34283477Mitogenic signaling and the relationship to cell cycle regulation in astrocytomas.
Q24291184Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1.
Q36713508PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma
Q38183283Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness.
Q40837811The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9).
Q40860408The integrin-linked kinase (ILK) suppresses anoikis
Q30165214The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migration.
Q28645742The protein kinase B/Akt signalling pathway in human malignancy
Q29547402The versatility and universality of calcium signalling
Q37628723There's something about ILK.
Q36364880Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation

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